Functional aspects of the human salivary cystatins in the oral environment, Oral Diseases, vol.55, issue.3, pp.234-240, 1999. ,
DOI : 10.1111/j.1601-0825.1999.tb00307.x
Formation of salivary-mucosal pellicle: the role of transglutaminase, Biochemical Journal, vol.284, issue.2, pp.557-564, 1992. ,
DOI : 10.1042/bj2840557
Coffee and its Consumption: Benefits and Risks, Critical Reviews in Food Science and Nutrition, vol.59, issue.4, pp.363-373, 2011. ,
DOI : 10.1007/s00125-009-1311-1
Responsiveness to 6-n-Propylthiouracil (PROP) Is Associated with Salivary Levels of Two Specific Basic Proline-Rich Proteins in Humans, PLoS ONE, vol.8, issue.2, p.30962, 2012. ,
DOI : 10.1371/journal.pone.0030962.t001
Caffeine ??? an atypical drug of dependence, Drug and Alcohol Dependence, vol.51, issue.1-2, pp.199-206, 1998. ,
DOI : 10.1016/S0376-8716(98)00077-5
Salivary Protein Profiles and Sensitivity to the Bitter Taste of Caffeine, Chemical Senses, vol.37, issue.1, pp.87-95, 2012. ,
DOI : 10.1093/chemse/bjr070
URL : https://hal.archives-ouvertes.fr/hal-00723339
Caffeine Metabolism, Genetics, and Perinatal Outcomes: A Review of Exposure Assessment Considerations during Pregnancy, Annals of Epidemiology, vol.15, issue.6, pp.460-466, 2005. ,
DOI : 10.1016/j.annepidem.2004.12.011
Caffeine (1, 3, 7-trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters, Journal of Food Science, vol.4, issue.3, pp.77-87, 2010. ,
DOI : 10.1111/j.1750-3841.2010.01561.x
Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG), J Cell Sci, vol.109, pp.2013-2021, 1996. ,
Caffeine suppresses TNF-?? production via activation of the cyclic AMP/protein kinase A pathway, International Immunopharmacology, vol.4, issue.10-11, pp.1409-1417, 2004. ,
DOI : 10.1016/j.intimp.2004.06.005
Dose and time dependent effects of caffeine on superoxide release, cell survival and DNA fragmentation of alveolar macrophages from rat lung, Toxicology, vol.149, issue.2-3, pp.101-108, 2000. ,
DOI : 10.1016/S0300-483X(00)00224-9
PKC and ERK1/2 regulate amylase promoter activity during differentiation of a salivary gland cell line, Journal of Cellular Physiology, vol.177, issue.2, pp.215-225, 2000. ,
DOI : 10.1002/1097-4652(200011)185:2<215::AID-JCP6>3.0.CO;2-L
on the Proliferation of Osteoblast-Like Cells (UMR106-01), Journal of Periodontology, vol.70, issue.3, pp.283-288, 1999. ,
DOI : 10.1902/jop.1999.70.3.283
Capsaicin Induces Cystatin S-like Substances in Submandibular Saliva of the Rat, Journal of Dental Research, vol.78, issue.10, pp.1609-1616, 1999. ,
DOI : 10.1177/00220345990780100501
A Complex Relationship among Chemical Concentration, Detection Threshold, and Suprathreshold Intensity of Bitter Compounds, Chemical Senses, vol.32, issue.3, pp.245-253, 2007. ,
DOI : 10.1093/chemse/bjl052
HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase, Journal of Cellular Physiology, vol.177, issue.2, pp.353-361, 2005. ,
DOI : 10.1002/jcp.20247
Distinct Mechanisms of [Ca2+]i Oscillations in HSY and HSG Cells: Role of Ca2+ Influx and Internal Ca2+ Store Recycling, The Journal of Membrane Biology, vol.181, issue.3, pp.185-193, 2001. ,
DOI : 10.1007/s00232-001-0020-6
Matrigel improves functional properties of human submandibular salivary gland cell line, The International Journal of Biochemistry & Cell Biology, vol.43, issue.4, pp.622-631, 2011. ,
DOI : 10.1016/j.biocel.2011.01.001
Relationships between ingestion and gustatory perception of caffeine, Pharmacology Biochemistry and Behavior, vol.43, issue.2, pp.513-521, 1992. ,
DOI : 10.1016/0091-3057(92)90186-J
Salivary secretion, taste and hyposalivation, Journal of Oral Rehabilitation, vol.18, issue.10, pp.711-723, 2007. ,
DOI : 10.1111/j.1741-2358.1997.00054.x
Salivary protein profiles and taste acceptance in infants: bitterness stands out ,
Effects of caffeine on human health, Food Additives and Contaminants, vol.135, issue.1, pp.1-30, 2003. ,
DOI : 10.1007/BF02245786
Proteomic Analysis of Human Whole and Parotid Salivas Following Stimulation by Different Tastes, Journal of Proteome Research, vol.5, issue.9, pp.2474-2480, 2006. ,
DOI : 10.1021/pr060189z
Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts, Journal of Cellular Physiology, vol.40, issue.3, pp.638-651, 2011. ,
DOI : 10.1002/jcp.22388
A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sj??gren's syndrome, Arthritis & Rheumatism, vol.79, issue.10, pp.3116-3125, 2011. ,
DOI : 10.1002/art.30450
Secretory protein synthesis and constitutive (vesicular) secretion by salivary gland Glandular mechanisms of salivary secretion, pp.73-88, 1998. ,
Short-Term Modification of Human Salivary Proteome Induced by Two Bitter Tastants, Urea and Quinine, Chemosensory Perception, vol.21, issue.17, pp.133-142, 2009. ,
DOI : 10.1007/s12078-009-9048-2
Tolerance to the humoral and hemodynamic effects of caffeine in man., Journal of Clinical Investigation, vol.67, issue.4, pp.1111-1117, 1981. ,
DOI : 10.1172/JCI110124
Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix, Differentiation, vol.52, issue.3, pp.247-255, 1993. ,
DOI : 10.1111/j.1432-0436.1993.tb00637.x
Effets of Caffeine and Theophylline on the Development of Dental Caries in Rats., Biological & Pharmaceutical Bulletin, vol.23, issue.3, pp.339-343, 2000. ,
DOI : 10.1248/bpb.23.339
Caffeine does not inhibit substance P-evoked intracellular Ca2+ mobilization in rat salivary acinar cells, Am J Physiol-Cell Physiol, vol.276, pp.915-922, 1999. ,
A Neoplastic Epithelial Duct Cell Line Established From An Irradiated Human Salivary Gland, Cancer, vol.18, issue.3, pp.745-752, 1981. ,
DOI : 10.1002/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7
Acetylcholine- and caffeine-evoked repetitive transient Ca(2+)-activated K+ and C1- currents in mouse submandibular cells., The Journal of Physiology, vol.449, issue.1, pp.109-120, 1992. ,
DOI : 10.1113/jphysiol.1992.sp019077
Matrigel-induced acinar differentiation is followed by apoptosis in HSG cells, Journal of Cellular Biochemistry, vol.177, issue.1, pp.284-295, 2008. ,
DOI : 10.1002/jcb.21404
New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sj??gren's syndrome, Clinical & Experimental Immunology, vol.29, issue.1, pp.53-61, 2010. ,
DOI : 10.1111/j.1365-2249.2010.04188.x
Effect of caffeine on the secretion of peroxidase in rat submandibular gland: A study of its mechanism of action, Archives of Oral Biology, vol.54, issue.2, pp.179-184, 2009. ,
DOI : 10.1016/j.archoralbio.2008.09.009
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria, Malaria Journal, vol.10, issue.1, p.144, 2011. ,
DOI : 10.1111/j.1365-2710.2004.00568.x
A Novel Family of Mammalian Taste Receptors, Cell, vol.100, issue.6, pp.693-702, 2000. ,
DOI : 10.1016/S0092-8674(00)80705-9
Alternative methods to animal experimentation -Scientific and ethical problems. Bulletin de l'Académie Nationale de Médecine, pp.1109-1119, 1995. ,
Inhibitory effects of caffeine on contractions and calcium movement in vascular and intestinal smooth muscle, British Journal of Pharmacology, vol.225, issue.2, pp.267-274, 1988. ,
DOI : 10.1111/j.1476-5381.1988.tb11430.x
Saliva the defender of the oral cavity, Oral Diseases, vol.347, issue.1, pp.12-22, 2002. ,
DOI : 10.1034/j.1601-0825.2002.1o816.x
Review: The physiology of saliva and transfer of drugs into saliva, Forensic Science International, vol.150, issue.2-3, pp.119-131, 2005. ,
DOI : 10.1016/j.forsciint.2004.10.026
Simultaneous measurement of Ca2+ and pH by laser cytometry using fluo-3 and SNARF-1, Cytometry, vol.24, issue.2, pp.99-105, 1996. ,
DOI : 10.1002/(SICI)1097-0320(19960601)24:2<99::AID-CYTO1>3.0.CO;2-C
Immortalization of normal human salivary gland cells with duct phenotype, myoepithelial phenotype, acinar phenotype, or squamous phenotype by transfection with SV40 ori-mutant deoxyribonucleic-acid, Laboratory Investigation, vol.69, pp.24-42, 1993. ,
Taste Receptor Genes, Annual Review of Nutrition, vol.27, issue.1, pp.389-414, 2007. ,
DOI : 10.1146/annurev.nutr.26.061505.111329
Buffer systems and buffer capacity of whole mouth saliva, Journal of Dental Research, vol.79, pp.1296-1296, 2000. ,
PTC/PROP tasting: Anatomy, psychophysics, and sex effects, Physiology & Behavior, vol.56, issue.6, pp.1165-1171, 1994. ,
DOI : 10.1016/0031-9384(94)90361-1
Synergy between genetic and tissue engineering: creating an artificial salivary gland, Periodontology 2000, vol.14, issue.1, pp.218-223, 2000. ,
DOI : 10.1038/77276
Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor, Nature, vol.337, issue.6205, pp.385-386, 1989. ,
DOI : 10.1038/337385a0
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976. ,
DOI : 10.1016/0003-2697(76)90527-3
Oral Mucosal Pellicle -Adsorption and Transpeptidation of Salivary Components to, Buccal Epithelial Cells. Biochemical Journal, vol.261, pp.887-896, 1989. ,
Formation of Salivary Mucosal Pellicle -the Role of Transglutaminase, Biochemical Journal, vol.284, pp.557-564, 1992. ,
The human TAS2R16 receptor mediates bitter taste in response to ??-glucopyranosides, Nature Genetics, vol.49, issue.3, pp.397-401, 2002. ,
DOI : 10.1038/ng1014
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sj??gren's syndrome before disease onset, Immunology and Cell Biology, vol.177, issue.1, pp.81-90, 2009. ,
DOI : 10.1002/art.1780400920
Coffee and its Consumption: Benefits and Risks, Critical Reviews in Food Science and Nutrition, vol.59, issue.4, pp.363-373, 2011. ,
DOI : 10.1007/s00125-009-1311-1
Responsiveness to 6-n-Propylthiouracil (PROP) Is Associated with Salivary Levels of Two Specific Basic Proline-Rich Proteins in Humans, PLoS ONE, vol.8, issue.2, p.30962, 2012. ,
DOI : 10.1371/journal.pone.0030962.t001
Age-Dependent Modifications of the Human Salivary Secretory Protein Complex, Journal of Proteome Research, vol.8, issue.8, pp.4126-4134, 2009. ,
DOI : 10.1021/pr900212u
Taste Receptor Cells That Discriminate Between Bitter Stimuli, Science, vol.291, issue.5508, pp.1557-1560, 2001. ,
DOI : 10.1126/science.1056670
Blue silver: A very sensitive colloidal Coomassie G-250 staining for proteome analysis, ELECTROPHORESIS, vol.25, issue.9, pp.1327-1333, 2004. ,
DOI : 10.1002/elps.200305844
Xerostomia: Clinical Aspects and Treatment, Gerodontology, vol.35, issue.50, 2003. ,
DOI : 10.1089/107999099313497
The salivary gland fluid secretion mechanism. The journal of Medical Investigation, pp.192-196, 2009. ,
Selective culture of different types of human parotid gland cells. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, pp.407-414, 2011. ,
T2Rs Function as Bitter Taste Receptors, Cell, vol.100, issue.6, pp.703-711, 2000. ,
DOI : 10.1016/S0092-8674(00)80706-0
Structure-activity relations for caffeine: a comparative study of the inotropic effects of the methylxanthines, imidazoles and related compounds on the frog's heart, The Journal of Physiology, vol.242, issue.3, pp.615-634, 1974. ,
DOI : 10.1113/jphysiol.1974.sp010726
Caffeine and coffee: effects on health and cardiovascular disease, Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, vol.109, issue.2, pp.173-189, 1994. ,
DOI : 10.1016/0742-8413(94)00048-F
Salivary changes in solution pH: A source of individual differences in sour taste perception, Physiology & Behavior, vol.40, issue.2, pp.221-227, 1987. ,
DOI : 10.1016/0031-9384(87)90211-3
Bitter taste in aging: Compound-specific decline in sensitivity, Physiology & Behavior, vol.56, issue.6, pp.1237-1241, 1994. ,
DOI : 10.1016/0031-9384(94)90371-9
Caffeine -an atypical drug of dependence. Drug and Alcohol Dependence, pp.199-206, 1998. ,
The Proteomes of Human Parotid and Submandibular/Sublingual Gland Salivas Collected as the Ductal Secretions, Journal of Proteome Research, vol.7, issue.5, 1994. ,
DOI : 10.1021/pr700764j
Ingestive responses of human newborns to salty, sour, and bitter stimuli., Journal of Comparative and Physiological Psychology, vol.89, issue.8, pp.966-970, 1975. ,
DOI : 10.1037/h0077171
in Adult Human Tissues and the Developing Submandibular Gland, DNA and Cell Biology, vol.21, issue.1, pp.47-65, 2002. ,
DOI : 10.1089/10445490252810311
Drug-related taste disturbance A contributing factor in geriatric syndromes. Canadian Family Physician, pp.1142-1147 ,
Bitter taste, phytonutrients, and the consumer: a review, American Journal of Clinical Nutrition, vol.72, pp.1424-1435, 2000. ,
New Light on an Old Story:?? The Solid-State Transformation of Ammonium Cyanate into Urea, Journal of the American Chemical Society, vol.120, issue.50, pp.13274-13275, 1998. ,
DOI : 10.1021/ja983285c
An update on minor salivary gland secretions, European Journal of Oral Sciences, vol.106, issue.5, 2010. ,
DOI : 10.1111/j.1600-0722.2010.00766.x
In-Mouth Amylase Activity Can Reduce Perception of Saltiness in Starch-Thickened Foods, Journal of Agricultural and Food Chemistry, vol.54, issue.23, pp.8869-8873, 2006. ,
DOI : 10.1021/jf061607n
The Relationship between Chemical Constitution and Taste, Proceedings of the National Academy of Sciences, vol.18, issue.1, 1932. ,
DOI : 10.1073/pnas.18.1.115
secretory responses in antigranulocytes ducts and acini of submandibular glands in vitro to parasympathetic or sympathetic nerve stimulation in rats. Cell and Tissue Research, pp.117-126, 1991. ,
The molecular physiology of taste transduction, Current Opinion in Neurobiology, vol.10, issue.4, pp.519-527, 2000. ,
DOI : 10.1016/S0959-4388(00)00118-5
Quinine overdose: Review of toxicity and treatment, Clinical Cardiology, vol.62, issue.6, pp.716-718, 1988. ,
DOI : 10.1002/clc.4960111012
A comparison of bacterial aggregation induced by saliva, lysozyme, and zinc, Infection and Immunity, vol.48, pp.204-210, 1985. ,
Comparative proteomic analysis of whole saliva from chronic periodontitis patients, Journal of Proteomics, vol.73, issue.7, pp.1334-1341, 2010. ,
DOI : 10.1016/j.jprot.2010.02.018
Caffeine Metabolism, Genetics, and Perinatal Outcomes: A Review of Exposure Assessment Considerations during Pregnancy, Annals of Epidemiology, vol.15, issue.6, pp.460-466, 2005. ,
DOI : 10.1016/j.annepidem.2004.12.011
Burning Mouth Syndrome Taste and smell disorders: Rhinology and Sinusology, pp.159-169, 1997. ,
Liver cell models in in vitro toxicology, Environmental Health Perspectives, vol.106, issue.Suppl 2, pp.511-532, 1998. ,
DOI : 10.1289/ehp.98106511
The genetics of phenylthiocarbamide perception, Annals of Human Biology, vol.28, pp.111-142, 2001. ,
FAT ABSORPTION IN THE NEWBORN, Acta Paediatrica, vol.9, issue.s299, pp.17-23, 1982. ,
DOI : 10.1016/S0022-3476(79)80604-6
Calcium antagonists cause dry mouth by inhibiting resting saliva secretion, Life Sciences, vol.81, issue.8, pp.683-690, 2007. ,
DOI : 10.1016/j.lfs.2007.07.005
Caffeine (1, 3, 7-trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters, Journal of Food Science, vol.4, issue.3, pp.77-87, 2010. ,
DOI : 10.1111/j.1750-3841.2010.01561.x
Decreased Parotid Saliva Gustin/Carbonic Anhydrase VI Secretion: An Enzyme Disorder Manifested by Gustatory and Olfactory Dysfunction, The American Journal of the Medical Sciences, vol.318, issue.6, pp.380-391, 1999. ,
DOI : 10.1016/S0002-9629(15)40663-9
Albumin and Cystatin Concentrations in Saliva of Healthy-Subjects and of Patients with Gingivitis or Periodontitis, Journal of Periodontal Research, vol.28, pp.43-48 ,
Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or gustatory disturbances, Archives of Oral Biology, vol.49, issue.7, pp.515-522, 2004. ,
DOI : 10.1016/j.archoralbio.2004.01.012
Calcium induces differentiation of primary human salivary acinar cells, Journal of Cellular Physiology, vol.109, issue.1, pp.55-63, 2002. ,
DOI : 10.1002/jcp.10149
MS characterization of multiple forms of alpha-amylase in human saliva, PROTEOMICS, vol.325, issue.17, pp.4597-4607, 2005. ,
DOI : 10.1002/pmic.200401316
Salivary Protein Profiling in Type 1 Diabetes Using Two-Dimensional Electrophoresis and Mass Spectrometry, Clinical Proteomics, vol.2, issue.1-2, pp.117-127, 2006. ,
DOI : 10.1385/CP:2:1:117
Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG), Journal of Cell Science, vol.109, pp.2013-2021, 1996. ,
Anatomy, Function, and Evaluation of the Salivary Glands, Salivary Gland Disorders, pp.1-16, 2007. ,
DOI : 10.1007/978-3-540-47072-4_1
Caffeine suppresses TNF-?? production via activation of the cyclic AMP/protein kinase A pathway, International Immunopharmacology, vol.4, issue.10-11, pp.1409-1417, 2004. ,
DOI : 10.1016/j.intimp.2004.06.005
Salivary Proteomics for Oral Cancer Biomarker Discovery, Clinical Cancer Research, vol.14, issue.19, pp.6246-6252, 2008. ,
DOI : 10.1158/1078-0432.CCR-07-5037
Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjogren's syndrome, Clinical and Experimental Immunology, vol.85, issue.1, pp.148-154, 2005. ,
DOI : 10.1002/art.10407
A Review of the Salivary Proteome and Peptidome and Saliva-derived Peptide Therapeutics, International Journal of Peptide Research and Therapeutics, vol.21, issue.Spec Iss B, pp.547-564, 2007. ,
DOI : 10.1007/s10989-007-9109-9
Age and sex effects on taste of sucrose, NaCl, citric acid and caffeine, Neurobiology of Aging, vol.2, issue.4, pp.315-318, 1981. ,
DOI : 10.1016/0197-4580(81)90041-5
Chewing Gum???Facts and Fiction: a Review of Gum-Chewing and Oral Health, Critical Reviews in Oral Biology & Medicine, vol.10, issue.3, pp.405-419, 1999. ,
DOI : 10.1177/10454411990100030901
Proteomic Analysis of Salivary Acidic Proline-Rich Proteins in Human Preterm and At-Term Newborns, Journal of Proteome Research, vol.6, issue.4, pp.1371-1377, 2007. ,
DOI : 10.1021/pr060520e
Dose and time dependent effects of caffeine on superoxide release, cell survival and DNA fragmentation of alveolar macrophages from rat lung, Toxicology, vol.149, issue.2-3, pp.101-108, 2000. ,
DOI : 10.1016/S0300-483X(00)00224-9
Does caffeine intake enhance absolute levels of cognitive performance?, Psychopharmacology, vol.100, issue.1-2, pp.45-52, 1993. ,
DOI : 10.1007/BF02246949
Proteomic Analysis of Whole Human Saliva Detects Enhanced Expression of Interleukin-1 Receptor Antagonist, Thioredoxin and Lipocalin-1 in Cigarette Smokers Compared to Non-Smokers, International Journal of Molecular Sciences, vol.11, issue.11, pp.4488-4505, 2010. ,
DOI : 10.3390/ijms11114488
Benzodiazepines and caffeine: effect on daytime sleepiness, performance, and mood, Psychopharmacology, vol.76, issue.2, pp.160-167, 1990. ,
DOI : 10.1007/BF02244120
In-vitro reconstitution of three-dimensional human salivary gland tissue structures, Differentiation, vol.75, issue.4, pp.318-324, 2007. ,
DOI : 10.1111/j.1432-0436.2006.00138.x
PKC and ERK1/2 regulate amylase promoter activity during differentiation of a salivary gland cell line, Journal of Cellular Physiology, vol.177, issue.2, pp.215-225, 2000. ,
DOI : 10.1002/1097-4652(200011)185:2<215::AID-JCP6>3.0.CO;2-L
Combined effects of caffeine and prostaglandin E-2 on the proliferation of osteoblast-like cells (UMR106-01) Journal of Periodontology, pp.283-288, 1999. ,
A proteomics approach to characterizing human submandibular gland cell lines by fluorescent two-dimensional differential in-gel electrophoresis, International Journal of Molecular Medicine, vol.17, pp.253-260, 2006. ,
DOI : 10.3892/ijmm.17.2.253
Caffeine and arrhythmia, American Journal of Clinical Nutrition, vol.81, pp.539-540, 2005. ,
Capsaicin Induces Cystatin S-like Substances in Submandibular Saliva of the Rat, Journal of Dental Research, vol.78, issue.10, pp.1609-1616, 1999. ,
DOI : 10.1177/00220345990780100501
A Complex Relationship among Chemical Concentration, Detection Threshold, and Suprathreshold Intensity of Bitter Compounds, Chemical Senses, vol.32, issue.3, pp.245-253, 2007. ,
DOI : 10.1093/chemse/bjl052
Histamine H1 Receptor Induces Cytosolic Calcium Increase and Aquaporin Translocation in Human Salivary Gland Cells, Histamine H1 Receptor Induces Cytosolic Calcium Increase and Aquaporin Translocation in Human Salivary Gland Cells, pp.403-412, 2009. ,
DOI : 10.1124/jpet.109.153023
Salivary carbonic anhydrase VI and its relation to salivary flow rate and buffer capacity in pregnant and non-pregnant women, Archives of Oral Biology, vol.48, issue.8, pp.547-551, 2003. ,
DOI : 10.1016/S0003-9969(03)00096-7
Salivary carbonic anhydrase isoenzyme VI, The Journal of Physiology, vol.57, issue.suppl. 1, pp.315-320, 1999. ,
DOI : 10.1111/j.1469-7793.1999.t01-1-00315.x
Matrigel: Basement membrane matrix with biological activity, Seminars in Cancer Biology, vol.15, issue.5, pp.378-386, 2005. ,
DOI : 10.1016/j.semcancer.2005.05.004
Taste Perception in Smokers and Non-smokers, BMJ, vol.1, issue.5223, pp.384-387, 1961. ,
DOI : 10.1136/bmj.1.5223.384
A calcium channel in human submandibular duct cell line, HSG cells, not regulated by P2U purinergic receptor-mediated intracellular calcium mobilization, Archives of Oral Biology, vol.42, issue.8, pp.547-557, 1997. ,
DOI : 10.1016/S0003-9969(97)89060-7
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685, 1970. ,
DOI : 10.1038/227680a0
HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase, Journal of Cellular Physiology, vol.177, issue.2, pp.353-361, 2005. ,
DOI : 10.1002/jcp.20247
caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption. Psychosomatic Medicine, pp.320-336, 1990. ,
Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland Cells: CORRELATION WITH INITIATION AND PROPAGATION OF [Ca2+] i WAVES, Journal of Biological Chemistry, vol.272, issue.25, pp.15765-15770, 1997. ,
DOI : 10.1074/jbc.272.25.15765
Secretion of Carbonic Anhydrase Isoenzyme VI (CA VI) from Human and Rat Lingual Serous von Ebner's Glands, Journal of Histochemistry & Cytochemistry, vol.49, issue.5, pp.657-662, 2001. ,
DOI : 10.1177/002215540104900513
Assessment of caffeine exposure: Caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines, Clinical Pharmacology and Therapeutics, vol.39, issue.1, pp.54-59, 1986. ,
DOI : 10.1038/clpt.1986.10
Saliva and dental caries Advances in Dental Research, pp.40-47, 2000. ,
Inhibitory effects of autoantibodies on the muscarinic receptors in Sj??gren's syndrome, Laboratory Investigation, vol.245, issue.11, pp.1430-1438, 2004. ,
DOI : 10.1038/labinvest.3700173
In human salivary gland cells, overexpression of E2F1 overcomes an Interferon-??- and tumor necrosis factor-??-induced growth arrest but does not result in complete mitosis, Journal of Cellular Physiology, vol.85, issue.3, pp.343-350, 1997. ,
DOI : 10.1002/(SICI)1097-4652(199709)172:3<343::AID-JCP8>3.0.CO;2-O
Distinct Mechanisms of [Ca2+]i Oscillations in HSY and HSG Cells: Role of Ca2+ Influx and Internal Ca2+ Store Recycling, The Journal of Membrane Biology, vol.181, issue.3, pp.185-193, 2001. ,
DOI : 10.1007/s00232-001-0020-6
Changes in skeletal muscle heat shock proteins: Pathological significance, Frontiers in Bioscience, vol.6, issue.1, pp.12-25, 2001. ,
DOI : 10.2741/Liu
Role of streptococcus-mutans in human dental decay, 1986. ,
Urea and formamide as a mixed plasticizer for thermoplastic starch, Polymer International, vol.53, pp.1780-1785, 2004. ,
Matrigel improves functional properties of human submandibular salivary gland cell line, The International Journal of Biochemistry & Cell Biology, vol.43, issue.4, pp.622-631, 2011. ,
DOI : 10.1016/j.biocel.2011.01.001
Role of Saliva in the Maintenance of Taste Sensitivity, Critical Reviews in Oral Biology & Medicine, vol.11, issue.2, pp.216-229, 2000. ,
DOI : 10.1177/10454411000110020501
Relationships between ingestion and gustatory perception of caffeine, Pharmacology Biochemistry and Behavior, vol.43, issue.2, pp.513-521, 1992. ,
DOI : 10.1016/0091-3057(92)90186-J
Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38, BMC Genetics, vol.11, issue.1, p.60, 2010. ,
DOI : 10.1186/1471-2156-11-60
The History of Antimalarial Drugs, 2001. ,
DOI : 10.1385/1-59259-111-6:15
Antimalarial chemotherapy. Mechanism of Action, Resistance and New Directions in Drug Discovery, pp.15-25 ,
DOI : 10.1385/1592591116
Salivary secretion, taste and hyposalivation, Journal of Oral Rehabilitation, vol.18, issue.10, pp.711-723, 2007. ,
DOI : 10.1111/j.1741-2358.1997.00054.x
Elucidation of mammalian bitter taste, Reviews of Physiology Biochemistry and Pharmacology, vol.115, pp.37-72, 2005. ,
DOI : 10.1007/s10254-005-0041-0
The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors, Chemical Senses, vol.35, issue.2, pp.157-170, 2010. ,
DOI : 10.1093/chemse/bjp092
Taste Perception with Age: Generic or Specific Losses in Threshold Sensitivity to the Five Basic Tastes?, Chemical Senses, vol.26, issue.7, pp.845-860, 2001. ,
DOI : 10.1093/chemse/26.7.845
Sucrose Taste Thresholds: Age-related Differences, Journal of Gerontology, vol.37, issue.1, pp.64-69, 1982. ,
DOI : 10.1093/geronj/37.1.64
The Effects of Sialoadenectomy and Exogenous EGF on Taste Bud Morphology and Maintenance, Chemical Senses, vol.25, issue.1, pp.9-19, 2000. ,
DOI : 10.1093/chemse/25.1.9
Human infant saliva peptidome is modified with age and diet transition, Journal of Proteomics, vol.75, issue.12, pp.3665-3673, 2012. ,
DOI : 10.1016/j.jprot.2012.04.028
Saliva electrophoretic protein profiles in infants: Changes with age and impact of teeth eruption and diet transition, Archives of Oral Biology, vol.56, issue.7, pp.634-642, 2011. ,
DOI : 10.1016/j.archoralbio.2010.12.015
Correlations of oral bacterial arginine and urea catabolism with caries experience. Oral Microbiology and Immunology, pp.89-95, 2009. ,
Effects of caffeine on human health. Food Additives and Contaminants Part a-Chemistry Analysis Control Exposure & Risk Assessment, pp.1-30, 2003. ,
Variability of human saliva composition: Possible relationships with fat perception and liking, Archives of Oral Biology, vol.57, issue.5, pp.556-566, 2012. ,
DOI : 10.1016/j.archoralbio.2011.09.016
Proteomic Analysis of Human Whole and Parotid Salivas Following Stimulation by Different Tastes, Journal of Proteome Research, vol.5, issue.9, pp.2474-2480, 2006. ,
DOI : 10.1021/pr060189z
Coffee, caffeine and blood pressure: a critical review, European Journal of Clinical Nutrition, vol.53, issue.11, pp.831-839, 1999. ,
DOI : 10.1038/sj.ejcn.1600899
??-Irradiation-induced cell cycle arrest and cell death in a human submandibular gland cell line: Effect of E2F1 expression, Journal of Cellular Physiology, vol.270, issue.2, pp.264-273, 1998. ,
DOI : 10.1002/(SICI)1097-4652(199811)177:2<264::AID-JCP8>3.0.CO;2-L
Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts, Journal of Cellular Physiology, vol.40, issue.3, pp.638-651, 2011. ,
DOI : 10.1002/jcp.22388
Subcellular Redistribution and Surface Exposure of the Ro52, Ro60 and La48 Autoantigens During Apoptosis in Human Ductal Epithelial Cells: a Possible Mechanism in the Pathogenesis of Sjogren's Syndrome, Scandinavian Journal of Immunology, vol.56, issue.5, pp.456-469, 2002. ,
DOI : 10.1046/j.1365-3083.2002.01072_79.x
Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans, American Journal of Clinical Nutrition, vol.92, issue.3, pp.539-545, 2010. ,
DOI : 10.3945/ajcn.2010.29418
Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Diseases, pp.117-129, 2002. ,
The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects, The Journal of Lipid Research, vol.53, issue.3, pp.561-566, 2012. ,
DOI : 10.1194/jlr.M021873
Peptides of human gingival crevicular fluid determined by HPLC-ESI-MS, European Journal of Oral Sciences, vol.369, issue.6, pp.462-468, 2005. ,
DOI : 10.1111/j.1600-0722.2005.00246.x
Abnormal basement membrane type IV collagen ??-chain composition in labial salivary glands in Sj??gren's syndrome, Arthritis & Rheumatism, vol.72, issue.6 Pt 1, pp.938-945, 2009. ,
DOI : 10.1002/art.24388
Use of replication deficient adenoviruses to investigate the role of G proteins in Ca2+ signalling in epithelial cells, Cell Calcium, vol.24, issue.2, pp.97-103, 1998. ,
DOI : 10.1016/S0143-4160(98)90077-X
Secretory protein synthesis and constitutive (vesicular) secretion by salivary gland Glandular mechanisms of salivary secretion, pp.73-88, 1998. ,
Inter-individual variability of protein patterns in saliva of healthy adults, Journal of Proteomics, vol.72, issue.5, pp.822-830, 2009. ,
DOI : 10.1016/j.jprot.2009.05.004
Short-Term Modification of Human Salivary Proteome Induced by Two Bitter Tastants, Urea and Quinine. Chemosensory Perception, pp.133-142, 2009. ,
Proteomic Identification of Salivary Biomarkers of Type-2 Diabetes, Journal of Proteome Research, vol.8, issue.1, pp.239-245, 2009. ,
DOI : 10.1021/pr8003776
The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12, Human Molecular Genetics, vol.19, issue.21, pp.4278-4285, 2010. ,
DOI : 10.1093/hmg/ddq324
Determination of quinine in beverages, pharmaceutical preparations and urine by isotachophoresis, Journal of Chromatography A, vol.320, issue.1, pp.245-252, 1985. ,
DOI : 10.1016/S0021-9673(01)90502-3
Caffeine and Adenosine, Journal of Alzheimer's Disease, vol.20, issue.s1, pp.3-15, 2010. ,
DOI : 10.3233/JAD-2010-1379
URL : https://hal.archives-ouvertes.fr/hal-00583532
3D-structure of cells of human salivary glands as seen by SEM, Microscopy Research and Technique, vol.5, issue.1, pp.5-20, 1993. ,
DOI : 10.1002/jemt.1070260103
Utilizing the R-index measure for threshold testing in model caffeine solutions, Food Quality and Preference, vol.16, issue.4, pp.283-289, 2005. ,
DOI : 10.1016/j.foodqual.2004.05.001
Building a Tree of Knowledge: Analysis of Bitter Molecules, Chemical Senses, vol.30, issue.7, pp.547-557, 2005. ,
DOI : 10.1093/chemse/bji048
Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix, Differentiation, vol.52, issue.3, pp.247-255, 1993. ,
DOI : 10.1111/j.1432-0436.1993.tb00637.x
5- AZACYTIDINE induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone. Cancer Research, pp.4453-4459, 1987. ,
Saliva-Bacterium Interactions in Oral Microbial Ecology, Critical Reviews in Oral Biology & Medicine, vol.5, issue.3, pp.203-248, 1994. ,
DOI : 10.1177/10454411940050030201
Proposed usage of animal tissue culture terms (revised, 1978. ,
Biochemical Composition of Human Saliva in Relation To Other Mucosal Fluids, Critical Reviews in Oral Biology & Medicine, vol.6, issue.2, pp.161-175, 1995. ,
DOI : 10.1177/10454411950060020501
Taste perception of bitter compounds in young and elderly persons: Relation to lipophilicity of bitter compounds, Neurobiology of Aging, vol.15, issue.6, pp.743-750, 1994. ,
DOI : 10.1016/0197-4580(94)90057-4
Effect of protease inhibitors on the sense of taste, Nutrition, vol.15, issue.10, pp.767-772, 1999. ,
DOI : 10.1016/S0899-9007(99)00152-5
Caffeine does not inhibit substance P-evoked intracellular Ca2+ mobilization in rat salivary acinar cells, American Journal of Physiology-Cell Physiology, vol.276, pp.915-922, 1999. ,
The Human Myoepithelial Cell Exerts Antiproliferative Effects on Breast Carcinoma Cells Characterized by p21WAF1/CIP1Induction, G2/M Arrest, and Apoptosis, WAF1/CIP1) induction, G, pp.394-403, 1998. ,
DOI : 10.1006/excr.1998.4066
Gustin concentration changes relative to salivary zinc and taste in humans., Proceedings of the National Academy of Sciences of the United States of America, pp.3867-3871, 1981. ,
DOI : 10.1073/pnas.78.6.3867
Caffeine-induced contraction of rat portal vein and effects of K-depolarization, Na-removal and low temperature Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, pp.75-85, 1991. ,
A Neoplastic Epithelial Duct Cell Line Established From An Irradiated Human Salivary Gland, Cancer, vol.18, issue.3, pp.745-752, 1981. ,
DOI : 10.1002/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7
Effect of NaCl and sucrose tastants on protein composition of oral fluid analysed by SELDI-TOF-MS, Archives of Oral Biology, vol.57, issue.9, pp.1200-1210, 2012. ,
DOI : 10.1016/j.archoralbio.2012.04.004
Conformational analysis of the antimalarial agent quinine, Structural Chemistry, vol.10, issue.2, pp.95-107, 1997. ,
DOI : 10.1007/BF02262845
Expression of Truncated Transient Receptor Potential protein 1?? (Trp1??): EVIDENCE THAT THE Trp1 C TERMINUS MODULATES STORE-OPERATED Ca2+ ENTRY, Journal of Biological Chemistry, vol.275, issue.47, pp.36483-36486, 2000. ,
DOI : 10.1074/jbc.C000529200
Making Sense of Taste, Scientific American, vol.284, issue.3, pp.32-39, 2006. ,
DOI : 10.1038/scientificamerican0301-32
Interaction of Saliva and Taste, Journal of Dental Research, vol.69, issue.3, pp.838-843, 1990. ,
DOI : 10.1177/00220345900690030101
Neuroendocrine effects of caffeine in normal subjects, Clinical Pharmacology and Therapeutics, vol.36, issue.3, pp.402-407, 1984. ,
DOI : 10.1038/clpt.1984.195
Salivary Glands, Human Histology, 2 nd Ed. Saint Louis: Mosby. p, pp.188-190, 1997. ,
Oral sensitivity to fatty acids, food consumption and BMI in human subjects, British Journal of Nutrition, vol.36, issue.01, pp.145-152, 2010. ,
DOI : 10.1038/sj.ijo.0803704
Breast cancer related proteins are present in saliva and are modulated secondary to ductal carcinoma in situ of the breast. Cancer Investigation, pp.159-167, 2008. ,
Matrigel-induced acinar differentiation is followed by apoptosis in HSG cells, Journal of Cellular Biochemistry, vol.177, issue.1, pp.284-295, 2008. ,
DOI : 10.1002/jcb.21404
In Defense of the Oral Cavity: Structure, Biosynthesis, and Function of Salivary Mucins, Annual Review of Physiology, vol.57, issue.1, pp.547-564, 1995. ,
DOI : 10.1146/annurev.ph.57.030195.002555
Introduction to mammalian salivary glands, Microscopy Research and Technique, vol.70, issue.1, pp.1-4, 1993. ,
DOI : 10.1002/jemt.1070260102
Microstructure of mammalian salivary glands and its relationship to diet Glandular mechanisms of salivary secretion, pp.21-35, 1998. ,
Disposition of Caffeine and Its Metabolites in Man, Journal of Pharmacology and Experimental Therapeutics, vol.224, pp.180-185, 1983. ,
The Fms-like tyrosine kinase 3 ligand, a mediator of B cell survival, is also a marker of lymphoma in primary Sj??gren's syndrome, Arthritis & Rheumatism, vol.60, issue.11, pp.3447-3456, 2010. ,
DOI : 10.1002/art.27611
Taste sensor, Journal of the Food Hygienic Society of Japan, vol.41, pp.336-341, 2000. ,
New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sj??gren's syndrome, Clinical & Experimental Immunology, vol.29, issue.1, pp.53-61, 2010. ,
DOI : 10.1111/j.1365-2249.2010.04188.x
Understanding salivary fluid and protein secretion, Oral Diseases, vol.43, issue.1, pp.3-11, 2002. ,
DOI : 10.1034/j.1601-0825.2002.10815.x
Morphological and functional differentiation of HSG cells: Role of extracellular matrix and trpc 1, Journal of Cellular Physiology, vol.177, issue.2, pp.416-423, 2007. ,
DOI : 10.1002/jcp.21035
Function of salivary histatin 5 for bitter substances. 88 th General Session and Exhibition of the IADR (International Association for Dental Research) Effects of caffeine on cognition and mood without caffeine abstinence, Psychopharmacology, vol.119, pp.14-17, 1995. ,
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: A precautionary comment, Molecular and Cellular Endocrinology, vol.23, issue.1, pp.1-9, 1981. ,
DOI : 10.1016/0303-7207(81)90112-X
N-of-1 trials of quinine efficacy in skeletal muscle cramps of the leg, British Journal of General Practice, vol.55, pp.181-185, 2005. ,
Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects Composition of saliva in mammalia, Journal of Periodontal Research. Australian Journal of Experimental Biology and Medical Science, vol.44, issue.59, pp.636-644, 1981. ,
Growth factor regulation of the amylase promoter in a differentiating salivary acinar cell line, Journal of Cellular Physiology, vol.177, issue.4, pp.628-635, 1998. ,
DOI : 10.1002/(SICI)1097-4652(199812)177:4<628::AID-JCP13>3.0.CO;2-L
New concepts on urea transport by facilitated diffusion. Revista De Nefrologia Dialisis Y Trasplante, pp.77-84, 2007. ,