J. C. Amiard, T. Caquet, and L. Lagadic, Les biomarqueurs parmi les méthodes d'évaluation de la qualité de l'environnement., in: Utilisation de biomarqueurs pour la surveillance de la qualité de l'environnement, Lavoisier ed, 1998.

M. Bamdad, P. Brousseau, and F. Denizeau, : evidence for a new detoxication mechanism in freshwater ciliates, FEBS Letters, vol.33, issue.3, pp.389-393, 1999.
DOI : 10.1016/S0014-5793(99)00978-3

M. Bamdad, S. Reader, C. A. Grolière, J. Bohatier, and F. Denizeau, Uptake and efflux of polycyclic aromatic hydrocarbons byTetrahymena pyriformis: Evidence for a resistance mechanism, Cytometry, vol.28, issue.2, pp.170-175, 1997.
DOI : 10.1002/(SICI)1097-0320(19970601)28:2<170::AID-CYTO11>3.0.CO;2-N

E. Beaulieu, M. Demeule, J. F. Pouliot, D. A. Averill-bates, G. F. Murphy et al., P-glycoprotein of blood brain barrier: cross-reactivity of MAb C219 with a 190 kDa protein in bovine and rat isolated brain capillaries, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1233, issue.1, pp.27-32, 1995.
DOI : 10.1016/0005-2736(94)00239-L

O. Camarès, D. F. Bamdad, and M. , Tetrahymena pyriformis partial mdr1 gene for putative Pglycoprotein, 2004.

M. C. Celander, Cocktail effects on biomarker responses in fish, Aquatic Toxicology, vol.105, issue.3-4, pp.72-77, 2011.
DOI : 10.1016/j.aquatox.2011.06.002

D. Jonge, M. Van-de-vijver, B. Blust, R. Bervoets, and L. , Responses of aquatic organisms to metal pollution in a lowland river in Flanders: A comparison of diatoms and macroinvertebrates, Science of The Total Environment, vol.407, pp.615-629, 2008.

R. Dudler and M. Sidler, [11] Arabidopsis MDR genes: Molecular cloning and protein chemical aspects, Methods Enzymol, vol.292, pp.162-173, 1998.
DOI : 10.1016/S0076-6879(98)92013-4

B. J. Dutka, Foreword, in: Microscale testing in aquatic toxicology, 1998.

M. Einicker-lamas, M. M. Morales, K. Miranda, J. Garcia-abreu, A. J. Oliveira et al., P-glycoprotein-like protein contributes to cadmium resistance in Euglena gracilis, Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, vol.173, issue.7, pp.559-564, 2003.
DOI : 10.1007/s00360-003-0365-5

M. Geisler, J. J. Blakeslee, R. Bouchard, O. R. Lee, V. Vincenzetti et al., Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1, The Plant Journal, vol.304, issue.2, pp.179-194, 2005.
DOI : 10.1111/j.1365-313X.2005.02519.x

J. H. Gerlach, J. A. Endicott, P. F. Juranka, G. Henderson, F. Sarangi et al., Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance, Nature, vol.323, issue.6096, pp.485-489, 1986.
DOI : 10.1038/324485a0

D. J. Krogstad, I. Y. Gluzman, B. L. Herwaldt, P. H. Schlesinger, and T. E. Wellems, Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum, Biochemical Pharmacology, vol.43, issue.1, pp.57-62, 1992.
DOI : 10.1016/0006-2952(92)90661-2

B. Kurelec, The Multixenobiotic Resistance Mechanism in Aquatic Organisms, Critical Reviews in Toxicology, vol.85, issue.1, pp.23-43, 1992.
DOI : 10.1073/pnas.84.1.265

L. Lagadic, T. Caquet, and J. C. Amiard, Biomarqueurs en Ecotoxicologie: principes et définitions, in: Des biomarqueurs en écotoxicologie, aspects fondamentaux, pp.1-7, 1997.

J. Loncar, M. Popovic, R. Zaja, and T. Smital, Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.151, issue.2, pp.209-215, 2010.
DOI : 10.1016/j.cbpc.2009.10.009

B. Marquez and V. B. , ABC Multidrug Transporters: Target for Modulation of Drug Pharmacokinetics and Drug-Drug Interactions, Current Drug Targets, vol.12, issue.5, pp.600-620, 2011.
DOI : 10.2174/138945011795378504

A. S. Mortensen, R. J. Letcher, M. V. Cangialosi, S. Chu, and A. Arukwe, Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids, Chemosphere, vol.83, issue.8, pp.1035-1044, 2011.
DOI : 10.1016/j.chemosphere.2011.01.067

J. F. Narbonne, Historique-Fondements biologiques de l'utilisation de biomarqueurs en écotoxicologie., in: Utilisation de biomarqueurs pour la surveillance de la qualité de l'environnement, Lavoisier ed, pp.1-7, 1998.

K. Natarajan, Y. Xie, M. R. Baer, and D. D. Ross, Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance, Biochemical Pharmacology, vol.83, issue.8, pp.1084-1103, 2012.
DOI : 10.1016/j.bcp.2012.01.002

M. H. Raaijmakers, ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia, Leukemia, vol.90, issue.10, pp.2094-2102, 2007.
DOI : 10.1097/01.ASN.0000019412.87412.BC

B. Sarkadi, L. Homolya, G. Szakacs, and A. Varadi, Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System, Physiological Reviews, vol.86, issue.4, pp.1179-1236, 2006.
DOI : 10.1152/physrev.00037.2005

A. A. Soldatov, [Red blood system in fish: peculiarities of its organisation and function], Zh Evol Biokhim Fiziol, vol.41, pp.217-223, 2005.

A. Sturm, C. Ziemann, K. I. Hirsch-ernst, and H. Segner, Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss, Am J Physiol Regul Integr Comp Physiol, vol.281, pp.1119-1126, 2001.

C. Vache, O. Camares, M. C. Cardoso-ferreira, B. Dastugue, I. Creveaux et al., A POTENTIAL GENOMIC BIOMARKER FOR THE DETECTION OF POLYCYCLIC AROMATIC HYDROCARBON POLLUTANTS: MULTIDRUG RESISTANCE GENE 49 IN DROSOPHILA MELANOGASTER, Environmental Toxicology and Chemistry, vol.26, issue.7, pp.1418-1424, 2007.
DOI : 10.1897/06-552R.1

C. Vache, O. Camares, F. De-graeve, B. Dastugue, A. Meiniel et al., DROSOPHILA MELANOGASTER P-GLYCOPROTEIN: A MEMBRANE DETOXIFICATION SYSTEM TOWARD POLYCYCLIC AROMATIC HYDROCARBON POLLUTANTS, Environmental Toxicology and Chemistry, vol.25, issue.2, pp.572-580, 2006.
DOI : 10.1897/04-425.1

URL : https://hal.archives-ouvertes.fr/ineris-00962995

J. M. Van-den-elsen, D. A. Kuntz, F. J. Hoedemaeker, and D. R. Rose, Antibody C219 recognizes an alpha -helical epitope on P-glycoprotein, Proceedings of the National Academy of Sciences of the United States of America, pp.13679-13684, 1999.
DOI : 10.1073/pnas.96.24.13679

R. Van-der-oost, J. Beyer, and N. P. Vermeulen, Fish bioaccumulation and biomarkers in environmental risk assessment: a review, Environmental Toxicology and Pharmacology, vol.13, issue.2, pp.57-149, 2003.
DOI : 10.1016/S1382-6689(02)00126-6

R. Zaja, R. S. Klobucar, and T. Smital, Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line, Aquatic Toxicology, vol.81, issue.4, pp.365-376, 2007.
DOI : 10.1016/j.aquatox.2006.12.015

M. Bamdad, P. Brousseau, and F. Denizeau, : evidence for a new detoxication mechanism in freshwater ciliates, FEBS Letters, vol.33, issue.3, pp.389-393, 1999.
DOI : 10.1016/S0014-5793(99)00978-3

M. Bamdad, S. Reader, C. A. Grolière, J. Bohatier, and F. Denizeau, Uptake and efflux of polycyclic aromatic hydrocarbons byTetrahymena pyriformis: Evidence for a resistance mechanism, Cytometry, vol.28, issue.2, pp.170-175, 1997.
DOI : 10.1002/(SICI)1097-0320(19970601)28:2<170::AID-CYTO11>3.0.CO;2-N

O. Camarès, D. F. Bamdad, and M. , Tetrahymena pyriformis partial mdr1 gene for putative Pglycoprotein, 2004.

M. C. Celander, Cocktail effects on biomarker responses in fish, Aquatic Toxicology, vol.105, issue.3-4, pp.72-77, 2011.
DOI : 10.1016/j.aquatox.2011.06.002

R. Dudler and M. Sidler, [11] Arabidopsis MDR genes: Molecular cloning and protein chemical aspects, Methods Enzymol, vol.292, pp.162-173, 1998.
DOI : 10.1016/S0076-6879(98)92013-4

M. Einicker-lamas, M. M. Morales, K. Miranda, J. Garcia-abreu, A. J. Oliveira et al., P-glycoprotein-like protein contributes to cadmium resistance in Euglena gracilis, Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, vol.173, issue.7, pp.559-564, 2003.
DOI : 10.1007/s00360-003-0365-5

M. Geisler, J. J. Blakeslee, R. Bouchard, O. R. Lee, V. Vincenzetti et al., Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1, The Plant Journal, vol.304, issue.2, pp.179-194, 2005.
DOI : 10.1111/j.1365-313X.2005.02519.x

J. H. Gerlach, J. A. Endicott, P. F. Juranka, G. Henderson, F. Sarangi et al., Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance, Nature, vol.323, issue.6096, pp.485-489, 1986.
DOI : 10.1038/324485a0

D. J. Krogstad, I. Y. Gluzman, B. L. Herwaldt, P. H. Schlesinger, and T. E. Wellems, Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum, Biochemical Pharmacology, vol.43, issue.1, pp.57-62, 1992.
DOI : 10.1016/0006-2952(92)90661-2

B. Kurelec, The Multixenobiotic Resistance Mechanism in Aquatic Organisms, Critical Reviews in Toxicology, vol.85, issue.1, pp.23-43, 1992.
DOI : 10.1073/pnas.84.1.265

J. Loncar, M. Popovic, R. Zaja, and T. Smital, Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.151, issue.2, pp.209-215, 2010.
DOI : 10.1016/j.cbpc.2009.10.009

B. Marquez and V. B. , ABC Multidrug Transporters: Target for Modulation of Drug Pharmacokinetics and Drug-Drug Interactions, Current Drug Targets, vol.12, issue.5, pp.600-620, 2011.
DOI : 10.2174/138945011795378504

J. Martin, Etude hydrobiologique et piscicole du bassin versant de la Veyre aval, p.32, 2005.

A. S. Mortensen, R. J. Letcher, M. V. Cangialosi, S. Chu, and A. Arukwe, Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids, Chemosphere, vol.83, issue.8, pp.1035-1044, 2011.
DOI : 10.1016/j.chemosphere.2011.01.067

K. Natarajan, Y. Xie, M. R. Baer, and D. D. Ross, Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance, Biochemical Pharmacology, vol.83, issue.8, pp.1084-1103, 2012.
DOI : 10.1016/j.bcp.2012.01.002

T. Oberdorff, D. Pont, B. Hugueny, and D. Chessel, A probabilistic model characterizing fish assemblages of French rivers: a framework for environmental assessment, Freshwater Biology, vol.45, issue.3, pp.399-415, 2001.
DOI : 10.1046/j.1365-2427.1999.00431.x

T. Oberdorff, D. Pont, B. Hugueny, and J. Porcher, Development and validation of a fish-based index for the assessment of 'river health' in France, Freshwater Biology, vol.2, issue.9, pp.1720-1734, 2002.
DOI : 10.1046/j.1365-2427.1999.00431.x

M. H. Raaijmakers, ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia, Leukemia, vol.90, issue.10, pp.2094-2102, 2007.
DOI : 10.1097/01.ASN.0000019412.87412.BC

R. Relyea and J. Hoverman, Assessing the ecology in ecotoxicology: a review and synthesis in freshwater systems, Ecology Letters, vol.154, issue.suppl.1, pp.1157-1171, 2006.
DOI : 10.1111/j.1461-0248.2006.00966.x

B. Sarkadi, L. Homolya, G. Szakacs, and A. Varadi, Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System, Physiological Reviews, vol.86, issue.4, pp.1179-1236, 2006.
DOI : 10.1152/physrev.00037.2005

A. A. Soldatov, [Red blood system in fish: peculiarities of its organisation and function], Zh Evol Biokhim Fiziol, vol.41, pp.217-223, 2005.

A. Sturm, C. Ziemann, K. I. Hirsch-ernst, and H. Segner, Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss, Am J Physiol Regul Integr Comp Physiol, vol.281, pp.1119-1126, 2001.

C. Vache, O. Camares, M. C. Cardoso-ferreira, B. Dastugue, I. Creveaux et al., A POTENTIAL GENOMIC BIOMARKER FOR THE DETECTION OF POLYCYCLIC AROMATIC HYDROCARBON POLLUTANTS: MULTIDRUG RESISTANCE GENE 49 IN DROSOPHILA MELANOGASTER, Environmental Toxicology and Chemistry, vol.26, issue.7, pp.1418-1424, 2007.
DOI : 10.1897/06-552R.1

C. Vache, O. Camares, F. De-graeve, B. Dastugue, A. Meiniel et al., DROSOPHILA MELANOGASTER P-GLYCOPROTEIN: A MEMBRANE DETOXIFICATION SYSTEM TOWARD POLYCYCLIC AROMATIC HYDROCARBON POLLUTANTS, Environmental Toxicology and Chemistry, vol.25, issue.2, pp.572-580, 2006.
DOI : 10.1897/04-425.1

URL : https://hal.archives-ouvertes.fr/ineris-00962995

J. M. Van-den-elsen, D. A. Kuntz, F. J. Hoedemaeker, and D. R. Rose, Antibody C219 recognizes an alpha -helical epitope on P-glycoprotein, Proceedings of the National Academy of Sciences of the United States of America, pp.13679-13684, 1999.
DOI : 10.1073/pnas.96.24.13679

R. Zaja, R. S. Klobucar, and T. Smital, Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line, Aquatic Toxicology, vol.81, issue.4, pp.365-376, 2007.
DOI : 10.1016/j.aquatox.2006.12.015

A. Du, Breuchin.et.de.la.Haute.Lanterne. Reproduction. http://www.aappma-­? breuchin-­?lanterne.com/reproduction.html Dernière consultation le, pp.8-08

N. Aarab, Les Biomarqueurs chez les poissons et les bivalves, 2004.

. Agence and . De, Le SDAGE en quelques mots, Adour.Garonne, 2010.

. Agences and . De, Système d'évaluation de la qualité de l, 2003.

J. D. Allen, R. F. Brinkhuis, J. Wijnholds, and A. H. Schinkel, The Mouse Bcrp1/Mxr, Abcp Gene. Cancer Research, vol.59, pp.4237-4241, 1999.

R. Allikmets, L. M. Schriml, A. Hutchinson, V. Romano-­?spica, and M. Dean, A Human Placenta-­?specific ATP-­?Binding Cassette Gene (ABCP) on Chromosome 4q22 That Is Involved in Multidrug Resistance, Cancer Research, vol.58, pp.5337-5339, 1998.

J. C. Amiard, C. Amiard-­?triquet, S. Barka, J. Pellerin, and P. S. Rainbow, Metallothioneins in aquatic invertebrates: Their role in metal detoxification and their use as biomarkers, Aquatic Toxicology, vol.76, issue.2, pp.160-202, 2006.
DOI : 10.1016/j.aquatox.2005.08.015

J. C. Amiard, T. Caquet, and L. Lagadic, Les biomarqueurs parmi les méthodes d'évaluation de la qualité de l'environnement, Utilisation de biomarqueurs pour la surveillance de la qualité de l'environnement, L. Lagadic, T. Caquet, J.C. Amiard, and F, 1998.

C. Amiard-­?triquet and J. C. Amiard, Les biomarqueurs dans l'évaluation de l'état écologique des milieux aquatiques, 2008.

A. J. Atkinson, W. A. Colburn, V. G. Degruttola, D. L. Demets, G. J. Downing et al., Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework, Clin Pharmacol Ther, vol.69, pp.89-95, 2001.

J. L. Baglinière, La truite commune (Salmo trutta L.), son origine, son aire de repartition, ses intérêts économiques et scientifiques, 1991.

W. Bai, Z. Zhang, W. Tian, X. He, Y. Ma et al., Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism, Journal of Nanoparticle Research, vol.43, issue.3, pp.1645-1654, 2010.
DOI : 10.1007/s11051-009-9740-9

M. Bamdad, P. Brousseau, and F. Denizeau, : evidence for a new detoxication mechanism in freshwater ciliates, FEBS Letters, vol.33, issue.3, pp.389-393, 1999.
DOI : 10.1016/S0014-5793(99)00978-3

M. Bamdad, S. Reader, C. A. Grolière, J. Bohatier, and F. Denizeau, Uptake and efflux of polycyclic aromatic hydrocarbons byTetrahymena pyriformis: Evidence for a resistance mechanism, Cytometry, vol.28, issue.2, pp.170-175, 1997.
DOI : 10.1002/(SICI)1097-0320(19970601)28:2<170::AID-CYTO11>3.0.CO;2-N

D. Lafontaine, Y. Gagné, F. Blaise, C. Costan, G. Gagnon et al., Biomarkers in zebra mussels (Dreissena polymorpha) for the assessment and monitoring of water quality of the St Lawrence River (Canada), Aquatic Toxicology, vol.50, issue.1-2, pp.51-71, 2000.
DOI : 10.1016/S0166-445X(99)00094-6

M. Dean and T. Annilo, EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATES, Annual Review of Genomics and Human Genetics, vol.6, issue.1, pp.123-142, 2005.
DOI : 10.1146/annurev.genom.6.080604.162122

M. H. Depledge, The rational basis for the use of biomarkers as ecotoxicological tools, Nondestructive biomarkers in, pp.261-285, 1994.

. Directive, Directive Européenne, CECE, vol.105105, 2008.

L. A. Doyle, R. , and D. D. , Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2), Oncogene, vol.22, issue.47, pp.7340-7358, 2003.
DOI : 10.1038/sj.onc.1206938

L. A. Doyle, W. Yang, L. V. Abruzzo, T. Krogmann, Y. Gao et al., A multidrug resistance transporter from human MCF-7 breast cancer cells, Proceedings of the National Academy of Sciences of the United States of America 95, pp.15665-15670, 1998.
DOI : 10.1073/pnas.95.26.15665

R. Dudler and M. Sidler, [11] Arabidopsis MDR genes: Molecular cloning and protein chemical aspects, Methods Enzymol, vol.292, pp.162-173, 1998.
DOI : 10.1016/S0076-6879(98)92013-4

B. J. Dutka, Foreword In Microscale testing in aquatic toxicology, p.p. Boca Raton, 1998.

M. Einicker-­?lamas, M. M. Morales, K. Miranda, J. Garcia-­?abreu, A. J. Oliveira et al., P-glycoprotein-like protein contributes to cadmium resistance in Euglena gracilis, Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, vol.173, issue.7, pp.559-564, 2003.
DOI : 10.1007/s00360-003-0365-5

T. Eisenblätter, S. Hüwel, and H. Galla, Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood???brain barrier, Brain Research, vol.971, issue.2, pp.221-231, 2003.
DOI : 10.1016/S0006-8993(03)02401-6

N. A. Eufemia and D. Epel, Induction of the multixenobiotic defense mechanism (MXR), P-glycoprotein, in the mussel Mytilus californianus as a general cellular response to environmental stresses, Aquatic Toxicology, vol.49, issue.1-2, pp.89-100, 2000.
DOI : 10.1016/S0166-445X(99)00068-5

P. Flammarion, A. Devaux, and J. Garric, Marqueurs biochimiques de pollution dans les écosystèmes auqatiques continentaux. Exemples d'utilisation et perspectives pour le gestionnaire. Bulletin Français de la Pêche et Pisciculture 357, pp.209-226, 2000.

M. Geisler, J. J. Blakeslee, R. Bouchard, O. R. Lee, V. Vincenzetti et al., Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1, The Plant Journal, vol.304, issue.2, pp.179-194, 2005.
DOI : 10.1111/j.1365-313X.2005.02519.x

J. H. Gerlach, J. A. Endicott, P. F. Juranka, G. Henderson, F. Sarangi et al., Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance, Nature, vol.323, issue.6096, pp.485-489, 1986.
DOI : 10.1038/324485a0

C. Gourlay, Biodisponibilité des hydrocarbures aromatiques polycycliques dans les écosystèmes aquatiques: influence de la matière organique naturelle et anthropique, Thèse de l'Ecole National du Génie Rural, des Eaux et Forêts, 2004.
DOI : 10.1051/tsm/200704047

M. Havelková, T. Tomá?-randák, J. Blahová, J. , I. Slatinská et al., Biochemical markers for the assessment of aquatic environment contamination, Interdisciplinary Toxicology, vol.1, issue.2, pp.169-181, 2008.
DOI : 10.2478/v10102-010-0034-y

M. J. Hemmer, L. A. Courtney, and L. S. Ortego, Immunohistochemical detection of P-glycoprotein in teleost tissues using mammalian polyclonal and monoclonal antibodies, Journal of Experimental Zoology, vol.52, issue.1, pp.69-77, 1995.
DOI : 10.1002/jez.1402720109

H. Toomey, B. Epel, and D. , Multixenobiotic Resistance in Urechis caupo Embryos: Protection From Environmental Toxins, The Biological Bulletin, vol.185, issue.3, pp.355-364, 1993.
DOI : 10.2307/1542476

Z. Holló, L. Homolya, T. Hegedüs, and B. Sarkadi, Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells, FEBS Letters, vol.30, issue.1-2, pp.99-104, 1996.
DOI : 10.1016/0014-5793(96)00237-2

K. W. Hung, M. F. Suen, Y. F. Chen, H. B. Cai, Z. X. Mo et al., Detection of water toxicity using cytochrome P450 transgenic zebrafish as live biosensor: For polychlorinated biphenyls toxicity, Biosensors and Bioelectronics, vol.31, issue.1, pp.548-553, 2012.
DOI : 10.1016/j.bios.2011.10.004

S. C. Hyde, P. Emsley, M. J. Hartshorn, M. M. Mimmack, U. Gileadi et al., Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport, Nature, vol.346, issue.6282, pp.362-365, 1990.
DOI : 10.1038/346362a0

D. Jochmans, P. Leyssen, and J. Neyts, A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE, Journal of Virological Methods, vol.183, issue.2, pp.176-179, 2012.
DOI : 10.1016/j.jviromet.2012.04.011

M. E. Jönsson, K. Gao, J. A. Olsson, J. V. Goldstone, and I. Brandt, Induction patterns of new CYP1 genes in environmentally exposed rainbow trout, Aquatic Toxicology, vol.98, issue.4, pp.311-321, 2010.
DOI : 10.1016/j.aquatox.2010.03.003

R. L. Juliano, L. , and V. , A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.455, issue.1, pp.152-162, 1976.
DOI : 10.1016/0005-2736(76)90160-7

L. Lagadic, T. Caquet, and J. C. Amiard, Biomarqueurs en Ecotoxicologie: principes et définitions. Des biomarqueurs en écotoxicologie, 1997.

E. M. Leslie, R. G. Deeley, C. , and S. P. , Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense, Toxicology and Applied Pharmacology, vol.204, issue.3, pp.216-237, 2005.
DOI : 10.1016/j.taap.2004.10.012

T. Litman, T. E. Druley, W. D. Stein, and S. E. Bates, From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance, Cellular and Molecular Life Sciences, vol.58, issue.7, pp.931-959, 2001.
DOI : 10.1007/PL00000912

M. Maliepaard, G. L. Scheffer, I. F. Faneyte, M. A. Van-gastelen, A. C. Pijnenborg et al., Subcellular Localization and Distribution of the Breast Cancer Resistance Protein Transporter in Normal Human Tissues, Cancer Research, vol.61, pp.3458-3464, 2001.

A. E. Mcelroy, J. W. Farrington, and J. M. Teal, Bioavailability of polycyclic aromatic hydrocarbons in the, 1989.

J. F. Payne, A. Mathieu, W. Melvin, and L. L. Fancey, Acetylcholinesterase, an old biomarker with a new future? Field trials in association with two urban rivers and a paper mill in Newfoundland, Marine Pollution Bulletin, vol.32, issue.2, pp.225-231, 1996.
DOI : 10.1016/0025-326X(95)00112-Z

P. Phuc, T. Nhung, D. Loan, D. Chung, N. et al., Differentiating of banked human umbilical cord blood-derived mesenchymal stem cells into insulin-secreting cells, In Vitro Cellular & Developmental Biology - Animal, vol.50, issue.9, pp.54-63, 2011.
DOI : 10.1007/s11626-010-9356-5

T. Smital, R. Sauerborn, and B. K. Hackenberger, Inducibility of the P-glycoprotein transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha, Aquatic Toxicology, vol.65, issue.4, pp.443-465, 2003.
DOI : 10.1016/S0166-445X(03)00175-9

J. J. Stegeman, M. Brouwer, D. Guilio, R. T. Förlin, L. Fowler et al., Molecular responses tu environmental contamination: enzyme and protein systems as indicators of chemical exposure effect, Biomarkers Biochemical, physiological, and histological markers of anthropogenic stress, pp.253-336, 1992.

B. Stieger, M. , and P. J. , Bile acid and xenobiotic transporters in liver, Current Opinion in Cell Biology, vol.10, issue.4, pp.462-467, 1998.
DOI : 10.1016/S0955-0674(98)80059-8

A. Sturm, C. Ziemann, K. I. Hirsch-­?ernst, and H. Segner, Expression and functional activity of P-­?glycoprotein in cultured hepatocytes from Oncorhynchus mykiss, Am J Physiol Regul Integr Comp Physiol, vol.281, pp.1119-1126, 2001.

C. Vache, O. Camares, M. C. Cardoso-­?ferreira, B. Dastugue, I. Creveaux et al., A POTENTIAL GENOMIC BIOMARKER FOR THE DETECTION OF POLYCYCLIC AROMATIC HYDROCARBON POLLUTANTS: MULTIDRUG RESISTANCE GENE 49 IN DROSOPHILA MELANOGASTER, Environmental Toxicology and Chemistry, vol.26, issue.7, pp.1418-1424, 2007.
DOI : 10.1897/06-552R.1

C. Vache, O. Camares, F. De-graeve, B. Dastugue, A. Meiniel et al., DROSOPHILA MELANOGASTER P-GLYCOPROTEIN: A MEMBRANE DETOXIFICATION SYSTEM TOWARD POLYCYCLIC AROMATIC HYDROCARBON POLLUTANTS, Environmental Toxicology and Chemistry, vol.25, issue.2, 2006.
DOI : 10.1897/04-425.1

URL : https://hal.archives-ouvertes.fr/ineris-00962995

A. Valdehita, M. L. Fernandez-­?cruz, F. Torrent, J. L. Sericano, and J. M. Navas, Differences in the induction of cyp1A and related genes in cultured rainbow trout Oncorhynchus mykiss. Additional considerations for the use of EROD activity as a biomarker, Journal of Fish Biology, vol.58, issue.1, pp.270-287, 2012.
DOI : 10.1111/j.1095-8649.2012.03338.x

R. Van-der-oost, J. Beyer, and N. P. Vermeulen, Fish bioaccumulation and biomarkers in environmental risk assessment: a review, Environmental Toxicology and Pharmacology, vol.13, issue.2, pp.57-149, 2003.
DOI : 10.1016/S1382-6689(02)00126-6

J. E. Van-montfoort, B. Hagenbuch, G. M. Groothuis, H. Koepsell, P. J. Meier et al., Drug Uptake Systems in Liver and Kidney, Current Drug Metabolism, vol.4, issue.3, pp.185-211, 2003.
DOI : 10.2174/1389200033489460

M. Vasak, Advances in metallothionein structure and functions, J. Trace Elem Med Biol, 2005.

S. Velamakanni, S. L. Wei, T. Janvilisri, and H. W. Van-veen, ABCG transporters: structure, substrate specificities and physiological roles, Journal of Bioenergetics and Biomembranes, vol.7, issue.Pt 1, pp.465-471, 2007.
DOI : 10.1007/s10863-007-9122-x

W. Sr, J. P. Goodale, B. C. Wise, S. S. Craig, G. A. Pongan et al., Silver nanospheres are cytotoxic and genotoxic to fish cells, Aquatic Toxicology, vol.97, pp.34-41, 2010.

. World and . Nuclear, Association. World Nuclear Power Reactors & Uranium Requirements. http://www.world-­?nuclear.org/info/reactors.html Dernière consultation le, pp.8-08

R. Zaja, D. Caminada, J. Loncar, K. Fent, and T. Smital, Development and characterization of P-glycoprotein 1 (Pgp1, ABCB1)-mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line, Toxicology and Applied Pharmacology, vol.227, issue.2, pp.207-218, 2008.
DOI : 10.1016/j.taap.2007.11.001

R. Zaja, R. S. Klobucar, and T. Smital, Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line, Aquatic Toxicology, vol.81, issue.4, pp.365-376, 2007.
DOI : 10.1016/j.aquatox.2006.12.015

R. Zaja, V. Munic, and T. Smital, Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes, Marine Environmental Research, vol.66, issue.1, pp.77-79, 2008.
DOI : 10.1016/j.marenvres.2008.02.028