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Radiorésistance des cancers du sein : rôle majeur du marqueur de cellules souches cancéreuses CD24

Abstract : This work focuses on the characterization of radiation-resistant breast cancer cells, responsible for relapse after radiotherapy. The “Cancer Stem Cells” (CSC) theory describes a radiation-resistant cellular sub-population, with enhanced capacity to induce tumors and proliferate. In this work, we show that only the CSC marker CD24-/low defines a radiation resistant cell population, able to transmit the “memory” of irradiation, expressed as long term genomic instability in the progeny of irradiated cells. We show that CD24 is not only a marker, but is an actor of radiation-response. So, CD24 expression controls cell proliferation in vitro and in vivo, and ROS level before and after irradiation. As a result, CD24-/low cells display enhanced radiation-resistance and genomic stability. For the first time, our results attribute a role to CD24-/low CSCs in the transmission of genomic instability. Moreover, by providing informations on tumor intrinsic radiation-sensitivity, CD24- marker could help to design new radiotherapy protocols.
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https://tel.archives-ouvertes.fr/tel-00926117
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Submitted on : Thursday, January 9, 2014 - 10:27:08 AM
Last modification on : Friday, October 23, 2020 - 4:34:05 PM
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  • HAL Id : tel-00926117, version 1

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Julie Bensimon. Radiorésistance des cancers du sein : rôle majeur du marqueur de cellules souches cancéreuses CD24. Médecine humaine et pathologie. Université Paris Sud - Paris XI, 2013. Français. ⟨NNT : 2013PA11T026⟩. ⟨tel-00926117⟩

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