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Extraction de l’éponge marine Axinella donnani et synthèse d’une chimiothèque d’analogues du dispacamide A

Abstract : Pyrrole-2-aminoimidazoles (P-2-AIs) are secondary metabolites specifically encountered in marine sponges. They are mainly found in Agelasidae, Halichondridae and Axinellidae families. Thus, the chemical study of the marine sponge Axinella donnani has led to the extension of the current knowledge about the diversity of the family and a better understanding of their biogenesis. Two batches of the sponges have been studied to lead to the isolation of 29 compounds: among them six P-2-AIs new dimers, a new mazacidin molecule and a new 3,5-bromotyrosine dimer. Their structures have been determined with 1D and 2D NMR spectroscopy experiments. Their absolute configuration has also been studied with circular dichroïsm. Additionally, 29 analogues of dipacamide A have been synthetized in order to test these molecules on various biological targets.
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Julie Munoz. Extraction de l’éponge marine Axinella donnani et synthèse d’une chimiothèque d’analogues du dispacamide A. Autre. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA112245⟩. ⟨tel-00919535⟩

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