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Dynamique adaptative des virus hautement variables à un nouvel environnement réplicatif

Abstract : Struggle for resources is a worldwide rule which has been first described by Malthus and extended to whole world of living organisms by Darwin in 1859 in “Origin of species”. Today, this concept has been enlarged to virological field, and is particularly adapted to describe highly variable viruses like Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) which have a quasispecies distribution in infected patients characterized by the co-existence of a number of distinct but related viral populations. Selection pressure on viral replicative environment (immune, antiviral drug treatment…), generally lead to a redistribution of the viral quasispecies with an increasing of the best adapted minor viral variants at the expense of major viral populations. Mathematical and bioinformatic modelization of this phenomenon through 6 infected patients cohorts by means of ultra-deep sequencing and an original bioinformatic package allowed discovery, characterization and evaluation of new diagnostic markers that could be used to prevent resistance emergence to antiviral drugs and to characterized new therapeutics antiviral targets.
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Submitted on : Tuesday, December 10, 2013 - 5:36:00 PM
Last modification on : Thursday, September 1, 2022 - 11:09:39 AM
Long-term archiving on: : Friday, March 14, 2014 - 10:15:18 AM


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  • HAL Id : tel-00916824, version 1



Christophe Rodriguez. Dynamique adaptative des virus hautement variables à un nouvel environnement réplicatif. Médecine humaine et pathologie. Université Paris-Est, 2012. Français. ⟨NNT : 2012PEST0074⟩. ⟨tel-00916824⟩



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