M. Morra, D. Howie, M. Grande, J. Sayos, and N. Wang, : A Progressive Immunodeficiency, Annual Review of Immunology, vol.19, issue.1, pp.657-682, 2001.
DOI : 10.1146/annurev.immunol.19.1.657

A. Coffey, R. Brooksbank, O. Brandau, T. Oohashi, and G. Howell, Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene, Nature Genetics, vol.20, issue.2, pp.129-135, 1998.
DOI : 10.1038/2424

K. Nichols, D. Harkin, S. Levitz, M. Krainer, and K. Kolquist, Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome, Proceedings of the National Academy of Sciences, vol.95, issue.23, pp.13765-13770, 1998.
DOI : 10.1073/pnas.95.23.13765

J. Sayos, C. Wu, M. Morra, N. Wang, and X. Zhang, The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM, Nature, vol.395, issue.6701, pp.462-469, 1998.
DOI : 10.1038/26683

D. Purtilo, C. Cassel, J. Yang, and R. Harper, X-LINKED RECESSIVE PROGRESSIVE COMBINED VARIABLE IMMUNODEFICIENCY (DUNCAN'S DISEASE), The Lancet, vol.305, issue.7913, pp.935-940, 1975.
DOI : 10.1016/S0140-6736(75)92004-8

C. Detre, M. Keszei, X. Romero, G. Tsokos, and C. Terhorst, SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions, Seminars in Immunopathology, vol.206, issue.2, pp.157-171, 2010.
DOI : 10.1007/s00281-009-0193-0

C. Ma, K. Nichols, and S. Tangye, Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of Molecules, Annual Review of Immunology, vol.25, issue.1, pp.337-379, 2007.
DOI : 10.1146/annurev.immunol.25.022106.141651

P. Schwartzberg, K. Mueller, H. Qi, and J. Cannons, SLAM receptors and SAP influence lymphocyte interactions, development and function, Nature Reviews Immunology, vol.174, issue.1, pp.39-46, 2009.
DOI : 10.1038/nature05257

A. Veillette, SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors, Cold Spring Harbor Perspectives in Biology, vol.2, issue.3, p.2469, 2010.
DOI : 10.1101/cshperspect.a002469

A. Veillette, Z. Dong, L. Perez-quintero, M. Zhong, C. Munoz et al., Importance and mechanism of ???switch??? function of SAP family adapters, Immunological Reviews, vol.199, issue.1, pp.229-239, 2009.
DOI : 10.1111/j.1600-065X.2009.00824.x

L. Shlapatska, S. Mikhalap, A. Berdova, O. Zelensky, and T. Yun, CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A, The Journal of Immunology, vol.166, issue.9, pp.5480-5487, 2001.
DOI : 10.4049/jimmunol.166.9.5480

J. Cannons, J. Wu, J. Gomez-rodriguez, J. Zhang, and B. Dong, Biochemical and Genetic Evidence for a SAP-PKC-?? Interaction Contributing to IL-4 Regulation, The Journal of Immunology, vol.185, issue.5, pp.2819-2827, 2010.
DOI : 10.4049/jimmunol.0902182

A. Aruffo and B. Seed, Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system., Proceedings of the National Academy of Sciences, vol.84, issue.23, pp.8573-8577, 1987.
DOI : 10.1073/pnas.84.23.8573

C. Asseman, S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie, An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation, The Journal of Experimental Medicine, vol.155, issue.7, pp.995-1004, 1999.
DOI : 10.1084/jem.187.7.1047

B. B. Au-­?yeung, S. Deindl, L. Y. Hsu, E. H. Palacios, S. E. Levin et al., The structure, regulation, and function of ZAP-70, Immunological Reviews, vol.3, issue.1, pp.41-57, 2009.
DOI : 10.1111/j.1600-065X.2008.00753.x

S. J. Aujla, Y. R. Chan, M. Zheng, M. Fei, D. J. Askew et al., IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia, Nature Medicine, vol.99, issue.3, pp.275-281, 2008.
DOI : 10.1038/nm1710

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901867

M. Awane, P. G. Andres, D. J. Li, and H. C. Reinecker, NF-­?kappa B-­?inducing kinase is a common mediator of IL-­?17-­?, TNF-­?alpha-­?, and IL-­?1 beta-­?induced chemokine promoter activation in intestinal epithelial cells, J Immunol, vol.162, pp.5337-5344, 1999.

M. Azuma, D. Ito, H. Yagita, K. Okumura, J. H. Phillips et al., B70 antigen is a second ligand for CTLA-4 and CD28, Nature, vol.366, issue.6450, pp.76-79, 1993.
DOI : 10.1038/366076a0

R. G. Baker, C. J. Hsu, D. Lee, M. S. Jordan, J. S. Maltzman et al., The Adapter Protein SLP-76 Mediates "Outside-In" Integrin Signaling and Function in T Cells, Molecular and Cellular Biology, vol.29, issue.20, pp.5578-5589, 2009.
DOI : 10.1128/MCB.00283-09

G. A. Bentley and R. A. Mariuzza, THE STRUCTURE OF THE T CELL ANTIGEN RECEPTOR, Annual Review of Immunology, vol.14, issue.1, pp.563-590, 1996.
DOI : 10.1146/annurev.immunol.14.1.563

M. Bergman, T. Mustelin, C. Oetken, J. Partanen, N. A. Flint et al., The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-­?505 and down regulates its catalytic activity, The EMBO journal, vol.11, pp.2919-2924, 1992.

E. Bettelli, Y. Carrier, W. Gao, T. Korn, T. B. Strom et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, vol.31, issue.7090, pp.235-238, 2006.
DOI : 10.1038/nature04753

D. Cefai, Y. C. Cai, H. Hu, R. , and C. , CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: common co-signals induced by CD80 and CD86, International Immunology, vol.8, issue.10, pp.1609-1616, 1996.
DOI : 10.1093/intimm/8.10.1609

S. Cemerski, J. Das, E. Giurisato, M. A. Markiewicz, P. M. Allen et al., The Balance between T Cell Receptor Signaling and Degradation at the Center of the Immunological Synapse Is Determined by Antigen Quality, Immunity, vol.29, issue.3, pp.414-422, 2008.
DOI : 10.1016/j.immuni.2008.06.014

A. C. Chan, M. Dalton, R. Johnson, G. H. Kong, T. Wang et al., Activation of ZAP-­?70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function, The EMBO journal, vol.14, pp.2499-2508, 1995.

A. C. Chan, M. Iwashima, C. W. Turck, and A. Weiss, Zap 70, Cell, vol.71, pp.649-662, 1992.
DOI : 10.1016/B978-012324719-3/50160-6

B. Chan, A. Lanyi, H. K. Song, J. Griesbach, M. Simarro-­?grande et al., SAP couples Fyn to SLAM immune receptors, Nature Cell Biology, vol.5, issue.2, pp.155-160, 2003.
DOI : 10.1038/ncb920

M. Morra, J. Lu, F. Poy, M. Martin, J. Sayos et al., Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells, The EMBO Journal, vol.20, issue.21, pp.5840-5852, 2001.
DOI : 10.1093/emboj/20.21.5840

M. Morra, M. Simarro-­?grande, M. Martin, A. S. Chen, A. Lanyi et al., Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients, Journal of Biological Chemistry, vol.276, issue.39, pp.36809-36816, 2001.
DOI : 10.1074/jbc.M101305200

W. A. Muller, C. M. Ratti, S. L. Mcdonnell, and C. , A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions, Journal of Experimental Medicine, vol.170, issue.2, pp.399-414, 1989.
DOI : 10.1084/jem.170.2.399

W. A. Muller, S. A. Weigl, X. Deng, and D. M. Phillips, PECAM-1 is required for transendothelial migration of leukocytes, Journal of Experimental Medicine, vol.178, issue.2, pp.449-460, 1993.
DOI : 10.1084/jem.178.2.449

A. Munitz, I. Bachelet, S. Fraenkel, G. Katz, O. Mandelboim et al., 2B4 (CD244) Is Expressed and Functional on Human Eosinophils, The Journal of Immunology, vol.174, issue.1, pp.110-118, 2005.
DOI : 10.4049/jimmunol.174.1.110

S. Munro, Lipid Rafts, Cell, vol.115, issue.4, pp.377-388, 2003.
DOI : 10.1016/S0092-8674(03)00882-1

N. Nagy, C. Cerboni, K. Mattsson, A. Maeda, P. Gogolak et al., SH2D1A and slam protein expression in human lymphocytes and derived cell lines, International Journal of Cancer, vol.134, issue.3, pp.439-447, 2000.
DOI : 10.1002/1097-0215(20001101)88:3<439::AID-IJC17>3.0.CO;2-#

A. Shahinian, K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara et al., Differential T cell costimulatory requirements in CD28-deficient mice, Science, vol.261, issue.5121, pp.609-612, 1993.
DOI : 10.1126/science.7688139

R. Sharifi, J. C. Sinclair, K. C. Gilmour, P. D. Arkwright, C. Kinnon et al., SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease, Blood, vol.103, issue.10, pp.3821-3827, 2004.
DOI : 10.1182/blood-2003-09-3359

E. K. Shim, C. S. Moon, G. Y. Lee, Y. J. Ha, S. K. Chae et al., Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase, FEBS Letters, vol.270, issue.1-3, pp.35-40, 2004.
DOI : 10.1016/j.febslet.2004.07.090

Y. Shinkai, S. Koyasu, K. Nakayama, K. M. Murphy, D. Y. Loh et al., Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes, Science, vol.259, issue.5096, pp.822-825, 1993.
DOI : 10.1126/science.8430336

L. M. Shlapatska, S. V. Mikhalap, A. G. Berdova, O. M. Zelensky, T. J. Yun et al., CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A, The Journal of Immunology, vol.166, issue.9, pp.5480-5487, 2001.
DOI : 10.4049/jimmunol.166.9.5480

M. J. Shlomchik and F. Weisel, Germinal center selection and the development of memory B and plasma cells, Immunological Reviews, vol.16, issue.1, pp.52-63, 2012.
DOI : 10.1111/j.1600-065X.2012.01124.x

F. Sicheri and J. Kuriyan, Structures of Src-family tyrosine kinases, Current Opinion in Structural Biology, vol.7, issue.6, pp.777-785, 1997.
DOI : 10.1016/S0959-440X(97)80146-7

S. P. Sidorenko, C. , and E. A. , Characterization of a cell surface glycoprotein IPO-­?3, expressed on activated human B and T lymphocytes, J Immunol, vol.151, pp.4614-4624, 1993.

M. Simarro, A. Lanyi, D. Howie, F. Poy, J. Bruggeman et al., SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9, International Immunology, vol.16, issue.5, pp.727-736, 2004.
DOI : 10.1093/intimm/dxh074

S. Sivori, S. Parolini, M. Falco, E. Marcenaro, R. Biassoni et al., 2B4 functions as a co-receptor in human NK cell activation, European Journal of Immunology, vol.30, issue.3, pp.787-793, 2000.
DOI : 10.1002/1521-4141(200003)30:3<787::AID-IMMU787>3.0.CO;2-I

J. E. Smith-­?garvin, G. A. Koretzky, J. , and M. S. , T Cell Activation, Annual Review of Immunology, vol.27, issue.1, pp.591-619, 2009.
DOI : 10.1146/annurev.immunol.021908.132706

J. H. Wang, R. Meijers, Y. Xiong, J. H. Liu, T. Sakihama et al., Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule, Proceedings of the National Academy of Sciences of the United States of America 98, pp.10799-10804, 2001.
DOI : 10.1073/pnas.191124098

N. Wang, S. Calpe, J. Westcott, W. Castro, C. Ma et al., Cutting Edge: The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse, The Journal of Immunology, vol.185, issue.10, pp.5683-5687, 2010.
DOI : 10.4049/jimmunol.1001974