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Immune regulations in a Drosophila model of Alzheimer's disease

Abstract : Alzheimer’s disease (AD) is characterized by the accumulation of amyloid β (Aβ) in the brain. Several lines of evidences point towards a strong link between AD and neuroinflammation. However, the exact molecular events of the innate immune reactions against Aβ need to be elucidated. We used Drosophila as a model organism to study the impact of innate immune reactions on AD. During my PhD I have been able to: (1) establish a Drosophila model to study the inflammatory responses inAD, (2) demonstrate that the Drosophila inflammatory IMD pathway plays a neuroprotective role in the development of AD-like phenotypes, (3) generate the IMD interactome dataset that could help elucidate the mechanisms linking AD to neuroinflammation, and (4) introduce a forward genetic screen for the identification of modifier genes of AD. We believe that the outcomes from our Drosophila studies could provide the basis for new therapeutic interventions against AD.
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Élie Maksoud. Immune regulations in a Drosophila model of Alzheimer's disease. Immunology. Université de Strasbourg, 2012. English. ⟨NNT : 2012STRAJ106⟩. ⟨tel-00911811⟩

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