Skip to Main content Skip to Navigation
New interface

L'érythropoïétine : un traitement de l'oedème cérébral de l'hypoxie cérébrale post-traumatiques

Abstract : Post-traumatic brain oedema and brain hypoxia play a key role for the development of secondary ischaemic lesions. Erythopoïetin (Epo) is an anti-oedematous agent in the impact-acceleration model. However its action on brain hypoxia remains unkonwn. Neuroprotective derivatives of Epo that lack haematopoïétic properties, like carbamylated Epo (CEpo), have been developped to counter Epo side effects. In this context, our study aimed to assess the effect of Epo and CEpo on post-traumatic diffuse brain oedema and brain oxygenation. CEpo (50 µg/Kg) decreased brain oedema assessed by diffusion-weighted MRI and specific gravimetry 6 hours after the trauma. The anti-oedematous effect of CEpo was linked to Erk inhibition and was associated with an improvement of cognitive and motor functions, evaluated until 10 days after the insult. MRI using the combination of BOLD contrast and blood volume fraction measurement demonstrated a decrease of local brain oxygenation in our model, without franck ischemia (measurement of mild transit time by a first passage method). Epo (5000 UI/Kg) improved brain oxygenation by decreasing post-traumatic cerebral capillaries collapse due to astrocytic end-foot swelling. All these results demonstrated that Epo and CEpo could be seen as promising neuroprotective agents in traumatic brain injury.
Document type :
Complete list of metadata

Cited literature [246 references]  Display  Hide  Download
Contributor : ABES STAR :  Contact
Submitted on : Monday, November 18, 2013 - 3:33:07 PM
Last modification on : Friday, March 25, 2022 - 9:41:34 AM
Long-term archiving on: : Wednesday, February 19, 2014 - 11:21:12 AM


Version validated by the jury (STAR)


  • HAL Id : tel-00905688, version 1



Pierre Bouzat. L'érythropoïétine : un traitement de l'oedème cérébral de l'hypoxie cérébrale post-traumatiques. Médecine humaine et pathologie. Université de Grenoble, 2013. Français. ⟨NNT : 2013GRENS005⟩. ⟨tel-00905688⟩



Record views


Files downloads