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Etude de la voie de signalisation et du complexe TOR (Target Of Rapamycin) chez Arabidopsis

Abstract : The TOR (Target Of Rapamycin) kinase has first been identified in yeast and mammals as being part of two different protein complexes that are implicated in the stimulation of cell growth in response to endogenous and exogenous stimuli. Since the discovery of this kinase in Arabidopsis, some studies have been led to characterize its role in plants and the influence of its expression level on the metabolism and development regulation.In this study, I worked on the influence of the TOR inactivation on the composition of the ribosome on its protein composition and on the phosphorylation status of these proteins and also on the organisation of the meristem at a molecular and cellular level.Regarding to the results I have obtained, I showed that TOR may regulate the abundance and/or the phosphorylation status of some proteins involved in the ribosome composition. Hence, TOR inactivation leads to a decrease of the phosphorylation level of RPS6 proteins and could regulate the abundance of acid proteins constitutive of the ribosomal stalk, a structure important for the translation regulation. The results obtained also suggest that TOR activity may be necessary to keep the meristem functional by the regulation of the main important pathways controlling division and differentiation in that structure.
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Thomas Dobrenel. Etude de la voie de signalisation et du complexe TOR (Target Of Rapamycin) chez Arabidopsis. Sciences agricoles. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA112291⟩. ⟨tel-00880882⟩

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