Multiple endocrine neoplasia--syndromes of the twentieth century, J ,
Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic References 1 Advances in Breast Cancer: Pathways to Personalized Medicine, Clin Cancer Res, vol.14, pp.7988-99, 2008. ,
The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting, Oncogene, vol.19, pp.968-88, 2000. ,
Multiple endocrine neoplasia--syndromes of the twentieth century, J ,
Multiple endocrine neoplasia type 1 associated with multiple lipomas, Medizinische Klinik, vol.35, issue.Suppl. 2, pp.546-555, 1998. ,
DOI : 10.1007/BF03042664
Somatic Mutations of the MEN1 Tumor Suppressor Gene Detected in Sporadic Angiofibromas, Journal of Investigative Dermatology, vol.111, issue.3, pp.539-579, 1998. ,
DOI : 10.1046/j.1523-1747.1998.00317.x
In search of tumor suppressing functions of menin, Molecular and Cellular Endocrinology, vol.265, issue.266, pp.265-26634, 2007. ,
DOI : 10.1016/j.mce.2006.12.032
Menin Promotes the Wnt Signaling Pathway in Pancreatic Endocrine Cells, Molecular Cancer Research, vol.6, pp.1894-907, 2008. ,
DOI : 10.1158/1541-7786.MCR-07-2206
Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin, Mol. Cell. Biol, pp.335-344, 2009. ,
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression, Mol Cell Biol, vol.24, pp.5639-5688, 2004. ,
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors, Proceedings of the National Academy of Sciences, vol.102, issue.3, pp.749-54, 2005. ,
DOI : 10.1073/pnas.0408836102
The Multiple Endocrine Neoplasia type 1 ,
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors ,
Mutant Mice Develop a Range of Endocrine Tumors Mimicking Multiple Endocrine Neoplasia Type 1, Molecular Endocrinology, vol.17, issue.9, pp.1880-92, 2003. ,
DOI : 10.1210/me.2003-0154
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice, Cancer Res, vol.63, pp.4836-4877, 2003. ,
Cre-mediated gene deletion in the mammary gland, Nucleic Acids Research, vol.25, pp.4323-4353, 1997. ,
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues, Mol Cell Biol, vol.24, pp.3125-3156, 2004. ,
Transgenic Models to Study Actions of Prolactin ,
Signal transducer and activator of transcription 5A/B in prostate and breast cancers, Endocrine Related Cancer, vol.15, issue.2, pp.367-90, 2008. ,
DOI : 10.1677/ERC-08-0013
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis, Cancer Cell, vol.10, pp.437-486, 2006. ,
Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors, Oncogene, vol.21, pp.5548-56, 2002. ,
In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53, Transgenic Research, vol.10, issue.25, pp.471-479, 2001. ,
Transgenic mice with mammary gland targeted CHAPITRE 2 : RÉSULTATS 96 ,
Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice, Transgenic Research, vol.10, pp.545-53, 2001. ,
Increased prevalence of primary hyperparathyroidism in treated breast cancer, J Endocrinol Invest, vol.24, pp.315-335, 2001. ,
Mouse models of transforming growth factor ?? impact in breast development and cancer, Endocrine Related Cancer, vol.12, issue.4, pp.749-60, 2005. ,
DOI : 10.1677/erc.1.00936
Cadherins and catenins in breast cancer, Current Opinion in Cell Biology, vol.17, issue.5 ,
DOI : 10.1016/j.ceb.2005.08.014
??n89??-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland, The Journal of Cell Biology, vol.120, issue.3, pp.555-68, 2001. ,
DOI : 10.1074/jbc.272.40.25243
??-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland, Oncogene, vol.20, issue.37, pp.5093-5102, 2001. ,
DOI : 10.1038/sj.onc.1204586
Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias, Proceedings of the National Academy of Sciences of the United States of America, vol.99, pp.219-243, 2002. ,
Dissecting the roles of ??-catenin and cyclin D1 during mammary development and neoplasia, Proceedings of the National Academy of Sciences, vol.100, issue.20, pp.11400-11405, 2003. ,
DOI : 10.1073/pnas.1534601100
Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription, Cell, vol.96, issue.1, pp.143-152, 1999. ,
DOI : 10.1016/S0092-8674(00)80967-8
Distribution of Menin-Occupied Regions in Chromatin Specifies a Broad Role of Menin in Transcriptional Regulation, Neoplasia, vol.9, issue.2, pp.101-107, 2007. ,
DOI : 10.1593/neo.06706
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter, Proceedings of the National Academy of Sciences, vol.100, issue.19, pp.10770-10775, 2003. ,
DOI : 10.1073/pnas.1834524100
Patterns of cell signaling pathway activation that characterize mammary development, Development, vol.135, issue.14, pp.2403-2413, 2008. ,
DOI : 10.1242/dev.019018
Transgenic Models to Study Actions of Prolactin in Mammary Neoplasia, Journal of Mammary Gland Biology and Neoplasia, vol.27, issue.Suppl 2, pp.29-40, 2008. ,
DOI : 10.1007/s10911-008-9073-9
Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages, Developmental Biology, vol.332, issue.1, pp.116-130, 2009. ,
DOI : 10.1016/j.ydbio.2009.05.555
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten, Proceedings of the National Academy of Sciences, vol.101, issue.6, pp.1725-1730, 2004. ,
DOI : 10.1073/pnas.0308217100
p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors, Molecular and Cellular Biology, vol.27, issue.4, pp.1495-1504, 2007. ,
DOI : 10.1128/MCB.01764-06
p18Ink4c and Pten Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control, Molecular and Cellular Biology, vol.26, issue.12, pp.4564-4576, 2006. ,
DOI : 10.1128/MCB.00266-06
N??oplasies endocriniennes multiples. Quand et comment les rechercher??? Apports r??cents de la g??n??tique, La Revue de M??decine Interne, vol.24, issue.11, pp.721-729, 2003. ,
DOI : 10.1016/S0248-8663(03)00212-1
MEN1 Missense Mutations Impair Sensitization to Apoptosis Induced by Wild-Type Menin in Endocrine Pancreatic Tumor Cells, Gastroenterology, vol.135, issue.5, 2008. ,
DOI : 10.1053/j.gastro.2008.07.031
URL : https://hal.archives-ouvertes.fr/hal-00391951
M??llerian-inhibiting substance function during mammalian sexual development, Cell, vol.79, issue.3, pp.415-425, 1994. ,
DOI : 10.1016/0092-8674(94)90251-8
Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs, Mechanisms of Development, vol.120, issue.5, pp.549-560, 2003. ,
DOI : 10.1016/S0925-4773(03)00039-X
Mutant Mice Develop a Range of Endocrine Tumors Mimicking Multiple Endocrine Neoplasia Type 1, Molecular Endocrinology, vol.17, issue.9, pp.1880-1892, 2003. ,
DOI : 10.1210/me.2003-0154
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice, Z. Q. Cancer Res, vol.63, pp.4836-4841, 2003. ,
Roles for Nkx3.1 in prostate development and cancer, Genes & Development, vol.13, issue.8, pp.966-977, 1999. ,
DOI : 10.1101/gad.13.8.966
Activation of ??-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation, Oncogene, vol.22, issue.25, pp.3875-3887, 2003. ,
DOI : 10.1038/sj.onc.1206426
Conditional Inactivation of the Men1 Gene Leads to Pancreatic and Pituitary Tumorigenesis but Does Not Affect Normal Development of These Tissues, Molecular and Cellular Biology, vol.24, issue.8, pp.3125-3131, 2004. ,
DOI : 10.1128/MCB.24.8.3125-3131.2004
PTEN Deficiency Is Fully Penetrant for Prostate Adenocarcinoma in C57BL/6 Mice via mTOR-Dependent Growth, The American Journal of Pathology, vol.174, issue.5, pp.1869-1879, 2009. ,
DOI : 10.2353/ajpath.2009.080055
Somatic Mutations of the MEN1 Tumor Suppressor Gene Detected in Sporadic Angiofibromas, Journal of Investigative Dermatology, vol.111, issue.3, pp.539-540, 1998. ,
DOI : 10.1046/j.1523-1747.1998.00317.x
CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2, The Journal of Clinical Endocrinology & Metabolism, vol.86, issue.12, pp.5658-5671, 2001. ,
DOI : 10.1210/jcem.86.12.8070
Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice, Oncogene, vol.20, issue.51, pp.7514-7523, 2001. ,
DOI : 10.1038/sj.onc.1204929
Expression of the MEN-1 gene in a large kindred with multiple endocrine neoplasia type 1, Journal of Internal Medicine, vol.40, issue.6, pp.465-470, 1998. ,
DOI : 10.1001/archsurg.133.2.126
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1, Human Molecular Genetics, vol.13, issue.20, pp.2399-2408, 2004. ,
DOI : 10.1093/hmg/ddh271
Wnt signaling: a common theme in animal??development, Genes & Development, vol.11, issue.24, pp.3286-3305, 1997. ,
DOI : 10.1101/gad.11.24.3286
Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin, Mol. Cell. Biol, pp.335-00309, 2009. ,
The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting???, Oncogene, vol.19, issue.8, pp.968-988, 2000. ,
DOI : 10.1038/sj.onc.1203277
Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1 , Science, vol.276, issue.5311, pp.404-407, 1997. ,
DOI : 10.1126/science.276.5311.404
Clinical and Molecular Aspects of Multiple Endocrine Neoplasia Type 1, Front Horm Res, vol.28, pp.50-80, 2001. ,
DOI : 10.1159/000061047
Menin Promotes the Wnt Signaling Pathway in Pancreatic Endocrine Cells, Molecular Cancer Research, vol.6, pp.1894-1907, 2008. ,
DOI : 10.1158/1541-7786.MCR-07-2206
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression, Proceedings of the National Academy of Sciences, vol.103, issue.4, pp.1018-1023, 2006. ,
DOI : 10.1073/pnas.0510347103
Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors, Molecular and Cellular Biochemistry, vol.3, issue.1-2, pp.33-42, 2007. ,
DOI : 10.1007/s11010-007-9551-1
Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53+/- Mutant Mice, Cancer Research, vol.64, issue.6, pp.1959-1965, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-2270
The Androgen Receptor Represses Transforming Growth Factor-?? Signaling through Interaction with Smad3, Journal of Biological Chemistry, vol.277, issue.2, pp.1240-1248, 2002. ,
DOI : 10.1074/jbc.M108855200
Analysis of loss of heterozygosity on chromosome 11q13 in atypical ductal hyperplasia and in situ carcinoma of the breast, Am J Pathol, vol.150, pp.297-303, 1997. ,
Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors, Brazilian Journal of Medical and Biological Research, vol.34, issue.7, pp.861-865, 2001. ,
DOI : 10.1590/S0100-879X2001000700004
Cadherins and catenins in breast cancer, Current Opinion in Cell Biology, vol.17, issue.5, pp.499-508, 2005. ,
DOI : 10.1016/j.ceb.2005.08.014
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors, Proceedings of the National Academy of Sciences, vol.98, issue.3, pp.1118-1123, 2001. ,
DOI : 10.1073/pnas.98.3.1118
Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout, Molecular and Cellular Biology, vol.23, issue.17, pp.6075-6085, 2003. ,
DOI : 10.1128/MCB.23.17.6075-6085.2003
Prostate cancer. The Lancet, pp.1710-1721, 2008. ,
Are Patients with Multiple Endocrine Neoplasia Type I Prone to Premature Death?, World Journal of Surgery, vol.24, issue.11, pp.1437-1441, 2000. ,
DOI : 10.1007/s002680010237
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis, Cancer Cell, vol.10, issue.5, pp.437-449, 2006. ,
DOI : 10.1016/j.ccr.2006.09.013
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse, Nature Genetics, vol.27, issue.2, pp.222-224, 2001. ,
DOI : 10.1038/84879
Neuroendocrine cells of the prostate and neuroendocrine differentiation in prostatic carcinoma: a review of morphologic aspects, Urology, vol.51, pp.121-124, 1998. ,
Lethality of Multiple Endocrine Neoplasia Type I, World Journal of Surgery, vol.22, issue.6, pp.581-586, 1998. ,
DOI : 10.1007/s002689900438
Effects of genetic background on tumorigenesis inp53-deficient mice, Molecular Carcinogenesis, vol.68, issue.1, pp.16-22, 1995. ,
DOI : 10.1002/mc.2940140105
Menin Links Estrogen Receptor Activation to Histone H3K4 Trimethylation, Cancer Research, vol.66, issue.9, pp.4929-4935, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-4461
Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas, Molecular and Cellular Endocrinology, vol.313, issue.1-2, 2009. ,
DOI : 10.1016/j.mce.2009.08.020
URL : https://hal.archives-ouvertes.fr/hal-00522862
The Multiple Endocrine Neoplasia type 1 (MEN1) tumor suppressor regulates PPAR{gamma}-dependent adipocyte differentiation, Mol. Cell. Biol, pp.1001-01008, 2009. ,
Proliferation of Estrogen Receptor-??-Positive Mammary Epithelial Cells Is Restrained by Transforming Growth Factor-??1 in Adult Mice, The American Journal of Pathology, vol.167, issue.2, pp.409-417, 2005. ,
DOI : 10.1016/S0002-9440(10)62985-9
Kinase-Inactive Glycogen Synthase Kinase 3?? Promotes Wnt Signaling and Mammary Tumorigenesis, Cancer Research, vol.65, issue.13, pp.5792-5801, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-1021
Menin Localizes to Chromatin Through an ATR-CHK1 Mediated Pathway After UV-Induced DNA Damage, Journal of Surgical Research, vol.133, issue.1, pp.29-37, 2006. ,
DOI : 10.1016/j.jss.2006.02.021
Increased prevalence of primary hyperparathyroidism in treated breast cancer, Journal of Endocrinological Investigation, vol.95, issue.5, pp.315-320, 2001. ,
DOI : 10.1007/BF03343867
Analysis of p27Kip1 Expression in Insulinomas Developed in Pancreatic ??-cell Specific Men1 Mutant Mice, Familial Cancer, vol.16, issue.3, pp.49-54, 2006. ,
DOI : 10.1007/s10689-005-2575-3
Tumour suppressor menin is essential for development of the pancreatic endocrine cells, Journal of Endocrinology, vol.199, issue.2, pp.287-298, 2008. ,
DOI : 10.1677/JOE-08-0289
Effect of Conditional Knockout of the Type II TGF-?? Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis, Cancer Research, vol.65, issue.6, pp.2296-2302, 2005. ,
DOI : 10.1158/0008-5472.CAN-04-3272
Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity, Molecular and Cellular Biology, vol.20, issue.16, pp.6147-6158, 2000. ,
DOI : 10.1128/MCB.20.16.6147-6158.2000
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency, Oncogene, vol.21, issue.42, pp.6446-6457, 2002. ,
DOI : 10.1038/sj.onc.1205892
Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation, Oncogene, vol.21, issue.42, pp.6434-6445, 2002. ,
DOI : 10.1038/sj.onc.1205822
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis, Proceedings of the National Academy of Sciences, vol.101, issue.49, pp.17204-17209, 2004. ,
DOI : 10.1073/pnas.0407693101
A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis, PLoS Genetics, vol.18, issue.7, 2009. ,
DOI : 10.1371/journal.pgen.1000547.t001
Do patients with multiple endocrine neoplasia syndrome type 1 benefit from periodical screening?, European Journal of Endocrinology, vol.149, issue.6, pp.577-582, 2003. ,
DOI : 10.1530/eje.0.1490577
Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1447, issue.1, pp.51-56, 1999. ,
DOI : 10.1016/S0167-4781(99)00132-3
Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-?? Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation, The American Journal of Pathology, vol.163, issue.4, pp.1539-1549, 2003. ,
DOI : 10.1016/S0002-9440(10)63510-9
Stabilization of ??-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia, Oncogene, vol.21, issue.26, pp.4099-4107, 2002. ,
DOI : 10.1038/sj.onc.1205562
Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene, Mammalian Genome, vol.10, issue.6, pp.592-596, 1999. ,
DOI : 10.1007/s003359901051
Menin, the product of the MEN1 gene, is a nuclear protein, Proceedings of the National Academy of Sciences, vol.95, issue.4, pp.1630-1634, 1998. ,
DOI : 10.1073/pnas.95.4.1630
Role of menin in the regulation of telomerase activity in normal and cancer cells, Int J Oncol, vol.33, pp.333-340, 2008. ,
SMAD3 Represses Androgen Receptormediated Transcription, Cancer Res, vol.61, pp.2112-2118, 2001. ,
Prolactin Signaling in Mammary Gland Development, Journal of Biological Chemistry, vol.272, issue.12, pp.7567-7569, 1997. ,
DOI : 10.1074/jbc.272.12.7567
The tumor suppressor protein menin interacts with NF-??B proteins and inhibits NF-??B-mediated transactivation, Oncogene, vol.20, issue.36, pp.4917-4925, 2001. ,
DOI : 10.1038/sj.onc.1204529
Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN 1-associated pancreatic endocrine tumors, Genes, Chromosomes and Cancer, vol.57, issue.3, pp.258-264, 1999. ,
DOI : 10.1002/(SICI)1098-2264(199911)26:3<258::AID-GCC11>3.0.CO;2-2
Multiple endocrine neoplasia type 1 associated with multiple lipomas, Medizinische Klinik, vol.35, issue.Suppl. 2, pp.546-549, 1998. ,
DOI : 10.1007/BF03042664
Primary Hyperparathyroidism Associatiated with Aldosterone-Producing Adrenocortical Adenoma and Breast Cancer: Relation to MEN1 Gene, Internal Medicine, vol.43, issue.4, pp.310-314, 2004. ,
DOI : 10.2169/internalmedicine.43.310
In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53, Transgenic Research, vol.10, issue.5, pp.471-478, 2001. ,
DOI : 10.1023/A:1012064911751
Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the Hoxc8 Locus, Molecular Cell, vol.13, issue.4, pp.587-597, 2004. ,
DOI : 10.1016/S1097-2765(04)00081-4
Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis, European Journal of Cancer, vol.43, issue.2, pp.402-414, 2007. ,
DOI : 10.1016/j.ejca.2006.08.038
Deregulation of anti-Mullerian hormone/BMP and transforming growth factor-?? pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice, Endocrine Related Cancer, vol.15, issue.1, pp.217-227, 2008. ,
DOI : 10.1677/ERC-06-0046
URL : https://hal.archives-ouvertes.fr/hal-00671020
Proliferation-Associated Expression of the MEN1 Gene as Revealed by In Situ Hybridization: Possible Role of the Menin as a Negative Regulator of Cell Proliferation Under DNA Damage, Laboratory Investigation, vol.135, issue.6, pp.797-804, 2000. ,
DOI : 10.1016/0165-4608(95)98126-J
JunD-Menin Interaction Regulates c-Jun-mediated AP-1 Transactivation, Endocrine Journal, vol.51, issue.3, pp.333-342, 2004. ,
DOI : 10.1507/endocrj.51.333
??n89??-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland, The Journal of Cell Biology, vol.120, issue.3, pp.555-568, 2001. ,
DOI : 10.1074/jbc.272.40.25243
Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation, Developmental Biology, vol.324, issue.2, pp.310-319, 2008. ,
DOI : 10.1016/j.ydbio.2008.09.029
Tumor spectrum analysis in p53-mutant mice, Current Biology, vol.4, issue.1, pp.1-7, 1994. ,
DOI : 10.1016/S0960-9822(00)00002-6
A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development, Oncogene, vol.19, issue.8, pp.1052-1058, 2000. ,
DOI : 10.1038/sj.onc.1203270
Menin associates with FANCD2, a protein involved in repair of DNA damage, Cancer Res, vol.63, pp.4204-4210, 2003. ,
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer, Nature Genetics, vol.29, issue.4, pp.418-425, 2001. ,
DOI : 10.1038/ng747
Cell cycle regulation of menin expression, Cancer Res, vol.59, pp.5097-5101, 1999. ,
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type ?? signaling, Proceedings of the National Academy of Sciences, vol.98, issue.7, pp.3837-3842, 2001. ,
DOI : 10.1073/pnas.061358098
Differential Modulation of Androgen Receptor-mediated Transactivation by Smad3 and Tumor Suppressor Smad4, Journal of Biological Chemistry, vol.277, issue.46, pp.43749-43756, 2002. ,
DOI : 10.1074/jbc.M205603200
Menin Controls Growth of Pancreatic ??-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus, Science, vol.318, issue.5851, pp.806-809, 2007. ,
DOI : 10.1126/science.1146812
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c, Proceedings of the National Academy of Sciences, vol.102, issue.41, pp.14659-14664, 2005. ,
DOI : 10.1073/pnas.0503484102
Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A- histone deacetylase complex, Cancer Res, vol.63, pp.6135-6139, 2003. ,
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis, Proceedings of the National Academy of Sciences of the United States of America, pp.2884-2889, 2002. ,
DOI : 10.1073/pnas.042688999
Stable overexpression of MEN1 suppresses tumorigenicity of RAS, Oncogene, vol.18, issue.43, pp.5936-5942, 1999. ,
DOI : 10.1038/sj.onc.1203005
Characterization of DNA damage-dependent cell cycle checkpoints in a menin-deficient model, DNA Repair, vol.8, issue.8, pp.944-952, 2009. ,
DOI : 10.1016/j.dnarep.2009.06.001
Development of Spontaneous Mammary Tumors in BALB/c p53 Heterozygous Mice, The American Journal of Pathology, vol.157, issue.6, pp.2151-2159, 2000. ,
DOI : 10.1016/S0002-9440(10)64853-5
Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis, PLoS Genetics, vol.4, issue.2, 2009. ,
DOI : 10.1371/journal.pgen.1000367.s010
Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression, Oncogene, vol.114, issue.25, pp.3537-3546, 2006. ,
DOI : 10.1038/sj.onc.1209400
Direct Binding of DNA by Tumor Suppressor Menin, Journal of Biological Chemistry, vol.279, issue.47, pp.49045-49054, 2004. ,
DOI : 10.1074/jbc.M409358200
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1, Journal of Biological Chemistry, vol.282, issue.43, pp.31332-31340, 2007. ,
DOI : 10.1074/jbc.M609555200
Activin Inhibits Pituitary Prolactin Expression and Cell Growth through Smads, Pit-1 and Menin, Molecular Endocrinology, vol.18, issue.6, pp.1558-1569, 2004. ,
DOI : 10.1210/me.2003-0470
Protein kinase CK2 in mammary gland tumorigenesis, Oncogene, vol.20, issue.25, pp.3247-3257, 2001. ,
DOI : 10.1038/sj.onc.1204411
Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice, Oncogene, vol.15, issue.18, pp.2133-2144, 1997. ,
DOI : 10.1038/sj.onc.1201593
Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis, The EMBO Journal, vol.19, issue.13, pp.3496-3506, 2000. ,
DOI : 10.1093/emboj/19.13.3496
Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice., Proceedings of the National Academy of Sciences, vol.92, issue.6, pp.2268-2272, 1995. ,
DOI : 10.1073/pnas.92.6.2268
A novel MEN1 intronic mutation associated with multiple endocrine neoplasia type 1, Clinical Endocrinology, vol.42, issue.5, pp.709-713, 2007. ,
DOI : 10.1210/en.2004-0865
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland, Development, vol.129, pp.4159-4170, 2002. ,
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice, Development, vol.130, issue.24, pp.6143-6153, 2003. ,
DOI : 10.1242/dev.00820
Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism, Cancer Res, vol.63, pp.8022-8028, 2003. ,
Somatic Mutation of p53 Leads to Estrogen Receptor ??-Positive and -Negative Mouse Mammary Tumors with High Frequency of Metastasis, Cancer Research, vol.64, issue.10, pp.3525-3532, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-3524
Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase, Cell, vol.113, issue.7, pp.881-889, 2003. ,
DOI : 10.1016/S0092-8674(03)00430-6
URL : http://doi.org/10.1016/s0092-8674(03)00430-6
Is the Achilles??? Heel for Prostate Cancer Therapy a Gain of Function in Androgen Receptor Signaling?, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.7, pp.2972-2982, 2003. ,
DOI : 10.1210/jc.2002-022038
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer, Proceedings of the National Academy of Sciences, vol.104, issue.29, pp.12111-12116, 2007. ,
DOI : 10.1073/pnas.0702969104
Targeted Overexpression of Vav3 Oncogene in Prostatic Epithelium Induces Nonbacterial Prostatitis and Prostate Cancer, Cancer Research, vol.68, issue.15, pp.6396-6406, 2008. ,
DOI : 10.1158/0008-5472.CAN-08-0645
Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1, International Journal of Cancer, vol.86, issue.2, pp.259-267, 2007. ,
DOI : 10.1002/ijc.22288
Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients, Cancer Res, vol.56, pp.5272-5278, 1996. ,
Tumorigenesis in mice carrying a truncating Brca1 mutation, Genes & Development, vol.15, issue.10, pp.1188-1193, 2001. ,
DOI : 10.1101/gad.879201
Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice, Oncogene, vol.20, issue.30, pp.3937-3948, 2001. ,
DOI : 10.1038/sj.onc.1204512
Role of p27 in prostate carcinogenesis, Cancer and Metastasis Reviews, vol.17, issue.4, pp.337-344, 1998. ,
DOI : 10.1023/A:1006133620914
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors, Blood, vol.113, issue.8, pp.1661-1669, 2009. ,
DOI : 10.1182/blood-2008-01-135012
A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression, Cancer Cell, vol.14, issue.2, pp.146-155, 2008. ,
DOI : 10.1016/j.ccr.2008.06.002
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model, Proceedings of the National Academy of Sciences of the United States of America, pp.7841-7846, 2003. ,
DOI : 10.1073/pnas.1232229100
17-??-estradiol inhibits transforming-growth-factor-??-induced MCF-7 cell migration by Smad3-repression, European Journal of Pharmacology, vol.534, issue.1-3, pp.39-47, 2006. ,
DOI : 10.1016/j.ejphar.2006.01.025
MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair, DNA Repair, vol.7, issue.3, pp.476-486, 2008. ,
DOI : 10.1016/j.dnarep.2007.12.009
Multiple endocrine neoplasia type 1, Orphanet Journal of Rare Diseases, vol.1, issue.1, p.38, 2006. ,
DOI : 10.1186/1750-1172-1-38
TGFbeta in Cancer, pp.215-230, 2008. ,
Smad transcription factors, Genes & Development, vol.19, issue.23, pp.2783-2810, 2005. ,
DOI : 10.1101/gad.1350705
Synergistic effects of inhibins and mullerian-inhibiting substance on testicular tumorigenesis, Mol Endocrinol, vol.9, pp.1337-1345, 1995. ,
Conditional deletion of the <I>Lkb1</I> gene in the mouse mammary gland induces tumour formation, The Journal of Pathology, vol.9999, 2009. ,
A mouse model of basal-like breast carcinoma with metaplastic elements, The Journal of Pathology, vol.20, issue.4, pp.389-398, 2007. ,
DOI : 10.1002/path.2124
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes, Human Molecular Genetics, vol.14, issue.15, pp.2209-2219, 2005. ,
DOI : 10.1093/hmg/ddi225
Somatostatin stimulates menin gene expression by inhibiting protein kinase A, AJP: Gastrointestinal and Liver Physiology, vol.295, issue.4, pp.843-854, 2008. ,
DOI : 10.1152/ajpgi.00607.2007
??-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland, Oncogene, vol.20, issue.37, pp.5093-5099, 2001. ,
DOI : 10.1038/sj.onc.1204586
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors, Proceedings of the National Academy of Sciences, vol.102, issue.3, pp.749-754, 2005. ,
DOI : 10.1073/pnas.0408836102
Genetic analysis of the Mullerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation., Genes & Development, vol.10, issue.20, pp.2577-2587, 1996. ,
DOI : 10.1101/gad.10.20.2577
Activation of different Wnt/??-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors, Oncogene, vol.21, issue.36, pp.5548-5556, 2002. ,
DOI : 10.1038/sj.onc.1205686
Activation of ??-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias, Proceedings of the National Academy of Sciences of the United States of America, pp.219-224, 2002. ,
DOI : 10.1073/pnas.012414099
Menin Suppresses Osteoblast Differentiation by Antagonizing the AP-1 Factor, JunD, Journal of Biological Chemistry, vol.280, issue.6, pp.4785-4791, 2005. ,
DOI : 10.1074/jbc.M408143200
Expression and Functional Analysis of Menin in a Multiple Endocrine Neoplasia Type 1 (MEN1) Patient with Somatic Loss of Heterozygosity in Chromosome 11q13 and Unidentified Germline Mutation of the MEN1 Gene, Endocrine, vol.29, issue.3, pp.485-490, 2006. ,
DOI : 10.1385/ENDO:29:3:485
The multiple endocrine neoplasia type 1 gene product, menin, inhibits the human prolactin promoter activity, Journal of Molecular Endocrinology, vol.29, issue.3, pp.297-304, 2002. ,
DOI : 10.1677/jme.0.0290297
BRCA1 and BRCA2: 1994 and beyond, Nature Reviews Cancer, vol.14, issue.9, pp.665-676, 2004. ,
DOI : 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.3.CO;2-2
The association between primary hyperparathyroidism and malignancy: nationwide cohort analysis on cancer incidence after parathyroidectomy, Endocrine Related Cancer, vol.14, issue.1, pp.135-140, 2007. ,
DOI : 10.1677/erc.1.01261
Menin, a Gene Product Responsible for Multiple Endocrine Neoplasia Type 1, Interacts with the Putative Tumor Metastasis Suppressor nm23, Biochemical and Biophysical Research Communications, vol.282, issue.5, pp.1206-1210, 2001. ,
DOI : 10.1006/bbrc.2001.4723
Advances in Breast Cancer: Pathways to Personalized Medicine, Clinical Cancer Research, vol.14, issue.24, pp.7988-7999, 2008. ,
DOI : 10.1158/1078-0432.CCR-08-1211
An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature, Breast Cancer Research and Treatment, vol.6, issue.5, 2008. ,
DOI : 10.1007/s10549-008-0056-8
Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse, Cancer Research, vol.68, issue.7, pp.2223-2232, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-5169
CDK Inhibitor p18INK4c Is a Downstream Target of GATA3 and Restrains Mammary Luminal Progenitor Cell Proliferation and Tumorigenesis, Cancer Cell, vol.15, issue.5, pp.389-401, 2009. ,
DOI : 10.1016/j.ccr.2009.03.004
p18Ink4c Collaborates with Men1 to Constrain Lung Stem Cell Expansion and Suppress Non-Small-Cell Lung Cancers, Cancer Research, vol.67, issue.7, pp.3162-3170, 2007. ,
DOI : 10.1158/0008-5472.CAN-06-4517
Multiple endocrine neoplasia type 1, European Journal of Internal Medicine, vol.19, issue.2, pp.99-103, 2008. ,
DOI : 10.1016/j.ejim.2007.08.004
Reduction of Menin Expression Enhances Cell Proliferation and Is Tumorigenic in Intestinal Epithelial Cells, Journal of Biological Chemistry, vol.279, issue.23, pp.24477-24484, 2004. ,
DOI : 10.1074/jbc.M401835200
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma, Proceedings of the National Academy of Sciences, vol.105, issue.7, pp.2521-2526, 2008. ,
DOI : 10.1073/pnas.0712021105
URL : https://hal.archives-ouvertes.fr/hal-00282559
Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110?? Predisposes Mammary Glands to Neoplastic Transformation, Cancer Research, vol.68, issue.23, pp.9643-9653, 2008. ,
DOI : 10.1158/0008-5472.CAN-08-1539
An atlas of mouse mammary gland development, Journal of Mammary Gland Biology and Neoplasia, vol.5, issue.2, pp.227-241, 2000. ,
DOI : 10.1023/A:1026499523505
Dissecting the roles of ??-catenin and cyclin D1 during mammary development and neoplasia, Proceedings of the National Academy of Sciences of the United States of America, pp.11400-11405, 2003. ,
DOI : 10.1073/pnas.1534601100
The Multiple Endocrine Neoplasia Type 1 Gene Product, Menin, Inhibits Insulin Production in Rat Insulinoma Cells, Endocrinology, vol.143, issue.6, pp.2437-2440, 2002. ,
DOI : 10.1210/endo.143.6.8950
Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1, Mammalian Genome, vol.57, issue.11, pp.872-877, 2004. ,
DOI : 10.1007/s00335-004-2395-z
Genome-Wide Analysis of Menin Binding Provides Insights into MEN1 Tumorigenesis, PLoS Genetics, vol.31, issue.4, p.51, 2006. ,
DOI : 10.1371/journal.pgen.0020051.sg001
Mutation of Tumor Suppressor Gene Men1 Acutely Enhances Proliferation of Pancreatic Islet Cells, Cancer Research, vol.66, issue.11, pp.5707-5715, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-4518
Functional Interaction between Tumor Suppressor Menin and Activator of S-Phase Kinase, Cancer Research, vol.64, issue.18, pp.6791-6796, 2004. ,
DOI : 10.1158/0008-5472.CAN-04-0724
Menin Induces Apoptosis in Murine Embryonic Fibroblasts, Journal of Biological Chemistry, vol.279, issue.11, pp.10685-10691, 2004. ,
DOI : 10.1074/jbc.M308073200
Mouse models of transforming growth factor ?? impact in breast development and cancer, Endocrine Related Cancer, vol.12, issue.4, pp.749-760, 2005. ,
DOI : 10.1677/erc.1.00936
Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee, Cancer Research, vol.64, issue.6, pp.2270-2305, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-0946
CDK inhibitors: positive and negative regulators of G1-phase progression, Genes & Development, vol.13, issue.12, pp.1501-1512, 1999. ,
DOI : 10.1101/gad.13.12.1501
Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast Lineage, Journal of Biological Chemistry, vol.278, issue.23, pp.21058-21069, 2003. ,
DOI : 10.1074/jbc.M302044200
Menin Is Required for Bone Morphogenetic Protein 2- and Transforming Growth Factor ??-regulated Osteoblastic Differentiation through Interaction with Smads and Runx2, Journal of Biological Chemistry, vol.279, issue.39, pp.40267-40275, 2004. ,
DOI : 10.1074/jbc.M401312200
Menin Inactivation Leads to Loss of Transforming Growth Factor ?? Inhibition of Parathyroid Cell Proliferation and Parathyroid Hormone Secretion, Cancer Research, vol.64, issue.6, pp.2222-2228, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-3334
Transfection of the Multiple Endocrine Neoplasia Type 1 Gene to a Human Endocrine Pancreatic Tumor Cell Line Inhibits Cell Growth and Affects Expression of JunD, ??-Like Protein 1/Preadipocyte Factor-1, Proliferating Cell Nuclear Antigen, and QM/Jif-1, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.5, pp.2326-2337, 2004. ,
DOI : 10.1210/jc.2003-031228
High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten+/-Mice, Cancer Res, vol.60, pp.3605-3611, 2000. ,
Characterization of the mouse Men1 gene and its expression during development, Oncogene, vol.17, issue.19, pp.2485-2493, 1998. ,
DOI : 10.1038/sj.onc.1202164
The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene, Molecular and Cellular Biology, vol.23, issue.2, pp.493-509, 2003. ,
DOI : 10.1128/MCB.23.2.493-509.2003
Liver-derived IGF1 enhances the androgenic response in prostate, Journal of Endocrinology, vol.199, issue.3, pp.489-497, 2008. ,
DOI : 10.1677/JOE-08-0406
Signal transducer and activator of transcription 5A/B in prostate and breast cancers, Endocrine Related Cancer, vol.15, issue.2, pp.367-390, 2008. ,
DOI : 10.1677/ERC-08-0013
MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors, PLoS ONE, vol.4, 2009. ,
Multiple endocrine neoplasia--syndromes of the twentieth century, J Clin Endocrinol Metab, vol.83, pp.2617-2620, 1998. ,
Relation between menin expression and NF-??B activity in an intestinal cell line, Molecular and Cellular Endocrinology, vol.291, issue.1-2, pp.109-115, 2008. ,
DOI : 10.1016/j.mce.2008.05.019
Multiple loci identified in a genome-wide association study of prostate cancer, Nature Genetics, vol.95, issue.3, pp.310-315, 2008. ,
DOI : 10.1210/jc.86.4.1801
Chromosomal instability in multiple endocrine neoplasia type 1 cytogenetic evaluation with DEB test, Cancer Genetics and Cytogenetics, vol.79, issue.2, pp.123-126, 1995. ,
DOI : 10.1016/0165-4608(95)98126-J
Pten Dose Dictates Cancer Progression in the Prostate, PLoS Biology, vol.101, issue.3, p.59, 2003. ,
DOI : 10.1371/journal.pbio.0000059.g006
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice, Cell, vol.55, issue.4, pp.619-625, 1988. ,
DOI : 10.1016/0092-8674(88)90220-6
Zone-Dependent Expression of Estrogen Receptors ?? and ?? in Human Benign Prostatic Hyperplasia, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.3, pp.1333-1340, 2003. ,
DOI : 10.1210/jc.2002-021015
Microsatellite instability and loss of heterozygosity at the MEN1 locus in lung carcinoid tumors: A novel approach using real-time PCR with melting curve analysis in histopathologic material, Oncology Reports, vol.15, pp.557-564, 2006. ,
DOI : 10.3892/or.15.3.557
Transgenic mice with mammary gland targeted expression of human cortactin do not develop (premalignant ) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice, BMC Cancer, vol.6, 2006. ,
Pituitary Disease in MEN Type 1 (MEN1): Data from the France-Belgium MEN1 Multicenter Study, Journal of Clinical Endocrinology & Metabolism, vol.87, issue.2, pp.457-465, 2002. ,
DOI : 10.1210/jc.87.2.457
Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation, European Journal of Endocrinology, vol.157, issue.3, pp.285-294, 2007. ,
DOI : 10.1530/EJE-07-0195
Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice, Transgenic Research, vol.10, issue.6, pp.545-553, 2001. ,
DOI : 10.1023/A:1013063514007
Cre-mediated gene deletion in the mammary gland, Nucleic Acids Research, vol.25, issue.21, pp.4323-4330, 1997. ,
DOI : 10.1093/nar/25.21.4323
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer, Cancer Cell, vol.4, issue.3, pp.209-221, 2003. ,
DOI : 10.1016/S1535-6108(03)00215-0
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic
mice, Nature, vol.369, issue.6482, pp.669-671, 1994. ,
DOI : 10.1038/369669a0
Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues, International Journal of Cancer, vol.16, issue.6, pp.877-881, 2000. ,
DOI : 10.1002/(SICI)1097-0215(20000315)85:6<877::AID-IJC23>3.0.CO;2-F
in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein, Human Mutation, vol.85, issue.1, pp.35-47, 2002. ,
DOI : 10.1002/humu.10092
Diagnostic Utility of Immunohistochemical Staining for p63, a Sensitive Marker of Prostatic Basal Cells, Modern Pathology, vol.15, issue.12, pp.1302-1308, 2002. ,
DOI : 10.1097/01.MP.0000038460.95912.6E
Smad4 as a Transcription Corepressor for Estrogen Receptor ??, Journal of Biological Chemistry, vol.278, issue.17, pp.15192-15200, 2003. ,
DOI : 10.1074/jbc.M212332200
Menin Missense Mutants Associated with Multiple Endocrine Neoplasia Type 1 Are Rapidly Degraded via the Ubiquitin-Proteasome Pathway, Molecular and Cellular Biology, vol.24, issue.15, pp.6569-6580, 2004. ,
DOI : 10.1128/MCB.24.15.6569-6580.2004
Menin, the Multiple Endocrine Neoplasia Type 1 Gene Product, Exhibits GTP-hydrolyzing Activity in the Presence of the Tumor Metastasis Suppressor nm23, Journal of Biological Chemistry, vol.277, issue.41, pp.38197-38204, 2002. ,
DOI : 10.1074/jbc.M204132200
Menin interacts with IQGAP1 to enhance intercellular adhesion of ??-cells, Oncogene, vol.123, issue.7, pp.973-982, 2009. ,
DOI : 10.1038/onc.2008.435
In search of tumor suppressing functions of menin, Molecular and Cellular Endocrinology, vol.265, issue.266, pp.265-266, 2007. ,
DOI : 10.1016/j.mce.2006.12.032
Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes, Cancer Cell, vol.14, issue.1, pp.36-46, 2008. ,
DOI : 10.1016/j.ccr.2008.05.003
The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis, Cell, vol.123, issue.2, pp.207-218, 2005. ,
DOI : 10.1016/j.cell.2005.09.025
Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression, Molecular and Cellular Biology, vol.24, issue.13, pp.5639-5649, 2004. ,
DOI : 10.1128/MCB.24.13.5639-5649.2004
Cooperation between FGF8b Overexpression and PTEN Deficiency in Prostate Tumorigenesis, Cancer Research, vol.66, issue.4, pp.2188-2194, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-3440