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Méthodologie d'extraction et d'analyse de réseaux de régulation de gènes : analyse de la réponse transcriptionnelle à l'irradiation chez S. cerevisiæ

Abstract : The cellular response to the DNA damage provoked by irradiation (IR) is relatively well studied, however, many observations show the involvement of the expression of many genes. We propose to identify the different potential patterns of the transcriptional response to IR and to reconstruct a gene regulatory network involved in its control. The first point of this work lies in the exploitation of the gene expression dynamics in conditions of genetic perturbations. The second point lies in the integration of systemic biological informations. We define an approach composed of one step of automated logical deduction of regulations from a strategy of perturbations and two induction steps that allow the analysis of the gene expression dynamics and the extraction of potential regulation from additional data. This approach allowed to identify, for the yeast, a complex response to IR and allowed to propose a regulation model which some relations have been experimentally validated.
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https://tel.archives-ouvertes.fr/tel-00877095
Contributor : Frédéric Davesne <>
Submitted on : Saturday, October 26, 2013 - 12:48:06 AM
Last modification on : Monday, February 15, 2021 - 10:42:07 AM
Long-term archiving on: : Friday, April 7, 2017 - 6:16:17 PM

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  • HAL Id : tel-00877095, version 1

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Nizar Touleimat. Méthodologie d'extraction et d'analyse de réseaux de régulation de gènes : analyse de la réponse transcriptionnelle à l'irradiation chez S. cerevisiæ. Bio-informatique [q-bio.QM]. Université d'Evry-Val d'Essonne, 2008. Français. ⟨tel-00877095⟩

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