T. , .. La-croissance-de, and P. , ) Test d'inhibition de, p.217

S. Sharma, S. K. Sharma, R. Modak, K. Karmodiya, N. Surolia et al., Mass Spectrometry-Based Systems Approach for Identification of Inhibitors of Plasmodium falciparum Fatty Acid Synthase, Antimicrobial Agents and Chemotherapy, vol.51, issue.7, pp.2552-2558, 2007.
DOI : 10.1128/AAC.00124-07

M. Kapoor, M. Jamal-dar, A. Surolia, and N. Surolia, Kinetic Determinants of the Interaction of Enoyl-ACP Reductase from Plasmodium falciparum with Its Substrates and Inhibitors, Biochemical and Biophysical Research Communications, vol.289, issue.4, pp.832-837, 2001.
DOI : 10.1006/bbrc.2001.6061

W. H. 91-perkin, IV.???On some new derivatives of coumarin, J. Chem. Soc., vol.24, issue.0, pp.37-55
DOI : 10.1039/JS8712400037

H. El-diwani, S. Nakkady, O. El-shabrawy, A. K. Gohar, and O. Hishmat, Reactions of some cinnamoyl benzofuran derivatives with activated nitriles and their biological activity, Archives of Pharmacal Research, vol.111, issue.22, pp.41-44, 1988.
DOI : 10.1007/BF02884766

F. A. Ragab, E. Eid, N. M. Hassan, G. S. Nissan, and Y. M. , Synthesis and Anti-inflammatory Activity of Some Benzofuran and Benzopyran-4-one Derivatives, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.60, issue.1, pp.110-120, 2012.
DOI : 10.1248/cpb.60.110

M. Masubuchi, H. Ebiike, K. Kawasaki, S. Sogabe, K. Morikami et al., Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase, Bioorganic & Medicinal Chemistry, vol.11, issue.20, pp.4463-4478, 2003.
DOI : 10.1016/S0968-0896(03)00429-2

C. Ryu, A. L. Song, J. Y. Lee, J. A. Hong, J. H. Yoon et al., Synthesis and antifungal activity of benzofuran-5-ols, Bioorganic & Medicinal Chemistry Letters, vol.20, issue.22, pp.6777-6780, 2010.
DOI : 10.1016/j.bmcl.2010.08.129

B. F. Abdel-wahab, H. A. Aziz, and E. M. Ahmed, Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles, European Journal of Medicinal Chemistry, vol.44, issue.6, pp.2632-2635, 2009.
DOI : 10.1016/j.ejmech.2008.09.029

D. E. 126-zembower and H. Zhang, Total Synthesis of Robustaflavone, a Potential Anti-Hepatitis B Agent, The Journal of Organic Chemistry, vol.63, issue.25, pp.9300-9305, 1998.
DOI : 10.1021/jo981186b

E. 129-awuah and A. Capretta, Access to Flavones via a Microwave-Assisted, One-Pot Sonogashira???Carbonylation???Annulation Reaction, Organic Letters, vol.11, issue.15, pp.3210-3213, 2009.
DOI : 10.1021/ol901043q

G. Maiti, R. Karmakar, R. N. Bhattacharya, and U. Kayal, A novel one pot route to flavones under dual catalysis, an organo- and a Lewis acid catalyst, Tetrahedron Letters, vol.52, issue.43, pp.5610-5612, 2011.
DOI : 10.1016/j.tetlet.2011.08.078

E. Fait, nommée couplage de Glaser, qui est favorisée par la présence d'oxygène. 133,134,135 Le mécanisme proposé est radicalaire (Schéma 32) 136 Le 4-éthynylanisole 71 réagirait de façon classique avec l'iodure de cuivre (I) pour donner l'alcyne cuivreux. Ce dernier, en présence d'oxygène dans le milieu, serait oxydé en alcyne cuivrique, Puis, une rupture homolytique de la liaison carbone-cuivre (II) aurait lieu générant le radical alcyne. Celui-ci réagirait avec un autre radical alcyne conduisant à la formation du dimère 76

. Dans-un-premier and . Temps, alcyne réagiraient ensemble dans une réaction de couplage de Sonogashira en présence de palladium (0) provenant de PdCl 2 (PPh 3 ) 2 et de cuivre (I) pour former le phénol éthylynique. Le cuivre (I) prendrait immédiatement le relais en se complexant à la triple liaison de l'alcyne et en présence d'une base

J. Seechurn, C. C. Kitching, M. O. Colacot, and T. J. , Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize, Angewandte Chemie International Edition, vol.653, issue.21, pp.5062-5085, 2012.
DOI : 10.1002/anie.201107017

J. Li, Name Reactions, pp.8-12, 2009.

. Le-formiate-d-'ammonium, mmol, 9 éq, p.31

. Après-avoir-refroidi-le-mélange-À-température-ambiante, celui-ci est filtré sur Célite ® et est lavé avec de l'éthanol ainsi qu'avec de l'acétate d'éthyle. Le filtrat jaune est concentré sous pression réduite. Le résidu obtenu est ensuite solubilisé dans une solution d'acide chlorhydrique 1N et de l'acétate d'éthyle. Le mélange est extrait deux fois avec de l'acétate d'éthyle. Les phases organiques rassemblées sont séchées sur MgSO 4 puis concentrées sous pression réduite. Le produit brut obtenu est purifié par chromatographie sur colonne de silice prépackée (éluant : gradient heptane à AcOEt, p.4

. Un-mélange-de-chrysine, 050 g, 0,20 mmol, 1 éq

. De-l-'acétate-d, éthyle et une solution d'acide chlorhydrique 1N sont ajoutés au milieu qui est extrait deux fois avec de l'acétate d'éthyle. Les phases organiques rassemblées sont lavées une fois avec une solution d'acide chlorhydrique 1N, une fois avec une solution aqueuse saturée en NaCl, séchées sur MgSO 4 et concentrées sous pression réduite. Le produit brut obtenu est purifié par chromatographie sur colonne de silice prépackée (éluant : gradient heptane à heptane, AcOEt, vol.8, issue.2

. Donner-la-flavone, 050 g, 69 %) sous la forme d'un solide amorphe blanc

. La-flavone-229, 100 g, 0,17 mmol) est solubilisée dans une solution d'acide chlorhydrique à 10 % dans le méthanol (3 ml) Le mélange réactionnel est agité à reflux pendant 2

. De-l-'eau-est-ensuite-ajoutée-au-milieu, Le précipité formé est filtré sur Büchner, est lavé avec de l'eau et est séché afin d'obtenir la flavone 230 (0,092 g, rendement quantitatif)

. Un-mélange-de-la-flavone, 077 g, 0,20 mmol, 1 éq.), de l'alcyne bromé 234, p.59

. Donner-la-flavone-bromée, 026 g, 22 %) sous la forme d'un solide amorphe jaune

. De-l-'eau-est-ajoutée-au-milieu-qui-est, acidifié avec une solution d'acide chlorhydrique 1N et est extrait deux fois avec de l'acétate d'éthyle. Les phases organiques rassemblées sont lavées quatre fois avec une solution aqueuse saturée en NaCl, séchées sur MgSO 4 et concentrées sous pression réduite. Le produit brut obtenu est purifié par chromatographie sur colonne de silice prépackée (éluant : gradient toluène à toluène, AcOEt, vol.8, issue.2

R. Brun, J. Blum, F. Chappuis, and C. Burri, Human African trypanosomiasis, The Lancet, vol.375, issue.9709, pp.148-159
DOI : 10.1016/S0140-6736(09)60829-1
URL : https://hal.archives-ouvertes.fr/hal-00648979

D. Malvy and F. Chappuis, Sleeping sickness, Clinical Microbiology and Infection, vol.17, issue.7, pp.986-995, 2011.
DOI : 10.1111/j.1469-0691.2011.03536.x

N. Baker, H. P. De-koning, P. Mäser, and D. Horn, Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story, Trends in Parasitology, vol.29, issue.3, pp.110-118
DOI : 10.1016/j.pt.2012.12.005

A. H. Fairlamb, Chemotherapy of human African trypanosomiasis: current and future prospects, Trends in Parasitology, vol.19, issue.11, pp.488-494, 2003.
DOI : 10.1016/j.pt.2003.09.002

E. M. Fèvre, K. Picozzi, J. Jannin, and S. Welburn, Human African Trypanosomiasis: Epidemiology and Control, C.; Maudlin, I. Adv. Parasit, vol.61, pp.167-221, 2006.
DOI : 10.1016/S0065-308X(05)61005-6

T. Wenzler, D. W. Boykin, M. A. Ismail, J. E. Hall, R. R. Tidwell et al., New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289, Antimicrobial Agents and Chemotherapy, vol.53, issue.10, pp.4185-4192, 2009.
DOI : 10.1128/AAC.00225-09

R. Brun, R. Don, and R. Jacobs, Development of novel drugs for human African trypanosomiasis, Future Microbiology, vol.6, issue.6, pp.677-691, 2011.
DOI : 10.2217/fmb.11.44

M. E. Davis and M. E. Brewster, Cyclodextrin-based pharmaceutics: past, present and future, Nature Reviews Drug Discovery, vol.126, issue.12, pp.1023-1035, 2004.
DOI : 10.1073/pnas.192581499

N. Baker, L. Glover, and J. C. Munday, Aguinaga Andrés, Proc. Natl. Acad. Sci. USA 2012, pp.10996-11001

A. Schmidt and R. L. Krauth-siegel, Enzymes of the Trypanothione Metabolism as Targets for Antitrypanosomal Drug Development, Current Topics in Medicinal Chemistry, vol.2, issue.11, pp.1239-1259, 2002.
DOI : 10.2174/1568026023393048

R. T. Eastman, F. S. Buckner, K. Yokoyama, M. H. Gelb, and W. C. Van-voorhis, Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation, The Journal of Lipid Research, vol.47, issue.2, pp.233-240, 2006.
DOI : 10.1194/jlr.R500016-JLR200

S. B. Lethu, M. Ginisty, D. Bosc, and J. Dubois, Discovery of a New Class of Protein Farnesyltransferase Inhibitors in the Arylthiophene Series, Journal of Medicinal Chemistry, vol.52, issue.20, pp.6205-6208, 2009.
DOI : 10.1021/jm901280q
URL : https://hal.archives-ouvertes.fr/hal-00424981

M. A. Biamonte, J. Wanner, and K. G. Le-roch, Recent advances in malaria drug discovery, Bioorganic & Medicinal Chemistry Letters, vol.23, issue.10, pp.2829-2843, 2013.
DOI : 10.1016/j.bmcl.2013.03.067

F. Calderón, D. M. Wilson, and F. Gamo, Antimalarial Drug Discovery, Prog. Med. Chem, vol.52, pp.97-151, 2013.
DOI : 10.1016/B978-0-444-62652-3.00003-X

F. Bruneel and . Med, Maladies Infect, pp.675-676, 2011.

A. J. Birkett, V. S. Moorthy, C. Loucq, C. E. Chitnis, and D. C. Kaslow, Malaria vaccine R&D in the Decade of Vaccines: Breakthroughs, challenges and opportunities, Vaccine, vol.31, issue.2, pp.233-243, 2013.
DOI : 10.1016/j.vaccine.2013.02.040

C. P. Sanchez, A. Dave, W. D. Stein, and M. Lanzer, Transporters as mediators of drug resistance in Plasmodium falciparum, International Journal for Parasitology, vol.40, issue.10, pp.1109-1118, 2010.
DOI : 10.1016/j.ijpara.2010.04.001

D. C. Swinney and J. Anthony, How were new medicines discovered?, Nature Reviews Drug Discovery, vol.2, issue.7, pp.507-519, 2011.
DOI : 10.1038/nrd3480

C. R. Chong, X. Chen, L. Shi, J. O. Liu, and D. Sullivan, A clinical drug library screen identifies astemizole as an antimalarial agent, Nature Chemical Biology, vol.319, issue.8, pp.415-416, 2006.
DOI : 10.1002/ddr.430080105

C. M. Marson, New and unusual scaffolds in medicinal chemistry, Chemical Society Reviews, vol.7, issue.11, pp.5514-5533, 2011.
DOI : 10.1039/c1cs15119c

N. Klein, I. Hurwitz, and R. Durvasula, Dynamic Models of Infectious Diseases, pp.2013-139

F. S. Buckner and J. A. Urbina, Recent developments in sterol 14-demethylase inhibitors for Chagas disease, International Journal for Parasitology: Drugs and Drug Resistance, vol.2, pp.236-242, 2012.
DOI : 10.1016/j.ijpddr.2011.12.002

I. Ogungbe and W. Setzer, Comparative Molecular Docking of Antitrypanosomal Natural Products into Multiple Trypanosoma brucei Drug Targets, Molecules, vol.14, issue.4, pp.1513-1536, 2009.
DOI : 10.3390/molecules14041513

J. S. Kaltenbronn, J. Quin-iii, B. R. Reisdorph, S. Klutchko, E. E. Reynolds et al., Benzofuran derivatives as ETA-selective, non-peptide endothelin antagonists, European Journal of Medicinal Chemistry, vol.32, issue.5, pp.425-431, 1997.
DOI : 10.1016/S0223-5234(97)81679-0

D. Yue, T. Yao, and R. C. Larock, Iodoanisoles and Terminal Alkynes, Followed by Electrophilic Cyclization, The Journal of Organic Chemistry, vol.70, issue.25, pp.10292-10296, 2005.
DOI : 10.1021/jo051299c
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586666

M. Jacubert, A. Hamze, O. Provot, J. Peyrat, J. Brion et al., p-Toluenesulfonic acid-mediated cyclization of o-(1-alkynyl)anisoles or thioanisoles: synthesis of 2-arylsubstituted benzofurans and benzothiophenes, Tetrahedron Letters, vol.50, issue.26, pp.3588-3592, 2009.
DOI : 10.1016/j.tetlet.2009.03.087

A. Arcadi, F. Blesi, S. Cacchi, G. Fabrizi, and A. Goggiamani, 2,5,7-Trisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process, Tetrahedron Letters, vol.52, issue.40, pp.5149-5152, 2011.
DOI : 10.1016/j.tetlet.2011.07.122

A. Arcadi, F. Blesi, S. Cacchi, G. Fabrizi, A. Goggiamani et al., Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process, Tetrahedron, vol.69, issue.7, pp.1857-1871, 2013.
DOI : 10.1016/j.tet.2012.12.058

L. M. Geary and P. G. Hultin, Modular Construction of 2-Substituted Benzo[b]furans from 1,2-Dichlorovinyl Ethers, Organic Letters, vol.11, issue.23, pp.5478-5481, 2009.
DOI : 10.1021/ol902307m

C. Jia, T. Kitamura, and Y. Fujiwara, Catalytic Functionalization of Arenes and Alkanes via C???H Bond Activation, Accounts of Chemical Research, vol.34, issue.8, pp.633-639, 2001.
DOI : 10.1021/ar000209h

A. Arcadi, S. Cacchi, M. Del-rosario, G. Fabrizi, and F. Marinelli, ]furans, The Journal of Organic Chemistry, vol.61, issue.26, pp.9280-9288, 1996.
DOI : 10.1021/jo961051a

Y. Hu, Y. Zhang, Z. Yang, and R. Fathi, ]furans, The Journal of Organic Chemistry, vol.67, issue.7, pp.2365-2368, 2002.
DOI : 10.1021/jo010839c

T. P. Cushnie and A. J. Lamb, Antimicrobial activity of flavonoids, International Journal of Antimicrobial Agents, vol.26, issue.5, pp.343-356, 2005.
DOI : 10.1016/j.ijantimicag.2005.09.002

H. P. Kim, K. H. Son, H. W. Chang, and S. S. Kang, Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms, Journal of Pharmacological Sciences, vol.96, issue.3, pp.229-245, 2004.
DOI : 10.1254/jphs.CRJ04003X

F. Galeotti, E. Barile, P. Curir, M. Dolci, and V. Lanzotti, Flavonoids from carnation (Dianthus caryophyllus) and their antifungal activity, Phytochemistry Letters, vol.1, issue.1, pp.44-48, 2008.
DOI : 10.1016/j.phytol.2007.10.001

S. Kuntz, U. Wenzel, and H. Daniel, Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines, European Journal of Nutrition, vol.38, issue.3, pp.133-142, 1999.
DOI : 10.1007/s003940050054

C. Jiang, R. Agarwal, and . Lü, Anti-Angiogenic Potential of a Cancer Chemopreventive Flavonoid Antioxidant, Silymarin: Inhibition of Key Attributes of Vascular Endothelial Cells and Angiogenic Cytokine Secretion by Cancer Epithelial Cells, Biochemical and Biophysical Research Communications, vol.276, issue.1, pp.371-378, 2000.
DOI : 10.1006/bbrc.2000.3474

P. M. Richardson, The Flavonoids: Advances in Research., Brittonia, vol.36, issue.1
DOI : 10.2307/2806301

H. Miyake, E. Takizawa, and M. Sasaki, Syntheses of Flavones via the Iodine-Mediated Oxidative Cyclization of 1,3-Diphenylprop-2-en-1-ones, Bulletin of the Chemical Society of Japan, vol.76, issue.4, pp.835-836, 2003.
DOI : 10.1246/bcsj.76.835

L. Zhao, H. Jin, L. Sun, H. Piao, and . Quan, Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives, Bioorganic & Medicinal Chemistry Letters, vol.15, issue.22, pp.5027-5029, 2005.
DOI : 10.1016/j.bmcl.2005.08.039

O. V. Singh and R. P. Kapoor, Dehydrogenation of flavanones to flavones using thallium(III) acetate(TTA), Tetrahedron Letters, vol.31, issue.10, pp.1459-1462, 1990.
DOI : 10.1016/S0040-4039(00)88832-2

J. Allan and R. Robinson, CCXC.???An accessible derivative of chromonol, J. Chem. Soc., Trans., vol.125, issue.0, pp.2192-2195, 1924.
DOI : 10.1039/CT9242502192

H. Göker, D. W. Boykin, and S. Y?ld?z, Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles, Bioorganic & Medicinal Chemistry, vol.13, issue.5, pp.1707-1714, 2005.
DOI : 10.1016/j.bmc.2004.12.006

D. E. Zembower and H. Zhang, Total Synthesis of Robustaflavone, a Potential Anti-Hepatitis B Agent, The Journal of Organic Chemistry, vol.63, issue.25, pp.9300-9305, 1998.
DOI : 10.1021/jo981186b

E. Awuah and A. Capretta, Access to Flavones via a Microwave-Assisted, One-Pot Sonogashira???Carbonylation???Annulation Reaction, Organic Letters, vol.11, issue.15, pp.3210-3213, 2009.
DOI : 10.1021/ol901043q

J. A. Seijas, M. P. Vázquez-tato, and R. Carballido-reboredo, Solvent-Free Synthesis of Functionalized Flavones under Microwave Irradiation, The Journal of Organic Chemistry, vol.70, issue.7, pp.2855-2858, 2005.
DOI : 10.1021/jo048685z

B. Freiermuth and C. Wentrup, Direct observation of .alpha.-oxo ketenes formed from 1,3-dioxin-4-ones and the enols of .beta.-keto esters, The Journal of Organic Chemistry, vol.56, issue.7, pp.2286-2289, 1991.
DOI : 10.1021/jo00007a008

J. Li, Name Reactions, 2009.

R. Wang, S. Mo, Y. Lu, and Z. Shen, Domino Sonogashira Coupling/Cyclization Reaction Catalyzed by Copper and ppb Levels of Palladium: A Concise Route to Indoles and Benzo[b]furans, Advanced Synthesis & Catalysis, vol.351, issue.5, pp.713-718, 2011.
DOI : 10.1002/adsc.201000730

S. Schweizer, J. Becht, and C. Le-drian, Development of Efficient and Reusable Diarylphosphinopolystyrene-Supported Palladium Catalysts for C???C Bond Forming Cross-Coupling Reactions, Advanced Synthesis & Catalysis, vol.6, issue.7, pp.1150-1158, 2007.
DOI : 10.1002/adsc.200600503

B. Schmidt, D. K. Ehlert, and H. A. Braun, E-1,2-Dichlorovinyl ethers as irreversible protease inhibitors, Tetrahedron Letters, vol.45, issue.8, pp.1751-1753, 2004.
DOI : 10.1016/j.tetlet.2003.12.088

L. Bras, G. Provot, O. Peyrat, J. Alami, M. Brion et al., Rapid microwave assisted hydration of internal arylalkynes in the presence of PTSA: an efficient regioselective access to carbonyl compounds, Tetrahedron Letters, vol.47, issue.31, pp.5497-5501, 2006.
DOI : 10.1016/j.tetlet.2006.05.155

V. Anuradha, P. V. Srinivas, R. Rao, K. Manjulatha, M. G. Purohit et al., Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L., Bioorganic & Medicinal Chemistry, vol.14, issue.20, pp.6820-6826, 2006.
DOI : 10.1016/j.bmc.2006.06.048

S. Tsai and J. P. Klinman, De Novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note, Bioorganic Chemistry, vol.31, issue.2, pp.172-190, 2003.
DOI : 10.1016/S0045-2068(03)00018-X

S. Pavanaram and R. Ramachandra, (L)Merr. II. The synthesis of compounds 'C' and 'D', Australian Journal of Chemistry, vol.9, issue.1, pp.132-136, 1956.
DOI : 10.1071/CH9560132

J. M. Keith, Selective ortho-cleavage of methoxymethyl- and 4-methoxybenzyl ethers, Tetrahedron Letters, vol.45, issue.13, pp.2739-2742, 2004.
DOI : 10.1016/j.tetlet.2004.02.039

F. R. Cruickshank and S. W. Benson, Carbon-hydrogen bond dissociation energy in methanol, The Journal of Physical Chemistry, vol.73, issue.3, pp.733-737, 1969.
DOI : 10.1021/j100723a041

B. H. Lipshutz and J. Keith, Selective deprotection of alkyl vs. aryl silyl ethers, Tetrahedron Letters, vol.39, issue.17, pp.2495-2498, 1998.
DOI : 10.1016/S0040-4039(98)00381-5

H. M. Kumar, B. V. Reddy, and E. Reddy, Iodine-Catalyzed Mild and Efficient Tetrahydropyranylation / Depyranylation of Alcohols, Chemistry Letters, vol.28, issue.9, pp.857-858, 1999.
DOI : 10.1246/cl.1999.857

T. W. Greene and P. G. Wuts, Protective Groups in Organic Synthesis, 1999.
DOI : 10.1002/0471220574

P. D. Lokhande, S. S. Sakate, K. N. Taksande, and B. Navghare, Dimethylsulfoxide???iodine catalysed deprotection of 2???-allyloxychalcones: synthesis of flavones, Tetrahedron Letters, vol.46, issue.9, pp.1573-1574, 2005.
DOI : 10.1016/j.tetlet.2004.12.041

R. C. Ronald and M. R. Winkle, Regioselective metallations of (methoxymethoxy)arenes, Tetrahedron, vol.39, issue.12, pp.2031-2042, 1983.
DOI : 10.1016/S0040-4020(01)91921-0

I. Thomsen and K. B. Torssell, Iodination of Resorcinol, 5-Methoxyresorcinol, Phloroglucinol and Resorcyclic Acid., Acta Chemica Scandinavica, vol.45, pp.539-545, 1991.
DOI : 10.3891/acta.chem.scand.45-0539

G. G. Haraldsson and J. Baldwin, A selective cleavage of aromatic benzyl ethers located ortho to a carbonyl group by magnesium bromide., Tetrahedron, vol.53, issue.1, pp.215-224, 1997.
DOI : 10.1016/S0040-4020(96)00964-7

J. Wrobel, J. Sredy, C. Moxham, A. Dietrich, Z. Li et al., ]thiophenes, Journal of Medicinal Chemistry, vol.42, issue.17, pp.3199-3202, 1999.
DOI : 10.1021/jm990260v

H. Kagawa, A. Shigematsu, S. Ohta, and Y. Harigaya, Preparative Monohydroxyflavanone Syntheses and a Protocol for Gas Chromatography-Mass Spectrometry Analysis of Monohydroxyflavanones, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.53, issue.5, pp.547-554, 2005.
DOI : 10.1248/cpb.53.547

M. Zhao, C. Kuang, Q. Yang, and X. Cheng, Cs2CO3-mediated synthesis of terminal alkynes from 1,1-dibromo-1-alkenes, Tetrahedron Letters, vol.52, issue.9, pp.992-994, 2011.
DOI : 10.1016/j.tetlet.2010.12.071

C. M. Starks, Phase-transfer catalysis. I. Heterogeneous reactions involving anion transfer by quaternary ammonium and phosphonium salts, Journal of the American Chemical Society, vol.93, issue.1, pp.195-199, 1971.
DOI : 10.1021/ja00730a033

T. Kishimoto, Y. Uraki, and M. Ubukata, Synthesis of ??-O-4-type artificial lignin polymers and their analysis by NMR spectroscopy, Organic & Biomolecular Chemistry, vol.28, issue.16, pp.2982-2987, 2008.
DOI : 10.1039/b805460f

S. K. Grover, A. C. Jain, and T. Seshadri, Methylenation studies of hydroxyflavonoids And derivatives of resorcinol, Tetrahedron, vol.20, issue.3, pp.555-564, 1964.
DOI : 10.1016/S0040-4020(01)98618-1

F. Berthet, Nouvelles approches synthétiques en série flavonique. Préparation d'homobisflavones et de flavones aminoalkylées, 1996.

E. Wedekind, D. W. Ber-boykin, H. E. Morton, and C. Yoakim, Zur Kenntniss der einfachsten Chlor??ther, Berichte der deutschen chemischen Gesellschaft, vol.246, issue.2, pp.1383-1386, 1903.
DOI : 10.1002/cber.19030360211

J. Quintin and G. Lewin, Regioselective 6-iodination of 5,7-dioxygenated flavones by benzyltrimethylammonium dichloroiodate, Tetrahedron Letters, vol.45, issue.18, pp.3635-3638, 2004.
DOI : 10.1016/j.tetlet.2004.03.038

S. Kajigaeshi, T. Kakinami, H. Yamasaki, S. Fujisaki, M. Kondo et al., Iodination of Phenols by Use of Benzyltrimethylammonium Dichloroiodate(1???), Chemistry Letters, vol.16, issue.11, pp.2109-2112, 1987.
DOI : 10.1246/cl.1987.2109

B. H. Nicolet and J. R. Sampey, POSITIVE HALOGENS ATTACHED TO CARBON IN THE AROMATIC SERIES. II. IODINE DERIVATIVES OF META-PHENYLENEDIAMINE AND OF RESORCINOL, Journal of the American Chemical Society, vol.49, issue.7, pp.1796-1801, 1927.
DOI : 10.1021/ja01406a020

R. B. Dateer, B. S. Shaibu, and R. Liu, Gold-Catalyzed Intermolecular [4+2] and [2+2+2] Cycloadditions of Ynamides with Alkenes, Angewandte Chemie International Edition, vol.13, issue.1, pp.113-117, 2012.
DOI : 10.1002/anie.201105921

T. Horie, H. Kourai, and N. Fujita, -Alkylation and Dealkylation of Flavonoids. VI. Demethylation of 8-Hydroxy-5,7-dimethoxyflavones with Anhydrous Aluminum Chloride or Bromide in Acetonitrile, Bulletin of the Chemical Society of Japan, vol.56, issue.12, pp.3773-3780, 1983.
DOI : 10.1246/bcsj.56.3773
URL : https://hal.archives-ouvertes.fr/hal-00488160

O. 'brien, J. Wilson, I. Orton, T. Pognan, and F. , Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity, European Journal of Biochemistry, vol.107, issue.17, pp.5421-5426, 2000.
DOI : 10.1046/j.1432-1327.2000.01606.x

I. M. Bastos, F. N. Motta, S. Charneau, J. M. Santana, and L. Dubost, Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice, Microbes and Infection, vol.12, issue.6, pp.457-466, 2010.
DOI : 10.1016/j.micinf.2010.02.007

W. Chen, P. Li, T. Miao, L. Meng, and L. Wang, An efficient tandem elimination???cyclization???desulfitative arylation of 2-(gem-dibromovinyl)phenols(thiophenols) with sodium arylsulfinates, Org. Biomol. Chem., vol.68, issue.3, pp.420-424, 2013.
DOI : 10.1039/C2OB27232F

P. Magnus, W. A. Freund, E. J. Moorhead, and T. Rainey, Formal Synthesis of (??)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction, Journal of the American Chemical Society, vol.134, issue.14, pp.6140-6142, 2012.
DOI : 10.1021/ja300900p

S. Boonsri, C. Gunawan, E. H. Krenske, and M. A. Rizzacasa, Synthetic studies towards the mulberry Diels???Alder adducts: H-bond accelerated cycloadditions of chalcones, Organic & Biomolecular Chemistry, vol.24, issue.30, pp.6010-6021, 2012.
DOI : 10.1039/c2ob25115a

O. Simon, B. Reux, J. J. La-clair, and M. Lear, Total Synthesis Confirms Laetirobin as a Formal Diels-Alder Adduct, Chemistry - An Asian Journal, vol.1, issue.2, pp.342-351, 2010.
DOI : 10.1002/asia.200900306

K. Sugamoto, Y. Matsusita, K. Matsui, C. Kurogi, and T. Matsui, Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei, Tetrahedron, vol.67, issue.29, pp.5346-5359, 2011.
DOI : 10.1016/j.tet.2011.04.104

T. Kumazawa, T. Minatogawa, S. Matsuba, S. Sato, and J. Onodera, An effective synthesis of isoorientin: the regioselective synthesis of a 6-C-glucosylflavone, Carbohydrate Research, vol.329, issue.3, pp.507-513, 2000.
DOI : 10.1016/S0008-6215(00)00226-3

Y. S. Lee, H. Y. Kim, Y. Kim, J. H. Seo, E. J. Roh et al., Small molecules that protect against ??-amyloid-induced cytotoxicity by inhibiting aggregation of ??-amyloid, Bioorganic & Medicinal Chemistry, vol.20, issue.16, pp.4921-4935, 2012.
DOI : 10.1016/j.bmc.2012.06.045

Z. Yang, H. B. Liu, C. M. Lee, H. M. Chang, and H. N. Wong, Compounds from Danshen. Part 7. Regioselective introduction of carbon-3 substituents to 5-alkyl-7-methoxy-2-phenylbenzo[b]furans: synthesis of a novel adenosine A1 receptor ligand and its derivatives, The Journal of Organic Chemistry, vol.57, issue.26, pp.7248-7257, 1992.
DOI : 10.1021/jo00052a046

N. Jun, G. Hong, and K. Jun, Synthesis and evaluation of 2???,4???,6???-trihydroxychalcones as a new class of tyrosinase inhibitors, Bioorganic & Medicinal Chemistry, vol.15, issue.6, pp.2396-2402, 2007.
DOI : 10.1016/j.bmc.2007.01.017

Y. L. Jin, S. Kim, Y. S. Kim, S. Kim, and H. S. Kim, The first total synthesis of glycyrol, Tetrahedron Letters, vol.49, issue.48, pp.6835-6837, 2008.
DOI : 10.1016/j.tetlet.2008.09.070

M. Mondal, V. G. Puranik, and N. P. Argade, A Facile Phenol-Driven Intramolecular Diastereoselective Thermal/Base-Catalyzed Dipolar [2 + 2] Annulation Reactions:?? An Easy Access to Complex Bioactive Natural and Unnatural Benzopyran Congeners, The Journal of Organic Chemistry, vol.72, issue.6, pp.2068-2076, 2007.
DOI : 10.1021/jo0624344