J. Gotman, Automatic Detection of Seizures and Spikes, Journal of Clinical Neurophysiology, vol.16, issue.2, pp.130-170, 1999.
DOI : 10.1097/00004691-199903000-00005

J. Gotman, Experiments in the automation and quantification of EEG interpretation localized brain lesions and epilepsy, 1976.

J. Gotman and L. Y. Wang, State-dependent spike detection: concepts and preliminary results, Electroencephalography and Clinical Neurophysiology, vol.79, issue.1, pp.11-20, 1991.
DOI : 10.1016/0013-4694(91)90151-S

F. Grouiller, L. Vercueil, A. Krainik, C. Segebarth, P. Kahane et al., A comparative study of different artefact removal algorithms for EEG signals acquired during functional MRI, NeuroImage, vol.38, issue.1, pp.124-161, 2007.
DOI : 10.1016/j.neuroimage.2007.07.025
URL : https://hal.archives-ouvertes.fr/inserm-00381736

P. Guedes-de-oliveira, C. Queiroz, and F. H. Lopes-da-silva, Spike detection based on a pattern recognition approach using a microcomputer, Electroencephalography and Clinical Neurophysiology, vol.56, issue.1, pp.97-103, 1983.
DOI : 10.1016/0013-4694(83)90011-1

G. Guelpa and A. Marie, La lutte contre l'épilepsie par la désintoxication et par la rééducation alimentaire. Rev Ther Médico-Chirurgicale, pp.8-13, 1911.

C. Heinrich, S. Lähteinen, F. Suzuki, A. Laharie, S. Huber et al., Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy, Neurobiology of Disease, vol.42, issue.1, pp.35-47, 2011.
DOI : 10.1016/j.nbd.2011.01.001
URL : https://hal.archives-ouvertes.fr/inserm-00592330

C. Heinrich, N. Nitta, A. Flubacher, M. Müller, A. Fahrner et al., Reelin Deficiency and Displacement of Mature Neurons, But Not Neurogenesis, Underlie the Formation of Granule Cell Dispersion in the Epileptic Hippocampus, Journal of Neuroscience, vol.26, issue.17, pp.264701-264714, 2006.
DOI : 10.1523/JNEUROSCI.5516-05.2006
URL : https://hal.archives-ouvertes.fr/inserm-00388242

D. V. Hinkley, Inference about the change-point from cumulative sum tests, Biometrika, vol.58, issue.3, pp.509-523, 1971.
DOI : 10.1093/biomet/58.3.509

G. Huberfeld, L. Wittner, S. Clemenceau, M. Baulac, K. Kaila et al., Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy, Journal of Neuroscience, vol.27, issue.37, pp.279866-73, 2007.
DOI : 10.1523/JNEUROSCI.2761-07.2007
URL : https://hal.archives-ouvertes.fr/inserm-00173026

B. H. Jansen and V. G. Rit, Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns, Biological Cybernetics, vol.580, issue.4, pp.357-66, 1995.
DOI : 10.1007/BF00199471

J. G. Jefferys, L. Menendez-de-la-prida, F. Wendling, A. Bragin, M. Avoli et al., Mechanisms of physiological and epileptic HFO generation, Progress in Neurobiology, vol.98, issue.3, pp.98250-64, 2012.
DOI : 10.1016/j.pneurobio.2012.02.005
URL : https://hal.archives-ouvertes.fr/hal-00904848

F. E. Jensen, C. D. Applegate, D. Holtzman, T. R. Belin, and J. L. Burchfiel, Epileptogenic effect of hypoxia in the immature rodent brain, Annals of Neurology, vol.15, issue.6, pp.629-666, 1991.
DOI : 10.1002/ana.410290610

B. Jupp, J. Williams, D. Binns, R. J. Hicks, L. Cardamone et al., Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE, Epilepsia, vol.934, issue.Suppl. 4, pp.531233-531277, 2012.
DOI : 10.1111/j.1528-1167.2012.03525.x

I. Kharatishvili, A. Sierra, R. J. Immonen, O. H. Gröhn, and A. Pitkänen, Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat, Experimental Neurology, vol.217, issue.1, pp.154-64, 2009.
DOI : 10.1016/j.expneurol.2009.01.026

R. Khawaled, A. Bruening-wright, J. P. Adelman, and J. Maylie, Bicuculline block of small-conductance calcium-activated potassium channels, Pfl???gers Archiv European Journal of Physiology, vol.438, issue.3, pp.314-335, 1999.
DOI : 10.1007/s004240050915

P. E. Kloeden and E. Platen, Numerical Solution of Stochastic Differential Equations (Stochastic Modelling and Applied Probability) First, 1992.

J. Y. Koh, M. P. Goldberg, D. M. Hartley, and D. W. Choi, Non-NMDA receptormediated neurotoxicity in cortical culture, J Neurosci, vol.10, issue.2, pp.693-705, 1990.

P. Kwan and M. J. Brodie, Early Identification of Refractory Epilepsy, New England Journal of Medicine, vol.342, issue.5, pp.314-323, 2000.
DOI : 10.1056/NEJM200002033420503

. Larousse, Available at: http://www.larousse.fr/dictionnaires/francais, p.30424, 2012.

P. C. Lauterbur, Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance, Nature, vol.178, issue.5394, pp.190-191, 1973.
DOI : 10.1038/242190a0

M. Lévesque, A. Bortel, J. Gotman, and M. Avoli, High-frequency (80???500Hz) oscillations and epileptogenesis in temporal lobe epilepsy, Neurobiology of Disease, vol.42, issue.3, pp.231-272, 2011.
DOI : 10.1016/j.nbd.2011.01.007

G. Li, S. Wang, H. Rabitz, S. Wang, and P. Jaffé, Global uncertainty assessments by high dimensional model representations (HDMR), Chemical Engineering Science, vol.57, issue.21, pp.4445-4460, 2002.
DOI : 10.1016/S0009-2509(02)00417-7

S. A. Lipton and P. A. Rosenberg, Excitatory amino acids as a final common pathway for neurologic disorders, N Engl J Med, vol.330, issue.9, pp.613-635, 1994.

F. H. Lopes-da-silva, A. Hoeks, H. Smits, and L. H. Zetterberg, Model of brain rhythmic activity, Kybernetik, vol.1, issue.1, pp.27-37, 1974.
DOI : 10.1007/BF00270757

F. H. Lopes-da-silva, K. Van-hulten, J. G. Lommen, W. Storm-van-leeuwen, C. W. Van-veelen et al., Automatic detection and localization of epileptic foci, Electroencephalography and Clinical Neurophysiology, vol.43, issue.1, pp.1-13, 1977.
DOI : 10.1016/0013-4694(77)90189-4

F. H. Lopes-da-silva, A. Van-rotterdam, P. Barts, E. Van-heusden, and W. Burr, Models of Neuronal Populations: The Basic Mechanisms of Rhythmicity, Prog Brain Res, pp.45281-308, 1976.
DOI : 10.1016/S0079-6123(08)60995-4

W. Löscher and C. Brandt, Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research, Pharmacological Reviews, vol.62, issue.4, pp.668-700, 2010.
DOI : 10.1124/pr.110.003046

W. Löscher and D. Schmidt, Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma, Epilepsia, vol.50, issue.suppl 7, pp.657-78, 2011.
DOI : 10.1111/j.1528-1167.2011.03024.x

E. L. Van-luijtelaar and A. M. Coenen, Two types of electrocortical paroxysms in an inbred strain of rats, Neuroscience Letters, vol.70, issue.3, pp.393-400, 1986.
DOI : 10.1016/0304-3940(86)90586-0

H. Matsumoto and C. Ajmone-marsan, Cortical cellular phenomena in experimental epilepsy: Interictal manifestations, Experimental Neurology, vol.9, issue.4, pp.286-304, 1964.
DOI : 10.1016/0014-4886(64)90025-1

T. K. Mcintosh, R. Vink, L. Noble, I. Yamakami, S. Fernyak et al., Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model, Neuroscience, vol.28, issue.1, pp.233-277, 1989.
DOI : 10.1016/0306-4522(89)90247-9

R. Meier, U. Häussler, A. Aertsen, C. Deransart, A. Depaulis et al., Short-term changes in bilateral hippocampal coherence precede epileptiform events, NeuroImage, vol.38, issue.1, pp.138-187, 2007.
DOI : 10.1016/j.neuroimage.2007.07.016
URL : https://hal.archives-ouvertes.fr/inserm-00385565

J. V. Nadler and . Minireview, Kainic acid as a tool for the study of temporal lobe epilepsy, Life Sciences, vol.29, issue.20, pp.2031-2073
DOI : 10.1016/0024-3205(81)90659-7

L. Nashef and J. W. Sander, Sudden unexpected deaths in epilepsy--where are we now? Seizure, pp.235-243, 1996.

A. Nehlig, Hippocampal MRI and other structural biomarkers: experimental approach to epileptogenesis, Biomarkers in Medicine, vol.5, issue.5, pp.585-97, 2011.
DOI : 10.2217/bmm.11.65

P. L. Nunez, A Study of Origins of the Time Dependencies of Scalp EEG: I - Theoretical Basis, IEEE Transactions on Biomedical Engineering, vol.28, issue.3, pp.271-80, 1981.
DOI : 10.1109/TBME.1981.324700

O. 'keefe, J. Dostrovsky, and J. , The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat, Brain Research, vol.34, issue.1, pp.171-176, 1971.
DOI : 10.1016/0006-8993(71)90358-1

O. Ozdamar and T. Kalayci, Detection of Spikes with Artificial Neural Networks Using Raw EEG, Computers and Biomedical Research, vol.31, issue.2, pp.122-164, 1998.
DOI : 10.1006/cbmr.1998.1475

E. S. Page, CONTINUOUS INSPECTION SCHEMES, Biometrika, vol.41, issue.1-2, pp.100-115, 1954.
DOI : 10.1093/biomet/41.1-2.100

. Paglioli, . Eliseu, A. Palmini, . Paglioli, D. Eduardo et al., Survival Analysis of the Surgical Outcome of Temporal Lobe Epilepsy Due to Hippocampal Sclerosis, Epilepsia, vol.45, issue.11, pp.451383-91, 2004.
DOI : 10.1056/NEJM200002033420503

P. F. Pinsky and J. Rinzel, Intrinsic and network rhythmogenesis in a reduced traub model for CA3 neurons, Journal of Computational Neuroscience, vol.76, issue.1-2, pp.39-60, 1994.
DOI : 10.1007/BF00962717

A. Pitkänen, Therapeutic approaches to epileptogenesis-Hope on the horizon, Epilepsia, vol.29, issue.suppl 2, pp.2-17, 2010.
DOI : 10.1111/j.1528-1167.2010.02602.x

A. Pitkänen and K. Lukasiuk, Mechanisms of epileptogenesis and potential treatment targets, The Lancet Neurology, vol.10, issue.2, pp.173-86, 2011.
DOI : 10.1016/S1474-4422(10)70310-0

E. Purcell, H. Torrey, and R. Pound, Resonance Absorption by Nuclear Magnetic Moments in a Solid, Physical Review, vol.69, issue.1-2, pp.37-38, 1946.
DOI : 10.1103/PhysRev.69.37

H. Rabitz and Ö. F. Ali?, General foundations of high-dimensional model representations, Journal of Mathematical Chemistry, vol.25, issue.2/3, pp.197-233, 1999.
DOI : 10.1023/A:1019188517934

S. Ramón-y-cajal, Histologie du système nerveux de l'homme & des vertébrés, Édition fr, 1909.
DOI : 10.5962/bhl.title.48637

V. Riban, V. Bouilleret, B. T. Pham-lê, J. Fritschy, C. Marescaux et al., Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy, Neuroscience, vol.112, issue.1, pp.101-112, 2002.
DOI : 10.1016/S0306-4522(02)00064-7

P. A. Robinson, P. N. Loxley, S. C. O-'connor, and C. J. Rennie, Modal analysis of corticothalamic dynamics, electroencephalographic spectra, and evoked potentials, Physical Review E, vol.63, issue.4, p.41909, 2001.
DOI : 10.1103/PhysRevE.63.041909

S. N. Roper, In utero irradiation of rats as a model of human cerebrocortical dysgenesis: a review, Epilepsy Research, vol.32, issue.1-2, pp.63-74, 1998.
DOI : 10.1016/S0920-1211(98)00040-0

E. Roux and A. Borrel, Tétanos cérébral et immunité contre le tétanos, Ann Inst Pasteur, vol.4, pp.225-239, 1898.

O. Sagher, Editorial: Epilepsy surgery, Journal of Neurosurgery, vol.118, issue.1, 2012.
DOI : 10.3171/2012.7.JNS121132

P. Salami, M. Lévesque, J. Gotman, and M. Avoli, A comparison between automated detection methods of high-frequency oscillations (80???500Hz) during seizures, Journal of Neuroscience Methods, vol.211, issue.2, pp.265-71, 2012.
DOI : 10.1016/j.jneumeth.2012.09.003

A. Saltelli, Making best use of model evaluations to compute sensitivity indices, Computer Physics Communications, vol.145, issue.2, pp.280-297, 2002.
DOI : 10.1016/S0010-4655(02)00280-1

B. Saltzberg, L. S. Lustick, and R. G. Heath, Detection of focal depth spiking in the scalp EEG of monkeys, Electroencephalography and Clinical Neurophysiology, vol.31, issue.4, pp.327-360, 1971.
DOI : 10.1016/0013-4694(71)90228-8

F. Semah, M. C. Picot, C. Adam, D. Broglin, A. Arzimanoglou et al., Is the underlying cause of epilepsy a major prognostic factor for recurrence?, Neurology, vol.51, issue.5, pp.511256-62, 1998.
DOI : 10.1212/WNL.51.5.1256

L. Senhadji, Approche multirésolution pour l'analyse des signaux non stationnaires, 1993.

L. Senhadji, J. Dillenseger, F. Wendling, C. Rocha, and A. Kinie, Wavelet analysis of EEG for three-dimensional mapping of epileptic events, Annals of Biomedical Engineering, vol.11, issue.5, pp.543-52, 1995.
DOI : 10.1007/BF02584454
URL : https://hal.archives-ouvertes.fr/inserm-00130049

L. Senhadji and F. Wendling, Epileptic transient detection: wavelets and time-frequency approaches, Neurophysiologie Clinique/Clinical Neurophysiology, vol.32, issue.3, pp.175-92, 2002.
DOI : 10.1016/S0987-7053(02)00304-0
URL : https://hal.archives-ouvertes.fr/inserm-00130050

S. Shinnar, D. C. Hesdorffer, D. R. Nordli, J. M. Pellock, C. O-'dell et al., Phenomenology of prolonged febrile seizures: Results of the FEBSTAT study, Neurology, vol.71, issue.3, pp.71170-71176, 2008.
DOI : 10.1212/01.wnl.0000310774.01185.97

J. R. Simon, J. F. Contrera, and M. J. Kuhar, Binding of [3H] kainic acid, and analogue of Lglutamate, to brain membranes, J Neurochem, vol.26, issue.1, pp.141-148, 1976.

M. Simonato, W. Löscher, A. J. Cole, F. E. Dudek, J. Engel et al., Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design, Epilepsia, vol.29, issue.Suppl. 3, pp.531860-1867, 2012.
DOI : 10.1111/j.1528-1167.2012.03541.x

I. Sobol?, Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates, Mathematics and Computers in Simulation, vol.55, issue.1-3, pp.271-280, 2001.
DOI : 10.1016/S0378-4754(00)00270-6

R. J. Staba and A. Bragin, High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms, Biomarkers in Medicine, vol.5, issue.5, pp.545-56, 2011.
DOI : 10.2217/bmm.11.72

K. J. Staley, Does plasticity of the GABA(A) reversal potential contribute to epileptogenesis?, Epilepsy Curr, vol.8, issue.4, pp.107-117, 2008.

L. J. Stephen, P. Kwan, and M. J. Brodie, Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment? Epilepsia, pp.357-62, 2001.

P. Suffczynski, F. Wendling, J. Bellanger, and F. H. Lopes-da-silva, Some Insights Into Computational Models of (Patho)physiological Brain Activity, Proceedings of the IEEE, pp.784-804, 2006.
DOI : 10.1109/JPROC.2006.871773

J. Wu, Microscopic model for selective permeation in ion channels, Biophysical Journal, vol.60, issue.1, pp.238-51, 1991.
DOI : 10.1016/S0006-3495(91)82046-X

L. C. Yeung, H. Z. Shouval, B. S. Blais, and L. N. Cooper, Synaptic homeostasis and input selectivity follow from a calcium-dependent plasticity model, Proceedings of the National Academy of Sciences, vol.101, issue.41, pp.14943-14951, 2004.
DOI : 10.1073/pnas.0405555101

K. Yoon, D. F. Covey, and S. M. Rothman, Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons., The Journal of Physiology, vol.464, issue.1, pp.423-462, 1993.
DOI : 10.1113/jphysiol.1993.sp019643

L. H. Zetterberg, L. Kristiansson, and K. Mossberg, Performance of a model for a local neuron population, Biological Cybernetics, vol.1, issue.1, pp.15-26, 1978.
DOI : 10.1007/BF00337367

T. Ziehn and A. S. Tomlin, GUI???HDMR ??? A software tool for global sensitivity analysis of complex models, Environmental Modelling & Software, vol.24, issue.7, pp.775-785, 2009.
DOI : 10.1016/j.envsoft.2008.12.002

M. Zijlmans, P. Jiruska, R. Zelmann, F. S. Leijten, J. G. Jefferys et al., High-frequency oscillations as a new biomarker in epilepsy, Annals of Neurology, vol.66, issue.Suppl 5, pp.169-78, 2012.
DOI : 10.1002/ana.22548

B. Molaee-ardekani, Effects of transcranial Direct Current Stimulation (tDCS) on cortical activity: A??computational modeling study, Brain Stimulation, vol.6, issue.1, 2012.
DOI : 10.1016/j.brs.2011.12.006
URL : https://hal.archives-ouvertes.fr/inserm-00664021

!. Ici, !. , !. , !. , !. Comme et al., !la! fonction!du!premier!ordre! !représente!la!contribution!marginale!du!-ème!paramètre!d'entrée! !à! la! caractéristique! de! sortie!.! La! fonction! du! second! ordre! !représente, 2002.

!. Monte, !. Carlo, and !. Saltelli, !Afin!de!réduire!le!nombre!d'échantillons,!(Rabitz & Ali?!1999)!a!proposé! une! approche! alternative! qui, 2001.

S. Blanchard, T. Papadopoulo, C. Bénar, N. Voges, M. Clerc et al., Relationship Between Flow and Metabolism in BOLD Signals: Insights from Biophysical Models, Brain Topography, vol.24, issue.7, pp.40-53, 2011.
DOI : 10.1007/s10548-010-0166-6
URL : https://hal.archives-ouvertes.fr/inserm-00613116

H. Rabitz and Ö. F. Ali?, General foundations of high-dimensional model representations, Journal of Mathematical Chemistry, vol.25, issue.2/3, pp.197-233, 1999.
DOI : 10.1023/A:1019188517934

A. Saltelli, Making best use of model evaluations to compute sensitivity indices, Computer Physics Communications, vol.145, issue.2, pp.280-297, 2002.
DOI : 10.1016/S0010-4655(02)00280-1