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Theses

Modélisation de la réponse antirétrovirale pour l’aide à l’optimisation thérapeutique et pharmaco-économique en Côte d’Ivoire

Abstract : Our thesis of Clinical pharmacy is a contribution to optimize the efficiency of antiretroviral therapy (ART) by modeling methods in Côte d'Ivoire. The first study was devoted to modeling the antiretroviral response from taxonomy of CD4 counts trajectories, using a meta-learning model of biomedical markers trajectories. This model applied to the taxonomy of the CD4 counts trajectories showed its interest in the identification of distinct classes of patients with particular characteristics justifying and/or determining the specific profile of meta-trajectories of the immunological marker during treatment. The second task was an assessment of the impact of key determinants of CD4 counts meta-trajectories on various types of immune response from an explanatory model with a logistic regression equation. Antiretroviral immune responses considered were expressed in terms of absence of CD4 gain, sub-optimal gain and optimal gain of CD4 at different periods of follow-up of ART. Finally the evaluation of the efficiency of first-line antiretroviral strategies in Côte d'Ivoire, was discussed in the last part with a projective pharmaco-economic model. We conducted a preliminary exploratory study opening up prospects to encourage the implementation of comprehensive pharmaco-economic assessments by modeling in Côte d'Ivoire. This study helped to highlight the unreliable methodological sections in a pharmaco-economic modeling of first-line ART in resource-limited settings
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Theses
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https://tel.archives-ouvertes.fr/tel-00863137
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Submitted on : Wednesday, September 18, 2013 - 11:58:11 AM
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  • HAL Id : tel-00863137, version 1

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Danho Pascal Abrogoua. Modélisation de la réponse antirétrovirale pour l’aide à l’optimisation thérapeutique et pharmaco-économique en Côte d’Ivoire. Médecine humaine et pathologie. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : 2011LYO10316⟩. ⟨tel-00863137⟩

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