B. 1. Weiss and R. A. , The discovery of endogenous retroviruses, Retrovirology, issue.3, p.67, 2006.

D. J. Griffiths, Endogenous retroviruses in the human genome sequence, Genome Biol, issue.26, p.1017, 2001.

J. L. Blond, F. Beseme, L. Duret, O. Bouton, F. Bedin et al., Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family, J Virol, issue.2, pp.73-1175, 1999.
URL : https://hal.archives-ouvertes.fr/hal-00428437

J. L. Frendo, D. Olivier, V. Cheynet, J. L. Blond, O. Bouton et al., Evain-Brion, and F. Mallet, Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation, Mol Cell Biol, issue.10, pp.23-3566, 2003.

F. Cosset and . Mallet, Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope, J Virol, vol.79, issue.9, pp.5585-93, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00021677

F. Mallet, O. Bouton, S. Prudhomme, V. Cheynet, G. Oriol et al., The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology, Proceedings of the National Academy of Sciences, vol.101, issue.6, pp.101-1731, 2004.
DOI : 10.1073/pnas.0305763101
URL : https://hal.archives-ouvertes.fr/hal-00427686

F. Mandrand, F. L. Mallet, and . Cosset, An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor, J Virol, issue.7, pp.74-3321, 2000.

S. Mi, X. Lee, X. Li, G. M. Veldman, H. Finnerty et al., Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis, Nature, issue.6771, pp.403-785, 2000.

H. S. Kim, O. Takenaka, and T. J. Crow, Isolation and phylogeny of endogenous retrovirus sequences belonging to the HERV-W family in primates, Journal of General Virology, vol.80, issue.10, pp.80-2613, 1999.
DOI : 10.1099/0022-1317-80-10-2613

E. Portoukalian, M. Retroviral-genes-leboyer, R. Tamouza, D. Charron, R. Faucard et al., Herpesviruses and gender in Multiple Sclerosis Human endogenous retrovirus type W (HERV-W) in schizophrenia: A new avenue of research at the gene-environment interface, J Neurol Sci World J Biol Psychiatry, issue.11, 2009.

. Seigneurin, Leptomeningeal cell line from multiple sclerosis with reverse transcriptase activity and viral particles, Res Virol, vol.140, issue.6, pp.551-61, 1989.

. Sotgiu, Multiple sclerosis-associated retrovirus (MSRV) in Sardinian MS patients, Neurology, vol.58, issue.3, pp.471-474, 2002.

A. Bonetti and . Dolei, Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6, J Gen Virol, pp.88-264, 2007.

H. Perron, L. Mekaoui, C. Bernard, F. Veas, I. Stefas et al., Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients, Biological Psychiatry, vol.64, issue.12, pp.64-1019, 2008.
DOI : 10.1016/j.biopsych.2008.06.028

F. Faucard, I. Veas, B. O. Stefas, J. Fabriek, P. Van-horssen et al., Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease, Mult Scler, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00826751

T. Rieckmann, J. J. Arzberger, H. Hauw, and . Lassmann, Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions, J Neurovirol, vol.11, issue.1, pp.23-33, 2005.

R. H. Yolken, H. Karlsson, F. Yee, N. L. Johnston-wilson, and E. F. Torrey, Endogenous retroviruses and schizophrenia, Brain Research Reviews, vol.31, issue.2-3, pp.31-33, 2000.
DOI : 10.1016/S0165-0173(99)00037-5

H. Perron, B. Lalande, B. Gratacap, A. Laurent, O. Genoulaz et al., Isolation of retrovirus from patients with multiple sclerosis, The Lancet, vol.337, issue.8745, pp.337-862, 1991.
DOI : 10.1016/0140-6736(91)92579-Q

T. Christensen, R. R. Tonjes, J. Zur-megede, K. Boller, and A. Moller-larsen, Reverse Transcriptase Activity and Particle Production in B Lymphoblastoid Cell Lines Established from Lymphocytes of Patients with Multiple Sclerosis, AIDS Research and Human Retroviruses, vol.15, issue.3, pp.285-91, 1999.
DOI : 10.1089/088922299311466

H. Marche and . Perron, Multiple sclerosis-associated retrovirus particles cause T lymphocyte-dependent death with brain hemorrhage in humanized SCID mice model

J. A. Garson, P. W. Tuke, P. Giraud, G. Paranhos-baccala, and H. Perron, Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis, The Lancet, vol.351, issue.9095, pp.351-384, 1998.
DOI : 10.1016/S0140-6736(98)24001-3

S. Sotgiu, G. Arru, G. Mameli, C. Serra, M. Pugliatti et al., Multiple sclerosis-associated retrovirus in early multiple sclerosis: a six-year follow-up of a Sardinian cohort, Multiple Sclerosis Journal, vol.2, issue.6, pp.12-698, 2006.
DOI : 10.1212/WNL.33.11.1444

C. Serra, S. Sotgiu, G. Mameli, M. Pugliatti, G. Rosati et al., Multiple sclerosis and multiple sclerosis-associated retrovirus in Sardinia, Neurological Sciences, vol.22, issue.2, pp.171-174, 2001.
DOI : 10.1007/s100720170019

. Nowak, MSRV pol sequence copy number as a potential marker of multiple sclerosis

A. Granieri and . Dolei, Inhibition of multiple-sclerosis-associated retrovirus as biomarker of interferon therapy, J Neurovirol, vol.14, issue.1, pp.73-80, 2008.

F. Komurian-pradel, G. Paranhos-baccala, F. Bedin, A. Ounanian-paraz, M. Sodoyer et al., Molecular Cloning and Characterization of MSRV-Related Sequences Associated with Retrovirus-like Particles, Virology, vol.260, issue.1, pp.1-9, 1999.
DOI : 10.1006/viro.1999.9792

F. Pradel, P. W. Mallet, C. Tuke, J. L. Voisset, B. Blond et al., Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis, Proc Natl Acad Sci, issue.14, pp.94-7583, 1997.

T. Brudek, P. Luhdorf, T. Christensen, H. J. Hansen, and A. Moller-larsen, Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV, Journal of Neuroimmunology, vol.187, issue.1-2, pp.147-55, 2007.
DOI : 10.1016/j.jneuroim.2007.04.003

K. Ruprecht, K. Obojes, V. Wengel, F. Gronen, K. S. Kim et al., Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: Implications for multiple sclerosis, Journal of Neurovirology, vol.11, issue.1, pp.65-71, 2006.
DOI : 10.1080/13550280600614973

N. Sutkowski, D. A. Conrad, B. T. Thorley-lawson, and . Huber, Epstein-Barr Virus Transactivates the Human Endogenous Retrovirus HERV-K18 that Encodes a Superantigen, Immunity, vol.15, issue.4, pp.579-89, 2001.
DOI : 10.1016/S1074-7613(01)00210-2

A. Bandeira and . Coutinho, V beta 17 gene polymorphism in wild-derived mouse strains: two amino acid substitutions in the V beta 17 region greatly alter T cell receptor specificity, Cell, vol.63, issue.4, pp.717-745, 1990.

A. Herman, N. Labrecque, J. Thibodeau, P. Marrack, J. W. Kappler et al., Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR., Proceedings of the National Academy of Sciences, vol.88, issue.22, pp.88-9954, 1991.
DOI : 10.1073/pnas.88.22.9954

J. W. Kappler, N. Roehm, and P. Marrack, T cell tolerance by clonal elimination in the thymus, Cell, vol.49, issue.2, pp.273-80, 1987.
DOI : 10.1016/0092-8674(87)90568-X

P. Marrack, E. Kushnir, and J. Kappler, A maternally inherited superantigen encoded by a mammary tumour virus, Nature, vol.349, issue.6309, pp.349-524, 1991.
DOI : 10.1038/349524a0

Y. Choi, J. W. Kappler, and P. Marrack, A superantigen encoded in the open reading frame of the 3??? long terminal repeat of mouse mammary tumour virus, Nature, vol.350, issue.6315, pp.350-203, 1991.
DOI : 10.1038/350203a0

. Macdonald, Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission, Cell, vol.74, issue.3, pp.529-569, 1993.

J. M. Marcel, P. N. Seigneurin, M. Marche, and . Lafon, Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation, Virology, vol.287, issue.2, pp.321-353, 2001.

H. Dougier, C. Lomparski, C. Villiers, A. Duperray, C. Bernard et al., The envelope of human endogenous retrovirus in neuroinflammation sclerosis: a coordinated immunological attack against myelin in the central nervous system, Retrovirology Cell, issue.6 23, pp.53-52, 1996.

K. C. Simon, K. L. Munger, and A. Ascherio, Vitamin D and multiple sclerosis, Current Opinion in Neurology, vol.25, issue.3, pp.246-51, 2012.
DOI : 10.1097/WCO.0b013e3283533a7e
URL : https://hal.archives-ouvertes.fr/inserm-01103094

. Fernandez, Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production, Eur J Clin Microbiol Infect Dis, vol.29, issue.7, pp.857-66, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00589489

B. Krone and J. M. Grange, Paradigms in multiple sclerosis: time for a change, time for a unifying concept, Inflammopharmacology, vol.8, issue.Suppl 6, pp.187-95, 2011.
DOI : 10.1007/s10787-011-0084-6

L. Fugger, M. A. Friese, and J. I. Bell, From genes to function: the next challenge to understanding multiple sclerosis, Nature Reviews Immunology, vol.130, issue.6, pp.408-425, 2009.
DOI : 10.1038/nri2554

C. Grau, C. Arnal, M. Delgado, G. Lucas, F. Izquierdo et al., IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D), PLoS One, vol.4, issue.1, p.4137, 2009.

P. A. Gourraud, H. F. Harbo, S. L. Hauser, and S. E. Baranzini, The genetics of multiple sclerosis: an up-to-date review, Immunological Reviews, vol.61, issue.Suppl., pp.87-103, 2012.
DOI : 10.1111/j.1600-065X.2012.01134.x

J. Correale and A. Villa, The blood???brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting, Autoimmunity, vol.268, issue.354, pp.148-60, 2007.
DOI : 10.1002/ana.10092

K. Wosik, R. Cayrol, A. Dodelet-devillers, F. Berthelet, M. Bernard et al., Angiotensin II Controls Occludin Function and Is Required for Blood Brain Barrier Maintenance: Relevance to Multiple Sclerosis, Journal of Neuroscience, vol.27, issue.34, pp.27-9032, 2007.
DOI : 10.1523/JNEUROSCI.2088-07.2007

S. Leech, J. Kirk, J. Plumb, and S. Mcquaid, Persistent endothelial abnormalities and blood?brain barrier leak in primary and secondary progressive multiple sclerosis, Neuropathology and Applied Neurobiology, vol.25, issue.1
DOI : 10.1111/j.1365-2990.2006.00781.x

W. F. Hickey, Basic principles of immunological surveillance of the normal central nervous system, Glia, vol.28, issue.2, pp.118-142, 2001.
DOI : 10.1002/glia.1101

J. Bednarczyk and K. Lukasiuk, Tight junctions in neurological diseases, Acta Neurobiol Exp, vol.71, issue.4, pp.393-408, 2011.

R. C. Janzer, M. C. Bush, T. G. , N. Puvanachandra, C. H. Horner et al., Astrocytes induce blood-brain barrier properties in endothelial cells Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice, Nature Neuron, vol.75, issue.232, pp.325-253, 1987.

A. Armulik, G. Genove, M. Mae, M. H. Nisancioglu, E. Wallgard et al., Pericytes regulate the blood???brain barrier, Nature, vol.57, issue.7323, pp.468-557, 2010.
DOI : 10.1038/nature09522

R. Daneman, L. Zhou, A. A. Kebede, and B. A. Barres, Pericytes are required for blood???brain barrier integrity during embryogenesis, Nature, vol.43, issue.7323, pp.468-562, 2010.
DOI : 10.1038/nature09513

A. M. Butt, H. C. Jones, and N. J. Abbott, Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study., The Journal of Physiology, vol.429, issue.1, pp.47-62, 1990.
DOI : 10.1113/jphysiol.1990.sp018243

. Minagar, Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms. Pathophysiology, pp.3-12, 2010.

I. A. Greenwood, P. O. Romero, and . Couraud, Blood-brain barrier-specific properties of a human adult brain endothelial cell line, Faseb J, issue.13, pp.19-1872, 2005.

K. Hatherell, P. O. Couraud, I. A. Romero, B. Weksler, and G. J. Pilkington, Development of a three-dimensional, all-human in vitro model of the blood???brain barrier using mono-, co-, and tri-cultivation Transwell models, Journal of Neuroscience Methods, vol.199, issue.2, pp.199-223, 2011.
DOI : 10.1016/j.jneumeth.2011.05.012

. Cervenak, Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1beta, TNF-alpha, and LPS, Cytometry A, issue.10, pp.77-962, 2010.

B. Lemaitre, E. Nicolas, L. Michaut, J. M. Reichhart, and J. A. Hoffmann, The Dorsoventral Regulatory Gene Cassette sp??tzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults, Cell, vol.86, issue.6, pp.86-973, 1996.
DOI : 10.1016/S0092-8674(00)80172-5

G. Trinchieri and A. Sher, Cooperation of Toll-like receptor signals in innate immune defence, Nature Reviews Immunology, vol.181, issue.3, pp.179-90, 2007.
DOI : 10.1038/nri2038

. Krizbai, Expression and regulation of toll-like receptors in cerebral endothelial cells

K. W. Boehme and T. Compton, Innate Sensing of Viruses by Toll-Like Receptors, Journal of Virology, vol.78, issue.15, pp.78-7867, 2004.
DOI : 10.1128/JVI.78.15.7867-7873.2004

S. Akira and K. Takeda, Toll-like receptor signalling, Nature Reviews Immunology, vol.303, issue.7, pp.499-511, 2004.
DOI : 10.1038/nri1391

A. P. West, A. A. Koblansky, and S. Ghosh, Recognition and Signaling by Toll-Like Receptors, Annual Review of Cell and Developmental Biology, vol.22, issue.1, pp.409-446, 2006.
DOI : 10.1146/annurev.cellbio.21.122303.115827

D. Burzyn, J. C. Rassa, D. Kim, I. Nepomnaschy, S. R. Ross et al., Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus, Journal of Virology, vol.78, issue.2, pp.78-576, 2004.
DOI : 10.1128/JVI.78.2.576-584.2004

M. W. Walsh, D. T. Freeman, L. J. Golenbock, R. W. Anderson, and . Finberg, Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus, Nat Immunol, vol.1, issue.5, pp.398-401, 2000.

M. Alejos, C. Silva, M. Galanos, P. Freudenberg, B. Ricciardi-castagnoli et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, issue.5396, pp.282-2085, 1998.

. Malo, Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4), J Exp Med, vol.189, issue.4, pp.615-640, 1999.

B. S. Park, D. H. Song, H. M. Kim, B. S. Choi, H. Lee et al., The structural basis of lipopolysaccharide recognition by the TLR4???MD-2 complex, Nature, vol.50, issue.7242, pp.458-1191, 2009.
DOI : 10.1038/nature07830

S. Dunzendorfer, H. K. Lee, K. Soldau, and P. S. Tobias, Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS-responses, The FASEB Journal, issue.10, pp.18-1117, 2004.
DOI : 10.1096/fj.03-1263fje

. Goyert, CD14-independent responses to LPS require a serum factor that is absent from neonates, J Immunol, vol.155, issue.11, pp.5337-5379, 1995.

T. Ohnishi, M. Muroi, and K. Tanamoto, MD-2 Is Necessary for the Toll-Like Receptor 4 Protein To Undergo Glycosylation Essential for Its Translocation to the Cell Surface, Clinical and Vaccine Immunology, vol.10, issue.3
DOI : 10.1128/CDLI.10.3.405-410.2003

A. F. Mcgettrick and L. A. , Localisation and trafficking of Toll-like receptors: an important mode of regulation, Current Opinion in Immunology, vol.22, issue.1, pp.20-27, 2010.
DOI : 10.1016/j.coi.2009.12.002

J. C. Kagan, T. Su, T. Horng, A. Chow, S. Akira et al., TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta, Nat Immunol, issue.94, pp.361-369, 2008.

S. Danese, E. Dejana, and C. Fiocchi, Immune Regulation by Microvascular Endothelial Cells: Directing Innate and Adaptive Immunity, Coagulation, and Inflammation, The Journal of Immunology, vol.178, issue.10, pp.178-6017, 2007.
DOI : 10.4049/jimmunol.178.10.6017

B. Opitz, S. Hippenstiel, J. Eitel, and N. Suttorp, Extra- and intracellular innate immune recognition in endothelial cells, Thrombosis and Haemostasis, issue.2, pp.98-319, 2007.
DOI : 10.1160/TH06-12-0694

D. W. Holman, R. S. Klein, and R. M. Ransohoff, The blood???brain barrier, chemokines and multiple sclerosis, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1812, issue.2, pp.1812-220, 2010.
DOI : 10.1016/j.bbadis.2010.07.019
URL : https://hal.archives-ouvertes.fr/hal-00652656

J. Greenwood, S. J. Heasman, J. I. Alvarez, A. Prat, R. Lyck et al., Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain, Neuropathology and Applied Neurobiology, vol.25, issue.1, pp.24-39, 2011.
DOI : 10.1111/j.1365-2990.2010.01140.x

Y. Kanouchi, S. Minatogawa, K. Mohri, F. Tsujioka, and . Kajiya, Monocyte transendothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions, Int J Cardiol, 2010.

L. Sorokin, The impact of the extracellular matrix on inflammation, Nature Reviews Immunology, vol.114, issue.10, pp.712-735
DOI : 10.1038/nri2852

S. Agrawal, P. Anderson, M. Durbeej, N. Van-rooijen, F. Ivars et al., Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis, The Journal of Experimental Medicine, vol.19, issue.4, pp.1007-1026, 2006.
DOI : 10.1093/hmg/ddh190

W. A. Muller, Mechanisms of leukocyte transendothelial migration, Annu Rev Pathol, issue.6, pp.323-367, 2011.

K. Ley, C. Laudanna, M. I. Cybulsky, and S. Nourshargh, Getting to the site of inflammation: the leukocyte adhesion cascade updated, Nature Reviews Immunology, vol.106, issue.9, pp.678-89, 2007.
DOI : 10.1038/nri2156

J. M. Antony, Y. Zhu, M. Izad, K. G. Warren, M. Vodjgani et al., Comparative Expression of Human Endogenous Retrovirus-W Genes in Multiple Sclerosis, AIDS Research and Human Retroviruses, vol.23, issue.10, pp.23-1251, 2007.
DOI : 10.1089/aid.2006.0274

P. Deb-rinker, T. A. Klempan, R. L. O-'reilly, E. F. Torrey, and S. M. Singh, Molecular Characterization of a MSRV-like Sequence Identified by RDA from Monozygotic Twin Pairs Discordant for Schizophrenia, Genomics, vol.61, issue.2, pp.61-133, 1999.
DOI : 10.1006/geno.1999.5946

J. M. Antony, A. M. Deslauriers, R. K. Bhat, K. K. Ellestad, and C. Power, Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1812, issue.2, 2011.
DOI : 10.1016/j.bbadis.2010.07.016
URL : https://hal.archives-ouvertes.fr/hal-00652653

E. A. Jaffe, R. L. Nachman, C. G. Becker, and C. R. Minick, Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA, Journal of Clinical Investigation, vol.52, issue.11, pp.52-2745, 1973.
DOI : 10.1172/JCI107470

D. C. Berendt and . Altieri, Molecular identification of a novel fibrinogen binding site on the first domain of ICAM-1 regulating leukocyte-endothelium bridging, J Biol Chem, vol.272, issue.1, pp.435-476, 1997.

S. Arbour, D. David, A. Stanimirovic, and . Prat, Activated leukocyte cell adhesion distinct from the initiation of signal transduction, J Biol Chem, issue.49, pp.277-47834, 2002.

. Kimoto, MD-2, a molecule that confers lipopolysaccharide responsiveness on Tolllike receptor 4, J Exp Med, vol.189, issue.11, pp.1777-82, 1999.

W. Held, H. Acha-orbea, H. R. Macdonald, and G. A. Waanders, Superantigens and retroviral infection: insights from mouse mammary tumor virus, Immunology Today, vol.15, issue.4, pp.184-90, 1994.
DOI : 10.1016/0167-5699(94)90317-4

G. Arru, G. M. Vito-astone, C. Serra, Y. Huang, H. Link et al., Multiple Sclerosis and HERV-W/MSRV: A multicentric Study, International journal of Biomedical science

O. Frank, M. Giehl, C. Zheng, R. Hehlmann, C. Leib-mosch et al., Human Endogenous Retrovirus Expression Profiles in Samples from Brains of Patients with Schizophrenia and Bipolar Disorders, Journal of Virology, vol.79, issue.17, pp.79-10890, 2005.
DOI : 10.1128/JVI.79.17.10890-10901.2005

H. Karlsson, S. Bachmann, J. Schroder, J. Mcarthur, E. F. Torrey et al., Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia, Proceedings of the National Academy of Sciences, vol.98, issue.8, pp.98-4634, 2001.
DOI : 10.1073/pnas.061021998

H. Karlsson, J. Schroder, S. Bachmann, C. Bottmer, and R. H. Yolken, HERV-W-related RNA detected in plasma from individuals with recent-onset schizophrenia or schizoaffective disorder, Molecular Psychiatry, vol.9, issue.1, pp.12-15, 2004.
DOI : 10.1038/sj.mp.4001439

. Karlsson, Elevated levels of human endogenous retrovirus-W transcripts in blood cells from patients with first episode schizophrenia, Genes Brain Behav, vol.7, issue.1, pp.103-115, 2008.

R. K. Bhat, K. K. Ellestad, B. M. Wheatley, R. Warren, R. A. Holt et al., Age- and Disease-Dependent HERV-W Envelope Allelic Variation in Brain: Association with Neuroimmune Gene Expression, PLoS ONE, vol.4, issue.4, p.19176, 2011.
DOI : 10.1371/journal.pone.0019176.s004

J. A. Perron and . Garson, Infrequency of detection of particle-associated

. Bettadapura, Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis, J Mol Med, vol.75, issue.2, pp.77-88, 1997.

M. Le, Une protéine d'enveloppe provenant du MSRV est retrouvée chez la plupart des patients atteints de sclérose en plaque (SEP) Cette protéine (Env-ms) a des propriétés proinflammatoires sur les cellules immunitaires et pourrait donc jouer un rôle dans la pathogenèse de la SEP en exacerbant la diapédèse leucocytaire observée dans le système nerveux central (SNC) des patients Cette étude vise principalement à analyser les effets de Env-ms sur la barrière hématoencéphalique (BHE) au niveau moléculaire et fonctionnel. Nous avons pu démontrer que l'enveloppe recombinante du MSRV était capable de stimuler plusieurs paramètres inflammatoires sur un modèle humain de BHE in vitro, la lignée HCMEC/D3. En effet, Env-ms induit une surexpression d'ICAM-1, une protéine impliquée dans l'adhésion des leucocytes aux cellules endothéliales, d'une manière dose dépendante ainsi qu'une production dose dépendante de cytokines pro-inflammatoires comme l'IL-6 et l'IL-8. De plus, par une approche utilisant des siRNAs, nous avons pu montrer que Env-ms était reconnue par le récepteur TLR4, un récepteur de l'immunité innée exprimé par les cellules endothéliales. Nous avons aussi montré par des essais fonctionnels que Env-ms stimulait de manière significative l'adhésion de cellules immunitaires activées à la monocouche de cellules endothéliales. Enfin, nous avons aussi mesuré les effets de Env-ms sur des cultures primaires de cellules endothéliales HUVEC et nous avons pu montrer que les propriétés pro-inflammatoires de la protéine d'enveloppe