Skip to Main content Skip to Navigation
Theses

Étude de nouvelles méthodologies d’arylation directe en séries azole et pyridine : Application à la synthèse de coeurs de thiopeptides antibiotiques de la série d

Abstract : Due to the emergence of multiresistant bacterial strains to standard antibacterial treatments, thiopeptides antibiotics are actually highly considered, though they are known for 60 years. They show an excellent antibiotic activity against multiresistant bacterial strains, and implement two originals inhibition mechanisms of protein synthesis, still unemployed in human therapy. However, the difficulty to prepare these complex macromolecules limits their pharmacological development. The development of a new strategy to synthetize the most complicated part of these macromolecules, their heterocyclic core, is studied here in. This approach is based on the study and the exploitation of novel direct C-H and C-X transition-metal-catalyzed couplings of mono- and bithiazoles units with a broad panel of heteroaromatics. Its viability is here demonstrated trough the multi-step synthesis of the common heterocyclic core of amythiamicins.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00857574
Contributor : Abes Star :  Contact
Submitted on : Tuesday, September 3, 2013 - 4:49:10 PM
Last modification on : Thursday, July 2, 2020 - 3:29:03 AM

File

Lassalas.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00857574, version 1

Citation

Pierrik Lassalas. Étude de nouvelles méthodologies d’arylation directe en séries azole et pyridine : Application à la synthèse de coeurs de thiopeptides antibiotiques de la série d. Autre. INSA de Rouen, 2012. Français. ⟨NNT : 2012ISAM0024⟩. ⟨tel-00857574⟩

Share

Metrics

Record views

590

Files downloads

3272