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Rôle du noyau paragigantocellulaire latéral dans le réseau du sommeil paradoxal chez le rat

Abstract : The LPGi is a ventrolateral medullary area that contains the highest number of Fos-labelled neurons during a paradoxical sleep (PS) hypersomnia. Ten % of these Fos neurons project to the locus coeruleus, a PS-Off area and 70% of these Fos neurons are GABAergic. Our hypothesis is that the LPGi contains PS-On neurons involved in the inhibition of the PS-Off nuclei. Our aim was to check this hypothesis by recording the unit activity of the LPGi neurons, by identifying the afferent areas to the LPGi and determining its projection areas activated during PS. We have used extracellular unit recordings in the unanethetized head-restrained rat model and coupled this method to a selective PS deprivation using the flower-pot method. The analysis of the firing rate of the LPGi neurons showed that there are three different groups, SP-On, SP-Off and indifferent neurons. Moreover, the SLD, a PS-On area, is the main afferent to the LPGi activated during PS rebound. Our conclusion is that the LPGi is involved in the network generating PS. The SLD, considered as the PS executive area through glutamatergic neurons, may excite the LPGi during this state. The LPGi, through its GABAergic neurons, may inhibit the facial motor nucleus. This work provides for the first time evidence for a SLD-ventrolateral medulla pathway and suggests that the LPGi participates in the muscular atonia occurring during PS
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  • HAL Id : tel-00857424, version 1

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Chrystelle Sirieix. Rôle du noyau paragigantocellulaire latéral dans le réseau du sommeil paradoxal chez le rat. Sciences agricoles. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : 2011LYO10049⟩. ⟨tel-00857424⟩

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