Skip to Main content Skip to Navigation
Theses

Fenestranes, cyclooctatriènes et leurs dérivés comme châssis moléculaires innovants pour le développement de plateformes modulables

Abstract : This PhD thesis was focused on the study of cascade reactions and allowed the access to a large variety of polycyclic compounds. The extension of several methods employing palladocatalyzed cascade reactions and their limits have been studied. Those cascades are initiated by a 4-exo-dig cyclocarbopalladation, followed by a Sonogashira coupling. With an adequate substrate and the appropriate conditions, the cascade reaction can even be extended by an alcynilation, followed by an eight p electron electrocyclization and a six p electron electrocyclization. Complex scaffolds are thus obtained in only a few steps: fenestradienes and cyclooctatrienes. Derivatives with various substituents in different positions have been synthesized, particularly with heteroatoms. Their access has been ensured by either linear synthesis or a platform approach. This project was completed by an in silico study of the scaffolds regarding their drug-like potential.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00855441
Contributor : Abes Star :  Contact
Submitted on : Thursday, August 29, 2013 - 2:22:29 PM
Last modification on : Thursday, July 19, 2018 - 1:07:05 PM
Long-term archiving on: : Thursday, April 6, 2017 - 10:30:52 AM

File

BOUDHAR_Aicha_2012_ED222.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00855441, version 1

Collections

Citation

Aicha Boudhar. Fenestranes, cyclooctatriènes et leurs dérivés comme châssis moléculaires innovants pour le développement de plateformes modulables. Autre. Université de Strasbourg, 2012. Français. ⟨NNT : 2012STRAF022⟩. ⟨tel-00855441⟩

Share

Metrics

Record views

1014

Files downloads

2517