Skip to Main content Skip to Navigation
Theses

Dynamic analysis of serum tumor marker decline during anti-cancer treatment using population kinetic modeling approach

Abstract : Several cancers are associated with abnormal serum concentrations of tumor markers such as prostate specific antigen (PSA) in prostate tumor diseases, alfa-fetoprotein (AFP) or human chorionic gonadotrophin (hCG) in germ cell tumors or persistent gestational trophoblastic diseases (GTD). Cancer treatment should induce decline of serum tumor marker concentrations. The predictive values of many kinetic parameters supposed to characterize tumor marker declines such as nadir, time-point cutoff, half-life, time to normalization etc…, have been reported in previous studies. However very few of them have been used in routine due to the lack of outcome reproducibility. Population pharmacokinetic approach-based modeling is already used in pharmacokinetic studies. It might be helpful to characterize tumor marker decline equations dynamically and overcome limitations of previous studies. The feasibility and the relevance of this approach were assessed in 4 studies involving: PSA titers in patients with prostate adenoma or cancer treated with surgery; hCG-AFP in non-seminomatous germ cell tumor patients treated with BEP regimen (Bleomycin-Etoposide-Cisplatin) and hCG in GTD patients treated with methotrexate. Tumor marker decline modeling was feasible in all studies provided the methodology was adjusted to marker specificities. Apparent clearance of hCG and PSA might enable identification of patients with unfavorable decline profiles and thereby with high risk of relapse. Confirmatory studies with independent cohorts of patients are warranted
Document type :
Theses
Complete list of metadatas

Cited literature [141 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00848364
Contributor : Abes Star :  Contact
Submitted on : Friday, July 26, 2013 - 10:12:14 AM
Last modification on : Friday, October 23, 2020 - 5:02:24 PM
Long-term archiving on: : Sunday, October 27, 2013 - 3:16:54 AM

File

TH2011_You_Benoit.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00848364, version 1

Collections

Citation

Benoît You. Dynamic analysis of serum tumor marker decline during anti-cancer treatment using population kinetic modeling approach. Human health and pathology. Université Claude Bernard - Lyon I, 2011. English. ⟨NNT : 2011LYO10042⟩. ⟨tel-00848364⟩

Share

Metrics

Record views

675

Files downloads

1151