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Modélisation dynamique des mécanismes de signalisation induits par l'hormone folliculo-stimulante et l'angiotensine

Abstract : Seven transmembrane receptor (7TMR) signaling controls the main human physiological functions. R7TMs are targeted by drugs and initiate large and complex networks responsible for physiological eff ects. In this thesis, we dynamically modelled the FSHR-induced network that have critical role in reproduction and the angiotensin receptor-induced network which regulates blood presure and is considered as a model 7TMR with the objective to understand their mechanisms of functionning and to predict experimentally unreachable data. Our modeling, based on ODE formalism, assumes each species as a variable and each kinetic rate as a parameter. Some parameters were unknown and required an adjustment. This led us to develop an environement allowing the comparaison of existing adjustment methods and to create a novel and efficient hybrid method well-adapted to the parametrization of signaling networks.
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https://tel.archives-ouvertes.fr/tel-00847767
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Submitted on : Wednesday, July 24, 2013 - 12:46:50 PM
Last modification on : Tuesday, March 17, 2020 - 1:55:27 AM
Long-term archiving on: : Friday, October 25, 2013 - 4:10:42 AM

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  • HAL Id : tel-00847767, version 1

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Domitille Heitzler. Modélisation dynamique des mécanismes de signalisation induits par l'hormone folliculo-stimulante et l'angiotensine. Bio-Informatique, Biologie Systémique [q-bio.QM]. Université François Rabelais - Tours, 2011. Français. ⟨tel-00847767⟩

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