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Programmes d’évaluation externe de la qualité : étude rétrospective de l’évolution de la qualité des résultats d’analyses de biologie clinique dans trois pays européens

Abstract : The external quality assessment (EQA) is an essential tool that allows medical laboratories to supervise the quality of their analyses. A retrospective analysis on 391.893 results originating from seven frequently measured analytes (glucose, calcium, triglycerides, creatine kinase, haemoglobin, HbA1c, and urinary proteins) was performed over a twelveyear period, from 1996 to 2007. For three analytes, the results accumulated by three European Centres – Swiss, French, and Belgian – organising EQA surveys were compared. A simple non-parametrical statistical approach was used to calculate the performances (inter-laboratory CV% and percentage of correct results) in order to include all EQA results, even aberrant values. The work allowed to calculate the performances of devices for the different analytes, to compare performances among the Centres and among two types of users – professional laboratories and medical offices – and, finally to calculate the evolution of performances over time. It turns out that performances among the Centres are comparable and that professional laboratory devices obtained better performances as compared with small laboratory devices used in medical offices. Concerning POCT devices, performances are not linked to the type of user but to the POCT type : certain types reach the same performances as laboratory devices, while others are below. A general improvement of performances is measured for both types of users, for most devices, and for all the analytes.
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Submitted on : Friday, July 19, 2013 - 4:12:16 PM
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  • HAL Id : tel-00846678, version 1

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Pierre-Alain Morandi. Programmes d’évaluation externe de la qualité : étude rétrospective de l’évolution de la qualité des résultats d’analyses de biologie clinique dans trois pays européens. Médecine humaine et pathologie. Université Claude Bernard - Lyon I, 2010. Français. ⟨NNT : 2010LYO10262⟩. ⟨tel-00846678⟩

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