W. Cates and J. , Estimates of the Incidence and Prevalence of Sexually Transmitted Diseases in the United States, Sexually Transmitted Diseases, vol.26, issue.Supplement, pp.2-7, 1999.
DOI : 10.1097/00007435-199904001-00002

M. Stanley, D. Lowy, and I. Frazer, Chapter 12: Prophylactic HPV vaccines: Underlying mechanisms, Vaccine, vol.24, pp.106-119, 2006.
DOI : 10.1016/j.vaccine.2006.05.110

G. Ada, Vaccines and vaccination, N Engl J Med, vol.345, issue.14, pp.1042-53, 2001.

R. Steinbrook, The Potential of Human Papillomavirus Vaccines, New England Journal of Medicine, vol.354, issue.11, pp.1109-1121, 2006.
DOI : 10.1056/NEJMp058305

G. Clifford and L. Villa, Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases, Vaccine, vol.24, pp.26-34, 2006.
DOI : 10.1016/j.vaccine.2006.05.026

D. Parkin and F. Bray, Chapter 2: The burden of HPV-related cancers, Vaccine, vol.24, pp.11-25, 2006.
DOI : 10.1016/j.vaccine.2006.05.111

N. Munoz and L. Gissmann, Chapter 1: HPV in the etiology of human cancer. Vaccine, pp.1-10, 2006.

C. Laimins and L. , Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity, Rev Med Virol, vol.16, issue.2, pp.83-97, 2006.

C. Derkay, Task Force on Recurrent Respiratory Papillomas: A Preliminary Report, Archives of Otolaryngology - Head and Neck Surgery, vol.121, issue.12, pp.1386-91, 1995.
DOI : 10.1001/archotol.1995.01890120044008

I. Frazer, Prevention of cervical cancer through papillomavirus vaccination, Nature Reviews Immunology, vol.4, issue.1, pp.46-54, 2004.
DOI : 10.1038/nri1260

M. Stanley, Human Papillomavirus Vaccines ??? Immune Responses, Vaccine, vol.30, issue.1, pp.16-22, 2006.
DOI : 10.1016/j.vaccine.2012.04.106

L. Koutsky and D. Harper, Chapter 13: Current findings from prophylactic HPV vaccine trials, Vaccine, vol.24, pp.114-135, 2006.
DOI : 10.1016/j.vaccine.2006.06.014

D. Nardelli-haefliger, D. Grandi, and P. , Specific Antibody Levels at the Cervix During the Menstrual Cycle of Women Vaccinated With Human Papillomavirus 16 Virus-Like Particles, JNCI Journal of the National Cancer Institute, vol.95, issue.15, pp.1128-1165, 2003.
DOI : 10.1093/jnci/djg018

W. Unger and E. , National registry for juvenile-onset recurrent respiratory papillomatosis, Arch Otolaryngol Head Neck Surg, vol.129, issue.9, pp.976-82, 2003.

P. Campisi and K. Simpson, The epidemiology of juvenile onset recurrent respiratory papillomatosis derived from a population level national database, The Laryngoscope, vol.129, issue.suppl 3, pp.1233-1278, 2010.
DOI : 10.1002/lary.20901

L. Armstrong and W. Reeves, Incidence and Prevalence of Recurrent Respiratory Papillomatosis among Children in Atlanta and Seattle, Clinical Infectious Diseases, vol.31, issue.1, pp.107-116, 2000.
DOI : 10.1086/313914

C. Derkay, Task Force on Recurrent Respiratory Papillomas: A Preliminary Report, Archives of Otolaryngology - Head and Neck Surgery, vol.121, issue.12, pp.1386-91, 1995.
DOI : 10.1001/archotol.1995.01890120044008

L. Armstrong, C. Derkay, and W. Reeves, Initial Results From the National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis, Archives of Otolaryngology???Head & Neck Surgery, vol.125, issue.7, pp.743-751, 1999.
DOI : 10.1001/archotol.125.7.743

H. Kashima and R. Hruban, Sites of Predilection in Recurrent Respiratory Papillomatosis, Annals of Otology, Rhinology & Laryngology, vol.13, issue.8, pp.580-583, 1993.
DOI : 10.1177/000348949310200802

D. Kimberlin and D. Malis, Juvenile onset recurrent respiratory papillomatosis: possibilities for successful antiviral therapy, Antiviral Research, vol.45, issue.2, pp.83-93, 2000.
DOI : 10.1016/S0166-3542(00)00064-4

F. Cutts and L. Markowitz, Human papillomavirus and HPV vaccines: a review. Bull World Health Organ, 2007.

M. Cooper, Papillomata of the Vocal Folds: A Review, Journal of Speech and Hearing Disorders, vol.36, issue.1, pp.51-60, 1971.
DOI : 10.1044/jshd.3601.51

I. Soldatski and N. Schepin, Tracheal, Bronchial, and Pulmonary Papillomatosis in Children, The Laryngoscope, vol.67, issue.10, 2005.
DOI : 10.1097/01.mlg.0000173155.57491.2a

R. Cole, C. Myer, and R. Cotton, Tracheotomy in children with recurrent respiratory papillomatosis. Head Neck, pp.226-256, 1989.

W. Reeves and E. Unger, National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis, Archives of Otolaryngology???Head & Neck Surgery, vol.129, issue.9, pp.976-82, 2003.
DOI : 10.1001/archotol.129.9.976

L. Zawadzka-g?os and M. Brzewski, Lower airway papillomatosis in children, International Journal of Pediatric Otorhinolaryngology, vol.67, issue.10, 2003.
DOI : 10.1016/S0165-5876(03)00191-5

C. Derkay, Recurrent Respiratory Papillomatosis, The Laryngoscope, vol.126, issue.1, pp.57-69, 2001.
DOI : 10.1097/00005537-200101000-00011

A. Abramson and B. Steinberg, Latent human papillomavirus infection is comparable in the larynx and trachea, Journal of Medical Virology, vol.184, issue.3, pp.473-480, 2004.
DOI : 10.1002/jmv.20013

J. Cason and J. Best, Perinatal infection and persistence of human papillomavirus types 16 and 18 in infants, Journal of Medical Virology, vol.186, issue.3, pp.209-227, 1995.
DOI : 10.1002/jmv.1890470305

P. Rice and J. Best, High prevalence of human papillomavirus type 16 infection among children, Journal of Medical Virology, vol.20, issue.1, pp.70-75, 2000.
DOI : 10.1002/(SICI)1096-9071(200005)61:1<70::AID-JMV11>3.0.CO;2-Y

C. Miller and B. Johnstone, Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta-analysis, 1982-1997, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.91, issue.6, pp.622-657, 2001.
DOI : 10.1067/moe.2001.115392

G. Borkowski and H. Luckhaupt, Recurrent respiratory papillomatosis associated with gastroesophageal reflux disease in children, European Archives of Oto-Rhino-Laryngology, vol.256, issue.7, pp.370-372, 1999.
DOI : 10.1007/s004050050166

M. Mckenna and L. Brodsky, Extraesophageal acid reflux and recurrent respiratory papilloma in children, International Journal of Pediatric Otorhinolaryngology, vol.69, issue.5, pp.597-605, 2005.
DOI : 10.1016/j.ijporl.2004.11.021

S. Pignatari, D. Marco, and E. , Gastroesophageal Reflux in patients with Recurrent Laryngeal Papillomatosis, Brazilian Journal of Otorhinolaryngology, vol.73, issue.2, pp.210-214, 2007.
DOI : 10.1016/S1808-8694(15)31068-5

B. Wiatrak and L. Lewis, Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population, The Laryngoscope, vol.111, issue.7806, 2004.
DOI : 10.1097/01.mlg.000148224.83491.0f

R. Rabah and L. Gregoire, Human Papillomavirus-11-associated Recurrent Respiratory Papillomatosis Is More Aggressive Than Human Papillomavirus-6-associated Disease, Pediatric and Developmental Pathology, vol.4, issue.1, pp.68-72, 2001.
DOI : 10.1007/s100240010105

L. Armstrong, C. Derkay, and W. Reeves, Initial Results From the National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis, Archives of Otolaryngology???Head & Neck Surgery, vol.125, issue.7, pp.743-751, 1999.
DOI : 10.1001/archotol.125.7.743

P. Goon and H. Sudhoff, Recurrent respiratory papillomatosis: an overview of current thinking and treatment, European Archives of Oto-Rhino-Laryngology, vol.263, issue.2, pp.147-51, 2008.
DOI : 10.1007/s00405-007-0546-z

L. Dmochowski and D. Dreyer, A study of submicroscopic structure and of virus particles in cells of human laryngeal papillomas, Tex Rep Biol Med, vol.22, pp.454-91, 1964.

W. Boyle and E. Lennette, ELECTRON MICROSCOPIC IDENTIFICATION OF PAPOVA VIRUS IN LARYNGEAL PAPILLOMA, The Laryngoscope, vol.83, issue.7, pp.1102-1110, 1973.
DOI : 10.1288/00005537-197307000-00013

J. Costa and W. Bauer, Presence of Human Papilloma Viral Antigens in Juvenile Multiple Laryngeal Papilloma, American Journal of Clinical Pathology, vol.75, issue.2, pp.194-201, 1981.
DOI : 10.1093/ajcp/75.2.194

L. Gissmann and H. Zur-hausen, Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma, J Virol, vol.44, issue.1, pp.393-400, 1982.

L. Gissmann and H. Zur-hausen, Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers., Proceedings of the National Academy of Sciences, vol.80, issue.2, pp.560-563, 1983.
DOI : 10.1073/pnas.80.2.560

G. Corbitt and W. Farrington, Human papillomavirus (HPV) genotypes associated with laryngeal papilloma., Journal of Clinical Pathology, vol.41, issue.3, pp.284-292, 1988.
DOI : 10.1136/jcp.41.3.284

P. Dickens and S. Larkin, Human papillomavirus 6, 11, and 16 in laryngeal papillomas, The Journal of Pathology, vol.i, issue.3, 1991.
DOI : 10.1002/path.1711650308

W. Reeves and E. Unger, National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis, Archives of Otolaryngology???Head & Neck Surgery, vol.129, issue.9, pp.976-82, 2003.
DOI : 10.1001/archotol.129.9.976

B. Bavinck, J. Berkhout, and R. , HPV infections and immunosuppression, Clinics in Dermatology, vol.15, issue.3, pp.427-464, 1997.
DOI : 10.1016/S0738-081X(96)00154-X

X. Sun, T. Wright, and . Jr, Human Papillomavirus Infection in Women Infected with the Human Immunodeficiency Virus, New England Journal of Medicine, vol.337, issue.19, pp.1343-1352, 1997.
DOI : 10.1056/NEJM199711063371903

J. Palefsky and E. Holly, Chapter 6: Immunosuppression and Co-infection with HIV, JNCI Monographs, vol.2003, issue.31, pp.41-47, 2003.
DOI : 10.1093/oxfordjournals.jncimonographs.a003481

M. Scott, M. Nakagawa, and A. Moscicki, Cell-Mediated Immune Response to Human Papillomavirus Infection, Clinical and Vaccine Immunology, vol.8, issue.2, pp.209-229, 2001.
DOI : 10.1128/CDLI.8.2.209-220.2001

A. Ferenczy and C. Hankins, Human papillomavirus and HIV coinfection and the risk of neoplasias of the lower genital tract: a review of recent developments, CMAJ, vol.169, issue.5, pp.431-435, 2003.

V. Gerein and H. Pfister, Children and partners of patients with recurrent respiratory papillomatosis have no evidence of the disease during long-term observation, International Journal of Pediatric Otorhinolaryngology, vol.70, issue.12, pp.2061-2067, 2006.
DOI : 10.1016/j.ijporl.2006.07.018

E. Miller, Changes in serum immunity during pregnancy, American Journal of Human Biology, vol.26, issue.3, pp.401-404, 2009.
DOI : 10.1002/ajhb.20882

G. Reinhard and A. Ruecker, Shifts in the TH1/TH2 Balance during Human Pregnancy Correlate with Apoptotic Changes, Biochemical and Biophysical Research Communications, vol.245, issue.3, pp.933-941, 1998.
DOI : 10.1006/bbrc.1998.8549

K. Hoshimoto and N. Inaba, Changes in Plasma Soluble CD26 and CD30 during Pregnancy: Markers of Th1/Th2 Balance?, Gynecologic and Obstetric Investigation, vol.50, issue.4, pp.260-263, 2000.
DOI : 10.1159/000010328

J. Szekeres-bartho, IMMUNOLOGICAL RELATIONSHIP BETWEEN THE MOTHER AND THE FETUS, International Reviews of Immunology, vol.155, issue.6, pp.471-95, 2002.
DOI : 10.1080/08830180215017

B. Wiatrak, Overview of recurrent respiratory papillomatosis. Curr Opin Otolaryngol Head Neck Surg, 2003.

V. Gerein and H. Pfister, Children and partners of patients with recurrent respiratory papillomatosis have no evidence of the disease during long-term observation, International Journal of Pediatric Otorhinolaryngology, vol.70, issue.12, pp.2061-2067, 2006.
DOI : 10.1016/j.ijporl.2006.07.018

K. Shah and H. Kashima, Risk factors for juvenile onset recurrent respiratory papillomatosis, The Pediatric Infectious Disease Journal, vol.17, issue.5, pp.372-378, 1998.
DOI : 10.1097/00006454-199805000-00005

H. Kashima and K. Shah, A Comparison of Risk Factors in Juvenile-Onset and Adult-Onset Recurrent Respiratory Papillomatosis, The Laryngoscope, vol.102, issue.1, pp.9-13, 1992.
DOI : 10.1288/00005537-199201000-00002

S. Stamataki and E. Ferekidis, Juvenile recurrent respiratory papillomatosis: Still a mystery disease with difficult management, Head & Neck, vol.2, issue.2, pp.155-62, 2007.
DOI : 10.1002/hed.20491

H. Smith and M. Strong, Topical Chemotherapy of Recurrent Respiratory Papillomatosis, Annals of Otology, Rhinology & Laryngology, vol.35, issue.5, pp.472-480, 1980.
DOI : 10.1177/000348948008900522

B. Steinberg, Recurrent Respiratory Papillomatosis: Clinical and Molecular Aspects. Contribution to HPV Today: Newsletter on Human Papillomavirus. No 10, pp.8-10, 2007.

C. Rosen and P. Bryson, Indole-3-Carbinol for recurrent respiratory papillomatosis: long-term results, Journal of Voice, vol.18, issue.2, 2004.
DOI : 10.1016/j.jvoice.2003.05.005

V. Gerein and H. Pfister, Use of Interferon-Alpha in Recurrent Respiratory Papillomatosis: 20-Year Follow-up, Annals of Otology, Rhinology & Laryngology, vol.47, issue.6, pp.463-71, 2005.
DOI : 10.1177/000348940511400608

M. Dalianis and T. , Human papillomavirus, viral load and proliferation rate in recurrent respiratory papillomatosis in response to alpha interferon treatment, J Gen Virol, vol.86, pp.1695-702, 2005.

N. Shehab, B. Sweet, and N. Hogikyan, Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis: A Review of the Literature, Pharmacotherapy, vol.47, issue.1, pp.977-89, 2005.
DOI : 10.1007/s100240010105

E. Rogan, The natural chemopreventive compound indole-3-carbinol: state of the science, Vivo, pp.221-229, 2006.

L. Man, M. Statham, and C. Rosen, Mucosal Bridge and Pitting of the True Vocal Fold: An Unusual Complication of Cidofovir Injection, Annals of Otology, Rhinology & Laryngology, vol.113, issue.4, pp.236-244, 2010.
DOI : 10.1016/j.jvoice.2003.07.007

J. Harcourt, G. Worley, and S. Leighton, Cimetidine treatment for recurrent respiratory papillomatosis, International Journal of Pediatric Otorhinolaryngology, vol.51, issue.2, pp.109-122, 1999.
DOI : 10.1016/S0165-5876(99)00279-7

A. Abramson and B. Steinberg, Latent human papillomavirus infection is comparable in the larynx and trachea, Journal of Medical Virology, vol.184, issue.3, pp.473-480, 2004.
DOI : 10.1002/jmv.20013

B. Jahan-parwar and G. Berke, Development of a Canine Model for Recurrent Respiratory Papillomatosis, Annals of Otology, Rhinology & Laryngology, vol.283, issue.12, pp.1011-1014, 2003.
DOI : 10.1177/000348940311201203

P. Nicholls and M. Stanley, Naturally Occurring, Nonregressing Canine Oral Papillomavirus Infection: Host Immunity, Virus Characterization, and Experimental Infection, Virology, vol.265, issue.2, pp.365-74, 1999.
DOI : 10.1006/viro.1999.0060

J. Dimasi, R. Hansen, and H. Grabowski, The price of innovation: new estimates of drug development costs, Journal of Health Economics, vol.22, issue.2, pp.151-85, 2003.
DOI : 10.1016/S0167-6296(02)00126-1

M. Witten, A return to time, cells, systems, and aging: II relational and reliability theoretic approaches to the study of senescence in living systems, Mechanisms of Ageing and Development, vol.27, issue.3, pp.323-363, 1984.
DOI : 10.1016/0047-6374(84)90056-3

M. Eisenberg, M. Samuels, and J. Distefano, L-T4 bioequivalence and hormone replacement studies via feedback control simulations. Thyroid, pp.1279-92, 2006.

J. Venter and J. , The complete genome sequence of the gastric pathogen Helicobacter pylori, Nature, 1997.

T. Nagel, M. Gimbrone, and . Jr, Vascular Endothelial Cells Respond to Spatial Gradients in Fluid Shear Stress by Enhanced Activation of Transcription Factors, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.19, issue.8, pp.1825-1859, 1999.
DOI : 10.1161/01.ATV.19.8.1825

F. Giorgi, L. Bruni, and R. Maggio, Receptor Oligomerization as a Process Modulating Cellular Semiotics, Biosemiotics, vol.2, issue.Suppl. 1, pp.157-76, 2010.
DOI : 10.1007/s12304-010-9085-x

N. Boulé and R. Sigal, Effects of Exercise on Glycemic Control and Body Mass in Type 2 Diabetes Mellitus, JAMA, vol.286, issue.10, pp.1218-1245, 2001.
DOI : 10.1001/jama.286.10.1218

L. Mehl and S. Manchanda, Use of Chaos Theory and Complex Systems Modeling to Study Alcohol Effects on Fetal Condition, Computers and Biomedical Research, vol.26, issue.5, pp.424-472, 1993.
DOI : 10.1006/cbmr.1993.1031

J. Roach and D. Galas, Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science, Apr, vol.30328, issue.5978, pp.636-645, 2010.

K. Dietz, J. Heesterbeek, M. Cojocaru, C. Bauch, and M. Johnston, Daniel Bernoulli's epidemiological model revisited Dynamics of vaccination strategies via projected dynamical systems, Math Biosci Bull Math Biol, vol.18069, issue.875, pp.1-211453, 2002.

H. Gadêlha and J. Kirkman-brown, Nonlinear instability in flagellar dynamics: a novel modulation mechanism in sperm migration?, Journal of The Royal Society Interface, vol.18, issue.2, pp.1689-97, 2010.
DOI : 10.1530/rep.0.1260259

W. Fletcher and Z. Yang, INDELible: A Flexible Simulator of Biological Sequence Evolution, Molecular Biology and Evolution, vol.26, issue.8, 2009.
DOI : 10.1093/molbev/msp098

S. Calvano and S. Lowry, A network-based analysis of systemic inflammation in humans, Nature. Oct, vol.13437, issue.7061, pp.1032-1039, 2005.

J. Heo and W. Goddard, Prediction of the 3D structure of FMRF-amide neuropeptides bound to the mouse MrgC11 GPCR and experimental validation. Chembiochem, pp.1527-1566, 2007.

A. Hill and Y. Kaznessis, SynBioSS: the synthetic biology modeling suite, Bioinformatics, vol.24, issue.21, pp.2551-2554, 2008.
DOI : 10.1093/bioinformatics/btn468

R. Bonneau and N. Baliga, A Predictive Model for Transcriptional Control of Physiology in a Free Living Cell, Cell, vol.131, issue.7, pp.1354-65, 2007.
DOI : 10.1016/j.cell.2007.10.053

E. Schadt and A. Lusis, An integrative genomics approach to infer causal associations between gene expression and disease, Nature Genetics, vol.69, issue.7, pp.710-717, 2005.
DOI : 10.1023/A:1018394410659

T. Querec and B. Pulendran, Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans, Nature Immunology, vol.8, issue.1, pp.116-141, 2009.
DOI : 10.1038/ni.1688

S. Berger and R. Iyengar, Role of systems pharmacology in understanding drug adverse events, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol.73, issue.2, 2010.
DOI : 10.1002/wsbm.114

R. Germain and I. Fraser, Systems Biology in Immunology: A Computational Modeling Perspective, Annual Review of Immunology, vol.29, issue.1, 2010.
DOI : 10.1146/annurev-immunol-030409-101317

Y. Louzoun, The evolution of mathematical immunology, Immunological Reviews, vol.7, issue.Suppl, pp.9-20, 2007.
DOI : 10.1111/j.1600-065X.2006.00495.x

P. Kim, D. Levy, and P. Lee, Modeling and Simulation of the Immune System as a Self-Regulating Network, Methods Enzymol, vol.467, pp.79-109, 2009.
DOI : 10.1016/S0076-6879(09)67004-X

A. Chavali and J. Papin, Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling, Trends in Immunology, vol.29, issue.12, pp.589-99, 2008.
DOI : 10.1016/j.it.2008.08.006

C. Lundegaard and M. Nielsen, Modeling the adaptive immune system: predictions and simulations, Bioinformatics, vol.23, issue.24, pp.3265-75, 2007.
DOI : 10.1093/bioinformatics/btm471

N. Rapin and O. Lund, Modelling the Human Immune System by Combining Bioinformatics and Systems Biology Approaches, Journal of Biological Physics, vol.68, issue.3-4, pp.3-4335, 2006.
DOI : 10.1007/s10867-006-9019-7

S. Forrest and C. Beauchemin, Computer immunology, Immunological Reviews, vol.21, issue.1, pp.176-97, 2007.
DOI : 10.1111/j.1600-065X.2007.00499.x

K. Raman, A. Bhat, and N. Chandra, A systems perspective of host???pathogen interactions: predicting disease outcome in tuberculosis, Mol. BioSyst., vol.5, issue.3, pp.516-546, 2010.
DOI : 10.1039/B912129C

A. Romanyukha, S. Rudnev, and I. Sidorov, Energy cost of infection burden: An approach to understanding the dynamics of host???pathogen interactions, Journal of Theoretical Biology, vol.241, issue.1, pp.1-13, 2006.
DOI : 10.1016/j.jtbi.2005.11.004

A. Sedaghat and R. Siliciano, Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle, Proceedings of the National Academy of Sciences, vol.105, issue.12
DOI : 10.1073/pnas.0711372105

C. Fraser, HIV recombination: what is the impact on antiretroviral therapy? J R Soc Interface, pp.489-503, 2005.

J. Guardiola, G. Izzo, and A. Vecchio, Simulating the effect of vaccine-induced immune responses on HIV infection, Human Immunology, vol.64, issue.9, pp.840-51, 2003.
DOI : 10.1016/S0198-8859(03)00139-3

P. Bovier and L. Loutan, Predicted 30-year protection after vaccination with an aluminum-free virosomal hepatitis A vaccine, Journal of Medical Virology, vol.28, issue.10, pp.1629-1663, 2010.
DOI : 10.1002/jmv.21883

J. Wilson and D. Nokes, Do we need 3 doses of hepatitis B vaccine?, Vaccine, vol.17, issue.20-21, pp.20-212667, 1999.
DOI : 10.1016/S0264-410X(99)00029-8

X. Dong and I. Androulakis, Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes. PLoS One, Feb, vol.185, issue.2, p.9249, 2010.

P. Foteinou and I. Androulakis, Modeling endotoxin-induced systemic inflammation using an indirect response approach, Mathematical Biosciences, vol.217, issue.1, pp.27-42, 2009.
DOI : 10.1016/j.mbs.2008.09.003

G. Wang, G. Krueger, and L. Buja, Mathematical model to simulate the cellular dynamics of infection with human herpesvirus-6 in EBV-negative infectious mononucleosis, Journal of Medical Virology, vol.79, issue.4, pp.569-77, 2003.
DOI : 10.1002/jmv.10522

G. Marchuk and G. Bocharov, Mathematical model of antiviral immune response. I. Data analysis, generalized picture construction and parameters evaluation for hepatitis B, Journal of Theoretical Biology, vol.151, issue.1, pp.1-40, 1991.
DOI : 10.1016/S0022-5193(05)80142-0

I. Baltcheva, L. Boudec, and J. , Lifelong dynamics of human CD4+CD25+ regulatory T cells: Insights from in vivo data and mathematical modeling, Journal of Theoretical Biology, vol.266, issue.2, pp.307-329, 2010.
DOI : 10.1016/j.jtbi.2010.06.024

J. Boissel and M. Dronne, Modelling methodology in physiopathology, Progress in Biophysics and Molecular Biology, vol.97, issue.1, 2008.
DOI : 10.1016/j.pbiomolbio.2007.10.005

URL : https://hal.archives-ouvertes.fr/hal-00859345

. Burroughs-wellcome, [7] p. of plates : ill., maps, ports. (some col.) ; 18 cm. RNB health series, 1914.

I. Frazer, Prevention of cervical cancer through papillomavirus vaccination, Nature Reviews Immunology, vol.4, issue.1, pp.46-54, 2004.
DOI : 10.1038/nri1260

L. Alexopoulou and R. Flavell, Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3, Nature, vol.413, issue.6857, pp.732-740, 2001.
DOI : 10.1038/35099560

D. Fraillery, N. Zosso, and D. Nardelli-haefliger, Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles. Vaccine, pp.2326-2360, 2009.

M. Scott, D. Stites, and A. Moscicki, Th1 cytokine patterns in cervical human papillomavirus infection, Clin Diagn Lab Immunol, vol.6, issue.5, pp.751-756, 1999.

A. Jong and S. Van-der-burg, Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6. Cancer Res, pp.5449-55, 2004.

A. García-piñeres and L. Pinto, Cytokine and chemokine profiles following vaccination with human papillomavirus type 16 L1 Virus-like particles. Clin Vaccine Immunol, pp.984-993, 2007.

T. Lehner, P. Anton, and I. Roitt, Mucosal immunity and vaccination against HIV The immune system. First of two parts, AIDS. N Engl J Med, vol.16343, issue.1, pp.37-49, 2000.

Y. Lei and X. Dong, Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area, Biomedical and Environmental Sciences, vol.22, issue.1, pp.55-61, 2009.
DOI : 10.1016/S0895-3988(09)60023-4

K. Hagiwara and A. Hattori, A genotype distribution of human papillomaviruses detected by polymerase chain reaction and direct sequencing analysis in a large sample of common warts in Japan, Journal of Medical Virology, vol.1288, issue.1, pp.107-119, 2005.
DOI : 10.1002/jmv.20421

F. Aubin and O. Chosidow, Presence and persistence of human papillomavirus types 1, 2, and 4 on emery boards after scraping off plantar warts, Journal of the American Academy of Dermatology, vol.62, issue.1, pp.151-154, 2010.
DOI : 10.1016/j.jaad.2009.04.034

URL : https://hal.archives-ouvertes.fr/hal-00484634

H. Yoo and K. Lee, Detection and Identification of Human Papillomavirus Types Isolated from Korean Patients with Flat Warts, Microbiology and Immunology, vol.42, issue.1, pp.633-641, 2005.
DOI : 10.1111/j.1348-0421.2005.tb03655.x

H. Rogers and M. Grossman, Acquired epidermodysplasia verruciformis, Journal of the American Academy of Dermatology, vol.60, issue.2, 2009.
DOI : 10.1016/j.jaad.2008.08.035

S. Begum and W. Westra, Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res, Feb, vol.1513, issue.4, pp.1186-91, 2007.

M. Gillison and D. Sidransky, Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers, Journal of the National Cancer Institute, vol.92, issue.9, pp.709-729, 2000.
DOI : 10.1093/jnci/92.9.709

C. Fakhry and M. Gillison, Clinical Implications of Human Papillomavirus in Head and Neck Cancers, Journal of Clinical Oncology, vol.24, issue.17, 2006.
DOI : 10.1200/JCO.2006.06.1291

K. Ang and M. Gillison, Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer, New England Journal of Medicine, vol.363, issue.1, pp.24-35, 2010.
DOI : 10.1056/NEJMoa0912217

N. Saunders and M. Silverman, Focal Epithelial Hyperplasia Caused by Human Papillomavirus 13, The Pediatric Infectious Disease Journal, vol.29, issue.6, pp.550-552, 2010.
DOI : 10.1097/INF.0b013e3181cf854c

F. Falaki and N. Pazooki, Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran, Journal of Oral Pathology & Medicine, vol.65, issue.10, pp.773-779, 2009.
DOI : 10.1111/j.1600-0714.2009.00784.x

V. Cuberos and G. Sanchez, Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: A case-control study, Journal of Clinical Virology, vol.37, issue.1, pp.21-27, 2006.
DOI : 10.1016/j.jcv.2006.04.003

D. Greenspan and Y. De-souza, ORAL "HAIRY" LEUCOPLAKIA IN MALE HOMOSEXUALS: EVIDENCE OF ASSOCIATION WITH BOTH PAPILLOMAVIRUS AND A HERPES-GROUP VIRUS, The Lancet, vol.324, issue.8407, pp.831-835, 1984.
DOI : 10.1016/S0140-6736(84)90872-9

J. Allam and N. Novak, Successful treatment of extensive human papillomavirus-associated oral leucoplakia with imiquimod, British Journal of Dermatology, vol.97, issue.Suppl. 4, pp.644-650, 2008.
DOI : 10.1111/j.1365-2133.2007.08374.x

S. Mckay and W. Lancaster, Human Papillomavirus (HPV) Transcripts in Malignant Inverted Papilloma are from Integrated HPV DNA, The Laryngoscope, vol.42, issue.8, pp.1428-1459, 2005.
DOI : 10.1097/01.mlg.0000168091.50584.b4

J. Beck and C. Bradford, Presence of human papillomavirus predicts recurrence of inverted papilloma. Otolaryngol Head Neck Surg, pp.49-55, 1995.

Y. Furuta and Y. Inuyama, Molecular Pathologic Study of Human Papillomavirus Infection in Inverted Papilloma and Squamous Cell Carcinoma of the Nasal Cavities and Paranasal Sinuses, The Laryngoscope, vol.101, issue.1, pp.79-85, 1991.
DOI : 10.1288/00005537-199101000-00015

B. Wiatrak, Overview of recurrent respiratory papillomatosis. Curr Opin Otolaryngol Head Neck Surg, 2003.

J. Lee and R. Smith, Recurrent Respiratory Papillomatosis, Korean Journal of Otorhinolaryngology-Head and Neck Surgery, vol.58, issue.12, pp.354-363, 2005.
DOI : 10.3342/kjorl-hns.2015.58.12.822

C. Derkay and B. Wiatrak, Recurrent Respiratory Papillomatosis: A Review, The Laryngoscope, vol.135, issue.7, pp.1236-1283, 2008.
DOI : 10.1097/MLG.0b013e31816a7135

T. Gallagher and C. Derkay, Recurrent respiratory papillomatosis: update Curr Opin Otolaryngol Head Neck Surg, pp.536-578, 2008.

P. Kao and H. Blaszyk, Esophageal squamous papillomatosis, European Journal of Gastroenterology & Hepatology, vol.17, issue.11, 2005.
DOI : 10.1097/00042737-200511000-00013

S. Mosca and A. Balzano, Squamous papilloma of the esophagus: Long-term follow up, Journal of Gastroenterology and Hepatology, vol.25, issue.8, pp.857-61, 2001.
DOI : 10.1002/(SICI)1097-0215(19990301)80:5<681::AID-IJC8>3.0.CO;2-A

R. Kibria and S. Ali, Esophageal squamous papillomatosis with dysplasia. Is there a role of balloon-based radiofrequency ablation therapy? Acta Gastroenterol Belg, pp.373-379, 2009.

N. Muñoz and C. Meijer, Epidemiologic classification of human papillomavirus types associated with cervical cancer, N Engl J Med Feb, vol.6348, issue.6, pp.518-545, 2003.

N. Muñoz, X. Bosch, and J. Kaldor, Does human papillomavirus cause cervical cancer? The state of the epidemiological evidence, British Journal of Cancer, vol.57, issue.1, pp.1-5, 1988.
DOI : 10.1038/bjc.1988.1

F. Bosch and K. Shah, Prevalence of Human Papillomavirus in Cervical Cancer, Obstetrical & Gynecological Survey, vol.50, issue.10, pp.796-802, 1995.
DOI : 10.1097/00006254-199510000-00015

J. Walboomers and N. Muñoz, Human papillomavirus is a necessary cause of invasive cervical cancer worldwide, The Journal of Pathology, vol.89, issue.1
DOI : 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F

J. Smith and G. Clifford, Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: A meta-analysis update, International Journal of Cancer, vol.189, issue.3, pp.621-653, 2007.
DOI : 10.1002/ijc.22527

M. Dürst and H. Zur-hausen, A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions., Proceedings of the National Academy of Sciences, vol.80, issue.12, pp.3812-3817, 1983.
DOI : 10.1073/pnas.80.12.3812

M. Boshart and H. Zur-hausen, A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer, EMBO J, vol.3, issue.5, pp.1151-1158, 1984.

Y. Tsunokawa and T. Sugimura, Presence of human papillomavirus type-16 and type-18 DNA sequences and their expression in cervical cancers and cell lines from japanese patients, International Journal of Cancer, vol.77, issue.4, pp.499-503, 1986.
DOI : 10.1002/ijc.2910370405

A. Moscicki and L. Villa, Updating the natural history of HPV and anogenital cancer, Vaccine, vol.5, 2006.

J. Doorbar, Molecular biology of human papillomavirus infection and cervical cancer, Clinical Science, vol.110, issue.5, 2006.
DOI : 10.1042/CS20050369

N. Muñoz and L. Gissmann, Chapter 1: HPV in the etiology of human cancer. Vaccine, pp.3-4, 2006.

A. Quayle, The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells, Journal of Reproductive Immunology, vol.57, issue.1-2, pp.61-79, 2002.
DOI : 10.1016/S0165-0378(02)00019-0

C. Wira and L. Shen, Innate and adaptive immunity in female genital tract: cellular responses and interactions, Immunological Reviews, vol.2, issue.1, pp.306-341, 2005.
DOI : 10.1038/sj.mn.7300054

J. Mestecky, Z. Moldoveanu, and M. Russell, Immunologic Uniqueness of the Genital Tract: Challenge for Vaccine Development, American Journal of Reproductive Immunology, vol.24, issue.5, pp.208-222, 2005.
DOI : 10.1016/S0264-410X(01)00051-2

I. Frazer, Prevention of cervical cancer through papillomavirus vaccination, Nature Reviews Immunology, vol.4, issue.1, pp.46-54, 2004.
DOI : 10.1038/nri1260

J. Ulmer, U. Valley, and R. Rappuoli, Vaccine manufacturing: challenges and solutions, Nature Biotechnology, vol.103, issue.11, 2006.
DOI : 10.1038/nbt1261

V. Abadie and B. Combadière, Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice. PLoS One):e8159. 169 Pulendran B. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology, Nat Rev Immunol, vol.49, issue.1210, pp.741-748, 2009.

R. Steinman and H. Hemmi, Dendritic Cells: Translating Innate to Adaptive Immunity, Curr Top Microbiol Immunol, vol.311, pp.17-58, 2006.
DOI : 10.1007/3-540-32636-7_2

Y. Shi and S. Devadas, Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know, Cell Research, vol.60, issue.2, pp.126-159, 2006.
DOI : 10.1038/362755a0

R. Zubler, Naive and memory B cells in T-cell-dependent and T-independent responses 173 Delves PJ, Roitt IM. The immune system. Second of two parts, Springer Semin Immunopathol N Engl J Med, vol.23343, issue.42, pp.405-19108, 2000.

T. Gourley and R. Ahmed, Generation and maintenance of immunological memory. Semin Immunol, 2004.

J. Wrammert and R. Ahmed, Maintenance of serological memory, Biological Chemistry, vol.389, issue.5, pp.537-546, 2008.
DOI : 10.1515/BC.2008.066

I. Amanna, N. Carlson, and M. Slifka, Duration of Humoral Immunity to Common Viral and Vaccine Antigens, New England Journal of Medicine, vol.357, issue.19, pp.1903-1918, 2007.
DOI : 10.1056/NEJMoa066092

P. Kim, P. Lee, and D. Levy, Modeling regulation mechanisms in the immune system, Journal of Theoretical Biology, vol.246, issue.1, pp.33-69, 2007.
DOI : 10.1016/j.jtbi.2006.12.012

H. Gudmundsdottir, A. Wells, and L. Turka, Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity, J Immunol, vol.162, issue.9, pp.5212-5235, 1999.

P. Heinrich and F. Schaper, Principles of interleukin (IL)-6-type cytokine signalling and its regulation, Biochemical Journal, vol.374, issue.1, pp.1-20, 2003.
DOI : 10.1042/bj20030407

P. Krammer, R. Arnold, and I. Lavrik, Life and death in peripheral T cells, Nature Reviews Immunology, vol.36, issue.7, pp.532-574, 2007.
DOI : 10.1038/nri2115

S. Sakaguchi and F. Powrie, Emerging Challenges in Regulatory T Cell Function and Biology, Science, vol.317, issue.5838, pp.627-636, 2007.
DOI : 10.1126/science.1142331

C. Harro and D. Lowy, Safety and Immunogenicity Trial in Adult Volunteers of a Human Papillomavirus 16 L1 Virus-Like Particle Vaccine, JNCI Journal of the National Cancer Institute, vol.93, issue.4, pp.284-92, 2001.
DOI : 10.1093/jnci/93.4.284

L. Shampine and S. Thompson, Solving DDEs in Matlab, Applied Numerical Mathematics, vol.37, issue.4, pp.441-458, 2001.
DOI : 10.1016/S0168-9274(00)00055-6

J. Scott and J. Davidson, Leukocyte labeling with 51 chromium. IV. The kinetics of chronic lymphocytic leukemic lymphocytes, Blood, vol.41, issue.1, pp.155-62, 1973.

D. Fulcher and A. Basten, B cell life span: A review, Immunology and Cell Biology, vol.179, issue.5, pp.446-55, 1997.
DOI : 10.1038/icb.1997.69

I. Amanna, N. Carlson, and M. Slifka, Duration of Humoral Immunity to Common Viral and Vaccine Antigens, New England Journal of Medicine, vol.357, issue.19, pp.1903-1918, 2007.
DOI : 10.1056/NEJMoa066092

S. Oehen and R. Zinkernagel, Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen, Journal of Experimental Medicine, vol.176, issue.5, pp.1273-81, 1992.
DOI : 10.1084/jem.176.5.1273

D. Gray and P. Matzinger, T cell memory is short-lived in the absence of antigen, Journal of Experimental Medicine, vol.174, issue.5, pp.969-74, 1991.
DOI : 10.1084/jem.174.5.969

B. Bellier and D. Klatzmann, Turning immunological memory into amnesia by depletion of dividing T cells, Proceedings of the National Academy of Sciences, vol.100, issue.25, pp.15017-15039, 2003.
DOI : 10.1073/pnas.1936194100

M. Maruyama, K. Lam, and K. Rajewsky, Memory B-cell persistence is independent of persisting immunizing antigen, Nature, vol.407, issue.6804, pp.636-678, 2000.

A. Müllbacher, The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen, Journal of Experimental Medicine, vol.179, issue.1, pp.317-338, 1994.
DOI : 10.1084/jem.179.1.317

. Sl, Elimination of aluminum adjuvants. Vaccine, pp.40-43, 2002.

H. Hogenesch, Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine, pp.34-43, 2002.

F. Ho and M. Khan, Distinct short-lived and long-lived antibody-producing cell populations, European Journal of Immunology, vol.128, issue.10, 1986.
DOI : 10.1002/eji.1830161018

J. Jacob, R. Kassir, and G. Kelsoe, In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations, Journal of Experimental Medicine, vol.173, issue.5, pp.1165-75, 1991.
DOI : 10.1084/jem.173.5.1165

R. Zubler, Naive and memory B cells in T-cell-dependent and T-independent responses, Springer Seminars in Immunopathology, vol.34, issue.Suppl 1, pp.405-424, 2001.
DOI : 10.1007/s281-001-8167-7

S. Olsson, Induction of immune memory following administration of a prophylactic quadrivalent human papillomavirus (HPV) types 6/11/16/18 L1 virus-like particle (VLP) vaccine, Vaccine, vol.25, issue.26, pp.4931-4940, 2007.
DOI : 10.1016/j.vaccine.2007.03.049

L. Villa, High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up, British Journal of Cancer, vol.17, issue.11, pp.1459-66, 2006.
DOI : 10.1093/aje/kwf180

B. Wiatrak and L. Lewis, Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population, The Laryngoscope, vol.111, issue.7806, 2004.
DOI : 10.1097/01.mlg.000148224.83491.0f

M. Einstein and G. Dubin, human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18???45 years, Human Vaccines, vol.5, issue.10, pp.705-724, 2009.
DOI : 10.4161/hv.5.10.9518

A. Rowhani-rahbar, Antibody Responses in Oral Fluid after Administration of Prophylactic Human Papillomavirus Vaccines, The Journal of Infectious Diseases, vol.200, issue.9, pp.1452-1457, 2009.
DOI : 10.1086/606026

M. Stanley, Human Papillomavirus Vaccines ??? Immune Responses, Vaccine, vol.30, issue.1, pp.16-22, 2006.
DOI : 10.1016/j.vaccine.2012.04.106

M. Einstein and G. Dubin, human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18???45 years, Human Vaccines, vol.5, issue.10, pp.705-724, 2009.
DOI : 10.4161/hv.5.10.9518

W. Ruiz and M. Esser, Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant, J Immune Based Ther Vaccines, vol.3, issue.12, 2005.

J. Bryan and D. Brown, Human papillomavirus type 11 neutralization in the athymic mouse xenograft system: Correlation with virus-like particle IgG concentration, Journal of Medical Virology, vol.61, issue.3, pp.185-193, 1997.
DOI : 10.1002/(SICI)1096-9071(199711)53:3<185::AID-JMV1>3.0.CO;2-4

J. Gélinas, J. Manoukian, and A. Côté, Lung involvement in juvenile onset recurrent respiratory papillomatosis: A systematic review of the literature, International Journal of Pediatric Otorhinolaryngology, vol.72, issue.4, pp.433-52, 2008.
DOI : 10.1016/j.ijporl.2007.12.003

R. Wu and B. Steinberg, Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas. Clin Cancer Res, pp.6155-61, 2005.

A. Gallego, G. , A. Aparicio, and L. , Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer, Clinical and Translational Oncology, vol.97, issue.11, pp.694-702, 2007.
DOI : 10.1007/s12094-007-0126-0

J. Mann and R. Dubois, Cyclooxygenase-2 and Gastrointestinal Cancer, The Cancer Journal, vol.10, issue.3, pp.145-52, 2004.
DOI : 10.1097/00130404-200405000-00001

M. Smith and P. Kantoff, Celecoxib Versus Placebo for Men With Prostate Cancer and a Rising Serum Prostate-Specific Antigen After Radical Prostatectomy and/or Radiation Therapy, Journal of Clinical Oncology, vol.24, issue.18, pp.2723-2731, 2006.
DOI : 10.1200/JCO.2005.03.7804

W. White and K. Verburg, Risk of Cardiovascular Events in Patients Receiving Celecoxib: A Meta-Analysis of Randomized Clinical Trials, The American Journal of Cardiology, vol.99, issue.1, pp.91-99, 2007.
DOI : 10.1016/j.amjcard.2006.07.069

L. Chen and D. Ashcroft, Risk of myocardial infarction associated with selective COX-2 inhibitors: Meta-analysis of randomised controlled trials, Pharmacoepidemiology and Drug Safety, vol.42, issue.7, pp.762-72, 2007.
DOI : 10.1002/pds.1409

D. Khanna, P. Khanna, and D. Furst, COX-2 controversy: where are we and where do we go from here?, InflammoPharmacology, vol.13, issue.4, pp.395-402, 2005.
DOI : 10.1163/156856005774415583

A. Hildesheim, Effect of Human Papillomavirus 16/18 L1 Viruslike Particle Vaccine Among Young Women With Preexisting Infection, JAMA, vol.298, issue.7, pp.743-53, 2007.
DOI : 10.1001/jama.298.7.743

F. Cutts, Human papillomavirus and HPV vaccines: a review. Bull World Health Organ, pp.719-745, 2007.

C. Derkay, Task Force on Recurrent Respiratory Papillomas: A Preliminary Report, Archives of Otolaryngology - Head and Neck Surgery, vol.121, issue.12, pp.1386-91, 1995.
DOI : 10.1001/archotol.1995.01890120044008

W. Unger and E. , National registry for juvenile-onset recurrent respiratory papillomatosis, Arch Otolaryngol Head Neck Surg, vol.129, issue.9, pp.976-82, 2003.

I. Frazer, HPV6b virus like particles are potent immunogens without adjuvant in man, Vaccine, vol.18, pp.11-121051, 2000.