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Synthèse stéréocontrôlée de dérivés, accepteurs potentiels des glycosyltransférases impliquées dans les voies de biosynthèse des protéoglycanes

Abstract : Osteoarthritis is a process leading to the degeneration of articular cartilage in which one of the major component is the proteoglycan (PG) aggrecan. It is composed of glycosaminoglycans (GAGs), mainly chondroitin sulfate (CS), covalently linked to a peptide backbone through the tetrasaccharide linkage region which is common to the two principal types of GAGs (CS and heparan sulfate (HS)). The PGs biosynthesis involves the sequential action of O-glycosyltransferases that add specifically each saccharide unit. In this biosynthesis, still poorly understood, the linkage region undergoes changes (sulfation and phosphorylation) that may be important for the polymerization of PGs in favor of the CS or the HS.The objective of this work was to synthesize, for the first time, a full collection of biotinylated trisaccharides variously monosulfated or not of the linkage region of PGs and biotinylated tetrasaccharides (linkage region and first aminosugar of CS), in order to determine the role of the possible sulfation within the biosynthetic pathway of PGs by the O-glycosyltransferases.
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Katia Ait-Mohand. Synthèse stéréocontrôlée de dérivés, accepteurs potentiels des glycosyltransférases impliquées dans les voies de biosynthèse des protéoglycanes. Autre. Université d'Orléans, 2012. Français. ⟨NNT : 2012ORLE2073⟩. ⟨tel-00843650⟩

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