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Conception, synthèse et étude de dérivés de C60 fonctionnalisés : applications biologiques et développement méthodologique

Abstract : Our team has recently built a polyvalent method that gives complex functionalized C60 hexa-adducts. This methodology permits to obtain products with original features. C60 acts as an inert scaffold, around which functionnalities are distributed in a well-defined octahedral space. The first part of this thesis describes exploitation of this methodology to create polycationics C60 hexa-adducts, which have shown remarkable gene delivery capabilities. Next, the synthetized polyamine dendrons were used to build supramolecular structure of C60 hexa-adducts, as micellar forms. The study of these self-assembled structures has guided us to design micelles of mannosylated C60 hexa-adducts, which biological applications are under investigation. In parallel a covalent synthesis has furnished a dendrimers-like multimannosylated C60 hexa-adduct. Based on the observation that our methodology to create C60 hexa-adduct is efficient only for a specific regio-selectivity, the last part of this thesis was devoted to the development of new synthetic routes to obtain C60 derivates with an original regio-selective control.
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https://tel.archives-ouvertes.fr/tel-00834861
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Submitted on : Monday, June 17, 2013 - 3:04:12 PM
Last modification on : Thursday, July 11, 2019 - 3:44:02 PM
Long-term archiving on: : Tuesday, April 4, 2017 - 11:31:08 PM

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David Sigwalt. Conception, synthèse et étude de dérivés de C60 fonctionnalisés : applications biologiques et développement méthodologique. Autre. Université de Strasbourg, 2013. Français. ⟨NNT : 2013STRAF010⟩. ⟨tel-00834861⟩

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