The maximum likelihood method, Messenger in Mathematics, p.55, 1912. ,
Statistical Methods for Research Workers en, p.73, 1925. ,
Most mammalian mRNAs are conserved targets of microRNAs, Genome Research, vol.19, issue.1, pp.92-105, 2009. ,
DOI : 10.1101/gr.082701.108
Genetics of Venous Thrombosis: Insights from a New Genome Wide Association Study, PLoS ONE, vol.42, issue.9, pp.25581-78, 2011. ,
DOI : 10.1371/journal.pone.0025581.s003
Stratégies de Recherches de Phénomènes d'Interactions dans les maladies multifactorielles thèse de doct. (2013) (cf, p.14 ,
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis (soumis) ,
Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene Expression, PLoS ONE, vol.7, issue.9, pp.45863-2012 ,
DOI : 10.1371/journal.pone.0045863.s003
miRBase: tools for microRNA genomics, Nucleic Acids Research, vol.36, issue.Database, pp.154-162, 2008. ,
DOI : 10.1093/nar/gkm952
URL : http://doi.org/10.1093/nar/gkm952
Neuronal activity modifies the DNA methylation landscape in the adult brain, Nature Neuroscience, vol.454, issue.10, pp.1345-51, 2011. ,
DOI : 10.1093/bioinformatics/btp092
Où est Charlie ? : le voyage fantastique, p.36, 1989. ,
MENDELIAN PROPORTIONS IN A MIXED POPULATION, Science, vol.28, issue.706, pp.49-50, 1908. ,
DOI : 10.1126/science.28.706.49
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk, Nature, vol.447, issue.7314, pp.460-464, 2010. ,
DOI : 10.1038/nature09386
The SU.VI.MAX Study, Archives of Internal Medicine, vol.164, issue.21, pp.2335-2377, 2004. ,
DOI : 10.1001/archinte.164.21.2335
URL : https://hal.archives-ouvertes.fr/hal-01346671
A simple sequentially rejective multiple test procedure, Scandinavian journal of statistics, p.67, 1979. ,
IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a, Journal of Cellular and Molecular Medicine, vol.98, issue.1 ,
DOI : 10.1111/j.1582-4934.2011.01307.x
Gene silencing by microRNAs: contributions of translational repression and mRNA decay, Nature Reviews Genetics, vol.457, issue.2, pp.99-110, 2011. ,
DOI : 10.1038/nrg2936
The International HapMap Project, Nature, vol.426, pp.789-96, 2003. ,
Structures genetiques des populations, Population (French Edition), vol.24, issue.6, pp.1155-1160, 1969. ,
DOI : 10.2307/1529739
Human MicroRNA Targets, PLoS Biology, vol.31, issue.11, pp.363-370, 2004. ,
DOI : 10.1371/journal.pbio.0020363.st013
URL : http://doi.org/10.1371/journal.pbio.0020363
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap, Bioinformatics, vol.24, issue.24, pp.2938-2947, 2008. ,
DOI : 10.1093/bioinformatics/btn564
Twins and the mystery of missing heritability: the contribution of gene-environment interactions, Journal of Internal Medicine, vol.8, issue.5, p.39, 2012. ,
DOI : 10.1111/j.1365-2796.2012.02587.x
A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia, Journal of Molecular and Cellular Cardiology, vol.51, issue.5 ,
DOI : 10.1016/j.yjmcc.2011.07.001
Identification of the cystic fibrosis gene: genetic analysis, Science, vol.245, issue.4922, pp.1073-80, 1989. ,
DOI : 10.1126/science.2570460
Complement Factor H Polymorphism in Age-Related Macular Degeneration, Science, vol.308, issue.5720, pp.385-394, 2005. ,
DOI : 10.1126/science.1109557
Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families, Blood, vol.84, issue.87, pp.1031-1035, 1994. ,
Combinatorial microRNA target predictions, Nature Genetics, vol.432, issue.5, pp.495-500, 2005. ,
DOI : 10.1093/nar/gkh023
URL : http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:bvb:12-bsb00084512-5
The widespread regulation of microRNA biogenesis, function and decay, Nature reviews. Genetics, vol.11, pp.597-610, 2010. ,
Hundreds of variants clustered in genomic loci and biological pathways affect human height, Nature, vol.42, issue.7317, pp.832-840, 2010. ,
DOI : 10.1038/nature09410
URL : https://hal.archives-ouvertes.fr/cea-00904990
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, vol.75, issue.5, pp.843-54, 1993. ,
DOI : 10.1016/0092-8674(93)90529-Y
URL : https://hal.archives-ouvertes.fr/in2p3-00597159
Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli, The Journal of biological chemistry, vol.233, pp.163-70, 1958. ,
Comparing gene expression networks in a multi-dimensional space to extract similarities and differences between organisms, Bioinformatics, vol.22, issue.11, pp.1359-66, 2006. ,
DOI : 10.1093/bioinformatics/btl087
URL : https://hal.archives-ouvertes.fr/hal-00091646
Contributions to Probability and Statistics : Essays in Honor of Harold Hotelling : Robust tests for equality of variances 278?292, pp.45-61, 1960. ,
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets, Cell, vol.120, issue.1, pp.15-20, 2005. ,
DOI : 10.1016/j.cell.2004.12.035
The Interaction of Selection and Linkage. I. General Considerations ; Heterotic Models, Genetics, vol.49, pp.49-67, 1964. ,
Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome, PLoS Genetics, vol.33, issue.5, pp.1002692-2012 ,
DOI : 10.1371/journal.pgen.1002692.s035
An Analysis of Human MicroRNA and Disease Associations, PLoS ONE, vol.31, issue.10, p.99, 2008. ,
DOI : 10.1371/journal.pone.0003420.s005
Screening large-scale association study data : exploiting interactions using random forests, BMC genetics, vol.5, issue.32, p.54, 2004. ,
Finding the missing heritability of complex diseases, Nature, vol.41, issue.7265, pp.747-53, 2009. ,
DOI : 10.1038/nature08494
Venous thrombosis: a multicausal disease, The Lancet, vol.353, issue.9159, pp.1167-1173, 1999. ,
DOI : 10.1016/S0140-6736(98)10266-0
Genetic Susceptibility to Thrombosis and Its Relationship to Physiological Risk Factors: The GAIT Study, The American Journal of Human Genetics, vol.67, issue.6, pp.1452-1459, 2000. ,
DOI : 10.1086/316903
Lessons from genome-wide association studies in venous thrombosis, Journal of Thrombosis and Haemostasis, vol.361, issue.Suppl. 1, pp.258-264, 2011. ,
DOI : 10.1111/j.1538-7836.2011.04311.x
Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach, Blood, vol.113, issue.21, pp.5298-5303, 2009. ,
DOI : 10.1182/blood-2008-11-190389
Genetics of Venous Thrombosis: Insights from a New Genome Wide Association Study, PLoS ONE, vol.42, issue.9, p.25581, 2011. ,
DOI : 10.1371/journal.pone.0025581.s003
Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?, British Journal of Haematology, vol.52, issue.Suppl. 1, pp.495-506, 2010. ,
DOI : 10.1111/j.1365-2141.2009.07975.x
Detecting gene???gene interactions that underlie human diseases, Nature Reviews Genetics, vol.8, issue.6, pp.392-404, 2009. ,
DOI : 10.1038/nrg2579
Finding the missing heritability of complex diseases, Nature, vol.41, issue.7265, pp.747-753, 2009. ,
DOI : 10.1038/nature08494
Missing heritability and strategies for finding the underlying causes of complex disease, Nature Reviews Genetics, vol.90, issue.6, pp.446-450, 2011. ,
DOI : 10.1038/nrg2809
Combined effects of thrombosis pathway gene variants predict cardiovascular events Polymorphisms in the protein C gene as risk factor for venous thrombosis Genome-wide haplotype association study identifies the SLC22A3- LPAL2-LPA gene cluster as a risk locus for coronary artery disease Genetic variation in F3 (tissue factor) and the risk of incident venous thrombosis: meta-analysis of eight studies, PLoS Genet Thromb Haemost Nat Genet Smith NL J Thromb Haemost, vol.3, issue.10, pp.120-132, 2007. ,
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project, Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease, pp.230-239152, 2012. ,
DOI : 10.1111/j.1365-2141.2011.09025.x
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levelsMAX Study: a randomized, placebocontrolled trial of the health effects of antioxidant vitamins and minerals, 3C Study Group: Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population, pp.1022335-2342316, 2003. ,
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap, Bioinformatics, vol.24, issue.24, pp.2938-2939, 2008. ,
DOI : 10.1093/bioinformatics/btn564
Statistical aspects of the analysis of data from retrospective studies of disease, J Natl Cancer Inst, vol.22, pp.719-748, 1959. ,
A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies, Bioinformatics, vol.23, issue.8, pp.1038-1039478, 2002. ,
DOI : 10.1093/bioinformatics/btm058
Sample size and optimal design for logistic regression with binary interaction, Statistics in Medicine, vol.38, issue.1, pp.36-46, 2008. ,
DOI : 10.1002/sim.2980
Analysis Online GmbH, European Bioinformatics Institute Wellcome Trust Genome Campus, vol.9, issue.10, 81677. ,
Identification of Mammalian microRNA Host Genes and Transcription Units, Genome Research, vol.14, issue.10a, pp.1902-1910, 2004. ,
DOI : 10.1101/gr.2722704
Processing of intronic microRNAs, The EMBO Journal, vol.13, issue.3, pp.775-783, 2007. ,
DOI : 10.1038/sj.emboj.7601512
miRBase: tools for microRNA genomics, Nucleic Acids Research, vol.36, issue.Database, pp.154-158, 2008. ,
DOI : 10.1093/nar/gkm952
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets, Cell, vol.120, issue.1, pp.15-20, 2005. ,
DOI : 10.1016/j.cell.2004.12.035
MicroRNAs: Target Recognition and Regulatory Functions, Cell, vol.136, issue.2, pp.215-233, 2009. ,
DOI : 10.1016/j.cell.2009.01.002
The widespread regulation of microRNA biogenesis, function and decay, Nature Reviews Genetics, vol.36, pp.597-610, 2010. ,
DOI : 10.1038/nrg2843
An Analysis of Human MicroRNA and Disease Associations, PLoS ONE, vol.31, issue.10, p.3420, 2008. ,
DOI : 10.1371/journal.pone.0003420.s005
MicroRNAs as a therapeutic target for cardiovascular diseases, Journal of Cellular and Molecular Medicine, vol.7, issue.4, pp.778-789, 2009. ,
DOI : 10.1111/j.1582-4934.2009.00744.x
Role of microRNAs in vascular diseases, inflammation, and angiogenesis, Cardiovascular Research, vol.79, issue.4, pp.581-588, 2008. ,
DOI : 10.1093/cvr/cvn156
MicroRNAs in lipid metabolism, Current Opinion in Lipidology, vol.22, issue.2, pp.86-92, 2011. ,
DOI : 10.1097/MOL.0b013e3283428d9d
MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus, Circulation, vol.123, issue.3, pp.236-238, 2011. ,
DOI : 10.1161/CIRCULATIONAHA.110.003855
Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer, Journal of Cellular and Molecular Medicine, vol.136, issue.1, 2011. ,
DOI : 10.1111/j.1582-4934.2011.01359.x
Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract, The American Journal of Human Genetics, vol.89, issue.5, 2011. ,
DOI : 10.1016/j.ajhg.2011.09.014
A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese, Cancer Epidemiology Biomarkers & Prevention, vol.18, issue.4, pp.1183-1187, 2009. ,
DOI : 10.1158/1055-9965.EPI-08-0814
Genetic variants of miRNA sequences and non???small cell lung cancer survival, Journal of Clinical Investigation, vol.118, pp.2600-2608, 2008. ,
DOI : 10.1172/JCI34934
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells, Genome Research, vol.18, issue.4, pp.610-621, 2008. ,
DOI : 10.1101/gr.7179508
miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy, Proceedings of the National Academy of Sciences, vol.106, issue.29, pp.12103-12108, 2009. ,
DOI : 10.1073/pnas.0811371106
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep, Nature Genetics, vol.125, issue.7, pp.813-818, 2006. ,
DOI : 10.1038/ng1810
The Human Angiotensin II Type 1 Receptor +1166 A/C Polymorphism Attenuates MicroRNA-155 Binding, Journal of Biological Chemistry, vol.282, issue.33, pp.24262-24269, 2007. ,
DOI : 10.1074/jbc.M701050200
Influence of sex and genetic variability on expression of X-linked genes in human monocytes, Genomics, vol.98, issue.5, pp.320-326, 2011. ,
DOI : 10.1016/j.ygeno.2011.06.009
The Choice of the Filtering Method in Microarrays Affects the Inference Regarding Dosage Compensation of the Active X-Chromosome, PLoS ONE, vol.24, issue.9, p.23956, 2011. ,
DOI : 10.1371/journal.pone.0023956.s003
Genetics and Beyond ??? The Transcriptome of Human Monocytes and Disease Susceptibility, PLoS ONE, vol.18, issue.5, p.10693, 2010. ,
DOI : 10.1371/journal.pone.0010693.s012
Integrating genome-wide genetic variations and monocyte expression data reveals transregulated gene modules in humans, PLoS Genet, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00711658
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models, Nature Reviews Immunology, vol.177, issue.10, pp.802-815, 2008. ,
DOI : 10.1016/j.atherosclerosis.2006.05.031
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk, Nature, vol.447, issue.7314, pp.460-464, 2010. ,
DOI : 10.1038/nature09386
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap, Bioinformatics, vol.24, issue.24, pp.2938-2939, 2008. ,
DOI : 10.1093/bioinformatics/btn564
A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data, Nucleic Acids Research, vol.38, issue.3, p.17, 2010. ,
DOI : 10.1093/nar/gkp942
On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study, PLoS Genetics, vol.56, issue.6, p.1000981, 2010. ,
DOI : 10.1371/journal.pgen.1000981.s003
MicroSNiPer: a web tool for prediction of SNP effects on putative microRNA targets, Human Mutation, vol.31, issue.11, pp.1223-1232, 2010. ,
DOI : 10.1002/humu.21349
Human MicroRNA Targets, PLoS Biology, vol.31, issue.11, p.363, 2004. ,
DOI : 10.1371/journal.pbio.0020363.st013
DIANA-microT web server: elucidating microRNA functions through target prediction, Nucleic Acids Research, vol.37, issue.Web Server, pp.273-276, 2009. ,
DOI : 10.1093/nar/gkp292
Combinatorial microRNA target predictions, Nature Genetics, vol.432, issue.5, pp.495-500, 2005. ,
DOI : 10.1093/nar/gkh023
Population genomics of human gene expression, Nature Genetics, vol.142, issue.10, pp.1217-1224, 2007. ,
DOI : 10.1038/ng2142
A genome-wide association study of global gene expression, Nature Genetics, vol.32, issue.10, pp.1202-1207, 2007. ,
DOI : 10.1038/ng2109
Mapping the Genetic Architecture of Gene Expression in Human Liver, PLoS Biology, vol.19, issue.5, p.107, 2008. ,
DOI : 10.1371/journal.pbio.0060107.st006
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes, Nature Genetics, vol.11, issue.10, pp.1208-1216, 2007. ,
DOI : 10.1038/ng2119
Detecting gene???gene interactions that underlie human diseases, Nature Reviews Genetics, vol.8, issue.6, pp.392-404, 2009. ,
DOI : 10.1038/nrg2579
Abundant Pleiotropy in Human Complex Diseases and Traits, The American Journal of Human Genetics, vol.89, issue.5, pp.607-618, 2011. ,
DOI : 10.1016/j.ajhg.2011.10.004
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2, Nature Genetics, vol.181, issue.11, pp.991-995, 2010. ,
DOI : 10.1038/jid.2009.211
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1, Nature Genetics, vol.447, issue.11, pp.985-990, 2011. ,
DOI : 10.1086/319501
Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications, Nature Reviews Genetics, vol.131, issue.8, pp.578-585, 2009. ,
DOI : 10.1038/nrg2628
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides, Nature, vol.24, issue.7369, pp.404-407, 2011. ,
DOI : 10.1016/j.cll.2006.07.006
Evidence of spatially bound gene regulation in Mus musculus: Decreased gene expression proximal to microRNA genomic location, Proceedings of the National Academy of Sciences, vol.104, issue.12, pp.5020-5025, 2007. ,
DOI : 10.1073/pnas.0611078104
Lower expression of genes near microRNA in C. elegans germline, BMC Bioinformatics, vol.7, issue.1, p.112, 2006. ,
DOI : 10.1186/1471-2105-7-112
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia, Human Molecular Genetics, vol.17, issue.23, pp.3631-3642, 2008. ,
DOI : 10.1093/hmg/ddn257
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6, The EMBO Journal, vol.8, issue.1, pp.209-221, 2010. ,
DOI : 10.1074/jbc.M800342200
TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6, Molecular Neurodegeneration, vol.6, issue.1, p.64, 2011. ,
DOI : 10.1016/j.cell.2008.11.050
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians, Nature Genetics, vol.5, issue.5, pp.591-595, 2009. ,
DOI : 10.1086/338688
HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis, Journal of Human Genetics, vol.1, issue.2, pp.108-114, 2009. ,
DOI : 10.1038/jhg.2008.15
HLA??????DPB1 and DPB2 are genetic loci for systemic sclerosis: A genome-wide association study in Koreans with replication in North Americans, Arthritis & Rheumatism, vol.2, issue.12, pp.3807-3814, 2009. ,
DOI : 10.1002/art.24982
Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster, European Journal of Paediatric Neurology, vol.15, issue.2, pp.163-166, 2011. ,
DOI : 10.1016/j.ejpn.2010.07.004
Study of the possible association of HLA class II, CD4, and CD3 polymorphisms with schizophrenia, American Journal of Medical Genetics, vol.19, issue.4, pp.372-377, 1994. ,
DOI : 10.1002/ajmg.1320540417
A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome, Science, vol.321, issue.5891, pp.956-960, 2008. ,
DOI : 10.1126/science.1160342
RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays, Genome Research, vol.18, issue.9, pp.1509-1517, 2008. ,
DOI : 10.1101/gr.079558.108
Gene silencing by microRNAs: contributions of translational repression and mRNA decay, Nature Reviews Genetics, vol.457, issue.2, pp.99-110, 2011. ,
DOI : 10.1038/nrg2936
Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy, Circulation: Cardiovascular Genetics, vol.4, issue.6, 2011. ,
DOI : 10.1161/CIRCGENETICS.111.960203
pcaMethods a bioconductor package providing PCA methods for incomplete data, Bioinformatics, vol.23, issue.9, pp.1164-1167, 2007. ,
DOI : 10.1093/bioinformatics/btm069
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease, Nature Genetics, vol.6, issue.4, pp.333-338, 2011. ,
DOI : 10.1038/ng.291
Multiple Hypotheses Testing with Weights, Scandinavian Journal of Statistics, vol.24, issue.3, pp.407-418, 1997. ,
DOI : 10.1111/1467-9469.00072
A Weighted-Holm Procedure Accounting for Allele Frequencies in Genomewide Association Studies, Genetics, vol.180, issue.1, pp.697-702, 2008. ,
DOI : 10.1534/genetics.108.089839
A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies, Bioinformatics, vol.23, issue.8, pp.1038-1039, 2007. ,
DOI : 10.1093/bioinformatics/btm058