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Etude mécanistique de réactions de couplage catalysées par des complexes du cuivre et du fer

Abstract : The use of copper and iron complexes as cross-coupling catalysts is now a challenge in today organic synthesis, due to their low cost and low toxicity. This work, in a first part, deals with mechanistic insights into C-N and C-O cross-couplings catalyzed by copper complexes. In a second part, the true role of iron in C-N cross-couplings processes is investigated. In a third part, two examples of iron-catalyzed C-C bond formations are investigated: a Kochi-type coupling between an aryl halide and a Grignard reagent, and a radical carbocyclization. Cyclic voltammetry, theoretical DFT calculations, NMR and EPR spectroscopies have been used as investigation tools.
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https://tel.archives-ouvertes.fr/tel-00833319
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  • HAL Id : tel-00833319, version 1

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Guillaume Lefèvre. Etude mécanistique de réactions de couplage catalysées par des complexes du cuivre et du fer. Chimie organique. Université Pierre et Marie Curie - Paris VI, 2012. Français. ⟨NNT : 2012PAO66236⟩. ⟨tel-00833319⟩

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