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Synthèse et étude de ligands redox pour le relargage de calcium contrôlé électrochimiquement

Abstract : The subject of the PhD thesis is the development of an electrochemically active calcium ligand in which the receptor site is directly coupled to an appropriate redox center allowing for controlling the capture and delivery of calcium ions in aqueous solution. The electrostatic interaction between the redox center and the chelated cation was directed in a way so that a change of the charge of the oxidized redox center provoked the metal ion ejection. This work describes the synthesis and the properties of four classes of such compounds based on the electrochemically active phenylenediamine. In particular thanks to the "semi-BAPTA" derivatives the principle of electrochemically driven calcium release in aqueous solution at physiological conditions was demonstrated and studied. Because of their relatively low affinity constants also BAPTA based redox ligands have been prepared and turned out to be potential probes for the application in biological systems
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  • HAL Id : tel-00833302, version 1

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Anne-Sophie Lefevre-Lambert. Synthèse et étude de ligands redox pour le relargage de calcium contrôlé électrochimiquement. Chimie analytique. Université Pierre et Marie Curie - Paris VI, 2012. Français. ⟨NNT : 2012PA066030⟩. ⟨tel-00833302⟩

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