Skip to Main content Skip to Navigation
Theses

Epidémiologie de la tuberculose et de la résistance aux antituberculeux

Abstract : Tuberculosis (TB) control is a major global public health issue. We used existing surveillance systems in two countries with different epidemiological profiles of tuberculosis (France and China) to evaluate patient management and antituberculosis drug resistance. In France, we first analyzed primary isoniazid monoresistance according to birth cohorts, demonstrating higher resistance rates among cohorts of young patients born in France. This result suggests recent transmission of such strains in France. Data currently available in the networks do not allow for further analysis to explain this increase (i.e. parental origins, exposure type, circulation of a particular clonal strain). In a second work, we showed that rifampin monoresistance incidence rate was very low (<1%), that its management was heterogeneous, and its treatment success rate not satisfactory. We suggest to implement a program identical to the one established for the management of multidrug resistant TB. In China, using a regional surveillance network, we confirmed that cough and belonging to a vulnerable population were risk factors for delayed diagnosis. The training of healthcare workers and patient's access to healthcare must be improved. Surveillance networks are key tools for collecting data, permitting the establishment of indicators of epidemiological TB characteristics, the basis of tuberculosis control programs
Document type :
Theses
Complete list of metadatas

Cited literature [56 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00833269
Contributor : Theses Bupmc <>
Submitted on : Wednesday, June 12, 2013 - 12:47:58 PM
Last modification on : Thursday, December 10, 2020 - 3:42:23 AM
Long-term archiving on: : Tuesday, April 4, 2017 - 7:58:15 PM

Identifiers

  • HAL Id : tel-00833269, version 1

Citation

Vanina Meyssonnier. Epidémiologie de la tuberculose et de la résistance aux antituberculeux. Santé publique et épidémiologie. Université Pierre et Marie Curie - Paris VI, 2012. Français. ⟨NNT : 2012PAO66665⟩. ⟨tel-00833269⟩

Share

Metrics

Record views

861

Files downloads

28364