Skip to Main content Skip to Navigation

Pd-catalyzed domino carbonylative/decarboxylative allylation

Abstract : The present thesis work dealt with the development on new palladium-catalyzed pseudo-domino sequences. A first pseudo-domino type I process featuring a carbonylation / decarboxylative allylation was designed with α-chloroacetophenone. The sequence allowed the selective monoallylation of readily available α-chloroketones derivatives in one single synthetic operation. This pseudo-domino sequence could be applied to variously substituted acetophenones. We also designed a three-step pseudo-domino reaction featuring N-allylation / carbopalladation / carbonylation. This sequence allowed us to prepare substituted indolines in one single synthetic operation from readily available substrates. The extension to a four step pseudo-domino sequence was also envisaged. Switching the alcohol used to allyl alcohol should merge both sequences, by adding a decarboxylative allylation step to the three-step process
Document type :
Complete list of metadata

Cited literature [163 references]  Display  Hide  Download
Contributor : Theses Bupmc Connect in order to contact the contributor
Submitted on : Monday, June 3, 2013 - 1:51:23 PM
Last modification on : Sunday, June 26, 2022 - 9:58:37 AM
Long-term archiving on: : Wednesday, September 4, 2013 - 4:13:10 AM


  • HAL Id : tel-00829489, version 1


Steven Giboulot. Pd-catalyzed domino carbonylative/decarboxylative allylation. Organic chemistry. Université Pierre et Marie Curie - Paris VI, 2012. English. ⟨NNT : 2012PAO66196⟩. ⟨tel-00829489⟩



Record views


Files downloads