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Ségrégation cellulaire lors de la neurogenèse précoce : les cadhérines font Sécession

Abstract : Cadherin transitions play a part in cell segregation phenomenon, involving an Epithelium Mesenchyme Transition phenomenon (EMT). However, during the development of the central nervous system, the E-/N-cadherin transition doesn't cause an EMT and, unlike the current model, our results show that the E-/N-cadherin switch is not a necessary element in morphogenetic movements of neurulation. The important part in the central nervous system development seems to be mainly the control of the kinetic of this E-/N-Cadherin switch. Avian central nervous system develops according to specific ways: in the anterior part of the embryo, the primary neurulation ; the secondary neurulation which ends to the development of the neural tube by cells accretion which central lumen is created by cavitation. In the thoracic part of the body, the neural tube develops in an original way, with few characteristics from the two classic processes. It is the transition neurulation. The neural precursor of the transition neural tube and secondary neural tube make an EMT, and then migrate in a coordinated and directed way thanks to the polarized deposit of fibronectin, induced by the protein of the planar cell polarity, Prickle, and then re-epithelialized themselves. Neural Crest cells represent a specific population of the neural tube cells. We show that these cells are different from the rest of neuroépithélium thanks to a repertory of expression of specific cadherins: E-Cadherin expressed by non-neural ectodermal cells, Cadherin-6B expressed by neural crest cells and N-cadherin expressed by canonical neural cells. This segregation is orchestrated by a subtle balance between BMP4 and FGF
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Submitted on : Thursday, May 30, 2013 - 2:38:27 PM
Last modification on : Friday, October 23, 2020 - 4:46:08 PM


  • HAL Id : tel-00828190, version 1


Alwyn Dady. Ségrégation cellulaire lors de la neurogenèse précoce : les cadhérines font Sécession. Biologie du développement. Université Pierre et Marie Curie - Paris VI, 2012. Français. ⟨NNT : 2012PAO66377⟩. ⟨tel-00828190⟩



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