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Theses

Pollution de l'air intérieur et santé respiratoire : prise en compte de la multi-pollution

Abstract : We studied the effects of exposure to multiple indoor air pollutants on allergic and respiratory health. The elements to consider for studying this phenomenon were, on one hand, the correlations between pollutants and, on the other hand, their potentially additive and synergistic effects. The analyses conducted in adults have shown that the prevalence of allergic and respiratory symptoms was higher in the dwellings highly polluted by many volatile organic compounds (VOCs). The observed health effects of VOCs were higher when the dwelling was also polluted by pet allergens. The analyses conducted in children have shown the difficulty to separate the effects of pollutants. However, we showed that poor air quality in schools was associated with an increased risk of respiratory symptoms. Some analyses on the total exposure to air pollution have implicated the combined effects of physico-chemical pollutants on respiratory function of children. The study of multi-pollution allowed to highlight the deleterious effect of some pollutants combined with other substances, although their individual effects were not detected. Our studies showed that associations were observed at concentrations lower than those observed in toxicological studies, involving the additive and synergistic effects between pollutants. Our results also provided some elements about the mechanism of action of indoor chemical pollutants on respiratory health, including their synergistic effects with allergens. In conclusion, our results showed combined effects between various pollutants on the respiratory health of adults and children.
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https://tel.archives-ouvertes.fr/tel-00827664
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Submitted on : Wednesday, May 29, 2013 - 3:30:09 PM
Last modification on : Monday, December 14, 2020 - 9:52:56 AM
Long-term archiving on: : Friday, August 30, 2013 - 7:55:09 AM

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  • HAL Id : tel-00827664, version 1

Citation

Cécile Billionnet. Pollution de l'air intérieur et santé respiratoire : prise en compte de la multi-pollution. Santé publique et épidémiologie. Université Pierre et Marie Curie - Paris VI, 2012. Français. ⟨NNT : 2012PAO66144⟩. ⟨tel-00827664⟩

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