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. Dans-ce-chapitre, Ces analyses sont lespremì eresàeres`eresà traiter un nombre aussi important de peptides non-ribosomiaux et de monomères Elles nous ont permis de mettre enévidenceenévidence des différences, de composition monomérique et de taille, entre les peptides synthétisés par les 6.3. Analyse du génome de Pseudomonas entomophila Fig. 6.5 ? Organisation des clusters des g` enes de la pyoverdine chez différentes espèces de Pseudomonas . Les g` enes homologues apparaissent dans la même couleur, nous avons réalisé un ensemble d'analyses statistiques sur les données contenues dans Norine, 2003.

P. Ravel and . Cornelis, Cette figure montre que l'organisation des clusters de la pyoverdine est très différente d'une espècè a l'autre. Le cluster de P. entomophila possède une organisation qui lui est propre et qui confirme l'hypothèse de la production d'une nouvelle pyoverdine par P. entomophila. En effet, seul le cluster de P. entomophila contient 5 g` enes NRPS potentiellement impliqués dans la synthèse de la partie peptidique de la pyoverdine, ce qui suggère la synthèse d'une nouvelle pyoverdine, Cependant, le cluster identifié chez P. entomophila contient un grand nombre de g` enes homologues avec les autres clusters identifiés au sein des autres espèces de Pseudomonas. 6.4. Validations expérimentales, 2003.

. La-colonne-est-conditionnée-par, mL de méthanol pur, rincée par 90 mL d'eau, l'´ echantillon (100 mL) est alors déposé. La colonne est ensuite lavée par 100 mL d'eau et séchéè a l'air. Les pyoverdines sontéluéessontéluées par 100

L. Résultats-montrent-bien-que-les-souches and P. , aeruginosa produisent bien une molécule qui fluoresce en réponsè a une carence en fer, contrairementàcontrairementà la souche B. subtilis 168. Ces résultats confirment l

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