L. Araujo, A. Lammertsma, C. Rhodes, E. Mcfalls, H. Iida et al., Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography, Circulation, vol.83, issue.3, pp.875-885, 1991.
DOI : 10.1161/01.CIR.83.3.875

J. Aupetit, D. Frassati, B. Bui-xuan, M. Freysz, G. Faucon et al., Efficacy of a ??-adrenergic receptor antagonist, propranolol, in preventing ischaemic ventricular fibrillation: dependence on heart rate and ischaemia duration, Cardiovascular Research, vol.37, issue.3, pp.646-655, 1998.
DOI : 10.1016/S0008-6363(97)00304-0

J. Aupetit, Q. Timour, J. Larbre, J. Loufoua-moundanga, I. Kioueh et al., Arrhythmogenicity of antiarrhythmic drugs and intraventricular conduction disorders: Possible aggravation by myocardial ischemia?Study in the porcine in situ heart, Cardiovascular Drugs and Therapy, vol.49, issue.2, pp.217-223, 1993.
DOI : 10.1007/BF00878511

J. Aupetit, Q. Timour, J. Loufoua-moundanga, L. Barral-cadiere, M. Lopez et al., Profibrillatory Effects of Lidocaine in the Acutely Ischemic Porcine Heart, Journal of Cardiovascular Pharmacology, vol.25, issue.5, pp.810-816, 1995.
DOI : 10.1097/00005344-199505000-00018

M. Avkiran, Basic Biology and Pharmacology of the Cardiac Sarcolemmal Sodium/Hydrogen Exchanger, Journal of Cardiac Surgery, vol.102, issue.s1, pp.3-12, 2003.
DOI : 10.1046/j.1540-8191.18.s1.2.x

M. Azbel, Universal biological scaling and mortality., Proceedings of the National Academy of Sciences, vol.91, issue.26, pp.12453-12457, 1994.
DOI : 10.1073/pnas.91.26.12453

S. Bangalore, S. Parkar, E. Grossman, and F. Messerli, A Meta-Analysis of 94,492 Patients With Hypertension Treated With Beta Blockers to Determine the Risk of New-Onset Diabetes Mellitus, The American Journal of Cardiology, vol.100, issue.8, pp.1254-1262, 2007.
DOI : 10.1016/j.amjcard.2007.05.057

M. Baruscotti, A. Bucchi, and D. Difrancesco, Physiology and pharmacology of the cardiac pacemaker (???funny???) current, Pharmacology & Therapeutics, vol.107, issue.1, pp.59-79, 2005.
DOI : 10.1016/j.pharmthera.2005.01.005

H. Bassiouny, C. Zarins, M. Kadowaki, and S. Glagov, Hemodynamic stress and experimental aortoiliac atherosclerosis, Journal of Vascular Surgery, vol.19, issue.3, pp.426-434, 1994.
DOI : 10.1016/S0741-5214(94)70069-9

S. Bertuglia and A. Giusti, Microvascular oxygenation, oxidative stress, NO suppression and superoxide dismutase during postischemic reperfusion, American Journal of Physiology - Heart and Circulatory Physiology, vol.285, issue.3, pp.1064-1071, 2003.
DOI : 10.1152/ajpheart.00124.2003

S. Bertuglia and A. Giusti, Microvascular Oxygenation and Oxidative Stress During Postischemic Reperfusion, Adv Exp Med Biol, vol.566, pp.23-29, 2005.
DOI : 10.1007/0-387-26206-7_4

M. Biel, A. Schneider, and C. Wahl, Cardiac HCN Channels Structure, Function, and Modulation, Trends in Cardiovascular Medicine, vol.12, issue.5, pp.206-212, 2002.
DOI : 10.1016/S1050-1738(02)00162-7

K. Boengler, R. Schulz, and G. Heusch, Loss of cardioprotection with ageing, Cardiovascular Research, vol.83, issue.2, pp.247-261, 2009.
DOI : 10.1093/cvr/cvp033

P. Bois and J. Lenfant, Isolated cells of the frog sinus venosus: properties of the inward current activated during hyperpolarization, Pfl???gers Archiv European Journal of Physiology, vol.385, issue.3, pp.339-346, 1990.
DOI : 10.1007/BF00392071

J. Borer, K. Fox, P. Jaillon, and G. Lerebours, Antianginal and Antiischemic Effects of Ivabradine, an If Inhibitor, in Stable Angina: A Randomized, Double-Blind, Multicentered, Placebo-Controlled Trial, Circulation, vol.107, issue.6, pp.817-823, 2003.
DOI : 10.1161/01.CIR.0000048143.25023.87

P. Bottomley, K. Wu, G. Gerstenblith, S. Schulman, A. Steinberg et al., Reduced Myocardial Creatine Kinase Flux in Human Myocardial Infarction: An In Vivo Phosphorus Magnetic Resonance Spectroscopy Study, Circulation, vol.119, issue.14, pp.1918-1924, 2009.
DOI : 10.1161/CIRCULATIONAHA.108.823187

H. Brown, D. Difrancesco, and S. Noble, Cardiac pacemaker oscillation and its modulation by autonomic transmitters, J Exp Biol, vol.81, pp.175-204, 1979.

B. Bui-xuan, J. Aupetit, M. Freysz, G. Faucon, and Q. Timour, Prevention by calcium antagonists of profibrillatory effects of class I antiarrhythmic drugs in acute myocardial ischemia: study in pig heart in situ, Pharmacotherapy, vol.17, issue.4, pp.737-745, 1997.

A. Camm and C. Lau, Electrophysiological Effects of a Single Intravenous Administration of Ivabradine (S 16257) in Adult Patients with Normal Baseline Electrophysiology, Drugs in R & D, vol.15, issue.2, pp.83-89, 2003.
DOI : 10.2165/00126839-200304020-00001

J. Jong, R. Marsman, J. Henriques, K. Koch, R. De-winter et al., Prognosis among survivors of primary ventricular fibrillation in the percutaneous coronary intervention era, American Heart Journal, vol.158, issue.3, pp.467-472, 2009.
DOI : 10.1016/j.ahj.2009.06.028

S. Dennis, W. Gevers, and L. Opie, Protons in ischemia: Where do they come from; Where do they go to?, Journal of Molecular and Cellular Cardiology, vol.23, issue.9, pp.1077-1086, 1991.
DOI : 10.1016/0022-2828(91)91642-5

D. Rosiers, C. Montgomery, J. Desrochers, S. Garneau, M. David et al., Interference of 3-hydroxyisobutyrate with measurements of ketone body concentration and isotopic enrichment by gas chromatography-mass spectrometry, Analytical Biochemistry, vol.173, issue.1, pp.96-105, 1988.
DOI : 10.1016/0003-2697(88)90165-0

D. Verniero, C. Hocht, C. Opezzo, J. Taira, and C. , CHANGES IN THE IN VITRO PHARMACODYNAMIC PROPERTIES OF METOPROLOL IN ATRIA ISOLATED FROM SPONTANEOUSLY HYPERTENSIVE RATS, Clinical and Experimental Pharmacology and Physiology, vol.268, issue.3, pp.161-165, 2007.
DOI : 10.1126/science.8160017

D. Verniero, C. Silberman, E. Mayer, M. Opezzo, J. Taira et al., In Vitro and In Vivo Pharmacodynamic Properties of Metoprolol in Fructose-fed Hypertensive Rats, Journal of Cardiovascular Pharmacology, vol.51, issue.6, pp.532-541, 2008.
DOI : 10.1097/FJC.0b013e3181730306

A. Diaz and J. Tardif, Heart Rate Slowing versus Other Pharmacological Antianginal Strategies, Adv Cardiol, vol.43, pp.65-78, 2006.
DOI : 10.1159/000095429

D. Difrancesco, current and its inhibition by heart rate-reducing agents, Current Medical Research and Opinion, vol.21, issue.7, pp.1115-1122, 2005.
DOI : 10.1185/030079905X50543

D. Difrancesco and J. Camm, Heart Rate Lowering by Specific and Selective If Current Inhibition with Ivabradine, Drugs, vol.109, issue.16, pp.1757-1765, 2004.
DOI : 10.2165/00003495-200464160-00003

D. Difrancesco, P. Ducouret, and R. Robinson, Muscarinic modulation of cardiac rate at low acetylcholine concentrations, Science, vol.243, issue.4891, pp.669-671, 1989.
DOI : 10.1126/science.2916119

D. Difrancesco and C. Tromba, Inhibition of the hyperpolarization-activated current (if) induced by acetylcholine in rabbit sino-atrial node myocytes., The Journal of Physiology, vol.405, issue.1, pp.477-491, 1988.
DOI : 10.1113/jphysiol.1988.sp017343

R. Ditchey, Y. Goto, and J. Lindenfeld, Myocardial oxygen requirements during experimental cardiopulmonary resuscitation, Cardiovascular Research, vol.26, issue.8, pp.791-797, 1992.
DOI : 10.1093/cvr/26.8.791

Z. Dong, P. Saikumar, J. Weinberg, and M. Venkatachalam, CALCIUM IN CELL INJURY AND DEATH, Annual Review of Pathology: Mechanisms of Disease, vol.1, issue.1, pp.405-434, 2006.
DOI : 10.1146/annurev.pathol.1.110304.100218

A. Dyer, V. Persky, J. Stamler, O. Paul, R. Shekelle et al., HEART RATE AS A PROGNOSTIC FACTOR FOR CORONARY HEART DISEASE AND MORTALITY: FINDINGS IN THREE CHICAGO EPIDEMIOLOGIC STUDIES, American Journal of Epidemiology, vol.112, issue.6, pp.736-749, 1980.
DOI : 10.1093/oxfordjournals.aje.a113046

D. Echt, P. Liebson, L. Mitchell, R. Peters, D. Obias-manno et al., Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo, New England Journal of Medicine, vol.324, issue.12, pp.781-788, 1991.
DOI : 10.1056/NEJM199103213241201

G. Faucon, J. Aupetit, I. Gerentes-chassagne, J. Loufoua-moundanga, J. Larbre et al., [Arrhythmogenic risk of antiarrhythmic drugs: study with class Ic drugs during myocardial ischemia], Bull Acad Natl Med, vol.175, issue.2, pp.217-224, 1991.

P. Ferdinandy, R. Schulz, and G. Baxter, Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning, Pharmacological Reviews, vol.59, issue.4, pp.418-458, 2007.
DOI : 10.1124/pr.107.06002

C. Fernandez, D. Rosiers, C. Previs, S. David, F. Brunengraber et al., Correction of13C Mass Isotopomer Distributions for Natural Stable Isotope Abundance, Journal of Mass Spectrometry, vol.31, issue.3, pp.255-262, 1996.
DOI : 10.1002/(SICI)1096-9888(199603)31:3<255::AID-JMS290>3.0.CO;2-3

R. Ferrari, Ischaemic heart disease: clinical improvement with metabolic approach, Rev Port Cardiol, vol.19, issue.5, pp.7-20, 2000.

R. Ferrari, A. Cargnoni, and C. Ceconi, Anti-ischaemic effect of ivabradine, Pharmacological Research, vol.53, issue.5, pp.435-439, 2006.
DOI : 10.1016/j.phrs.2006.03.018

W. Gaskell, On the Innervation of the Heart, with especial reference to the Heart of the Tortoise, The Journal of Physiology, vol.4, issue.2-3, pp.43-230, 1883.
DOI : 10.1113/jphysiol.1883.sp000121

R. Gazmuri, I. Ayoub, J. Kolarova, and M. Karmazyn, Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1, Critical Care Medicine, vol.30, issue.Supplement, pp.166-171, 2002.
DOI : 10.1097/00003246-200204001-00010

R. Gazmuri, M. Berkowitz, and H. Cajigas, Myocardial effects of ventricular fibrillation in the isolated rat heart, Critical Care Medicine, vol.27, issue.8, pp.1542-1550, 1999.
DOI : 10.1097/00003246-199908000-00023

G. Giannoglou, Y. Chatzizisis, C. Zamboulis, G. Parcharidis, D. Mikhailidis et al., Elevated heart rate and atherosclerosis: An overview of the pathogenetic mechanisms, International Journal of Cardiology, vol.126, issue.3, pp.302-312, 2008.
DOI : 10.1016/j.ijcard.2007.08.077

A. Gomez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli et al., Increased Exchange Current but Normal Ca2+ Transport via Na+-Ca2+ Exchange During Cardiac Hypertrophy After Myocardial Infarction, Circulation Research, vol.91, issue.4, pp.323-330, 2002.
DOI : 10.1161/01.RES.0000031384.55006.DB

S. Gordon, W. Arsenault, M. Longnecker, D. Boothe, M. Miller et al., Pharmacodynamics of Carvedilol in Conscious, Healthy Dogs, Journal of Veterinary Internal Medicine, vol.85, issue.9A, pp.297-304, 2006.
DOI : 10.1111/j.1939-1676.2006.tb02860.x

A. Gupta, V. Chacko, and R. Weiss, Abnormal energetics and ATP depletion in pressure-overload mouse hearts: in vivo high-energy phosphate concentration measures by noninvasive magnetic resonance, AJP: Heart and Circulatory Physiology, vol.297, issue.1, pp.59-64, 2009.
DOI : 10.1152/ajpheart.00178.2009

B. Guth, G. Heusch, R. Seitelberger, R. J. , and J. , Mechanism of beneficial effect of beta-adrenergic blockade on exercise- induced myocardial ischemia in conscious dogs, Circulation Research, vol.60, issue.5, pp.738-746, 1987.
DOI : 10.1161/01.RES.60.5.738

N. Hagiwara, H. Irisawa, and M. Kameyama, Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells., The Journal of Physiology, vol.395, issue.1, pp.233-253, 1988.
DOI : 10.1113/jphysiol.1988.sp016916

A. Hall and S. Palmer, The heart rate hypothesis: ready to be tested, Heart, vol.94, issue.5, pp.561-565, 2008.
DOI : 10.1136/hrt.2007.118760

W. Han, W. Bao, Z. Wang, and S. Nattel, Comparison of Ion-Channel Subunit Expression in Canine Cardiac Purkinje Fibers and Ventricular Muscle, Circulation Research, vol.91, issue.9, pp.790-797, 2002.
DOI : 10.1161/01.RES.0000039534.18114.D9

J. Hazey, D. Yang, L. Powers, S. Previs, F. David et al., Tracing Gluconeogenesis with Deuterated Water: Measurement of Low Deuterium Enrichments on Carbons 6 and 2 of Glucose, Analytical Biochemistry, vol.248, issue.1, pp.158-167, 1997.
DOI : 10.1006/abio.1997.2068

U. Heidland and B. Strauer, Left Ventricular Muscle Mass and Elevated Heart Rate Are Associated With Coronary Plaque Disruption, Circulation, vol.104, issue.13, pp.1477-1482, 2001.
DOI : 10.1161/hc3801.096325

R. Henning and D. Sawmiller, Vasoactive intestinal peptide: cardiovascular effects, Cardiovascular Research, vol.49, issue.1, pp.27-37, 2001.
DOI : 10.1016/S0008-6363(00)00229-7

E. Henze, H. Schelbert, J. Barrio, J. Egbert, H. Hansen et al., Evaluation of myocardial metabolism, with N-13-and C-11-labeled amino acids and positron computed tomography, J Nucl Med, vol.23, issue.8, pp.671-681, 1982.

G. Heusch, Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents, British Journal of Pharmacology, vol.425, issue.Suppl L, pp.1589-1601, 2008.
DOI : 10.1038/sj.bjp.0707673

G. Heusch, D. Baumgart, P. Camici, W. Chilian, L. Gregorini et al., ??-Adrenergic Coronary Vasoconstriction and Myocardial Ischemia in Humans, Circulation, vol.101, issue.6, pp.689-694, 2000.
DOI : 10.1161/01.CIR.101.6.689

G. Heusch, A. Skyschally, P. Gres, P. Van-caster, D. Schilawa et al., Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction, European Heart Journal, vol.29, issue.18, pp.2265-2275, 2008.
DOI : 10.1093/eurheartj/ehn337

L. Hine, N. Laird, P. Hewitt, and C. Tc, Meta-analytic Evidence Against Prophylactic Use of Lidocaine in Acute Myocardial Infarction, Archives of Internal Medicine, vol.149, issue.12, pp.2694-2698, 1989.
DOI : 10.1001/archinte.1989.00390120056011

H. Iida, I. Kanno, and S. Miura, Rapid measurement of cerebral blood flow with positron emission tomography, Ciba Found Symp, vol.163, pp.23-37, 1991.

C. Indolfi, B. Guth, S. Miyazaki, T. Miura, R. Schulz et al., Heart rate reduction improves myocardial ischemia in swine: role of interventricular blood flow redistribution, Am J Physiol, vol.261, pp.910-917, 1991.

C. Indolfi, R. J. , and J. , The role of heart rate in myocardial ischemia and infarction: Implications of myocardial perfusion-contraction matching, Progress in Cardiovascular Diseases, vol.36, issue.1, pp.61-74, 1993.
DOI : 10.1016/0033-0620(93)90022-6

C. Investigators, Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators, N Engl J Med, vol.321, issue.6, pp.406-412, 1989.

T. Ishii, M. Takano, L. Xie, A. Noma, and H. Ohmori, Molecular Characterization of the Hyperpolarization-activated Cation Channel in Rabbit Heart Sinoatrial Node, Journal of Biological Chemistry, vol.274, issue.18, pp.12835-12839, 1999.
DOI : 10.1074/jbc.274.18.12835

M. Janse and A. Wit, Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction, Physiol Rev, vol.69, issue.4, pp.1049-1169, 1989.

R. Jennings, K. Reimer, R. Jones, and R. Peyton, High Energy Phosphates, Anaerobic Glycolysis and Irreversibility in Ischemia, Adv Exp Med Biol, vol.161, pp.403-419, 1983.
DOI : 10.1007/978-1-4684-4472-8_23

R. Joannides, N. Moore, M. Iacob, P. Compagnon, G. Lerebours et al., Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise, British Journal of Clinical Pharmacology, vol.1, issue.2, pp.127-137, 2006.
DOI : 10.1161/01.CIR.0000118464.48959.1C

X. Jouven, J. Empana, P. Schwartz, M. Desnos, D. Courbon et al., Heart-Rate Profile during Exercise as a Predictor of Sudden Death, New England Journal of Medicine, vol.352, issue.19, pp.1951-1958, 2005.
DOI : 10.1056/NEJMoa043012

S. Kalaycioglu, V. Sinci, Y. Imren, and E. Oz, Metoprolol Prevents Ischemia-Reperfusion Injury by Reducing Lipid Peroxidation, Japanese Circulation Journal, vol.63, issue.9, pp.718-721, 1999.
DOI : 10.1253/jcj.63.718

J. Kaplan, S. Manuck, and T. Clarkson, The influence of heart rate on coronary artery atherosclerosis, J Cardiovasc Pharmacol, vol.10, issue.103, pp.100-102, 1987.

U. Kaupp and R. Seifert, Molecular Diversity of Pacemaker Ion Channels, Annual Review of Physiology, vol.63, issue.1, pp.235-257, 2001.
DOI : 10.1146/annurev.physiol.63.1.235

A. Keith and M. Flack, The Form and Nature of the Muscular Connections between the Primary Divisions of the Vertebrate Heart, J Anat Physiol, vol.41, pp.172-189, 1907.

F. Kette, M. Weil, R. Gazmuri, J. Bisera, and E. Rackow, Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation, Critical Care Medicine, vol.21, issue.6, pp.901-906, 1993.
DOI : 10.1097/00003246-199306000-00020

M. Khairallah, F. Labarthe, B. Bouchard, G. Danialou, B. Petrof et al., Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons, AJP: Heart and Circulatory Physiology, vol.286, issue.4, pp.1461-1470, 2004.
DOI : 10.1152/ajpheart.00942.2003

N. Khan and F. Mcalister, Re-examining the efficacy of ??-blockers for the treatment of hypertension: a meta-analysis, Canadian Medical Association Journal, vol.174, issue.12, pp.1737-1742, 2006.
DOI : 10.1503/cmaj.060110

C. Kien, R. Murray, A. Ailabouni, P. Powers, J. Kepner et al., Stable isotope model for assessing production of short chain fatty acids from colonderived sugar: application in pigs, J Nutr, vol.126, issue.12, pp.3069-3076, 1996.

L. King and L. Opie, Glucose and glycogen utilisation in myocardial ischemia ??? Changes in metabolism and consequences for the myocyte, Mol Cell Biochem, vol.180, issue.12, pp.3-26, 1998.
DOI : 10.1007/978-1-4615-5687-9_1

R. Kloner and R. Jennings, Consequences of Brief Ischemia: Stunning, Preconditioning, and Their Clinical Implications: Part 1, Circulation, vol.104, issue.24, pp.2981-2989, 2001.
DOI : 10.1161/hc4801.100038

R. Kloner and R. Jennings, Consequences of Brief Ischemia: Stunning, Preconditioning, and Their Clinical Implications: Part 2, Circulation, vol.104, issue.25, pp.3158-3167, 2001.
DOI : 10.1161/hc5001.100039

M. Kobara, T. Tatsumi, S. Matoba, Y. Yamahara, C. Nakagawa et al., Effect of Ischemic Preconditioning on Mitochondrial Oxidative Phosphorylation and High Energy Phosphates in Rat Hearts, Journal of Molecular and Cellular Cardiology, vol.28, issue.2, pp.417-428, 1996.
DOI : 10.1006/jmcc.1996.0038

M. Kochs, T. Eggeling, and V. Hombach, Pharmacological therapy in coronary heart disease: Prevention of life-threatening ventricular tachyarrhythmias and sudden cardiac death, European Heart Journal, vol.14, issue.suppl E, pp.107-119, 1993.
DOI : 10.1093/eurheartj/14.suppl_E.107

B. Koplan and W. Stevenson, Ventricular Tachycardia and Sudden Cardiac Death, Mayo Clinic Proceedings, vol.84, issue.3, pp.289-297, 2009.
DOI : 10.4065/84.3.289

A. Krismer, V. Wenzel, K. Stadlbauer, V. Mayr, H. Lienhart et al., Vasopressin during cardiopulmonary resuscitation: A progress report, Critical Care Medicine, vol.32, issue.Supplement, pp.432-435, 2004.
DOI : 10.1097/01.CCM.0000134267.91520.C0

F. Labarthe, R. Gelinas, D. Rosiers, and C. , Medium-chain Fatty Acids as Metabolic Therapy in Cardiac Disease, Cardiovascular Drugs and Therapy, vol.83, issue.2, pp.97-106, 2008.
DOI : 10.1007/s10557-008-6084-0

F. Labarthe, M. Khairallah, B. Bouchard, W. Stanley, D. Rosiers et al., Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid, AJP: Heart and Circulatory Physiology, vol.288, issue.3, pp.1425-1436, 2005.
DOI : 10.1152/ajpheart.00722.2004

P. Lama, Systemic adverse effects of beta-adrenergic blockers: an evidence-based assessment, American Journal of Ophthalmology, vol.134, issue.5, pp.749-760, 2002.
DOI : 10.1016/S0002-9394(02)01699-9

V. Large, H. Brunengraber, M. Odeon, and M. Beylot, Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis, Am J Physiol, vol.2721, issue.1

L. Heuzey and J. , N??ud sinusal et canaux ioniques : physiologie et r??gulation, Th??rapie, vol.59, issue.5, pp.491-494, 2004.
DOI : 10.2515/therapie:2004085

E. Lesnefsky, S. Moghaddas, B. Tandler, J. Kerner, and C. Hoppel, Mitochondrial Dysfunction in Cardiac Disease: Ischemia???Reperfusion, Aging, and Heart Failure, Journal of Molecular and Cellular Cardiology, vol.33, issue.6, pp.1065-1089, 2001.
DOI : 10.1006/jmcc.2001.1378

H. Levine, Rest heart rate and life expectancy, J Am Coll Cardiol, vol.30, issue.4, pp.1104-1106, 1997.

J. Li, M. Lang, X. Mao, L. Tian, and Y. Feng, Antiapoptosis and Mitochondrial Effect of Pioglitazone Preconditioning in the Ischemic/reperfused Heart of Rat, Cardiovascular Drugs and Therapy, vol.401, issue.4, pp.283-291, 2008.
DOI : 10.1007/s10557-008-6115-x

D. Liem, H. Honda, J. Zhang, D. Woo, and P. P. , Past and present course of cardioprotection against ischemia- reperfusion injury, Journal of Applied Physiology, vol.103, issue.6, pp.2129-2136, 2007.
DOI : 10.1152/japplphysiol.00383.2007

M. Lindbom, T. Ramunddal, G. Camejo, F. Waagstein, and E. Omerovic, In Vivo Effects of Myocardial Creatine Depletion on Left Ventricular Function Morphology and Lipid Metabolism: Study in a Mouse Model, Journal of Cardiac Failure, vol.14, issue.2, pp.161-166, 2008.
DOI : 10.1016/j.cardfail.2007.10.020

H. Linderholm, B. Essen-gustavsson, and L. Thornell, Low succinate dehydrogenase (SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria, Journal of Internal Medicine, vol.38, issue.Suppl. 358, pp.43-52, 1990.
DOI : 10.1111/j.1365-2796.1990.tb00191.x

L. Lindholm, B. Carlberg, and O. Samuelsson, Should ?? blockers remain first choice in the treatment of primary hypertension? A meta-analysis, The Lancet, vol.366, issue.9496, pp.1545-1553, 2005.
DOI : 10.1016/S0140-6736(05)67573-3

K. Lindner, F. Ahnefeld, W. Schuermann, and I. Bowdler, Epinephrine and Norepinephrine in Cardiopulmonary Resuscitation, Chest, vol.97, issue.6, pp.1458-1462, 1990.
DOI : 10.1378/chest.97.6.1458

A. Linke, S. Erbs, and R. Hambrecht, Exercise and the Coronary Circulation???Alterations and Adaptations in Coronary Artery Disease, Progress in Cardiovascular Diseases, vol.48, issue.4, pp.270-284, 2006.
DOI : 10.1016/j.pcad.2005.10.001

J. Liu, C. Wang, Y. Murakami, G. Gong, Y. Ishibashi et al., Mitochondrial ATPase and high-energy phosphates in failing hearts

L. Lopez-bescos, S. Filipova, and R. Martos, Long-Term Safety and Efficacy of Ivabradine in Patients with Chronic Stable Angina, Cardiology, vol.108, issue.4, pp.387-396, 2007.
DOI : 10.1159/000108387

A. Ludwig, X. Zong, F. Hofmann, and M. Biel, Structure and Function of Cardiac Pacemaker Channels, Cellular Physiology and Biochemistry, vol.9, issue.4-5, pp.179-186, 1999.
DOI : 10.1159/000016315

V. Mootha, A. Arai, and R. Balaban, Maximum oxidative phosphorylation capacity of the mammalian heart, Am J Physiol, vol.272, issue.2 2, pp.769-775, 1997.

K. Moshal, N. Metreveli, I. Frank, and S. Tyagi, Mitochondrial MMP Activation, Dysfunction and Arrhythmogenesis in Hyperhomocysteinemia, Current Vascular Pharmacology, vol.6, issue.2, pp.84-92, 2008.
DOI : 10.2174/157016108783955301

P. Mulder and C. Thuillez, Heart Rate Slowing for Myocardial Dysfunction/Heart Failure, Adv Cardiol, vol.43, pp.97-105, 2006.
DOI : 10.1159/000095431

M. Nachlas, M. Davidson, J. Goldberg, and A. Seligman, Colorimetric method for the measurement of isocitric dehydrogenase activity, J Lab Clin Med, vol.62, pp.148-158, 1963.

J. Neely and H. Morgan, Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle, Annual Review of Physiology, vol.36, issue.1, pp.413-459, 1974.
DOI : 10.1146/annurev.ph.36.030174.002213

S. Neubauer, Influence of left ventricular pressures and heart rate on myocardial high-energy phosphate metabolism, Basic Research in Cardiology, vol.93, issue.0, pp.102-107, 1998.
DOI : 10.1007/s003950050231

S. Neubauer, The Failing Heart ??? An Engine Out of Fuel, New England Journal of Medicine, vol.356, issue.11, pp.1140-1151, 2007.
DOI : 10.1056/NEJMra063052

R. Neumar, C. Brown, P. Van-ligten, J. Hoekstra, R. Altschuld et al., Estimation of myocardial ischemic injury during ventricular fibrillation with total circulatory arrest using high-energy phosphates and lactate as metabolic markers, Annals of Emergency Medicine, vol.20, issue.3, pp.222-229, 1991.
DOI : 10.1016/S0196-0644(05)80927-8

J. Niemann, C. Cairns, J. Sharma, and R. Lewis, Treatment of prolonged ventricular fibrillation. Immediate countershock versus high-dose epinephrine and CPR preceding countershock, Circulation, vol.85, issue.1, pp.281-287, 1992.
DOI : 10.1161/01.CIR.85.1.281

T. Nishino, K. Okamoto, B. Eger, and E. Pai, Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase, FEBS Journal, vol.281, issue.13, pp.3278-3289, 2008.
DOI : 10.1111/j.1742-4658.2008.06489.x

D. Nul, H. Doval, H. Grancelli, S. Varini, S. Soifer et al., Heart Rate Is a Marker of Amiodarone Mortality Reduction in Severe Heart Failure, The GESICA-GEMA Investigators. Grupo de Estudio de la Sobrevida en la Insuficiencia
DOI : 10.1016/S0735-1097(97)00066-1

P. Palatini, D. Longo, V. Zaetta, D. Perkovic, R. Garbelotto et al., Evolution of blood pressure and cholesterol in stage 1 hypertension: role of autonomic nervous system activity, Journal of Hypertension, vol.24, issue.7, pp.1375-1381, 2006.
DOI : 10.1097/01.hjh.0000234118.25401.1c

G. Pierce and N. Dhalla, Mechanisms of the defect in cardiac myofibrillar function during diabetes, Am J Physiol, vol.2482, issue.1, pp.170-175, 1985.

H. Piper, T. Noll, and B. Siegmund, Mitochondrial function in the oxygen depleted and reoxygenated myocardial cell, Cardiovascular Research, vol.28, issue.1, pp.1-15, 1994.
DOI : 10.1093/cvr/28.1.1

F. Quinn, S. Currie, A. Duncan, S. Miller, R. Sayeed et al., Exchanger in the Rabbit, The Journal of Physiology, vol.273, issue.1, pp.229-242, 2003.
DOI : 10.1113/jphysiol.2003.050716

T. Rassaf and P. Luedike, Between nitros(yl)ation and nitration: Regulation of thioredoxin-1 in myocardial ischemia/reperfusion injury, Journal of Molecular and Cellular Cardiology, vol.49, issue.3, 2010.
DOI : 10.1016/j.yjmcc.2010.06.001

J. Reil and M. Bohm, The role of heart rate in the development of cardiovascular disease, Clinical Research in Cardiology, vol.91, issue.9, pp.585-592, 2007.
DOI : 10.1007/s00392-007-0537-5

J. Reil, G. Reil, and M. Bohm, Heart Rate Reduction by If-Channel Inhibition and its Potential Role in Heart Failure with Reduced and Preserved Ejection Fraction, Trends in Cardiovascular Medicine, vol.19, issue.5, pp.152-157, 2009.
DOI : 10.1016/j.tcm.2009.09.002

J. Rittenberger, J. Bost, and J. Menegazzi, Time to give the first medication during resuscitation in out-of-hospital cardiac arrest, Resuscitation, vol.70, issue.2, pp.201-206, 2006.
DOI : 10.1016/j.resuscitation.2005.12.006

F. Rocchiccioli, N. Lepetit, and P. Bougneres, Capillary gas-liquid chromatographic/mass spectrometric measurement of plasma acetate content and (2-13C) acetate enrichment, Biological Mass Spectrometry, vol.248, issue.9, pp.816-819, 1989.
DOI : 10.1002/bms.1200180927

J. Roelandt, P. Klootwijk, J. Lubsen, and M. Janse, Sudden death during longterm ambulatory monitoring, European Heart Journal, vol.5, issue.1, pp.7-20, 1984.
DOI : 10.1093/oxfordjournals.eurheartj.a061555

D. Rohrer, K. Desai, J. Jasper, M. Stevens, D. Regula et al., Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects., Proceedings of the National Academy of Sciences, vol.93, issue.14, pp.7375-7380, 1996.
DOI : 10.1073/pnas.93.14.7375

G. Rosano, C. Vitale, and M. Volterrani, Heart rate in ischemic heart disease. The innovation of ivabradine: More than pure heart rate reduction, Advances in Therapy, vol.30, issue.4, pp.202-210, 2010.
DOI : 10.1007/s12325-010-0030-9

T. Rosenbaum and S. Gordon, Quickening the Pace, Neuron, vol.42, issue.2, pp.193-196, 2004.
DOI : 10.1016/S0896-6273(04)00199-0

M. Rubart and D. Zipes, Mechanisms of sudden cardiac death, Journal of Clinical Investigation, vol.115, issue.9, pp.2305-2315, 2005.
DOI : 10.1172/JCI26381

W. Ruzyllo, M. Tendera, I. Ford, and K. Fox, Antianginal Efficacy and Safety of Ivabradine Compared with Amlodipine in Patients with Stable Effort Angina Pectoris, Drugs, vol.152, issue.23, pp.393-405, 2007.
DOI : 10.2165/00003495-200767030-00005

M. Saha and M. Marber, If at first you don't succeed try ... a new target in the treatment of angina, European Heart Journal, vol.26, issue.23, pp.2482-2483, 2005.
DOI : 10.1093/eurheartj/ehi575

J. Salem, W. Stanley, and M. Cabrera, Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism, BioMedical Engineering OnLine, vol.3, issue.1, p.15, 2004.
DOI : 10.1186/1475-925X-3-15

B. Santoro, D. Liu, H. Yao, D. Bartsch, E. Kandel et al., Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain, Cell, vol.93, issue.5, pp.717-729, 1998.
DOI : 10.1016/S0092-8674(00)81434-8

L. Saxon, Sudden cardiac death: epidemiology and temporal trends, Rev Cardiovasc Med, vol.6, issue.2, pp.12-20, 2005.

S. Schaefer, G. Schwartz, J. Gober, A. Wong, S. Camacho et al., Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia. Phosphorus-31 nuclear magnetic resonance studies of porcine myocardium in vivo., Journal of Clinical Investigation, vol.85, issue.3, pp.706-713, 1990.
DOI : 10.1172/JCI114495

C. Schamroth and L. Schamroth, electrocardiogram of me month: Ventricular Aneurysm: The Effect of a Complicating Left Anterior Hemiblock, Chest, vol.85, issue.2, pp.276-277, 1984.
DOI : 10.1378/chest.85.2.276

S. Schmidt-ott, C. Bletz, C. Vahl, W. Saggau, S. Hagl et al., Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium, Basic Research in Cardiology, vol.27, issue.3, pp.358-366, 1990.
DOI : 10.1007/BF01907128

L. Schwartz, K. Reimer, M. Crago, and R. Jennings, Pharmacological preconditioning with diazoxide slows energy metabolism during sustained ischemia, Exp Clin Cardiol, vol.12, issue.3, pp.139-147, 2007.

S. Scolletta and B. Biagioli, Energetic myocardial metabolism and oxidative stress: Let's make them our friends in the fight against heart failure, Biomedicine & Pharmacotherapy, vol.64, issue.3, pp.203-207, 2010.
DOI : 10.1016/j.biopha.2009.10.002

V. Sharma, P. Dhillon, R. Wambolt, H. Parsons, R. Brownsey et al., Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat, AJP: Heart and Circulatory Physiology, vol.294, issue.4, pp.1609-1620, 2008.
DOI : 10.1152/ajpheart.00949.2007

R. Shaw and R. Y. , Electrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure, Circulation Research, vol.80, issue.1, pp.124-138, 1997.
DOI : 10.1161/01.RES.80.1.124

W. Shi, R. Wymore, H. Yu, J. Wu, R. Wymore et al., Distribution and Prevalence of Hyperpolarization-Activated Cation Channel (HCN) mRNA Expression in Cardiac Tissues, Circulation Research, vol.85, issue.1, pp.1-6, 1999.
DOI : 10.1161/01.RES.85.1.e1

M. Silverman, D. Grove, C. Upshaw, and J. , Why Does the Heart Beat?: The Discovery of the Electrical System of the Heart, Circulation, vol.113, issue.23, pp.2775-2781, 2006.
DOI : 10.1161/CIRCULATIONAHA.106.616771

L. Simon, B. Ghaleh, L. Puybasset, J. Giudicelli, and A. Berdeaux, Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs, J Pharmacol Exp Ther, vol.275, issue.2, pp.659-666, 1995.

B. Singh, ??-Adrenergic Blockers as Antiarrhythmic and Antifibrillatory Compounds: An Overview, Journal of Cardiovascular Pharmacology and Therapeutics, vol.10, issue.4 suppl, pp.3-14, 2005.
DOI : 10.1177/10742484050100i402

N. Sodha, R. Clements, J. Feng, Y. Liu, C. Bianchi et al., The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia???reperfusion injury?????????, European Journal of Cardio-Thoracic Surgery, vol.33, issue.5, pp.906-913, 2008.
DOI : 10.1016/j.ejcts.2008.01.047

W. Stanley, F. Recchia, and G. Lopaschuk, Myocardial Substrate Metabolism in the Normal and Failing Heart, Physiological Reviews, vol.85, issue.3, pp.1093-1129, 2005.
DOI : 10.1152/physrev.00006.2004

I. Stiell, G. Wells, B. Field, D. Spaite, L. Nesbitt et al., Advanced Cardiac Life Support in Out-of-Hospital Cardiac Arrest, New England Journal of Medicine, vol.351, issue.7, pp.647-656, 2004.
DOI : 10.1056/NEJMoa040325

M. Stoll, M. Quentin, A. Molojavyi, V. Thamer, and U. Decking, Spatial heterogeneity of myocardial perfusion predicts local potassium channel expression and action potential duration, Cardiovascular Research, vol.77, issue.3, pp.489-496, 2008.
DOI : 10.1093/cvr/cvm060

P. Stone, R. Gibson, S. Glasser, M. Dewood, J. Parker et al., Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. The ASIS Study Group, Circulation, vol.82, issue.6, pp.1962-1972, 1990.
DOI : 10.1161/01.CIR.82.6.1962

S. Sulfi and A. Timmis, Ivabradine - the first selective sinus node If channel inhibitor in the treatment of stable angina, International Journal of Clinical Practice, vol.4, issue.Suppl. 1, pp.222-228, 2006.
DOI : 10.1111/j.1742-1241.2006.00817.x

J. Tardif, Clinical Results of If Current Inhibition by Ivabradine, Drugs, vol.27, issue.4, pp.35-41, 2007.
DOI : 10.2165/00003495-200767002-00005

J. Tardif, I. Ford, M. Tendera, M. Bourassa, and K. Fox, Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina, European Heart Journal, vol.26, issue.23, pp.2529-2536, 2005.
DOI : 10.1093/eurheartj/ehi586

S. Tawara, Das Reizleitungssystem Des Säugetierherzens [The Conduction System of the Mammalian Heart], 1906.

J. Tellez, H. Dobrzynski, I. Greener, G. Graham, E. Laing et al., Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit, Circulation Research, vol.99, issue.12, pp.1384-1393, 2006.
DOI : 10.1161/01.RES.0000251717.98379.69

C. Thollon, C. Cambarrat, J. Vian, J. Prost, J. Peglion et al., Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49, British Journal of Pharmacology, vol.8, issue.Suppl. L, pp.37-42, 1994.
DOI : 10.1111/j.1476-5381.1994.tb13025.x

R. Verrier and M. Josephson, Impact of Sleep on Arrhythmogenesis, Circulation: Arrhythmia and Electrophysiology, vol.2, issue.4, pp.450-459, 2009.
DOI : 10.1161/CIRCEP.109.867028

R. Verrier and T. Nieminen, T-Wave Alternans as a Therapeutic Marker for Antiarrhythmic Agents, Journal of Cardiovascular Pharmacology, vol.55, issue.6, pp.544-554, 2010.
DOI : 10.1097/FJC.0b013e3181d6b781

R. Verrier and A. Tan, Heart rate, autonomic markers, and cardiac mortality, Heart Rhythm, vol.6, issue.11, pp.68-75, 2009.
DOI : 10.1016/j.hrthm.2009.07.017
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776094

J. Vilaine, : Une nouvelle approche th??rapeutique des cardiopathies isch??miques, m??decine/sciences, vol.22, issue.1, pp.87-94, 2006.
DOI : 10.1051/medsci/200622187
URL : http://www.erudit.org/revue/ms/2006/v22/n1/012240ar.pdf

J. Vilaine, J. Bidouard, L. Lesage, H. Reure, and J. Peglion, Anti-Ischemic Effects of Ivabradine, a Selective Heart Rate-Reducing Agent, in Exercise-Induced Myocardial Ischemia in Pigs, Journal of Cardiovascular Pharmacology, vol.42, issue.5, pp.688-696, 2003.
DOI : 10.1097/00005344-200311000-00016

G. Vincent, Phénotypage métabolique du coeur sain et malade basé sur l'analyse d'isotopomères de masse marqués au carbone 13: implications du citrate

G. Vincent, M. Khairallah, B. Bouchard, D. Rosiers, and C. , Metabolic phenotyping of the diseased rat heart using 13C-substrates and ex vivo perfusion in the working mode, Mol Cell Biochem, vol.242, issue.12, pp.89-99, 2003.
DOI : 10.1007/978-1-4757-4712-6_12

A. Vogt, A. Elsasser, A. Pott-beckert, C. Ackermann, S. Vetter et al., Myocardial energy metabolism in ischemic preconditioning and cardioplegia: A metabolic control analysis, Molecular and Cellular Biochemistry, vol.198, issue.1-2, pp.223-232, 2005.
DOI : 10.1007/s11010-005-7576-x

J. Wang, X. Guo, and N. Dhalla, Modification of myosin protein and gene expression in failing hearts due to myocardial infarction by enalapril or losartan, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1690, issue.2, pp.177-184, 2004.
DOI : 10.1016/j.bbadis.2004.06.004

J. Wang, X. Liu, B. Ren, H. Rupp, N. Takeda et al., Modification of Myosin Gene Expression by Imidapril in Failing Heart due to Myocardial Infarction, Journal of Molecular and Cellular Cardiology, vol.34, issue.7, pp.847-857, 2002.
DOI : 10.1006/jmcc.2002.2023

P. Wang, C. Zaragoza, and W. Holman, Sodium???Hydrogen Exchange Inhibition and ??-Blockade Additively Decrease Infarct Size, The Annals of Thoracic Surgery, vol.83, issue.3, pp.1121-1127, 2007.
DOI : 10.1016/j.athoracsur.2006.10.039

S. Wang, J. Radhakrishnan, I. Ayoub, J. Kolarova, D. Taglieri et al., Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury, Journal of Applied Physiology, vol.103, issue.1, pp.55-65, 2007.
DOI : 10.1152/japplphysiol.01167.2006

R. Weiss, P. Bottomley, C. Hardy, and G. Gerstenblith, Regional Myocardial Metabolism of High-Energy Phosphates during Isometric Exercise in Patients with Coronary Artery Disease, New England Journal of Medicine, vol.323, issue.23, pp.1593-1600, 1990.
DOI : 10.1056/NEJM199012063232304

F. Wu, E. Zhang, J. Zhang, R. Bache, and D. Beard, Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts, The Journal of Physiology, vol.94, issue.17, pp.4193-4208, 2008.
DOI : 10.1113/jphysiol.2008.154732

W. Zagotta, N. Olivier, K. Black, E. Young, R. Olson et al., Structural basis for modulation and agonist specificity of HCN pacemaker channels, Nature, vol.425, issue.6954, pp.200-205, 2003.
DOI : 10.1038/nature01922

J. Zhang, D. Liem, M. Mueller, Y. Wang, C. Zong et al., Altered Proteome Biology of Cardiac Mitochondria Under Stress Conditions, Journal of Proteome Research, vol.7, issue.6, pp.2204-2214, 2008.
DOI : 10.1021/pr070371f

Z. Zhao and J. Vinten-johansen, Myocardial apoptosis and ischemic preconditioning, Cardiovascular Research, vol.55, issue.3, pp.438-455, 2002.
DOI : 10.1016/S0008-6363(02)00442-X

W. Zheng, M. Brown, T. Brock, R. Bjercke, and R. Tomanek, Bradycardia-Induced Coronary Angiogenesis Is Dependent on Vascular Endothelial Growth Factor, Circulation Research, vol.85, issue.2, pp.192-198, 1999.
DOI : 10.1161/01.RES.85.2.192

J. Roelandt, P. Klootwijk, and J. Lubsen, Sudden death during longterm ambulatory monitoring, European Heart Journal, vol.5, issue.1, pp.7-20, 1984.
DOI : 10.1093/oxfordjournals.eurheartj.a061555

M. Janse and A. Wit, Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction, Physiol Rev, vol.69, pp.1049-1169, 1989.

Q. Timour, J. Aupetit, and J. Loufoua-moundanga, Class Ic antiarrhythmic drugs and myocardial ischaemia: study in the pig heart in situ, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.343, issue.6, pp.645-651, 1991.
DOI : 10.1007/BF00184297

J. Aupetit, Q. Timour, and J. Larbre, Arrhythmogenicity of antiarrhythmic drugs and intraventricular conduction disorders: Possible aggravation by myocardial ischemia?Study in the porcine in situ heart, Cardiovascular Drugs and Therapy, vol.49, issue.2, pp.217-223, 1993.
DOI : 10.1007/BF00878511

J. Aupetit, Q. Timour, and J. Loufoua-moundanga, Profibrillatory Effects of Lidocaine in the Acutely Ischemic Porcine Heart, Journal of Cardiovascular Pharmacology, vol.25, issue.5, pp.810-816, 1995.
DOI : 10.1097/00005344-199505000-00018

B. Bui-xuan, J. Aupetit, and M. Freysz, Cardiac ??-adrenoceptor activation and ventricular fibrillation under normal and ischaemic conditions, Cardiovascular Research, vol.32, issue.6, pp.1056-1063, 1996.
DOI : 10.1016/S0008-6363(96)00156-3

J. Aupetit, D. Frassati, and B. Bui-xuan, Efficacy of a ??-adrenergic receptor antagonist, propranolol, in preventing ischaemic ventricular fibrillation: dependence on heart rate and ischaemia duration, Cardiovascular Research, vol.37, issue.3, pp.646-655, 1998.
DOI : 10.1016/S0008-6363(97)00304-0

D. Difrancesco and J. Camm, Heart Rate Lowering by Specific and Selective If Current Inhibition with Ivabradine, Drugs, vol.109, issue.16, pp.1757-1765, 2004.
DOI : 10.2165/00003495-200464160-00003

P. Colin, B. Ghaleh, and L. Hittinger, Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise

P. Mulder, S. Barbier, and A. Chagraoui, Long-Term Heart Rate Reduction Induced by the Selective If Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure, Circulation, vol.109, issue.13, pp.1674-1679, 2004.
DOI : 10.1161/01.CIR.0000118464.48959.1C

L. Simon, B. Ghaleh, and L. Puybasset, Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs, J Pharmacol Exp Ther, vol.275, pp.659-666, 1995.

J. Vilaine, J. Bidouard, and L. Lesage, Anti-Ischemic Effects of Ivabradine, a Selective Heart Rate-Reducing Agent, in Exercise-Induced Myocardial Ischemia in Pigs, Journal of Cardiovascular Pharmacology, vol.42, issue.5, pp.688-696, 2003.
DOI : 10.1097/00005344-200311000-00016

P. Colin, B. Ghaleh, and X. Monnet, Contributions of heart rate and contractility to myocardial oxygen balance during exercise, American Journal of Physiology - Heart and Circulatory Physiology, vol.284, issue.2, pp.676-682, 2003.
DOI : 10.1152/ajpheart.00564.2002

X. Monnet, B. Ghaleh, and P. Colin, Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning

X. Monnet, C. P. Ghaleh, and B. , Heart rate reduction during exercise-induced myocardial ischaemia and stunning, European Heart Journal, vol.25, issue.7, pp.579-586, 2004.
DOI : 10.1016/j.ehj.2003.10.010

C. Thollon, J. Bidouard, and C. Cambarrat, Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257, European Journal of Pharmacology, vol.339, issue.1, pp.43-51, 1997.
DOI : 10.1016/S0014-2999(97)01364-2

A. Tabib and R. Loire, Quantitative morphometry of myocardial necrosis Anatomical and enzymatic correlates, clinical index for estimating the amount of necrosed tissue, Arch Mal Coeur Vaiss, vol.74, pp.641-648, 1981.

J. Aupetit, B. Bui-xuan, and I. Kioueh, Opposite change with ischaemia in the antifibrillatory effects of class I and class IV antiarrhythmic drugs resulting from the alteration in ion transmembrane exchanges related to depolarization, Canadian Journal of Physiology and Pharmacology, vol.78, issue.3, pp.208-216, 2000.
DOI : 10.1139/y99-129

F. Vaillant, P. Tsibiribi, and G. Bricca, Trimetazidine Protective Effect Against Ischemia-Induced Susceptibility to Ventricular Fibrillation in Pigs, Cardiovascular Drugs and Therapy, vol.79, issue.1, pp.29-36, 2008.
DOI : 10.1007/s10557-007-6076-5

J. Aupetit, Q. Timour, and M. Freysz, Vulnerability to ventricular fibrillation related to ischemia: comparison of the acute effects of betablockers and calcium antagonists, Arch Int Pharmacodyn Ther, vol.327, pp.25-39, 1994.

Q. Timour, J. Aupetit, and M. Freysz, Possible prevention by amlodipine of ventricular fibrillation related to brief ischemia episodes, Canadian Journal of Physiology and Pharmacology, vol.74, issue.12, pp.1308-1314, 1996.
DOI : 10.1139/y96-139

Q. Timour, B. Bui-xuan, and G. Faucon, Delay by a calcium antagonist, amlodipine, of the onset of primary ventricular fibrillation in myocardial ischemia, Cardiovascular Drugs and Therapy, vol.46, issue.Suppl 1, pp.447-454, 1996.
DOI : 10.1007/BF00051109

B. Bui-xuan, J. Aupetit, and M. Freysz, Prevention by calcium antagonists of profibrillatory effects of class I antiarrhythmic drugs in acute myocardial ischemia: study in pig heart in situ, Pharmacotherapy, vol.17, pp.737-745, 1997.

A. Kleber, Extracellular potassium accumulation in acute myocardial ischemia*, Journal of Molecular and Cellular Cardiology, vol.16, issue.5, pp.389-394, 1984.
DOI : 10.1016/S0022-2828(84)80610-0

J. Renaud, Internal pH, Na+, and Ca2+ regulation by trimetazidine during cardiac cell acidosis, Cardiovascular Drugs and Therapy, vol.50, issue.Suppl 26, pp.677-686, 1988.
DOI : 10.1007/BF02125756

C. Lyons, M. Burgess, and J. Abildskov, Effects of acute hyperkalemia on cardiac excitability, American Heart Journal, vol.94, issue.6, pp.755-763, 1977.
DOI : 10.1016/S0002-8703(77)80217-2

R. Ferrari, A. Cargnoni, and C. Ceconi, Anti-ischaemic effect of ivabradine, Pharmacological Research, vol.53, issue.5, pp.435-439, 2006.
DOI : 10.1016/j.phrs.2006.03.018

M. Hennersdorf, Possibilities of reducing heart rate by I(f)-channel inhibitor, Med Klin (Munich), vol.101, pp.150-152, 2006.

F. Mahlberg-gaudin, M. Bouly, and C. Chezaubernard, Pharmacological Basics of ??-Current Inhibition, Heart Drug, vol.5, issue.1, pp.14-20, 2005.
DOI : 10.1159/000083381

J. Vilaine, The discovery of the selective If current inhibitor ivabradineA new therapeutic approach to ischemic heart disease, Pharmacological Research, vol.53, issue.5, pp.424-434, 2006.
DOI : 10.1016/j.phrs.2006.03.016

M. Hindman and G. Wagner, Arrhythmias during myocardial infarction: mechanisms, significance, and therapy, Cardiovasc Clin, vol.11, pp.81-102, 1980.

P. Tsibiribi, C. Bui-xuan, and B. Bui-xuan, The effects of ropivacaine at clinically relevant doses on myocardial ischemia in pigs, Journal of Anesthesia, vol.27, issue.Suppl, pp.341-343, 2006.
DOI : 10.1007/s00540-006-0429-2

R. Coronel and F. Wilms-schopman, Origin of ischemia-induced phase 1b ventricular arrhythmias in pig hearts, Journal of the American College of Cardiology, vol.39, issue.1, pp.166-176, 2002.
DOI : 10.1016/S0735-1097(01)01686-2

I. Montreal-heart, Departments of Nutrition

J. Tardif, Heart rate as a treatable cardiovascular risk factor, British Medical Bulletin, vol.90, issue.1, pp.71-84, 2009.
DOI : 10.1093/bmb/ldp016

S. Bangalore, G. Kamalakkannan, and F. Messerli, ??-blockers: No longer an option for uncomplicated hypertension, Current Cardiology Reports, vol.115, issue.6, pp.441-446, 2007.
DOI : 10.1007/BF02938387

J. Cruickshank, Are we misunderstanding beta-blockers, International Journal of Cardiology, vol.120, issue.1, pp.10-27, 2007.
DOI : 10.1016/j.ijcard.2007.01.069

P. Lama, Systemic adverse effects of beta-adrenergic blockers: an evidence-based assessment, American Journal of Ophthalmology, vol.134, issue.5, pp.749-760, 2002.
DOI : 10.1016/S0002-9394(02)01699-9

J. Wright, J. Oakes, R. Lukas, M. Anderson, K. Bell et al., Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial, JAMA, vol.292, pp.2227-2236, 2004.

S. Neubauer, The Failing Heart ??? An Engine Out of Fuel, New England Journal of Medicine, vol.356, issue.11, pp.1140-1151, 2007.
DOI : 10.1056/NEJMra063052

W. Stanley, F. Recchia, and G. Lopaschuk, Myocardial Substrate Metabolism in the Normal and Failing Heart, Physiological Reviews, vol.85, issue.3, pp.1093-1129, 2005.
DOI : 10.1152/physrev.00006.2004

D. An, G. Kewalramani, D. Qi, T. Pulinilkunnil, S. Ghosh et al., ??-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload, AJP: Endocrinology and Metabolism, vol.288, issue.6, pp.1120-1127, 2005.
DOI : 10.1152/ajpendo.00588.2004

R. Fardoun, Carvedilol versus Cardioselective ??-Blockers for the Treatment of Hypertension in Patients with Type 2 Diabetes Mellitus, Pharmacotherapy, vol.9, issue.2, pp.1491-1500, 2006.
DOI : 10.1007/s00228-004-0729-0

K. Furuki, Y. Nanjo, T. Imaizumi, J. Borer, and J. Tardif, Higher heart rate may predispose to obesity and diabetes mellitus: 20-year prospective study in a general population Efficacy of ivabradine, a selective I(f) inhibitor, in patients with chronic stable angina pectoris and diabetes mellitus, Am J Hypertens Am J Cardiol, vol.22105, issue.12, pp.151-15529, 2009.

D. Difrancesco and J. Borer, The Funny Current, Drugs, vol.1015, issue.Supplement 2
DOI : 10.2165/00003495-200767002-00003

G. Lerebours, F. Mahlberg-gaudin, and C. Thuillez, Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure, Circulation, vol.109, pp.1674-1679, 2004.

P. Milliez, S. Messaoudi, J. Nehme, C. Rodriguez, J. Samuel et al., Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure, AJP: Heart and Circulatory Physiology, vol.296, issue.2, pp.435-441, 2009.
DOI : 10.1152/ajpheart.00591.2008

P. Colin, B. Ghaleh, X. Monnet, L. Hittinger, and A. Berdeaux, Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs, Journal of Pharmacology and Experimental Therapeutics, vol.308, issue.1, pp.236-240, 2004.
DOI : 10.1124/jpet.103.059717

C. Ceconi, A. Cargnoni, G. Francolini, G. Parinello, and R. Ferrari, Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart, Cardiovascular Research, vol.84, issue.1, pp.72-82, 2009.
DOI : 10.1093/cvr/cvp158

P. Colin, B. Ghaleh, X. Monnet, J. Su, L. Hittinger et al., Contributions of heart rate and contractility to myocardial oxygen balance during exercise, American Journal of Physiology - Heart and Circulatory Physiology, vol.284, issue.2, pp.676-682, 2003.
DOI : 10.1152/ajpheart.00564.2002

G. Heusch, Pleiotropic action(s) of the bradycardic agent ivabradine: cardiovascular protection beyond heart rate reduction, British Journal of Pharmacology, vol.33, issue.7, pp.970-971, 2008.
DOI : 10.1038/bjp.2008.347

S. Sack, F. Katus, H. Dengler, and T. , Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients, Transplantation, vol.88, pp.835-841, 2009.

W. Padua-filho, D. Brasil, H. Neves, O. Gomes, and E. Bocchi, Effects of metoprolol and amiodarone combination on heart rate, myocardial contractility and coronary flow: Study in isolated perfused rat hearts, Exp Clin Cardiol, vol.9, pp.133-137, 2004.

M. Allard, H. Parsons, R. Saeedi, R. Wambolt, and R. Brownsey, AMPK and metabolic adaptation by the heart to pressure overload, AJP: Heart and Circulatory Physiology, vol.292, issue.1, pp.140-148, 2007.
DOI : 10.1152/ajpheart.00424.2006

P. Chevalier, Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study, J Cardiovasc Pharmacol, vol.52, pp.548-554, 2008.

P. Mulder and C. Thuillez, Heart Rate Slowing for Myocardial Dysfunction/Heart Failure, Adv Cardiol, vol.43, pp.97-105, 2006.
DOI : 10.1159/000095431

J. Abbott, R. Broadstone, D. Ward, and R. Pyle, Hemodynamic effects of orally administered carvedilol in healthy conscious dogs, American Journal of Veterinary Research, vol.66, issue.4, pp.637-641, 2005.
DOI : 10.2460/ajvr.2005.66.637

S. Kalaycioglu, V. Sinci, Y. Imren, and E. Oz, Pharmacodynamics of carvedilol in conscious, healthy dogs Metoprolol prevents ischemia-reperfusion injury by reducing lipid peroxidation, J Vet Intern Med Jpn Circ J, vol.2063, issue.39, pp.297-304718, 1999.

B. Kobilka, Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects, Proc Natl Acad Sci U S A, vol.93, pp.7375-7380, 1996.

W. Manati, F. Vaillant, M. Bost, V. Maffre, D. Belhani et al., Protective role of selenium supplementation against cardiac lesions induced by the combination of levomepromazine and risperidone in the rabbit, Human & Experimental Toxicology, vol.327, issue.8, pp.461-468, 2009.
DOI : 10.1177/0960327109106968

D. Belhani, L. Fanton, F. Vaillant, J. Descotes, W. Manati et al., Cardiac Lesions Induced by Testosterone: Protective Effects of Dexrazoxane and Trimetazidine, Cardiovascular Toxicology, vol.7, issue.5A, pp.64-73, 2009.
DOI : 10.1007/s12012-009-9041-7

L. Fanton, D. Belhani, F. Vaillant, A. Tabib, L. Gomez et al., Heart lesions associated with anabolic steroid abuse: Comparison of post-mortem findings in athletes and norethandrolone-induced lesions in rabbits, Experimental and Toxicologic Pathology, vol.61, issue.4, pp.317-340, 2009.
DOI : 10.1016/j.etp.2008.09.007

F. Vaillant, P. Tsibiribi, G. Bricca, B. Bui-xuan, A. Bescond-jacquet et al., Trimetazidine Protective Effect Against Ischemia-Induced Susceptibility to Ventricular Fibrillation in Pigs, Cardiovascular Drugs and Therapy, vol.79, issue.1, pp.29-36, 2008.
DOI : 10.1007/s10557-007-6076-5

F. Vaillant, F. Turrel, M. Bost, G. Bricca, J. Descotes et al., Role of selenium in heart lesions produced by neuroleptics in the rabbit, Journal of Applied Toxicology, vol.87, issue.2, pp.212-218, 2008.
DOI : 10.1002/jat.1279