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Etude épidémiologique des travailleurs exposés au risque d'incorporation d'uranium

Abstract : This work is a pilot-study among nuclear fuel cycle workers potentially exposed to alpha radiation. Internal exposure from inhalation of uranium compounds during uranium conversion and enrichment operations was estimated at the AREVA NC Pierrelatte plant. A plant specific semi-quantitative job exposure matrix (JEM) was elaborated for 2709 workers employed at this plant between 1960 and 2006. The JEM has permitted to estmate the exposure to uranium and 16 other categories of pollutants and to calculate individual cumulative exposure score. Noumerous correlations were detected between uranium compounds exposure and exposure to other pollutants, such as asbestos, ceramic refractive fibers, TCE and so on. 1968-2005 mortality follow-up showed a slightly increasing risk of mortality from pleural cancer, rectal cancer and lymphatique cancer on the basis of national mortality rates. Analyses of association between cancer mortality and uranium exposure suggested an increase in mortality due to lung cancer among workers exposed to slowly soluble uranium compounds derived from natural and reprocessed uranium. However this results were based on a small number of observed deaths. These rusults are concordant with previously reported results from other cohorts of workers potentially exposed to uranium. Experimental studies of biokinetic and action mecanism of slowly soluble uranium oxides bear the biological plausibility of the observed results. Influence of bias was reduced by taking into account of possible confoundings incuding coexposure to other carcinogenic pollutants and tobbacco consumption in the study. Nevertheless, at this stage statistical power of analyses is too limited to obtain more conclusive results, notably on lymphatic cancer mortality. This pilote study shows the feasability of an epidemiological investigation among workers at risk of internal exposure to uranium and other alpha emitters at the national level. It demonstrates the importance of exposure assessement for all carcinogenic pollutants likely to be associated with uranium exposure. Accounting for these associated exposures in analyses is also important especially for cancer outcomes. In a wider context, this work provides additional data on a possible carcinogenic effect of protracted uranium exposure and alpha radiation in humans.
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Submitted on : Friday, April 12, 2013 - 12:11:39 PM
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  • HAL Id : tel-00812524, version 1

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Irina Guseva Canu. Etude épidémiologique des travailleurs exposés au risque d'incorporation d'uranium. Santé publique et épidémiologie. Université Pierre et Marie Curie - Paris VI, 2008. Français. ⟨NNT : 2008PA066314⟩. ⟨tel-00812524⟩

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