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DETERMINANTS PHYSIOLOGIQUES DES POTENTIELS EVOQUES RESPIRATOIRES - APPLICATION AU SYNDROME D'APNEES OBSTRUCTIVES DU SOMMEIL

Abstract : Respiratory-related evoked potentials (RREP) reflect the activity of cortical neurons in response to occlusions of the airway at the mouth during inspiration. They may provide insights into afferents pathways and cortical processes underlying suprapontine control of breathing and perception of respiratory sensations. This thesis aimed at clarifying the origin of the RREP and at assessing whether severe obstructive sleep apnea syndrome (OSAS) would be associated to changes in their characteristics, during wakefulness. The first study of this thesis showed that predominant diaphragm fatigue did not affect the RREP. The second study showed that upper airway afferents were a paramount source for the early components of the RREP. The third study showed that upper airway anesthesia did not modify the RREP. The results of the fourth study were consistent with a normal projection to the cortex of sensory inputs related to upper airway occlusion, in severe OSAS patients during wakefulness. However, these results were also consistent with an impairment of the cortical processing of these inputs. The role of this impairment in the pathogenesis of OSAS remains to be assessed. Together with other published data, the results of this thesis suggest that the sources and the determinants of the RREP may be multiple and complex. Further investigations are therefore needed before clinical applications.
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Submitted on : Thursday, April 4, 2013 - 10:55:49 AM
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  • HAL Id : tel-00807706, version 1

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Christine Donzel-Raynaud. DETERMINANTS PHYSIOLOGIQUES DES POTENTIELS EVOQUES RESPIRATOIRES - APPLICATION AU SYNDROME D'APNEES OBSTRUCTIVES DU SOMMEIL. Pneumologie et système respiratoire. Université Pierre et Marie Curie - Paris VI, 2007. Français. ⟨NNT : 2007PA066137⟩. ⟨tel-00807706⟩

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