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ANALYSE DES MECANISMES DE PENETRATION INTRAMEMBRANAIRE DE PORPHYRINES GLYCOCONJUGUEES UTILISABLES EN THERAPIE PHOTODYNAMIQUE DES CANCERS: MODELISATION DES INTERACTIONS SPECIFIQUES ET NON-SPECIFIQUES

Abstract : The complexity of biological membranes is the cause of artificial membrane models development as essential tools for understanding the mechanisms of interaction between drugs and cell membrane. This thesis focuses on the study of specific and non specific interactions between new glycoconjugated porphyrins used in photodynamic therapy (PDT) and retinoblastoma biomimetic membrane models (monolayers, supported planar bilayers and liposomes) expressing at their surface a mannose specific lectin. The main characterization techniques used in this study, are the Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) and Dynamic Light Scattering (DLS). Glycoconjugated porphyrins are proved as promising molecules which are able to interact in a non specific (passive penetration) and specific ways (Lectin-like receptors targeting) with retinoblastoma membrane models.
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https://tel.archives-ouvertes.fr/tel-00800719
Contributor : Ali Makky Connect in order to contact the contributor
Submitted on : Thursday, March 14, 2013 - 12:02:29 PM
Last modification on : Saturday, June 25, 2022 - 8:31:40 PM
Long-term archiving on: : Sunday, April 2, 2017 - 12:50:41 PM

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  • HAL Id : tel-00800719, version 1

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Ali Makky. ANALYSE DES MECANISMES DE PENETRATION INTRAMEMBRANAIRE DE PORPHYRINES GLYCOCONJUGUEES UTILISABLES EN THERAPIE PHOTODYNAMIQUE DES CANCERS: MODELISATION DES INTERACTIONS SPECIFIQUES ET NON-SPECIFIQUES. Biophysique [physics.bio-ph]. Université Paris Sud - Paris XI, 2010. Français. ⟨NNT : ⟩. ⟨tel-00800719⟩

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