R. Abbas and B. A. Hug, Effect of Ketoconazole on the Pharmacokinetics of Oral Bosutinib in Healthy Subjects, The Journal of Clinical Pharmacology, vol.8, issue.12, pp.1721-1727, 2011.
DOI : 10.1177/0091270010387427

W. B. Abrams and R. Pocelinko, Clinical Pharmacological Studies With Debrisoquin Sulfate, a New Antihypertensive Agent, The Journal of New Drugs, vol.14, issue.5, pp.268-283, 1964.
DOI : 10.1002/j.1552-4604.1964.tb00372.x

V. Agarwal and R. P. Kommaddi, Drug Metabolism in Human Brain: High Levels of Cytochrome P4503A43 in Brain and Metabolism of Anti-Anxiety Drug Alprazolam to Its Active Metabolite, PLoS ONE, vol.238, issue.6, p.2337, 2008.
DOI : 10.1371/journal.pone.0002337.g008

L. Aigrain and D. Pompon, Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase, EMBO reports, vol.1770, issue.7, pp.742-747, 2009.
DOI : 10.1021/bi800787m

M. Al-anizy and N. J. Horley, Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain, FEBS Journal, vol.235, issue.5, pp.936-947, 2006.
DOI : 10.1002/prot.340110407

S. F. Altschul and T. L. Madden, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389

T. Andersson and J. O. Miners, Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism, British Journal of Clinical Pharmacology, vol.224, issue.Suppl., pp.521-530, 1993.
DOI : 10.1111/j.1365-2125.1993.tb00410.x

A. J. Annalora and D. B. Goodin, Crystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D Metabolism, Journal of Molecular Biology, vol.396, issue.2, pp.441-451, 2010.
DOI : 10.1016/j.jmb.2009.11.057

J. Axelrod, The enzymatic demethylation of ephedrine, J Pharmacol Exp Ther, vol.114, issue.4, pp.430-438, 1955.

D. Baker and A. Sali, Protein Structure Prediction and Structural Genomics, Science, vol.294, issue.5540, pp.93-96, 2001.
DOI : 10.1126/science.1065659

H. J. Barnes, [1] Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli, Methods Enzymol, vol.272, pp.3-14, 1996.
DOI : 10.1016/S0076-6879(96)72003-7

T. H. Bayburt and S. G. Sligar, Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks, Proceedings of the National Academy of Sciences, vol.99, issue.10, pp.6725-6730, 2002.
DOI : 10.1073/pnas.062565599

A. Bellamine and Y. Wang, Characterization of the CYP4A11 gene, a second CYP4A gene in humans, Archives of Biochemistry and Biophysics, vol.409, issue.1, pp.221-227, 2003.
DOI : 10.1016/S0003-9861(02)00545-3

K. Berka and E. Anzenbacherova, Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site, Journal of Inorganic Biochemistry, vol.110, pp.46-50, 2012.
DOI : 10.1016/j.jinorgbio.2012.02.010

K. Berka and T. Hendrychova, Membrane Position of Ibuprofen Agrees with Suggested Access Path Entrance to Cytochrome P450 2C9 Active Site, The Journal of Physical Chemistry A, vol.115, issue.41, pp.11248-11255, 2011.
DOI : 10.1021/jp204488j

S. Bhamre and H. K. Anandatheerthavarada, Microsomal cytochrome P450 in human brain regions, Biochemical Pharmacology, vol.44, issue.6, pp.1223-1225, 1992.
DOI : 10.1016/0006-2952(92)90390-5

H. S. Bosch and A. Dinklage, Physics Programme for Initial Operation of Wendelstein 7-X, Contributions to Plasma Physics, vol.50, issue.68, pp.687-694, 2010.
DOI : 10.1002/ctpp.201010101

J. U. Bowie and R. Luthy, A method to identify protein sequences that fold into a known three-dimensional structure, Science, vol.253, issue.5016, pp.164-170, 1991.
DOI : 10.1126/science.1853201

M. M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976.
DOI : 10.1016/0003-2697(76)90527-3

B. B. Brodie and J. Axelrod, Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes, Science, vol.121, issue.3147, pp.603-604, 1955.
DOI : 10.1126/science.121.3147.603

B. R. Brooks and C. L. Brooks, CHARMM: The biomolecular simulation program, Journal of Computational Chemistry, vol.103, issue.13, pp.1545-1614, 2009.
DOI : 10.1002/jcc.21287

L. R. Brown and K. Wuthrich, NMR and ESR studies of the interactions of cytochrome c with mixed cardiolipin-phosphatidylcholine vesicles, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.468, issue.3, pp.389-410, 1977.
DOI : 10.1016/0005-2736(77)90290-5

J. Bylund and J. Ericsson, Analysis of Cytochrome P450 Metabolites of Arachidonic and Linoleic Acids by Liquid Chromatography???Mass Spectrometry with Ion Trap MS2, Analytical Biochemistry, vol.265, issue.1, pp.55-68, 1998.
DOI : 10.1006/abio.1998.2897

J. Bylund and C. Zhang, Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain, Biochemical and Biophysical Research Communications, vol.296, issue.3, pp.677-684, 2002.
DOI : 10.1016/S0006-291X(02)00918-X

J. Cali and M. Sobol, Screen for cytochrome P450 activity using luminescent assay, Cell Notes, issue.13, pp.8-10, 2005.

D. A. Case and T. A. Darden, Amber 11, 2010.

J. B. Cheng and D. L. Motola, De-orphanization of Cytochrome P450 2R1: A MICROSOMAL VITAMIN D 25-HYDROXYLASE, Journal of Biological Chemistry, vol.278, issue.39, pp.38084-38093, 2003.
DOI : 10.1074/jbc.M307028200

C. W. Chiang and H. C. Yeh, Crystal Structure of the Human Prostacyclin Synthase, Journal of Molecular Biology, vol.364, issue.3, pp.266-274, 2006.
DOI : 10.1016/j.jmb.2006.09.039

S. Christakos and D. V. Ajibade, Vitamin D: Metabolism, Endocrinology and Metabolism Clinics of North America, vol.39, issue.2, pp.243-253, 2010.
DOI : 10.1016/j.ecl.2010.02.002

S. S. Chuang and C. Helvig, CYP2U1, a Novel Human Thymus- and Brain-specific Cytochrome P450, Catalyzes ??- and (??-1)-Hydroxylation of Fatty Acids, Journal of Biological Chemistry, vol.279, issue.8, pp.6305-6314, 2004.
DOI : 10.1074/jbc.M311830200

A. Claude, THE CONSTITUTION OF PROTOPLASM, Science, vol.97, issue.2525, pp.451-456, 1943.
DOI : 10.1126/science.97.2525.451

B. Clement, M. H. Schultze-mosgau, and H. Wohlers, Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative, Biochemical Pharmacology, vol.46, issue.12, pp.2249-67, 1994.
DOI : 10.1016/0006-2952(93)90616-5

V. Cojocaru and K. Balali-mood, Structure and Dynamics of the Membrane-Bound Cytochrome P450 2C9, PLoS Computational Biology, vol.15, issue.3, p.1002152, 2011.
DOI : 10.1371/journal.pcbi.1002152.s016

V. Cojocaru and P. J. Winn, The ins and outs of cytochrome P450s, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.3, pp.390-401, 2007.
DOI : 10.1016/j.bbagen.2006.07.005

C. Cole and J. D. Barber, The Jpred 3 secondary structure prediction server, Nucleic Acids Research, vol.36, issue.Web Server, pp.197-201, 2008.
DOI : 10.1093/nar/gkn238

C. Colovos and T. O. Yeates, Verification of protein structures: Patterns of nonbonded atomic interactions, Protein Science, vol.245, issue.9, pp.1511-1519, 1993.
DOI : 10.1002/pro.5560020916

M. L. Connolly, Solvent-accessible surfaces of proteins and nucleic acids, Science, vol.221, issue.4612, pp.709-713, 1983.
DOI : 10.1126/science.6879170

A. Conti and M. H. Bickel, History of Drug Metabolism: Discoveries of the Major Pathways in the 19th Century, Drug Metabolism Reviews, vol.2, issue.1, pp.1-50, 1977.
DOI : 10.1002/cber.187701001101

M. Conti and J. P. Harwood, Effect of gonadotropin-induced receptor regulation on biological responses of isolated rat luteal cells, J Biol Chem, vol.252, issue.24, pp.8869-8874, 1977.

D. Y. Cooper and S. Levin, Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems, Science, vol.147, issue.3656, pp.400-402, 1965.
DOI : 10.1126/science.147.3656.400

J. Cosme and E. F. Johnson, Engineering Microsomal Cytochrome P450 2C5 to Be a Soluble, Monomeric Enzyme: MUTATIONS THAT ALTER AGGREGATION, PHOSPHOLIPID DEPENDENCE OF CATALYSIS, AND MEMBRANE BINDING, Journal of Biological Chemistry, vol.275, issue.4, pp.2545-2553, 2000.
DOI : 10.1074/jbc.275.4.2545

X. Cui and D. R. Nelson, A Novel Human Cytochrome P450 4F Isoform (CYP4F11): cDNA Cloning, Expression, and Genomic Structural Characterization, Genomics, vol.68, issue.2, pp.161-166, 2000.
DOI : 10.1006/geno.2000.6276

M. J. De-groot and N. P. Vermeulen, A Three-Dimensional Protein Model for Human Cytochrome P450 2D6 Based on the Crystal Structures of P450 101, P450 102, and P450 108, Chemical Research in Toxicology, vol.9, issue.7, pp.1079-1091, 1996.
DOI : 10.1021/tx960003i

D. Lemos-chiarandini, C. , and A. B. Frey, Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies, The Journal of Cell Biology, vol.104, issue.2, pp.209-219, 1987.
DOI : 10.1083/jcb.104.2.209

N. M. Devore and K. M. Meneely, Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine Febs, 2011.

N. M. Devore and E. E. Scott, Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001, Nature, vol.264, issue.7383, pp.116-119, 2012.
DOI : 10.1038/nature10743

N. M. Devore and B. D. Smith, Key Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A Enzymes, Drug Metabolism and Disposition, vol.36, issue.12, pp.2582-2590, 2008.
DOI : 10.1124/dmd.108.023770

A. Devos and C. L. Cardenas, Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.83, issue.2, pp.105-110, 2010.
DOI : 10.1016/j.plefa.2010.06.005

S. Ding and B. G. Lake, -450 CYP2A7, Biochemical Journal, vol.306, issue.1, pp.161-166, 1995.
DOI : 10.1042/bj3060161
URL : https://hal.archives-ouvertes.fr/cea-01058940

T. L. Domanski and C. Finta, cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450, Mol Pharmacol, vol.59, issue.2, pp.386-392, 2001.

F. Dutheil and P. Beaune, Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain, Biochimie, vol.90, issue.3, pp.426-436, 2008.
DOI : 10.1016/j.biochi.2007.10.007

F. Dutheil and S. Dauchy, Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function, Drug Metabolism and Disposition, vol.37, issue.7, pp.1528-1538, 2009.
DOI : 10.1124/dmd.109.027011

R. C. Edgar, MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic Acids Research, vol.32, issue.5, pp.1792-1797, 2004.
DOI : 10.1093/nar/gkh340
URL : http://doi.org/10.1093/nar/gkh340

B. Eiermann and P. O. Edlund, 1-and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans, Drug Metab Dispos, vol.26, issue.11, pp.1096-1101, 1998.

M. Ekroos and T. Sjogren, Structural basis for ligand promiscuity in cytochrome P450 3A4, Proceedings of the National Academy of Sciences, vol.103, issue.37, pp.13682-13687, 2006.
DOI : 10.1073/pnas.0603236103

S. W. Ellis and G. P. Hayhurst, Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6, Biochemical Journal, vol.345, issue.3, pp.565-571, 2000.
DOI : 10.1042/bj3450565

D. Eramian and M. Y. Shen, A composite score for predicting errors in protein structure models, Protein Science, vol.52, issue.7, pp.1653-1666, 2006.
DOI : 10.1110/ps.062095806

R. W. Estabrook and D. Y. Cooper, The Light Reversible Carbon Monoxide Inhibition of the Steroid C21-Hydroxylase System of the Adrenal Cortex, Biochem Z, vol.338, pp.741-755, 1963.

R. W. Estabrook and J. I. Mason, The heterologous expression of the cytochromes P450: A new approach for the study of enzyme activities and regulation, Advances in Enzyme Regulation, vol.31, pp.365-383, 1991.
DOI : 10.1016/0065-2571(91)90024-G

N. Eswar and . Webb, Comparative protein structure modeling using Modeller, Curr Protoc Bioinformatics Chapter, vol.5, issue.6, 2006.

G. Facciola and M. Hidestrand, Cytochrome P 450 isoforms involved in melatonin metabolism in human liver microsomes, European Journal of Clinical Pharmacology, vol.56, issue.12, pp.881-888, 2001.
DOI : 10.1007/s002280000245

X. Fang and Y. Kobayashi, Stoichiometry of 7-ethoxycoumarin metabolism by cytochrome P450 2B1 wild-type and five active-site mutants, FEBS Letters, vol.111, issue.1, pp.77-80, 1997.
DOI : 10.1016/S0014-5793(97)01173-3

M. Fer and Y. Dreano, Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450, Archives of Biochemistry and Biophysics, vol.471, issue.2, pp.116-125, 2008.
DOI : 10.1016/j.abb.2008.01.002

D. Fishelovitch and S. Shaik, Theoretical Characterization of Substrate Access/Exit Channels in the Human Cytochrome P450 3A4 Enzyme: Involvement of Phenylalanine Residues in the Gating Mechanism, The Journal of Physical Chemistry B, vol.113, issue.39, pp.13018-13025, 2009.
DOI : 10.1021/jp810386z

C. W. Fisher and D. L. Caudle, High-level expression of functional human cytochrome P450 1A2 in Escherichia coli, FASEB J, vol.6, issue.2, pp.759-764, 1992.

U. Fuhr and A. Jetter, Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the ???Cocktail??? Approach, Clinical Pharmacology & Therapeutics, vol.75, issue.2, pp.270-283, 2007.
DOI : 10.1038/sj.clpt.6100050

T. Fukami and M. Nakajima, CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele, The Pharmacogenomics Journal, vol.742, issue.6, pp.401-412, 2006.
DOI : 10.1016/j.bcp.2005.05.029

P. Gajendrarao and N. Krishnamoorthy, Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site, Journal of Molecular Graphics and Modelling, vol.28, issue.6, pp.524-532, 2010.
DOI : 10.1016/j.jmgm.2009.11.010

D. Garfinkel, Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions, Archives of Biochemistry and Biophysics, vol.77, issue.2, pp.493-509, 1958.
DOI : 10.1016/0003-9861(58)90095-X

S. C. Gay and M. B. Shah, Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-A Resolution, Molecular Pharmacology, vol.77, issue.4, pp.529-538, 2010.
DOI : 10.1124/mol.109.062570

D. Ghosh and J. Griswold, Structural basis for androgen specificity and oestrogen synthesis in human aromatase, Nature, vol.53, issue.7226, pp.219-223, 2009.
DOI : 10.1038/nature07614

D. A. Gideon and R. Kumari, What is the Functional Role of N-terminal Transmembrane Helices in the Metabolism Mediated by Liver Microsomal Cytochrome P450 and its Reductase?, Cell Biochemistry and Biophysics, vol.417, issue.5, 2012.
DOI : 10.1007/s12013-012-9339-0

A. Gomez and J. Nekvindova, Colorectal Cancer-Specific Cytochrome P450 2W1: Intracellular Localization, Glycosylation, and Catalytic Activity, Molecular Pharmacology, vol.78, issue.6, pp.1004-1011, 2010.
DOI : 10.1124/mol.110.067652

D. S. Goodsell and G. M. Morris, Automated docking of flexible ligands: Applications of autodock, Journal of Molecular Recognition, vol.106, issue.1, pp.1-5, 1996.
DOI : 10.1002/(SICI)1099-1352(199601)9:1<1::AID-JMR241>3.0.CO;2-6

O. Gotoh, Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences, J Biol Chem, vol.267, issue.1, pp.83-90, 1992.

S. E. Graham and J. A. Peterson, How Similar Are P450s and What Can Their Differences Teach Us?, Archives of Biochemistry and Biophysics, vol.369, issue.1, pp.24-29, 1999.
DOI : 10.1006/abbi.1999.1350

C. P. Granvil and K. W. Krausz, 4-Hydroxylation of Debrisoquine by Human CYP1A1 and Its Inhibition by Quinidine and Quinine, Journal of Pharmacology and Experimental Therapeutics, vol.301, issue.3, pp.1025-1032, 2002.
DOI : 10.1124/jpet.301.3.1025

J. T. Groves and G. A. Mcclusky, Aliphatic hydroxylation via oxygen rebound. Oxygen transfer catalyzed by iron, Journal of the American Chemical Society, vol.98, issue.3, pp.859-861, 1976.
DOI : 10.1021/ja00419a049

F. P. Guengerich, Human Cytochrome P450 Enzymes. Cytochrome P450 : Structure, Mechanism ans Biochemistry, pp.377-530, 2005.

F. P. Guengerich and M. V. Martin, Measurement of cytochrome P450 and NADPH???cytochrome P450 reductase, Nature Protocols, vol.205, issue.9, pp.1245-1251, 2009.
DOI : 10.1038/nprot.2009.121

F. P. Guengerich and Z. Tang, Approaches to deorphanization of human and microbial cytochrome P450 enzymes, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1814, issue.1, pp.139-145, 2011.
DOI : 10.1016/j.bbapap.2010.05.005

F. P. Guengerich and Z. L. Wu, Function of human cytochrome P450s: Characterization of the orphans, Biochemical and Biophysical Research Communications, vol.338, issue.1, pp.465-469, 2005.
DOI : 10.1016/j.bbrc.2005.08.079

F. Hannemann and A. Bichet, Cytochrome P450 systems???biological variations of electron transport chains, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.3, pp.330-344, 2007.
DOI : 10.1016/j.bbagen.2006.07.017

T. Hashizume and S. Imaoka, Involvement of CYP2J2 and CYP4F12 in the Metabolism of Ebastine in Human Intestinal Microsomes, Journal of Pharmacology and Experimental Therapeutics, vol.300, issue.1, pp.298-304, 2002.
DOI : 10.1124/jpet.300.1.298

M. Hayano and M. C. Lindberg, On the mechanism of the C-11??-hydroxylatlon of steroids; a study with H2O18 and O218, Archives of Biochemistry and Biophysics, vol.59, issue.2, pp.529-532, 1955.
DOI : 10.1016/0003-9861(55)90520-8

M. J. Headlam and M. C. Wilce, The F???G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1617, issue.1-2, pp.96-108, 2003.
DOI : 10.1016/j.bbamem.2003.09.007

M. Hiratsuka and H. Nozawa, Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.599, issue.1-2, pp.98-104, 2006.
DOI : 10.1016/j.mrfmmm.2006.02.008

T. Hiroi and T. Chow, Catalytic Specificity of CYP2D Isoforms in Rat and Human, Drug Metabolism and Disposition, vol.30, issue.9, pp.970-976, 2002.
DOI : 10.1124/dmd.30.9.970

W. His, Ueber das Stoffwechselproduct des Pyridins, Archiv f??r Experimentelle Pathologie und Pharmakologie, vol.22, issue.3-5, pp.253-260, 1887.
DOI : 10.1007/BF01991325

R. W. Hooft and G. Vriend, Errors in protein structures, Nature, vol.381, issue.6580, p.272, 1996.
DOI : 10.1038/381272a0

P. C. Howard and T. Aoyama, The metabolism of 1-nitropyrene by human cytochromes P450, Carcinogenesis, vol.11, issue.9, pp.1539-1542, 1990.
DOI : 10.1093/carcin/11.9.1539

W. L. Hubbell and C. Altenbach, Rhodopsin structure, dynamics, and activation: A perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking, Adv Protein Chem, vol.63, pp.243-290, 2003.
DOI : 10.1016/S0065-3233(03)63010-X

R. Huey and G. M. Morris, A semiempirical free energy force field with charge-based desolvation, Journal of Computational Chemistry, vol.65, issue.6, pp.1145-1152, 2007.
DOI : 10.1002/jcc.20634

T. Inaba and S. V. Otton, Deficient metabolism of debrisoquine and sparteine, Clinical Pharmacology and Therapeutics, vol.27, issue.4, pp.547-549, 1980.
DOI : 10.1038/clpt.1980.77

M. Ingelman-sundberg, The human genome project and novel aspects of cytochrome 450 research, Toxicology and Applied Pharmacology, vol.207, issue.2, pp.52-56, 2005.
DOI : 10.1016/j.taap.2005.01.030

M. Ingelman-sundberg and J. Blanck, Reduction of Cytochrome P-450 LM2 by NADPH in Reconstituted Phospholipid Vesicles is Dependent on Membrane Charge, European Journal of Biochemistry, vol.643, issue.1, pp.157-162, 1983.
DOI : 10.1063/1.432601

M. Ingelman-sundberg and T. Haaparanta, Membrane charge as effector of cytochrome P-450LM2 catalyzed reactions in reconstituted liposomes, Biochemistry, vol.20, issue.14, pp.4100-4106, 1981.
DOI : 10.1021/bi00517a024

W. Jiang and D. Ghosh, Motion and Flexibility in Human Cytochrome P450 Aromatase, PLoS ONE, vol.15, issue.2, p.32565, 2012.
DOI : 10.1371/journal.pone.0032565.s017

D. T. Jones, Protein secondary structure prediction based on position-specific scoring matrices, Journal of Molecular Biology, vol.292, issue.2, pp.195-202, 1999.
DOI : 10.1006/jmbi.1999.3091

M. Karlgren and M. Backlund, Characterization and tissue distribution of a novel human cytochrome P450???CYP2U1, Biochemical and Biophysical Research Communications, vol.315, issue.3, pp.679-685, 2004.
DOI : 10.1016/j.bbrc.2004.01.110

M. Karlgren and A. Gomez, Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1, Biochemical and Biophysical Research Communications, vol.341, issue.2, pp.451-458, 2006.
DOI : 10.1016/j.bbrc.2005.12.200

M. Karlgren and S. Miura, Novel extrahepatic cytochrome P450s, Toxicology and Applied Pharmacology, vol.207, issue.2, pp.57-61, 2005.
DOI : 10.1016/j.taap.2004.12.022

M. Katagiri and B. N. Ganguli, A Soluble Cytochrome P-450 Functional in Methylene Hydroxylation, J Biol Chem, vol.243, issue.12, p.3543, 1968.

W. Keller, M. Keller on the Conversion of Benzoic into Hippuric Acid, BMJ, vol.1, issue.13, pp.256-257, 1842.
DOI : 10.1136/bmj.s1-4.13.256
URL : https://hal.archives-ouvertes.fr/hal-00509230

C. R. Kinsolving and N. L. Munro, The Objective and Timing of Drug Disposition Studies, Appendix V. A Comparison of the Bioavailability of Three Dosage Forms of Terfenadine, Drug Metabolism Reviews, vol.15, issue.2, pp.285-290, 1975.
DOI : 10.3109/03602537508993762

G. J. Kleywegt and T. A. Jones, Detection, delineation, measurement and display of cavities in macromolecular structures, Acta Crystallographica Section D Biological Crystallography, vol.50, issue.2, pp.50-178, 1994.
DOI : 10.1107/S0907444993011333

M. Klingenberg, Pigments of rat liver microsomes, Archives of Biochemistry and Biophysics, vol.75, issue.2, pp.376-386, 1958.
DOI : 10.1016/0003-9861(58)90436-3

W. Koch and P. Hoppmann, Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population, European Heart Journal, vol.27, issue.21, pp.2524-2529, 2006.
DOI : 10.1093/eurheartj/ehl231

A. S. Konagurthu and J. C. Whisstock, MUSTANG: A multiple structural alignment algorithm, Proteins: Structure, Function, and Bioinformatics, vol.365, issue.3, pp.559-574, 2006.
DOI : 10.1002/prot.20921

P. Kremers and P. Beaune, Cytochrome P-450 Monooxygenase Activities in Human and Rat Liver Microsomes, European Journal of Biochemistry, vol.35, issue.3, pp.599-606, 1981.
DOI : 10.1016/0022-4731(76)90204-1

E. Y. Krynetski and V. L. Drutsa, High yield expression of functionally active human liver CYP2D6 in yeast cells, Pharmacogenetics, vol.5, issue.2, pp.103-109, 1995.
DOI : 10.1097/00008571-199504000-00007

S. Kumar, Comparative modeling and molecular docking of orphan human CYP4V2 protein with fatty acid substrates: Insights into substrate specificity, Bioinformation, vol.7, issue.7, pp.360-365, 2011.
DOI : 10.6026/97320630007360

M. Kumarakulasingham and P. H. Rooney, Cytochrome P450 Profile of Colorectal Cancer: Identification of Markers of Prognosis, Clinical Cancer Research, vol.11, issue.10, pp.3758-3765, 2005.
DOI : 10.1158/1078-0432.CCR-04-1848

P. Lafite, Etude du cytochrome P450 2J2 humain : Recherche de substrats et d'inhibiteurs sélectifs, p.283, 2007.

P. Lafite and S. Dijols, Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2, Bioorganic & Medicinal Chemistry Letters, vol.16, issue.10, pp.2777-2780, 2006.
DOI : 10.1016/j.bmcl.2006.02.004
URL : https://hal.archives-ouvertes.fr/hal-00110053

M. Lahde and H. Raunio, Expression of Human Placental Cytochrome P450 Aromatase (CYP19) cDNA in Insect Cells Using a Luciferase-Based Baculovirus Vector, Biochemical and Biophysical Research Communications, vol.197, issue.3, pp.1511-1517, 1993.
DOI : 10.1006/bbrc.1993.2648

B. G. Lake, Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment, Food and Chemical Toxicology, vol.37, issue.4, pp.423-453, 1999.
DOI : 10.1016/S0278-6915(99)00010-1

D. C. Lamb and L. Lei, The First Virally Encoded Cytochrome P450, Journal of Virology, vol.83, issue.16, pp.8266-8269, 2009.
DOI : 10.1128/JVI.00289-09

M. Lanz and R. Theurillat, Characterization of stereoselectivity and genetic polymorphism of the debrisoquine hydroxylation in manvia analysis of urinary debrisoquine and 4-hydroxydebrisoquine by capillary electrophoresis, Electrophoresis, vol.64, issue.10, pp.1875-1881, 1997.
DOI : 10.1002/elps.1150181025

R. A. Laskowski and M. W. Macarthur, PROCHECK: a program to check the stereochemical quality of protein structures, Journal of Applied Crystallography, vol.26, issue.2, pp.283-291, 1993.
DOI : 10.1107/S0021889892009944

B. Lee and F. M. Richards, The interpretation of protein structures: Estimation of static accessibility, Journal of Molecular Biology, vol.55, issue.3, pp.379-400, 1971.
DOI : 10.1016/0022-2836(71)90324-X

C. A. Lee and D. Neul, Identification of Novel Substrates for Human Cytochrome P450 2J2, Drug Metabolism and Disposition, vol.38, issue.2, pp.347-356, 2010.
DOI : 10.1124/dmd.109.030270

A. Li and X. Jiao, Bietti Crystalline Corneoretinal Dystrophy Is Caused by Mutations in the Novel Gene CYP4V2, The American Journal of Human Genetics, vol.74, issue.5, pp.817-826, 2004.
DOI : 10.1086/383228

W. Li and Y. Tang, Molecular modeling of human cytochrome P450 2W1 and its interactions with substrates, Journal of Molecular Graphics and Modelling, vol.28, issue.2, pp.170-176, 2009.
DOI : 10.1016/j.jmgm.2009.06.002

W. Li and Y. Tang, Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking, Proteins: Structure, Function, and Bioinformatics, vol.34, issue.2, pp.938-949, 2008.
DOI : 10.1002/prot.21778

X. C. Li and J. Baudry, Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450, Proceedings of the National Academy of Sciences, vol.101, issue.9, pp.2939-2944, 2004.
DOI : 10.1073/pnas.0308691101

Y. C. Li and C. W. Chiang, Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change, Journal of Biological Chemistry, vol.283, issue.5, pp.2917-2926, 2008.
DOI : 10.1074/jbc.M707470200

T. Lightfoot and S. W. Ellis, Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling, Xenobiotica, vol.26, issue.3, pp.219-233, 2000.
DOI : 10.3109/00498259409043216

J. Ling and K. A. Johnson, METABOLISM AND EXCRETION OF ERLOTINIB, A SMALL MOLECULE INHIBITOR OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE, IN HEALTHY MALE VOLUNTEERS, Drug Metabolism and Disposition, vol.34, issue.3, pp.420-426, 2006.
DOI : 10.1124/dmd.105.007765

L. Cardenas, C. L. , and N. Renault, Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population, Gene, vol.487, issue.1, pp.10-20, 2011.
DOI : 10.1016/j.gene.2011.07.015

M. Lobanov and N. S. Bogatyreva, Radius of gyration as an indicator of protein structure compactness, Molecular Biology, vol.42, issue.4, pp.701-706, 2008.
DOI : 10.1134/S0026893308040195

M. A. Lomize and I. D. Pogozheva, OPM database and PPM web server: resources for positioning of proteins in membranes, Nucleic Acids Research, vol.40, issue.D1, pp.370-376, 2012.
DOI : 10.1093/nar/gkr703

S. K. Ludemann and V. Lounnas, How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms, Journal of Molecular Biology, vol.303, issue.5, pp.797-811, 2000.
DOI : 10.1006/jmbi.2000.4154

H. Lundbeck, Summary of product characteristics. Ebixa (memantine hydrochloride), pp.1-13, 2002.

M. H. Luria and E. D. Freis, Treatment of Hypertension with Debrisoquin Sulfate (Declinax), Curr Ther Res Clin Exp, vol.7, pp.289-296, 1965.

D. S. Mackay and S. Halford, Focus on Molecules: Cytochrome P450 family 4, subfamily V, Exp Eye Res, issue.2CYP4V2, 2011.

S. L. Malcolm and T. R. Marten, Determination of debrisoquin and its 4-hydroxy metabolite in plasma by gas chromatography/mass spectrometry, Analytical Chemistry, vol.48, issue.6, pp.807-809, 1976.
DOI : 10.1021/ac60370a045

D. J. Mandell and E. A. Coutsias, Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling, Nature Methods, vol.6, issue.8, pp.551-552, 2009.
DOI : 10.1016/j.jmb.2007.07.050

D. Mansuy, The great diversity of reactions catalyzed by cytochromes P450, Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, vol.121, issue.1-3, pp.1-3, 1998.
DOI : 10.1016/S0742-8413(98)10026-9

D. Mansuy and P. Battioni, Diversity of reactions catalysed by heme-thiolate proteins. Biochemistry and binding : activation of small molecules, pp.1-15, 2000.

D. Mansuy and P. Battioni, Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases, European Journal of Biochemistry, vol.12, issue.2, pp.267-285, 1989.
DOI : 10.1016/0006-2952(76)90398-1

N. Mast and W. L. Liao, Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase, Archives of Biochemistry and Biophysics, vol.483, issue.1, pp.81-89, 2009.
DOI : 10.1016/j.abb.2009.01.002

N. Mast and M. A. White, Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain, Proceedings of the National Academy of Sciences, vol.105, issue.28, pp.9546-9551, 2008.
DOI : 10.1073/pnas.0803717105

L. J. Mcguffin and K. Bryson, The PSIPRED protein structure prediction server, Bioinformatics, vol.16, issue.4, pp.404-405, 2000.
DOI : 10.1093/bioinformatics/16.4.404

G. Mikus and A. A. Somogyi, -demethylation to oripavine: Genetic differences between two rat strains, Xenobiotica, vol.37, issue.11, pp.1501-1509, 1991.
DOI : 10.3109/00498259109044400
URL : https://hal.archives-ouvertes.fr/hal-01268181

G. M. Morris and R. Huey, AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility, Journal of Computational Chemistry, vol.22, issue.16, pp.2785-2791, 2009.
DOI : 10.1002/jcc.21256
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760638

O. Mortimer and K. Persson, Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: Relationship to the presence of immunoidentified cytochrome P-450IID1, Clinical Pharmacology and Therapeutics, vol.47, issue.1, pp.27-35, 1990.
DOI : 10.1038/clpt.1990.4

G. C. Mueller and J. A. Miller, The reductive cleavage of 4-dimethylaminoazobenzene by rat liver; the intracellular distribution of the enzyme system and its requirement for triphosphopyridine nucleotide, J Biol Chem, vol.180, issue.3, pp.1125-1136, 1949.

A. W. Munro and D. G. Leys, P450 BM3: the very model of a modern flavocytochrome, Trends in Biochemical Sciences, vol.27, issue.5, pp.250-257, 2002.
DOI : 10.1016/S0968-0004(02)02086-8

G. I. Murray and S. Patimalla, Profiling the expression of cytochrome P450 in breast cancer, Histopathology, vol.7, issue.Suppl. 5, pp.202-211, 2010.
DOI : 10.1111/j.1365-2559.2010.03606.x

M. Nakano and E. J. Kelly, Expression and Characterization of CYP4V2 as a Fatty Acid ??-Hydroxylase, Drug Metabolism and Disposition, vol.37, issue.11, pp.2119-2122, 2009.
DOI : 10.1124/dmd.109.028530

T. Nakayama and K. Arai, 16?? HYDROXYLATION OF DEHYDROEPIANDROSTERONE BY HUMAN FETAL TISSUES, Endocrinologia Japonica, vol.14, issue.3, pp.269-275, 1967.
DOI : 10.1507/endocrj1954.14.269

D. R. Nelson, Cytochrome P450 Nomenclature, Methods Mol Biol, vol.107, pp.15-24, 1998.
DOI : 10.1385/0-89603-519-0:15

D. R. Nelson and D. C. Zeldin, Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants, Pharmacogenetics, vol.14, issue.1, pp.1-18, 2004.
DOI : 10.1097/00008571-200401000-00001

T. A. Nguyen and M. Tychopoulos, Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo, Molecular Pharmacology, vol.73, issue.4, pp.1122-1133, 2008.
DOI : 10.1124/mol.107.042861
URL : https://hal.archives-ouvertes.fr/hal-00363368

T. Nilsson and I. V. Ivanov, LC???MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22, Archives of Biochemistry and Biophysics, vol.494, issue.1, pp.64-71, 2010.
DOI : 10.1016/j.abb.2009.11.013

K. Nishihara and M. Kanemori, Chaperone coexpression plasmids: differential and synergistic roles of DnaK-DnaJ-GrpE and GroEL-GroES in assisting folding of an allergen of Japanese cedar pollen, Cryj2, in Escherichia coli, Appl Environ Microbiol, vol.64, issue.5, pp.1694-1699, 1998.

S. L. Nyberg and H. J. Mann, Extrahepatic metabolism of 4-methylumbelliferone and lidocaine in the anhepatic rabbit, Drug Metab Dispos, vol.24, issue.6, pp.643-648, 1996.

S. Oakley and L. S. Vedula, Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis, PLoS ONE, vol.47, issue.Pt 2, p.32070, 2012.
DOI : 10.1371/journal.pone.0032070.s007

A. Oda and N. Yamaotsu, New AMBER force field parameters of heme iron for cytochrome P450s determined by quantum chemical calculations of simplified models, Journal of Computational Chemistry, vol.21, issue.8, pp.818-826, 2005.
DOI : 10.1002/jcc.20221

Y. Ohta and S. Kawato, Dynamic structures of adrenocortical cytochrome P-450 in proteoliposomes and microsomes: protein rotation study, Biochemistry, vol.31, issue.50, pp.12680-12687, 1992.
DOI : 10.1021/bi00165a019

O. V. Olesen and K. Linnet, Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes, Drug Metab Dispos, vol.25, issue.6, pp.740-744, 1997.

T. Omura and A. Ito, [7] Biosynthesis and intracellular sorting of mitochondrial forms of cytochrome P450, Methods Enzymol, vol.206, pp.75-81, 1991.
DOI : 10.1016/0076-6879(91)06078-H

T. Omura and R. Sato, A New Cytochrome in Liver Microsomes, J Biol Chem, vol.237, issue.4, p.1375, 1962.

T. Omura and R. Sato, A new cytochrome in liver microsomes, J Biol Chem, vol.237, pp.1375-1376, 1962.

P. R. Ortiz-de-montellano and . Ed, Cytochrome P450: structure, mechanism, and biochemistry, 2005.

M. Otyepka and J. Skopalik, What common structural features and variations of mammalian P450s are known to date?, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.3, pp.376-389, 2007.
DOI : 10.1016/j.bbagen.2006.09.013

M. J. Paine and L. A. Mclaughlin, Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6, Journal of Biological Chemistry, vol.278, issue.6, pp.4021-4027, 2003.
DOI : 10.1074/jbc.M209519200

G. E. Palade and P. Siekevitz, LIVER MICROSOMES: AN INTEGRATED MORPHOLOGICAL AND BIOCHEMICAL STUDY, The Journal of Cell Biology, vol.2, issue.2, pp.171-200, 1956.
DOI : 10.1083/jcb.2.2.171
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223971

Y. Pan and B. A. Abd-rashid, Heterologous Expression of Human Cytochromes P450 2D6 and CYP3A4 in Escherichia coli and Their Functional Characterization, The Protein Journal, vol.33, issue.8, pp.581-591, 2011.
DOI : 10.1007/s10930-011-9365-6

C. J. Patten and H. Ishizaki, Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells, Archives of Biochemistry and Biophysics, vol.299, issue.1, pp.163-171, 1992.
DOI : 10.1016/0003-9861(92)90258-X

S. K. Paulson and H. F. Deluca, Subcellular location and properties of rat renal 25- hydroxyvitamin D3-1 alpha-hydroxylase, J Biol Chem, vol.260, issue.21, pp.11488-11492, 1985.

R. Pearce and D. Greenway, Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation, Archives of Biochemistry and Biophysics, vol.298, issue.1, pp.211-225, 1992.
DOI : 10.1016/0003-9861(92)90115-D

M. Petrek and P. Kosinova, MOLE: A Voronoi Diagram-Based Explorer of Molecular Channels, Pores, and Tunnels, Structure, vol.15, issue.11, pp.1357-1363, 2007.
DOI : 10.1016/j.str.2007.10.007

M. Petrek and M. Otyepka, CAVER: a new tool to explore routes from protein clefts, pockets and cavities, BMC Bioinformatics, vol.7, issue.1, p.316, 2006.
DOI : 10.1186/1471-2105-7-316

M. A. Peyronneau and J. P. Renaud, Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5, European Journal of Biochemistry, vol.35, issue.1, pp.109-116, 1992.
DOI : 10.1016/0300-9084(90)90070-W

J. C. Phillips and R. Braun, Scalable molecular dynamics with NAMD, Journal of Computational Chemistry, vol.84, issue.16, pp.1781-1802, 2005.
DOI : 10.1002/jcc.20289

I. A. Pikuleva and N. Mast, Studies of Membrane Topology of Mitochondrial Cholesterol Hydroxylases CYPs 27A1 and 11A1, Lipids, vol.279, issue.12, pp.1127-1132, 2008.
DOI : 10.1007/s11745-008-3234-x

J. Pontius and J. Richelle, Deviations from Standard Atomic Volumes as a Quality Measure for Protein Crystal Structures, Journal of Molecular Biology, vol.264, issue.1, pp.121-136, 1996.
DOI : 10.1006/jmbi.1996.0628

P. R. Porubsky and K. P. Battaile, Human Cytochrome P450 2E1 Structures with Fatty Acid Analogs Reveal a Previously Unobserved Binding Mode, Journal of Biological Chemistry, vol.285, issue.29, pp.22282-22290, 2010.
DOI : 10.1074/jbc.M110.109017

P. R. Porubsky and K. M. Meneely, Structures of Human Cytochrome P-450 2E1: INSIGHTS INTO THE BINDING OF INHIBITORS AND BOTH SMALL MOLECULAR WEIGHT AND FATTY ACID SUBSTRATES, Journal of Biological Chemistry, vol.283, issue.48, pp.33698-33707, 2008.
DOI : 10.1074/jbc.M805999200

C. K. Poulos and E. F. Johnson, Structures of cytochromes P450 enzymes, Cytochrome P450 : Structure,Mechanism, and Biochemistry, 2005.

T. L. Poulos, Cytochrome P450 flexibility, Proceedings of the National Academy of Sciences, vol.100, issue.23, pp.13121-13122, 2003.
DOI : 10.1073/pnas.2336095100

T. L. Poulos and B. C. Finzel, The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450, J Biol Chem, vol.260, issue.30, pp.16122-16130, 1985.

T. L. Poulos and B. C. Finzel, High-resolution crystal structure of cytochrome P450cam, Journal of Molecular Biology, vol.195, issue.3, pp.687-700, 1987.
DOI : 10.1016/0022-2836(87)90190-2

E. Rat and I. Billaut-laden, Evidence for a functional genetic polymorphism of the human retinoic acid???metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida, Birth Defects Research Part A: Clinical and Molecular Teratology, vol.34, issue.6, pp.491-498, 2006.
DOI : 10.1002/bdra.20275

C. A. Reilly and G. S. Yost, Metabolism of Capsaicinoids by P450 Enzymes: A Review of Recent Findings on Reaction Mechanisms, Bio-Activation, and Detoxification Processes, Drug Metabolism Reviews, vol.17, issue.1, pp.685-706, 2006.
DOI : 10.1021/tx00011a001

B. J. Ring and J. S. Gillespie, Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism, Drug Metabolism and Disposition, vol.30, issue.3, pp.319-323, 2002.
DOI : 10.1124/dmd.30.3.319

J. Rittle and M. T. Green, Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics, Science, vol.330, issue.6006, pp.933-937, 2010.
DOI : 10.1126/science.1193478

S. P. Rivera and S. T. Saarikoski, Identification of a Novel Dioxin-Inducible Cytochrome P450, Molecular Pharmacology, vol.61, issue.2, pp.255-259, 2002.
DOI : 10.1124/mol.61.2.255

A. G. Roberts and M. J. Cheesman, Intramolecular Heme Ligation of the Cytochrome P450 2C9 R108H Mutant Demonstrates Pronounced Conformational Flexibility of the B???C Loop Region: Implications for Substrate Binding, Biochemistry, vol.49, issue.40, pp.8700-8708, 2010.
DOI : 10.1021/bi100911q

G. A. Roberts and G. Grogan, Identification of a New Class of Cytochrome P450 from a Rhodococcus sp., Journal of Bacteriology, vol.184, issue.14, pp.3898-3908, 2002.
DOI : 10.1128/JB.184.14.3898-3908.2002

O. Roche and R. Kiyama, Ligand???Protein DataBase:?? Linking Protein???Ligand Complex Structures to Binding Data, Journal of Medicinal Chemistry, vol.44, issue.22, pp.3592-3598, 2001.
DOI : 10.1021/jm000467k

L. Rodriguez-pazos and M. Ginarte, Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effects, British Journal of Dermatology, vol.64, issue.4, pp.906-911, 2011.
DOI : 10.1111/j.1365-2133.2011.10454.x

C. E. Roselli and M. Liu, Brain Aromatization: Classic Roles and New Perspectives, Seminars in Reproductive Medicine, vol.27, issue.03, pp.207-217, 2009.
DOI : 10.1055/s-0029-1216274
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902157

P. Rowland and F. E. Blaney, Crystal Structure of Human Cytochrome P450 2D6, Journal of Biological Chemistry, vol.281, issue.11, pp.7614-7622, 2006.
DOI : 10.1074/jbc.M511232200

A. Roy and A. Kucukural, I-TASSER: a unified platform for automated protein structure and function prediction, Nature Protocols, vol.59, issue.4, pp.725-738, 2010.
DOI : 10.1038/nprot.2010.5

T. Rylander and E. P. Neve, Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1), Biochemical and Biophysical Research Communications, vol.281, issue.2, pp.529-535, 2001.
DOI : 10.1006/bbrc.2001.4390

R. Sanchez-ponce and F. P. Guengerich, Untargeted Analysis of Mass Spectrometry Data for Elucidation of Metabolites and Function of Enzymes, Analytical Chemistry, vol.79, issue.9, pp.3355-3362, 2007.
DOI : 10.1021/ac0622781

S. Sansen and M. H. Hsu, Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants, Archives of Biochemistry and Biophysics, vol.464, issue.2, pp.197-206, 2007.
DOI : 10.1016/j.abb.2007.04.028

S. Sansen and J. K. Yano, Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2, Journal of Biological Chemistry, vol.282, issue.19, pp.14348-14355, 2007.
DOI : 10.1074/jbc.M611692200

M. S. Sansom and P. C. Biggin, Molecular Simulations and Biomembranes: From Biophysics to Function, 2010.
DOI : 10.1039/9781849732154

H. A. Sasame and M. M. Ames, Cytochrome P-450 and NADPH cytochrome C reductase in rat brain: Formation of catechols and reactive catechol metabolites, Biochemical and Biophysical Research Communications, vol.78, issue.3, pp.919-926, 1977.
DOI : 10.1016/0006-291X(77)90510-1

J. B. Schenkman and S. G. Sligar, Substrate interaction with cytochrome P-450, Pharmacology & Therapeutics, vol.12, issue.1, pp.43-71, 1981.
DOI : 10.1016/0163-7258(81)90075-9

O. M. Schmiedeberg and H. , On the metabolic product after feeding camphor, Hoppe-Seyler's Z. Physiol. Chem, vol.3, p.442, 1879.

G. A. Schoch and J. K. Yano, Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID, Journal of Biological Chemistry, vol.283, issue.25, pp.17227-17237, 2008.
DOI : 10.1074/jbc.M802180200

G. A. Schoch and J. K. Yano, Structure of Human Microsomal Cytochrome P450 2C8: EVIDENCE FOR A PERIPHERAL FATTY ACID BINDING SITE, Journal of Biological Chemistry, vol.279, issue.10, pp.9497-9503, 2004.
DOI : 10.1074/jbc.M312516200

I. F. Sevrioukova and T. L. Poulos, Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir, Proceedings of the National Academy of Sciences, vol.107, issue.43, pp.18422-18427, 2010.
DOI : 10.1073/pnas.1010693107

M. L. Shank-retzlaff and G. M. Raner, Membrane Topology of Cytochrome P450 2B4 in Langmuir???Blodgett Monolayers, Archives of Biochemistry and Biophysics, vol.359, issue.1, pp.82-88, 1998.
DOI : 10.1006/abbi.1998.0889

C. J. Sigrist and L. Cerutti, PROSITE, a protein domain database for functional characterization and annotation, Nucleic Acids Research, vol.38, issue.Database, pp.161-166, 2010.
DOI : 10.1093/nar/gkp885

B. D. Smith and J. L. Sanders, Structure of the Human Lung Cytochrome P450 2A13, Journal of Biological Chemistry, vol.282, issue.23, pp.17306-17313, 2007.
DOI : 10.1074/jbc.M702361200

G. Smith and C. R. Wolf, Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases, The Lancet, vol.361, issue.9366, pp.1336-1343, 2003.
DOI : 10.1016/S0140-6736(03)13081-4

R. Sobierajski and S. Bruijn, Damage mechanisms of MoN/SiN multilayer optics for next-generation pulsed XUV light sources, Optics Express, vol.19, issue.1, pp.193-205, 2011.
DOI : 10.1364/OE.19.000193

C. Sridar and N. T. Snider, Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6, Drug Metabolism and Disposition, vol.39, issue.5, pp.782-788, 2011.
DOI : 10.1124/dmd.110.036707

K. Stark and M. Dostalek, Expression and purification of orphan cytochrome P450???4X1 and oxidation of anandamide, FEBS Journal, vol.118, issue.14, pp.3706-3717, 2008.
DOI : 10.1111/j.1742-4658.2008.06518.x

K. Stark and Z. L. Wu, mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1, Drug Metabolism and Disposition, vol.36, issue.9, pp.1930-1937, 2008.
DOI : 10.1124/dmd.108.022020

J. O. Stern and J. Peisach, A model compound study of the CO-adduct of cytochrome P-450, J Biol Chem, vol.249, issue.23, pp.7495-7498, 1974.

D. M. Stresser and M. I. Broudy, HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE, Drug Metabolism and Disposition, vol.32, issue.1, pp.105-112, 2004.
DOI : 10.1124/dmd.32.1.105

N. Strushkevich and S. A. Usanov, Structural Basis of Human CYP51 Inhibition by Antifungal Azoles, Journal of Molecular Biology, vol.397, issue.4, pp.1067-1078, 2010.
DOI : 10.1016/j.jmb.2010.01.075

N. Strushkevich and S. A. Usanov, Structural Analysis of CYP2R1 in Complex with Vitamin D3, Journal of Molecular Biology, vol.380, issue.1, pp.95-106, 2008.
DOI : 10.1016/j.jmb.2008.03.065

M. Taimi and C. Helvig, A Novel Human Cytochrome P450, CYP26C1, Involved in Metabolism of 9-cis and All-trans Isomers of Retinoic Acid, Journal of Biological Chemistry, vol.279, issue.1, pp.77-85, 2004.
DOI : 10.1074/jbc.M308337200

N. Takaya and S. Suzuki, Cytochrome P450nor, a Novel Class of Mitochondrial Cytochrome P450 Involved in Nitrate Respiration in the Fungus Fusarium oxysporum, Archives of Biochemistry and Biophysics, vol.372, issue.2, pp.340-346, 1999.
DOI : 10.1006/abbi.1999.1499

Z. Tang and S. G. Salamanca-pinzon, Human cytochrome P450 4F11: Heterologous expression in bacteria, purification, and characterization of catalytic function, Archives of Biochemistry and Biophysics, vol.494, issue.1, pp.86-93, 2010.
DOI : 10.1016/j.abb.2009.11.017

B. J. Thomas and R. Rothstein, Elevated recombination rates in transcriptionally active DNA, Cell, vol.56, issue.4, pp.619-630, 1989.
DOI : 10.1016/0092-8674(89)90584-9

Y. Uno and K. Matsuno, Cloning, Expression, and Characterization of CYP3A43 in Cynomolgus Macaque (Macaca fascicularis), Drug Metabolism Letters, vol.3, issue.4, pp.228-233, 2009.
DOI : 10.2174/187231209790218127

P. Urban and G. Truan, -450s, Biochemical Society Transactions, vol.21, issue.4, pp.1028-1034, 1993.
DOI : 10.1042/bst0211028
URL : https://hal.archives-ouvertes.fr/in2p3-00459276

A. Ure, On Hippuric Acid and Its Tests, BMJ, vol.1, issue.42, pp.317-318, 1840.
DOI : 10.1136/bmj.s1-2.42.317

G. Van-meer and D. R. Voelker, Membrane lipids: where they are and how they behave, Nature Reviews Molecular Cell Biology, vol.18, issue.2, pp.112-124, 2008.
DOI : 10.1038/nrm2330

A. D. Vaz and D. F. Mcginnity, Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant, Proceedings of the National Academy of Sciences, vol.95, issue.7, pp.95-3555, 1998.
DOI : 10.1073/pnas.95.7.3555

M. Vincent-viry and S. Deshayes, Hydroxylation of Debrisoquine Using Perfused Liver Isolated from Sprague Dawley and DA Rats: Comparison With In-vivo Results, Journal of Pharmacy and Pharmacology, vol.7, issue.2, pp.695-700, 1988.
DOI : 10.1111/j.2042-7158.1988.tb06997.x

C. Von-wachenfeldt and T. H. Richardson, Microsomal P450 2C3 Is Expressed as a Soluble Dimer inEscherichia coliFollowing Modifications of Its N-terminus, Archives of Biochemistry and Biophysics, vol.339, issue.1, pp.107-114, 1997.
DOI : 10.1006/abbi.1996.9859

A. Wang and U. Savas, Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound, Journal of Biological Chemistry, vol.287, issue.14, 2012.
DOI : 10.1074/jbc.M111.307918

A. Wang and U. Savas, Structural Characterization of the Complex between ??-Naphthoflavone and Human Cytochrome P450 1B1, Journal of Biological Chemistry, vol.286, issue.7, pp.5736-5743, 2011.
DOI : 10.1074/jbc.M110.204420

C. Wang and P. Bradley, Protein???Protein Docking with Backbone Flexibility, Journal of Molecular Biology, vol.373, issue.2, pp.503-519, 2007.
DOI : 10.1016/j.jmb.2007.07.050

M. Wang and D. L. Roberts, Three-dimensional structure of NADPH-cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes, Proceedings of the National Academy of Sciences, vol.94, issue.16, pp.94-8411, 1997.
DOI : 10.1073/pnas.94.16.8411

M. Warner and C. Kohler, Regional Distribution of Cytochrome P-450 in the Rat Brain: Spectral Quantitation and Contribution of P-450b,e and P-450c,d, Journal of Neurochemistry, vol.45, issue.4, pp.1057-1065, 1988.
DOI : 10.1016/0006-8993(86)90754-7

K. S. Watts and P. Dalal, ConfGen: A Conformational Search Method for Efficient Generation of Bioactive Conformers, Journal of Chemical Information and Modeling, vol.50, issue.4, pp.534-546, 2010.
DOI : 10.1021/ci100015j

M. R. Wester and C. D. Stout, Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5, Methods Enzymol, vol.357, pp.73-79, 2002.
DOI : 10.1016/S0076-6879(02)57667-9

M. R. Wester and J. K. Yano, The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-A Resolution, Journal of Biological Chemistry, vol.279, issue.34, pp.35630-35637, 2004.
DOI : 10.1074/jbc.M405427200

P. R. Wilderman and M. B. Shah, Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography, Journal of Biological Chemistry, vol.285, issue.49, pp.38602-38611, 2010.
DOI : 10.1074/jbc.M110.180646

P. A. Williams and J. Cosme, Mammalian Microsomal Cytochrome P450 Monooxygenase, Molecular Cell, vol.5, issue.1, pp.121-131, 2000.
DOI : 10.1016/S1097-2765(00)80408-6

P. A. Williams and J. Cosme, Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features, Journal of Inorganic Biochemistry, vol.81, issue.3, pp.183-190, 2000.
DOI : 10.1016/S0162-0134(00)00102-1

P. A. Williams and J. Cosme, Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone, Science, vol.305, issue.5684, pp.683-686, 2004.
DOI : 10.1126/science.1099736

P. A. Williams and J. Cosme, Crystal structure of human cytochrome P450 2C9 with bound warfarin, Nature, vol.424, issue.6947, pp.464-468, 2003.
DOI : 10.1038/nature01862

R. T. Williams and . Ed, Detoxication Mechanisms : The Metabolism of Drugs and Allied Organic Compounds, 1947.

P. J. Winn and V. Cojocaru, The ins and outs of the cytochromes P450: understanding the mechanics of a key drug metabolising enzyme family, Febs J, vol.274, pp.261-261, 2007.

F. Wöhler, Tiedemann's, Z. Physiol, vol.1, p.142, 1824.

S. Wu and J. Skolnick, Ab initio modeling of small proteins by iterative TASSER simulations, BMC Biology, vol.5, issue.1, p.17, 2007.
DOI : 10.1186/1741-7007-5-17

Z. Wu and C. D. Sohl, Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1, Molecular Pharmacology, vol.69, issue.6, pp.2007-2014, 2006.
DOI : 10.1124/mol.106.023648

Z. L. Wu and C. J. Bartleson, Heterologous expression, purification, and properties of human cytochrome P450 27C1, Archives of Biochemistry and Biophysics, vol.445, issue.1, pp.138-146, 2006.
DOI : 10.1016/j.abb.2005.11.002

Z. L. Wu and J. Qiao, Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression, Biotechnology Letters, vol.7, issue.10, pp.1589-1593, 2009.
DOI : 10.1007/s10529-009-0059-5

C. Xia and D. Hamdane, Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding, Journal of Biological Chemistry, vol.286, issue.18, pp.16246-16260, 2011.
DOI : 10.1074/jbc.M111.230532

J. K. Yano and M. R. Wester, The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-A Resolution, Journal of Biological Chemistry, vol.279, issue.37, pp.38091-38094, 2004.
DOI : 10.1074/jbc.C400293200

H. Yoshioka and N. Kasai, Enzymatic properties of human CYP2W1 expressed in Escherichia coli, Biochemical and Biophysical Research Communications, vol.345, issue.1, pp.169-174, 2006.
DOI : 10.1016/j.bbrc.2006.04.080

A. Yu and R. L. Haining, Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?, Drug Metab Dispos, vol.29, issue.11, pp.1514-1520, 2001.

A. M. Yu and C. P. Granvil, The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine, Journal of Pharmacology and Experimental Therapeutics, vol.304, issue.2, pp.539-546, 2003.
DOI : 10.1124/jpet.102.043786

A. M. Yu and J. R. Idle, Screening for endogenous substrates reveals that CYP2D6 is a 5- methoxyindolethylamine O-demethylase, Pharmacogenetics, vol.13, issue.6, pp.307-319, 2003.
DOI : 10.1097/00008571-200306000-00002

X. Yuan and T. C. Ta, Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor, PLoS ONE, vol.4, issue.5, p.5609, 2009.
DOI : 10.1371/journal.pone.0005609.s008

C. H. Yun and R. A. Okerholm, Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation, Drug Metab Dispos, vol.21, issue.3, pp.403-409, 1993.

A. Zawaira and L. Y. Ching, An Expanded, Unified Substrate Recognition Site Map for Mammalian Cytochrome P450s: Analysis of Molecular Interactions Between 15 Mammalian CYP450 Isoforms and 868 Substrates, Current Drug Metabolism, vol.12, issue.7, pp.684-700, 2011.
DOI : 10.2174/138920011796504554

Q. Zhao and S. Modi, Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 ?? resolution, Protein Science, vol.116, issue.2, pp.298-306, 1999.
DOI : 10.1110/ps.8.2.298

Y. Zhao and M. A. White, Structure of Microsomal Cytochrome P450 2B4 Complexed with the Antifungal Drug Bifonazole: INSIGHT INTO P450 CONFORMATIONAL PLASTICITY AND MEMBRANE INTERACTION, Journal of Biological Chemistry, vol.281, issue.9, pp.5973-5981, 2006.
DOI : 10.1074/jbc.M511464200

Y. Zhen and O. Slanar, 3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio, Drug Metabolism and Disposition, vol.34, issue.9, pp.1563-1574, 2006.
DOI : 10.1124/dmd.105.008920