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Axe cerveau-intestin et contrôle de la prise alimentaire : exemple d'altérations chez un modèle animal de schizophrénie

Abstract : The brain-gut axis refers to the bidirectional interaction between the gut and the brain. Although leptin, a hormone released from fat tissue, is involved in the brain-gut axis control, its mechanism of action in the enteric nervous system has not been studied so far. Nowadays, brain-gut axis dysfunctions are supposed to be in close connection with schizophrenia. Therefore, the goals of this work were to determine 1) the effects of leptin on rat enteric nervous system neurotransmission and 2) peripheral alterations in the NVHL neurodevelopmental rat model of schizophrenia. We showed that leptin modulates inhibitory and excitatory enteric motor neurons activity in jejunum and proximal colon. Implication of intrinsic primary afferent neurons was discussed. In NVHL rats, we showed a decrease in body mass, some hormonal variations, jejunal inflammation and gastro-intestinal mechanical activities alterations. The relation peripheral alterations, like vagus nerve dysfunction, and the physiopathology of schizophrenia was discussed.
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Florian Voinot. Axe cerveau-intestin et contrôle de la prise alimentaire : exemple d'altérations chez un modèle animal de schizophrénie. Endocrinologie et métabolisme. Université de Strasbourg, 2012. Français. ⟨NNT : 2012STRAJ058⟩. ⟨tel-00790379⟩

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