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Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique

Abstract : Our thesis works concern the development of new methods of synthesis allowing a rapid and effective access to variously functionalized pyrazolo [1,5-a] pyrimidines derivatives.First, we were explored the study and the application of the condensation of the pyran-2 one with 5(3)-amino-3 (5)-arylpyrazoles whether it is by classic heating or under microwaves. Indeed, we have described the first example of the direct and regioselective palladium-catalyzed (hetero)arylation of 5,7-dimethylpyrazolo[1,5-a]pyrimidine, the reaction may be inducted to occur at either an sp2 or an sp3 carbon atom.The last part of this report was dedicated to the preparation of some 7-substituted pyrazolo[1,5-a]pyrimidines via a one-pot two steps palladium-catalyzed direct CH-arylation followed by a saponification-decarboxylation.
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Ibtissam Bassoude. Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique. Autre. Université d'Orléans, 2012. Français. ⟨NNT : 2012ORLE2025⟩. ⟨tel-00789954⟩

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