K. Asahina, T. P. Barry, K. Aida, and N. Fusetani, Biosynthesis of, 1990.

K. Asahina, J. G. Lambert, and H. J. Goos, Bioconversion of 17-Alpha-Hydroxyprogesterone into 17- Alpha,20-Alpha-Dihydroxy-4-Pregnen-3-One and 17-Alpha,20-Beta-Dihydroxy-4-Pregnen-3-One by Flounder (Platichthys-Flesus) Spermatozoa, Zoological Science, issue.6, pp.11-859, 1994.

J. F. Baroiller, Y. Guiguen, and A. Fostier, Endocrine and environmental aspects of sex differentiation in fish, Cellular and Molecular Life Sciences, vol.55, issue.7, pp.910-931, 1999.
DOI : 10.1007/s000180050344

D. Baron, A. Fostier, B. Breton, and Y. Guiguen, Androgen and estrogen treatments alter steady state messengers RNA (mRNA) levels of testicular steroidogenic enzymes in the rainbow trout, Oncorhynchus mykiss, Molecular Reproduction and Development, vol.100, issue.4, pp.471-480, 2005.
DOI : 10.1002/mrd.20229

M. Blazquez and F. Piferrer, Cloning, sequence analysis, tissue distribution, and sex-specific expression of the neural form of P450 aromatase in juvenile sea bass (Dicentrarchus labrax), Molecular and Cellular Endocrinology, vol.219, issue.1-2, pp.83-94, 2004.
DOI : 10.1016/j.mce.2004.01.006

J. Bouma and J. J. Nagler, Estrogen Receptor-?? Protein Localization in the Testis of the Rainbow Trout (Oncorhynchus mykiss) During Different Stages of the Reproductive Cycle1, Biology of Reproduction, vol.65, issue.1, pp.60-65, 2001.
DOI : 10.1095/biolreprod65.1.60

F. Brion, C. R. Tyler, X. Palazzi, B. Laillet, J. M. Porcher et al., Impacts of 17[beta]-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile-and adult-life stages in zebrafish, Aquatic Toxicology, pp.68-193, 2004.

F. Brion, N. Hinfray, O. Palluel, J. Maillard, I. Anglade et al., Effect of (xeno)-estrogens on zebrafish P450c17 (C17-lyase) mRNA and protein expression in gonadal tissue, Cybium, vol.1717, issue.2, pp.20-32, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00450197

S. Carreau, Germ cells: a new source of estrogens in the male gonad, Molecular and Cellular Endocrinology, vol.178, issue.1-2, pp.65-72, 2001.
DOI : 10.1016/S0303-7207(01)00411-7

S. Carreau, C. Delalande, D. Silandre, S. Bourguiba, and S. Lambard, Aromatase and estrogen receptors in male reproduction, Molecular and Cellular Endocrinology, vol.246, issue.1-2, pp.65-68, 2006.
DOI : 10.1016/j.mce.2005.11.021

S. Carreau, H. Bouraima-lelong, and C. Delalande, Estrogens ??? new players in spermatogenesis, Reproductive Biology, vol.11, issue.3, pp.174-93, 2011.
DOI : 10.1016/S1642-431X(12)60065-5

J. E. Cavaco, B. Van-blijswijk, J. F. Leatherland, H. J. Goos, and R. W. Schulz, Androgen-induced changes in Leydig cell ultrastructure and steroidogenesis in juvenile African catfish, Clarias gariepinus, Cell and Tissue Research, vol.297, issue.2, pp.291-300, 1999.
DOI : 10.1007/s004410051357

D. Valle, L. Ramina, A. Vianello, S. Belvedere, P. Colombo et al., Cloning of two mRNA variants of brain aromatase cytochrome P450 in rainbow trout (Oncorhynchus mykiss Walbaum), The Journal of Steroid Biochemistry and Molecular Biology, vol.82, issue.1, pp.19-32, 2002.
DOI : 10.1016/S0960-0760(02)00143-7

D. Waal, P. P. Leal, M. C. Garcia-lopez, A. Liarte, S. De-jonge et al., Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis, Journal of Endocrinology, vol.202, issue.2, pp.287-97, 2009.
DOI : 10.1677/JOE-09-0050
URL : https://hal.archives-ouvertes.fr/ineris-00963210

N. Diotel, Y. L. Page, K. Mouriec, S. Tong, E. Pellegrini et al., Aromatase in the brain of teleost fish: Expression, regulation and putative functions, Frontiers in Neuroendocrinology, vol.31, issue.2, pp.31-172, 2010.
DOI : 10.1016/j.yfrne.2010.01.003
URL : https://hal.archives-ouvertes.fr/hal-00472008

H. Feitsma, M. C. Leal, P. B. Moens, E. Cuppen, and R. W. Schulz, Mlh1 Deficiency in Zebrafish Results in Male Sterility and Aneuploid as Well as Triploid Progeny in Females, Genetics, vol.175, issue.4, pp.175-1561, 2007.
DOI : 10.1534/genetics.106.068171

A. L. Filby, K. L. Thorpe, and C. R. Tyler, Multiple molecular effect pathways of an environmental oestrogen in fish, Journal of Molecular Endocrinology, vol.37, issue.1, pp.121-155, 2006.
DOI : 10.1677/jme.1.01997

A. Garcia-lopez, H. De-jonge, R. H. Nobrega, P. P. De-waal, W. Van-dijk et al., Studies in Zebrafish Reveal Unusual Cellular Expression Patterns of Gonadotropin Receptor Messenger Ribonucleic Acids in the Testis and Unexpected Functional Differentiation of the Gonadotropins, Endocrinology, vol.151, issue.5, pp.151-2349, 2010.
DOI : 10.1210/en.2009-1227

M. Govoroun, O. M. Mcmeel, H. Mecherouki, T. J. Smith, and Y. Guiguen, 17beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis, Endocrinology, issue.5, pp.142-1841, 2001.

S. Halm, N. Pounds, S. Maddix, M. Rand-weaver, J. P. Sumpter et al., Exposure to exogenous 17[beta]-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows, Aquatic Toxicology, pp.3-4, 2002.

S. Halm, J. Y. Kwon, M. Rand-weaver, J. P. Sumpter, N. Pounds et al., Cloning and gene expression of P450 17-lyase cDNA in the gonads and brain of the fathead minnow Pimephales promelas, General and Comparative Endocrinology, vol.17, issue.1303, pp.20-256, 2003.

N. Hinfray, O. Palluel, C. Turies, C. Cousin, J. M. Porcher et al., Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish (Danio rerio), Environmental Toxicology, pp.332-339, 2006.
DOI : 10.1002/tox.20203
URL : https://hal.archives-ouvertes.fr/hal-00096021

N. Hinfray, D. Baudiffier, M. C. Leal, J. M. Porcher, S. Ait-aissa et al., Characterization of testicular expression of P450 17alpha-hydroxylase, zebrafish and its perturbation by the pharmaceutical fungicide clotrimazole, pp.309-326, 2011.
URL : https://hal.archives-ouvertes.fr/ineris-00961766

T. Kobayashi, M. Nakamura, H. Kajiura-kobayashi, G. Young, and Y. Nagahama, Immunolocalization of steroidogenic enzymes (P450scc, P450c17, P450arom, and 3??-HSD) in immature and mature testes of rainbow trout ( Oncorhynchus mykiss ), Cell and Tissue Research, vol.292, issue.3, pp.573-577, 1998.
DOI : 10.1007/s004410051086

Y. Kobayashi, T. Kobayashi, M. Nakamura, T. Sunobe, C. E. Morrey et al., Characterization of Two Types of Cytochrome P450 Aromatase in the Serial-sex Changing Gobiid Fish, Trimma okinawae, Zoological Science, vol.21, issue.4, pp.417-442, 2004.
DOI : 10.2108/zsj.21.417

M. Kotula-balak, R. Zielinska, J. Glogowski, R. K. Kowalski, B. Sarosiek et al., Aromatase expression in testes of XY, YY, and XX rainbow trout (Oncorhynchus mykiss), Comparative Biochemistry and Physiology -Part A: Molecular & Integrative Physiology, pp.188-196, 2008.

A. Menuet, E. Pellegrini, I. Anglade, O. Blaise, V. Laudet et al., Molecular Characterization of Three Estrogen Receptor Forms in Zebrafish: Binding Characteristics, Transactivation Properties, and Tissue Distributions1, Biology of Reproduction, vol.66, issue.6, pp.66-1881, 2002.
DOI : 10.1095/biolreprod66.6.1881

A. Menuet, E. Pellegrini, F. Brion, M. M. Gueguen, I. Anglade et al., Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene, The Journal of Comparative Neurology, vol.102, issue.4, pp.304-324, 2005.
DOI : 10.1002/cne.20497
URL : https://hal.archives-ouvertes.fr/hal-00294769

T. Miura, K. Yamauchi, H. Takahashi, and Y. Nagahama, Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica)., Proceedings of the National Academy of Sciences, vol.88, issue.13, pp.88-5774, 1991.
DOI : 10.1073/pnas.88.13.5774

A. D. Rolland, J. J. Lareyre, A. S. Goupil, J. Montfort, M. J. Ricordel et al., Expression profiling of rainbow trout testis development identifies evolutionary conserved genes involved in spermatogenesis, BMC Genomics, vol.10, issue.1, p.546, 2009.
DOI : 10.1186/1471-2164-10-546
URL : https://hal.archives-ouvertes.fr/inserm-00663561

N. Sakai, H. Ueda, N. Suzuki, and Y. Nagahama, INVOLVEMENT OF SPERM IN THE PRODUCTION OF 17??,20??-DIHYDROXY-4-PREGNEN-3-ONE IN THE TESTIS OF SPERMIATING RAINBOW TROUT, SALMO GAIRDNERI , Biomedical Research, vol.10, issue.2, pp.131-138, 1989.
DOI : 10.2220/biomedres.10.131

S. J. Sawyer, K. A. Gerstner, and G. V. Callard, Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: Gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation, General and Comparative Endocrinology, vol.147, issue.2, pp.108-117, 2006.
DOI : 10.1016/j.ygcen.2005.12.010

R. W. Schulz, M. Liemburg, Á. García-lópez, W. V. Dijk, and J. Bogerd, Androgens modulate testicular androgen production in African catfish (Clarias gariepinus) depending on the stage of maturity and type of androgen, General and Comparative Endocrinology, vol.156, issue.1, pp.154-163, 2008.
DOI : 10.1016/j.ygcen.2008.01.002

R. W. Schulz, L. R. De-frança, J. Lareyre, F. Legac, H. Chiarini-garcia et al., Spermatogenesis in fish, General and Comparative Endocrinology, vol.165, issue.3, pp.390-411, 2010.
DOI : 10.1016/j.ygcen.2009.02.013
URL : https://hal.archives-ouvertes.fr/hal-01205002

G. Sreenivasulu and B. Senthilkumaran, A role for cytochrome P450 17[alpha]-hydroxylase/c17-20 lyase during shift in steroidogenesis occurring in ovarian follicles prior to oocyte maturation, The Journal of Steroid Biochemistry and Molecular Biology, vol.115, pp.3-5, 2009.

J. Vinas and F. Piferrer, Stage-Specific Gene Expression During Fish Spermatogenesis as Determined by Laser-Capture Microdissection and Quantitative-PCR in Sea Bass (Dicentrarchus labrax) Gonads1, Biology of Reproduction, vol.79, issue.4, pp.738-785, 2008.
DOI : 10.1095/biolreprod.108.069708

M. Vosges, L. Page, Y. Chung, B. C. Combarnous, Y. Porcher et al., 17??-Ethinylestradiol disrupts the ontogeny of the forebrain GnRH system and the expression of brain aromatase during early development of zebrafish, Aquatic Toxicology, vol.99, issue.4, pp.479-91, 2010.
DOI : 10.1016/j.aquatox.2010.06.009
URL : https://hal.archives-ouvertes.fr/hal-00592402

X. G. Wang and L. Orban, Anti-M??llerian hormone and 11 ??-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males, Developmental Dynamics, vol.71, issue.5, pp.1329-1367, 2007.
DOI : 10.1002/dvdy.21129

C. Wu, R. Patino, K. B. Davis, and X. Chang, Localization of Estrogen Receptor ?? and ?? RNA in Germinal and Nongerminal Epithelia of the Channel Catfish Testis, General and Comparative Endocrinology, vol.124, issue.1, pp.12-20, 2001.
DOI : 10.1006/gcen.2001.7668

H. Yu, H. Cheng, Y. Guo, L. Xia, and R. Zhou, Alternative splicing and differential expression of P450c17 (CYP17) in gonads during sex transformation in the rice field eel, Biochemical and Biophysical Research Communications, vol.307, issue.1, pp.165-171, 2003.
DOI : 10.1016/S0006-291X(03)01137-9

W. Zhang, L. Zhou, B. Senthilkumaran, B. Huang, C. C. Sudhakumari et al., Molecular cloning of two isoforms of 11??-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus, General and Comparative Endocrinology, vol.165, issue.1, pp.34-41, 2010.
DOI : 10.1016/j.ygcen.2009.05.018

X. Zhang, M. Hecker, J. Park, A. R. Tompsett, J. Newsted et al., Real-time PCR array to study effects of chemicals on the Hypothalamic???Pituitary???Gonadal axis of the Japanese medaka, Aquatic Toxicology, vol.88, issue.3, pp.173-182, 2008.
DOI : 10.1016/j.aquatox.2008.04.009

E. Abraham, O. Palevitch, S. Ijiri, S. J. Du, Y. Gothilf et al., Early Development of Forebrain Gonadotrophin-Releasing Hormone (GnRH) Neurones and the Role of GnRH as an Autocrine Migration Factor, Journal of Neuroendocrinology, vol.244, issue.3, pp.394-405, 2008.
DOI : 10.1016/S0012-1606(03)00039-3

F. F. Almeida, C. Kristoffersen, G. L. Taranger, and R. W. Schulz, Spermatogenesis in Atlantic Cod (Gadus morhua): A Novel Model of Cystic Germ Cell Development1, Biology of Reproduction, vol.78, issue.1, pp.27-34, 2008.
DOI : 10.1095/biolreprod.107.063669

D. Alsop, J. Matsumoto, S. Brown, and G. Van-der-kraak, Retinoid requirements in the reproduction of zebrafish, General and Comparative Endocrinology, vol.156, issue.1, pp.51-62, 2008.
DOI : 10.1016/j.ygcen.2007.11.008

K. Altundag and N. K. Ibrahim, Aromatase Inhibitors in Breast Cancer: An Overview, The Oncologist, vol.11, issue.6, pp.553-562, 2006.
DOI : 10.1634/theoncologist.11-6-553

M. A. Amer, T. Miura, C. Miura, and K. Yamauchi, Involvement of Sex Steroid Hormones in the Early Stages of Spermatogenesis in Japanese Huchen (Hucho perryi???)1, Biology of Reproduction, vol.65, issue.4, pp.1057-1066, 2001.
DOI : 10.1095/biolreprod65.4.1057

H. R. Andersen, A. M. Vinggaard, T. H. Rasmussen, I. M. Gjermandsen, and E. C. Bonefeld-jorgensen, Effects of Currently Used Pesticides in Assays for Estrogenicity, Androgenicity, and Aromatase Activity in Vitro, Toxicology and Applied Pharmacology, vol.179, issue.1, pp.1-12, 2002.
DOI : 10.1006/taap.2001.9347

O. Andreu-sanchez, L. C. Paraiba, C. M. Jonsson, and J. M. Carrasco, Acute toxicity and bioconcentration of fungicide tebuconazole in zebrafish (Danio rerio), Environmental Toxicology, vol.229, issue.2, pp.109-116, 2010.
DOI : 10.1002/tox.20618

G. T. Ankley, D. C. Bencic, J. E. Cavallin, K. M. Jensen, M. D. Kahl et al., Dynamic Nature of Alterations in the Endocrine System of Fathead Minnows Exposed to the Fungicide Prochloraz, Toxicological Sciences, vol.112, issue.2, pp.344-353, 2009.
DOI : 10.1093/toxsci/kfp227

G. T. Ankley, J. E. Cavallin, E. J. Durhan, K. M. Jensen, M. D. Kalh et al., A time-course analysis of effects of the steroidogenesis inhibitor ketoconazole on components of the hypothalamic-pituitary-gonadal axis of fathead minnows, Aquatic Toxicology, vol.114, issue.115, pp.88-95, 2012.
DOI : 10.1016/j.aquatox.2012.02.012

G. T. Ankley, K. M. Jensen, M. D. Kahl, E. A. Makynen, L. S. Blake et al., KETOCONAZOLE IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS): REPRODUCTIVE TOXICITY AND BIOLOGICAL COMPENSATION, Environmental Toxicology and Chemistry, vol.26, issue.6, pp.1214-1223, 2007.
DOI : 10.1897/06-428R.1

G. T. Ankley, M. D. Kahl, K. M. Jensen, M. W. Hornung, J. J. Korte et al., Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas), Toxicological Sciences, vol.67, issue.1, pp.121-130, 2002.
DOI : 10.1093/toxsci/67.1.121

A. Arukwe, T. Nordtug, T. M. Kortner, A. S. Mortensen, and O. G. Brakstad, Modulation of steroidogenesis and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to water-soluble fraction of crude oil, Environmental Research, vol.107, issue.3, pp.362-370, 2008.
DOI : 10.1016/j.envres.2008.02.009

M. Ayub and M. J. Levell, Inhibition of testicular 17??-hydroxylase and 17,20-lyase but not 3??-hydroxysteroid dehydrogenase-isomerase or 17??-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs, Journal of Steroid Biochemistry, vol.28, issue.5, pp.521-531, 1987.
DOI : 10.1016/0022-4731(87)90511-5

D. Baron, J. Cocquet, X. H. Xia, M. Fellous, Y. Guiguen et al., An evolutionary and functional analysis of FoxL2 in rainbow trout gonad differentiation, Journal of Molecular Endocrinology, vol.33, issue.3, pp.705-715, 2004.
DOI : 10.1677/jme.1.01566

V. Bemanian, R. Male, and A. Goksøyr, The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR-and ERalpha-signalling pathways, Comp Hepatol, 2004.

M. Birkhoj, C. Nellemann, K. Jarfelt, H. Jacobsen, H. R. Andersen et al., The combined antiandrogenic effects of five commonly used pesticides, Toxicology and Applied Pharmacology, vol.201, issue.1, pp.10-20, 2004.
DOI : 10.1016/j.taap.2004.04.016

J. Bitman, H. C. Cecil, and G. F. Fries, Inhibition of Avian Shell Gland Carbonic Anhydrase by Ddt, Federation Proceedings, vol.29, issue.2, p.349, 1970.

B. Borg, Androgens in teleost fishes, Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, vol.109, issue.3, pp.219-245, 1994.
DOI : 10.1016/0742-8413(94)00063-G

F. Brion, N. Hinfray, O. Palluel, J. Maillard, I. Anglade et al., Effect of (xeno)-estrogens on zebrafish P450c17 (C17- lyase) mRNA and protein expression in gonadal tissue, Cybium, vol.1717, issue.322, pp.20-245, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00450197

F. Brion, B. M. Nilsen, J. K. Eidem, A. Goksoyr, and J. M. Porcher, ), Environmental Toxicology and Chemistry, vol.19, issue.8, pp.1699-1708, 2002.
DOI : 10.1002/etc.5620210823

R. H. Bromilow, A. A. Evans, and P. H. Nicholls, Factors affecting degradation rates of five triazole fungicides in two soil types: 1. Laboratory incubations, Pesticide Science, vol.55, issue.12, pp.1129-1134, 1999.

R. H. Bromilow, A. A. Evans, and P. H. Nicholls, Factors affecting degradation rates of five triazole fungicides in two soil types: 2. Field studies, Pesticide Science, vol.38, issue.124, pp.1135-1142, 1999.
DOI : 10.1002/(SICI)1096-9063(199912)55:12<1135::AID-PS73>3.0.CO;2-1

A. R. Brown, L. K. Bickley, L. Page, G. Hosken, D. J. Paull et al., Are Toxicological Responses in Laboratory (Inbred) Zebrafish Representative of Those in Outbred (Wild) Populations? ??? A Case Study with an Endocrine Disrupting Chemical, Environmental Science & Technology, vol.45, issue.9, pp.4166-4172, 2011.
DOI : 10.1021/es200122r

G. Bryan and P. Gibbs, Impact of low concentrations of tributyltin (previous termTBT) next term on marine organisms: A review, pp.323-361, 1991.

A. G. Byskov, C. Y. Andersen, L. Nordholm, H. Thogersen, G. L. Xia et al., Chemical structure of sterols that activate oocyte meiosis, Nature, vol.374, issue.6522, pp.559-562, 1995.
DOI : 10.1038/374559a0

B. Campbell, J. T. Dickey, and P. Swanson, Endocrine Changes During Onset of Puberty in Male Spring Chinook Salmon, Oncorhynchus tshawytscha1, Biology of Reproduction, vol.69, issue.6, pp.2109-2117, 2003.
DOI : 10.1095/biolreprod.103.020560

X. T. Chang, T. Kobayashi, B. Senthilkumaran, H. Kobayashi-kajura, C. C. Sudhakumari et al., Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus), General and Comparative Endocrinology, vol.141, issue.2, pp.101-115, 2005.
DOI : 10.1016/j.ygcen.2004.11.020

K. Cheshenko, F. Brion, L. Page, Y. Hinfray, N. Pakdel et al., Expression of Zebra Fish Aromatase cyp19a and cyp19b Genes in Response to the Ligands of Estrogen Receptor and Aryl Hydrocarbon Receptor, Toxicological Sciences, vol.96, issue.2, pp.255-267, 2007.
DOI : 10.1093/toxsci/kfm003
URL : https://hal.archives-ouvertes.fr/hal-00140538

K. Cheshenko, F. Pakdel, H. Segner, O. Kah, and R. I. Eggen, Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish, General and Comparative Endocrinology, vol.155, issue.1, pp.31-62, 2008.
DOI : 10.1016/j.ygcen.2007.03.005
URL : https://hal.archives-ouvertes.fr/hal-00195359

Y. Clermont, Kinetics of Spermatogenesis in Mammals -Seminiferous Epithelium Cycle and Spermatogonial Renewal, Physiological Reviews, vol.52, issue.1, p.198, 1972.

T. Colborn and C. Clement, Chemically-induced alterations in sexual and functional development--the wildlife/human connection, Colborn T CC, 1992.

T. Colborn, F. S. Saal, and A. M. Soto, Developmental effects of endocrine-disrupting chemicals in wildlife and humans, Environmental Health Perspectives, vol.101, issue.5, pp.378-384, 1993.
DOI : 10.1289/ehp.93101378

A. Cosnefroy, F. Brion, B. Guillet, N. Laville, J. M. Porcher et al., A stable fish reporter cell line to study estrogen receptor transactivation by environmental (xeno)estrogens, Toxicology in Vitro, vol.23, issue.8, pp.1450-1454, 2009.
DOI : 10.1016/j.tiv.2009.07.003
URL : https://hal.archives-ouvertes.fr/hal-00453656

P. P. De-waal, M. C. Leal, A. Garcia-lopez, S. Liarte, H. De-jonge et al., Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis, Journal of Endocrinology, vol.202, issue.2, pp.287-297, 2009.
DOI : 10.1677/JOE-09-0050
URL : https://hal.archives-ouvertes.fr/ineris-00963210

P. P. De-waal, D. S. Wang, W. A. Nijenhuis, R. W. Schulz, and J. Bogerd, Functional characterization and expression analysis of the androgen receptor in zebrafish (Danio rerio) testis, Reproduction, vol.136, issue.2, pp.225-234, 2008.
DOI : 10.1530/REP-08-0055

M. E. Delorenzo, B. Thompson, E. Cooper, J. Moore, and M. H. Fulton, A long-term monitoring study of chlorophyll, microbial contaminants, and pesticides in a coastal residential stormwater pond and its adjacent tidal creek, Environmental Monitoring and Assessment, vol.59, issue.1???2, pp.343-359, 2012.
DOI : 10.1007/s10661-011-1972-3

A. Di-masi, E. De-marinis, P. Ascenzi, and M. Marino, Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects, Molecular Aspects of Medicine, vol.30, issue.5, pp.297-343, 2009.
DOI : 10.1016/j.mam.2009.04.002

L. Dinapoli and B. Capel, SRY and the Standoff in Sex Determination, Molecular Endocrinology, vol.22, issue.1, pp.1-9, 2008.
DOI : 10.1210/me.2007-0250

N. Diotel, J. L. Do-rego, I. Anglade, C. Vaillant, E. Pellegrini et al., Activity and expression of steroidogenic enzymes in the brain of adult zebrafish, European Journal of Neuroscience, vol.170, issue.1, pp.45-56, 2011.
DOI : 10.1111/j.1460-9568.2011.07731.x
URL : https://hal.archives-ouvertes.fr/hal-00616835

N. Diotel, L. Page, Y. Mouriec, K. Tong, S. K. Pellegrini et al., Aromatase in the brain of teleost fish: Expression, regulation and putative functions, Frontiers in Neuroendocrinology, vol.31, issue.2, pp.172-192, 2010.
DOI : 10.1016/j.yfrne.2010.01.003
URL : https://hal.archives-ouvertes.fr/hal-00472008

R. C. Eaton and R. D. Farley, Spawning Cycle and Egg Production of Zebrafish, Brachydanio rerio, in the Laboratory, Copeia, vol.1974, issue.1, pp.195-204, 1974.
DOI : 10.2307/1443023

C. Eil, Ketoconazole Binds to the Human Androgen Receptor, Hormone and Metabolic Research, vol.24, issue.08, pp.367-370, 1992.
DOI : 10.1055/s-2007-1003337

S. Ekins, C. Chang, S. Mani, M. D. Krasowski, E. J. Reschly et al., Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites, Molecular Pharmacology, vol.72, issue.3, pp.592-603, 2007.
DOI : 10.1124/mol.107.038398

A. Espinelingroff, CLINICAL RELEVANCE OF ANTIFUNGAL RESISTANCE, Infectious Disease Clinics of North America, vol.11, issue.4, p.929, 1997.
DOI : 10.1016/S0891-5520(05)70398-6

M. C. Fishman, GENOMICS: Zebrafish--the Canonical Vertebrate, Science, vol.294, issue.5545, pp.1290-1291, 2001.
DOI : 10.1126/science.1066652

P. M. Forlano, D. L. Deitcher, D. A. Myers, and A. H. Bass, Anatomical distribution and cellular basis for high levels of aromatase activity in the brain of teleost fish: Aromatase enzyme and mRNA expression identify glia as source, Journal of Neuroscience, vol.21, issue.22, pp.8943-8955, 2001.

A. Garcia-lopez, J. Bogerd, J. C. Granneman, W. Van-dijk, J. M. Trant et al., Leydig Cells Express Follicle-Stimulating Hormone Receptors in African Catfish, Endocrinology, vol.150, issue.1, pp.357-365, 2009.
DOI : 10.1210/en.2008-0447

W. Ge, Gonadotropins and their paracrine signaling network in the zebrafish ovary, Fish Physiology and Biochemistry, vol.105, issue.2-3, pp.209-214, 2005.
DOI : 10.1007/s10695-006-0026-1

N. H. Georgopapadakou, Antifungals: mechanism of action and resistance, established and novel drugs, Current Opinion in Microbiology, vol.1, issue.5, pp.547-557, 1998.
DOI : 10.1016/S1369-5274(98)80087-8

A. Gonzalez and F. Piferrer, Characterization of aromatase activity in the sea bass: effects of temperature and different catalytic properties of brain and ovarian homogenates and microsomes, Journal of Experimental Zoology, vol.88, issue.5, pp.500-510, 2002.
DOI : 10.1002/jez.90005

S. V. Good-avila, S. Yegorov, S. Harron, J. Bogerd, P. Glen et al., Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis, BMC Evolutionary Biology, vol.9, issue.1, p.19, 2009.
DOI : 10.1186/1471-2148-9-293

Y. Gothilf, J. A. Munozcueto, C. A. Sagrillo, M. Selmanoff, T. T. Chen et al., Three Forms of Gonadotropin-Releasing Hormone in a Perciform Fish (Sparus Aurata): Complementary Deoxyribonucleic Acid Characterization and Brain Localization1, Biology of Reproduction, vol.55, issue.3, pp.636-645, 1996.
DOI : 10.1095/biolreprod55.3.636

M. Govoroun, J. Chyb, and B. Breton, Immunological Cross-Reactivity between Rainbow Trout GTH I and GTH II and Their ?? and ?? Subunits: Application to the Development of Specific Radioimmunoassays, General and Comparative Endocrinology, vol.111, issue.1, pp.28-37, 1998.
DOI : 10.1006/gcen.1998.7087

M. Govoroun, O. M. Mcmeel, H. Mecherouki, T. J. Smith, and Y. Guiguen, 17 betaestradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis, Endocrinology, vol.142, issue.5, pp.1841-1848, 2001.

L. E. Gray, V. S. Wilson, T. Stoker, C. Lambright, J. Furr et al., Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals1, International Journal of Andrology, vol.113, issue.1, pp.96-104, 2006.
DOI : 10.1016/j.toxlet.2003.09.012

K. Guan, K. Nayernia, L. S. Maier, S. Wagner, R. Dressel et al., Pluripotency of spermatogonial stem cells from adult mouse testis, Nature, vol.385, issue.7088, pp.1199-1203, 2006.
DOI : 10.1038/nature04697

Y. Gueguen, K. Mouzat, L. Ferrari, E. Tissandie, J. M. Lobaccaro et al., Cytochromes P450: xenobiotic metabolism, regulation and clinical importance, Annales De Biologie Clinique, vol.64, issue.6, pp.535-548, 2006.

M. Heneweer, M. Van-den-berg, and J. T. Sanderson, A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromatase, Toxicology Letters, vol.146, issue.2, pp.183-194, 2004.
DOI : 10.1016/j.toxlet.2003.10.002

M. D. Hernando, M. Mezcua, A. R. Fernandez-alba, and D. Barcelo, Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments, Talanta, vol.69, issue.2, pp.334-342, 2006.
DOI : 10.1016/j.talanta.2005.09.037

A. J. Hill, H. Teraoka, W. Heideman, and R. E. Peterson, Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity, Toxicological Sciences, vol.86, issue.1, pp.6-19, 2005.
DOI : 10.1093/toxsci/kfi110

M. J. Hilton and K. V. Thomas, Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography???electrospray tandem mass spectrometry, Journal of Chromatography A, vol.1015, issue.1-2, pp.129-141, 2003.
DOI : 10.1016/S0021-9673(03)01213-5

N. Hinfray, J. M. Porcher, and F. Brion, Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.144, issue.3, pp.252-262, 2006.
DOI : 10.1016/j.cbpc.2006.09.002
URL : https://hal.archives-ouvertes.fr/ineris-00961905

C. A. Hitchcock, to azole antifungal agents, Biochemical Society Transactions, vol.21, issue.4, pp.1039-1047, 1993.
DOI : 10.1042/bst0211039

A. K. Hotchkiss, C. V. Rider, C. R. Blystone, V. S. Wilson, P. C. Hartig et al., Fifteen Years after "Wingspread"--Environmental Endocrine Disrupters and Human and Wildlife Health: Where We are Today and Where We Need to Go, Toxicological Sciences, vol.105, issue.2, pp.235-259, 2008.
DOI : 10.1093/toxsci/kfn030

S. Houwing, L. M. Kamminga, E. Berezikov, D. Cronembold, A. Girard et al., A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish, Cell, vol.129, issue.1, pp.69-82, 2007.
DOI : 10.1016/j.cell.2007.03.026

J. Huggett, K. Dheda, S. Bustin, and A. Zumla, Real-time RT-PCR normalisation; strategies and considerations, Genes and Immunity, vol.50, issue.4, pp.279-284, 2005.
DOI : 10.1038/sj.gene.6364190

I. T. Huhtaniemi and A. P. Themmen, Mutations in Human Gonadotropin and Gonadotropin-Receptor Genes, Endocrine, vol.26, issue.3, pp.207-217, 2005.
DOI : 10.1385/ENDO:26:3:207

A. M. Husoy, M. S. Myers, M. L. Willis, T. K. Collier, M. Celander et al., Immunohistochemical Localization of CYP1A-Like and CYP3A-like Isozymes in Hepatic and Extrahepatic Tissues of Atlantic Cod (Gadus morhua L), a Marine Fish, Toxicology and Applied Pharmacology, vol.129, issue.2, pp.294-308, 1994.
DOI : 10.1006/taap.1994.1254

C. A. Ihunnah, M. X. Jiang, and W. Xie, Nuclear receptor PXR, transcriptional circuits and metabolic relevance, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1812, issue.8, pp.1812-956, 2011.
DOI : 10.1016/j.bbadis.2011.01.014
URL : https://hal.archives-ouvertes.fr/hal-00706537

S. Ijiri, H. Kaneko, T. Kobayashi, D. S. Wang, F. Sakai et al., Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus1, Biology of Reproduction, vol.78, issue.2, pp.333-341, 2008.
DOI : 10.1095/biolreprod.107.064246

T. Ikeuchi, T. Kobayashi, and Y. Nagahama, Androgen Receptor alpha and beta in the Nile tilapia (Oreochromis niloticus) Gonad. Perspective in Comparative Endocrinology: Unity and Diversity, pp.1249-1255, 2001.

S. R. Jeng, J. Pasquier, W. S. Yueh, G. R. Chen, Y. H. Lee et al., Differential regulation of the expression of cytochrome P450 aromatase, estrogen and androgen receptor subtypes in the brain???pituitary???ovarian axis of the Japanese eel (Anguilla japonica) reveals steroid dependent and independent mechanisms, General and Comparative Endocrinology, vol.175, issue.1, pp.163-172, 2012.
DOI : 10.1016/j.ygcen.2011.11.005

S. Jobling, N. Beresford, M. Nolan, T. Rodgers-gray, G. C. Brighty et al., Altered Sexual Maturation and Gamete Production in Wild Roach (Rutilus rutilus) Living in Rivers That Receive Treated Sewage Effluents1, Biology of Reproduction, vol.66, issue.2, pp.272-281, 2002.
DOI : 10.1095/biolreprod66.2.272

S. Jobling, M. Nolan, C. R. Tyler, G. Brighty, and J. P. Sumpter, Widespread Sexual Disruption in Wild Fish, Environmental Science & Technology, vol.32, issue.17, pp.2498-2506, 1998.
DOI : 10.1021/es9710870

M. Kahle, I. J. Buerge, A. Hauser, M. D. Muller, and T. Poiger, Azole Fungicides: Occurrence and Fate in Wastewater and Surface Waters, Environmental Science & Technology, vol.42, issue.19, pp.7193-7200, 2008.
DOI : 10.1021/es8009309

H. Kamei, T. Ohira, Y. Yoshiura, N. Uchida, H. Nagasawa et al., Expression of a biologically active recombinant follicle stimulating hormone of Japanese Eel Anguilla japonica using methylotropic yeast, Pichia pastoris, General and Comparative Endocrinology, vol.134, issue.3, pp.244-254, 2003.
DOI : 10.1016/S0016-6480(03)00259-4

R. J. Kavlock, G. P. Daston, C. Derosa, P. Fennercrisp, L. E. Gray et al., Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop, Environmental Health Perspectives, vol.104, issue.Suppl 4, pp.715-740, 1996.
DOI : 10.1289/ehp.96104s4715

Y. Kazeto, M. Kohara, T. Miura, C. Miura, S. Yamaguchi et al., Japanese Eel Follicle-Stimulating Hormone (Fsh) and Luteinizing Hormone (Lh): Production of Biologically Active Recombinant Fsh and Lh by Drosophila S2 Cells and Their Differential Actions on the Reproductive Biology1, Biology of Reproduction, vol.79, issue.5, pp.938-946, 2008.
DOI : 10.1095/biolreprod.108.070052

C. Klausen, T. Tsuchiya, J. P. Chang, and H. R. Habibi, PKC and ERK are differentially involved in gonadotropin-releasing hormone-induced growth hormone gene expression in the goldfish pituitary, AJP: Regulatory, Integrative and Comparative Physiology, vol.289, issue.6, pp.1625-1633, 2005.
DOI : 10.1152/ajpregu.00188.2005

H. W. Laale, The biology and use of zebrafish, Brachydanio rerio in fisheries research.. A literature review, Journal of Fish Biology, vol.59, issue.2, p.121, 1977.
DOI : 10.1111/j.1440-169X.1973.00169.x

C. Lacey, S. Basha, A. Morrissey, and J. M. Tobin, Occurrence of pharmaceutical compounds in wastewater process streams in Dublin, Ireland, Environmental Monitoring and Assessment, vol.166, issue.2, pp.1049-1062, 2012.
DOI : 10.1007/s10661-011-2020-z

R. Lavado, R. Thibaut, D. Raldua, R. Martin, and C. Porte, First evidence of endocrine disruption in feral carp from the Ebro River, Toxicology and Applied Pharmacology, vol.196, issue.2, pp.247-257, 2004.
DOI : 10.1016/j.taap.2003.12.012

L. Gac, F. Lareyre, J. J. Montfort, J. Esquerre, D. Houlgatte et al., Transcriptional analysis of spermatogenesis regulation by sex steroids in trout, Cybium, vol.32, issue.2, pp.119-121, 2008.

L. Gac, F. Loir, M. Lebail, P. Y. Ollitrault, and M. , Insulin-like growth factor (IGF-I) mRNA and IGF-I receptor in trout testis and in isolated spermatogenic and Sertoli cells, Molecular Reproduction and Development, vol.60, issue.1, pp.23-35, 1996.
DOI : 10.1002/(SICI)1098-2795(199605)44:1<23::AID-MRD3>3.0.CO;2-V

M. C. Leal, P. P. De-waal, A. Garcia-lopez, S. X. Chen, J. Bogerd et al., Zebrafish primary testis tissue culture: An approach to study testis function ex vivo, General and Comparative Endocrinology, vol.162, issue.2, pp.134-138, 2009.
DOI : 10.1016/j.ygcen.2009.03.003

J. Legler, L. M. Zeinstra, F. Schuitemaker, P. H. Lanser, J. Bogerd et al., Comparison of in Vivo and in Vitro Reporter Gene Assays for Short-Term Screening of Estrogenic Activity, Environmental Science & Technology, vol.36, issue.20, pp.4410-4415, 2002.
DOI : 10.1021/es010323a

Z. Lele and P. H. Krone, The zebrafish as a model system in developmental, toxicological and transgenic research, Biotechnology Advances, vol.14, issue.1, pp.57-72, 1996.
DOI : 10.1016/0734-9750(96)00004-3

G. Lemaire, G. De-sousa, and R. Rahmani, A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides, Biochemical Pharmacology, vol.68, issue.12, pp.2347-2358, 2004.
DOI : 10.1016/j.bcp.2004.07.041

C. Lethimonier, T. Madigou, J. A. Munoz-cueto, J. J. Lareyre, and O. Kah, Evolutionary aspects of GnRHs, GnRH neuronal systems and GnRH receptors in teleost fish, General and Comparative Endocrinology, vol.135, issue.1, pp.1-16, 2004.
DOI : 10.1016/j.ygcen.2003.10.007
URL : https://hal.archives-ouvertes.fr/hal-00295299

B. Levavi-sivan, J. Bogerd, E. L. Mananos, A. Gomez, and J. J. Lareyre, Perspectives on fish gonadotropins and their receptors, General and Comparative Endocrinology, vol.165, issue.3, pp.412-437, 2010.
DOI : 10.1016/j.ygcen.2009.07.019
URL : https://hal.archives-ouvertes.fr/hal-01204994

M. D. Li and J. J. Ford, A comprehensive evolutionary analysis based on nucleotide and amino acid sequences of the alpha- and beta-subunits of glycoprotein hormone gene family, Journal of Endocrinology, vol.156, issue.3, pp.529-542, 1998.
DOI : 10.1677/joe.0.1560529

Z. H. Li, K. J. Kroll, K. M. Jensen, D. L. Villeneuve, G. T. Ankley et al., A computational model of the hypothalamic-pituitary-gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17 alpha-ethynylestradiol and 17 betatrenbolone, Bmc Systems Biology, vol.5, p.22, 2011.

M. Loir, Spermatogonia of rainbow trout: II. in vitro study of the influence of pituitary hormones, growth factors and steroids on mitotic activity, Molecular Reproduction and Development, vol.118, issue.4, pp.434-442, 1999.
DOI : 10.1002/(SICI)1098-2795(199908)53:4<434::AID-MRD9>3.0.CO;2-L

M. Loir and F. Legac, Insulin-Like Growth Factor-I and -II Binding and Action on DNA Synthesis in Rainbow Trout Spermatogonia and Spermatocytes1, Biology of Reproduction, vol.51, issue.6, pp.1154-1163, 1994.
DOI : 10.1095/biolreprod51.6.1154

M. Pereira, M. L. Wheeler, J. R. Thorpe, K. L. Burkhardt-holm, and P. , Development of an ex vivo brown trout (Salmo trutta fario) gonad culture for assessing chemical effects on steroidogenesis, Aquatic toxicology, vol.101, pp.3-4, 2011.

J. I. Mason, B. A. Murry, M. Olcott, and J. J. Sheets, Imidazole antimycotics: Inhibitors of steroid aromatase, Biochemical Pharmacology, vol.34, issue.7, pp.1087-1092, 1985.
DOI : 10.1016/0006-2952(85)90613-6

S. L. Matta, D. A. Vilela, H. P. Godinho, and L. R. Franca, ) Model, Endocrinology, vol.143, issue.3, pp.970-978, 2002.
DOI : 10.1210/endo.143.3.8666

A. T. Mccurley and G. V. Callard, Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment, BMC Molecular Biology, vol.9, issue.1, p.12, 2008.
DOI : 10.1186/1471-2199-9-102

P. Melamed, N. Eliahu, M. Ofir, B. Levavisivan, J. Smal et al., The effects of gonadal development and sex steroids on growth hormone secretion in the male tilapia hybrid (Oreochromis niloticus ??? O. aureus), Fish Physiology and Biochemistry, vol.69, issue.(Suppl. 2, pp.267-277, 1995.
DOI : 10.1007/BF00004065

A. Menuet, E. Pellegrini, F. Brion, M. M. Gueguen, I. Anglade et al., Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene, The Journal of Comparative Neurology, vol.102, issue.4, pp.304-320, 2005.
DOI : 10.1002/cne.20497
URL : https://hal.archives-ouvertes.fr/hal-00294769

W. L. Miller, Molecular Biology of Steroid Hormone Synthesis*, Endocrine Reviews, vol.9, issue.3, pp.295-318, 1988.
DOI : 10.1210/edrv-9-3-295

C. L. Miranda, M. C. Henderson, and D. R. Buhler, Evaluation of Chemicals as Inhibitors of Trout Cytochrome P450s, 35th Annual Meeting of the Society-of-Toxicology, 1998.
DOI : 10.1006/taap.1997.8341

C. Miura, T. Higashino, and T. Miura, A Progestin and an Estrogen Regulate Early Stages of Oogenesis in Fish1, Biology of Reproduction, vol.77, issue.5, pp.822-828, 2007.
DOI : 10.1095/biolreprod.107.061408

T. Miura and C. Miura, Japanese Eel: A Model for Analysis of Spermatogenesis, Zoological Science, vol.18, issue.8, pp.1055-1063, 2001.
DOI : 10.2108/zsj.18.1055

T. Miura, C. Miura, T. Ohta, M. R. Nader, T. Todo et al., Estradiol-17?? Stimulates the Renewal of Spermatogonial Stem Cells in Males, Biochemical and Biophysical Research Communications, vol.264, issue.1, pp.230-234, 1999.
DOI : 10.1006/bbrc.1999.1494

T. Miura, C. Miura, K. Yamauchi, and Y. Nagahama, Human Recombinant Activin Induces Proliferation of Spermatogonia in-Vitro in the Japanese Eel Anguilla-Japonica, Fisheries Science, vol.61, issue.3, pp.434-437, 1995.

T. Miura, T. Ohta, C. I. Miura, and K. Yamauchi, Complementary Deoxyribonucleic Acid Cloning of Spermatogonial Stem Cell Renewal Factor, Endocrinology, vol.144, issue.12, pp.5504-5510, 2003.
DOI : 10.1210/en.2003-0800

G. Moles, A. Gomez, M. Carrillo, and S. Zanuy, Development of a homologous enzyme-linked immunosorbent assay for European sea bass FSH. Reproductive cycle plasma levels in both sexes and in yearling precocious and non-precocious males, General and Comparative Endocrinology, vol.176, issue.1, pp.70-78, 2005.
DOI : 10.1016/j.ygcen.2011.12.029

G. Monod, A. Demones, and A. Fostier, Inhibition of ovarian microsomal aromatase and follicular oestradiol secretion by imidazole fungicides in Rainbow trout, Marine Environmental Research, vol.35, issue.1-2, pp.153-157, 1993.
DOI : 10.1016/0141-1136(93)90030-4

A. S. Mortensen, C. C. Tolfsen, and A. Arukwe, ) Primary Hepatocyte Culture, Journal of Toxicology and Environmental Health, Part A, vol.54, issue.1-2, pp.1-19, 2006.
DOI : 10.1016/S0048-9697(99)00226-0

M. Nakamoto, A. Suzuki, M. Matsuda, Y. Nagahama, and N. Shibata, Testicular type Sox9 is not involved in sex determination but might be in the development of testicular structures in the medaka, Oryzias latipes, Biochemical and Biophysical Research Communications, vol.333, issue.3, pp.729-736, 2005.
DOI : 10.1016/j.bbrc.2005.05.158

J. P. Nash, D. E. Kime, L. T. Van-der-ven, P. W. Wester, F. Brion et al., Long-Term Exposure to Environmental Concentrations of the Pharmaceutical Ethynylestradiol Causes Reproductive Failure in Fish, Environmental Health Perspectives, vol.112, issue.17, pp.1725-1733, 2004.
DOI : 10.1289/ehp.7209
URL : https://hal.archives-ouvertes.fr/ineris-00961892

E. Noaksson, M. Linderoth, A. T. Bosveld, and L. Balk, Altered steroid metabolism in several teleost species exposed to endocrine disrupting substances in refuse dump leachate, General and Comparative Endocrinology, vol.134, issue.3, pp.273-284, 2003.
DOI : 10.1016/S0016-6480(03)00267-3

R. H. Nobrega, S. R. Batlouni, and L. R. Franca, An overview of functional and stereological evaluation of spermatogenesis and germ cell transplantation in fish, Fish Physiology and Biochemistry, vol.44, issue.1, pp.197-206, 2009.
DOI : 10.1007/s10695-008-9252-z

A. Ohisson, N. Cedergreen, A. Oskarsson, and E. Ulleras, Mixture effects of imidazole fungicides on cortisol and aldosterone secretion in human adrenocortical H295R cells, Toxicology, vol.275, pp.1-3, 2010.

T. Ohta, H. Miyake, C. Miura, H. Kamei, K. Aida et al., Follicle-Stimulating Hormone Induces Spermatogenesis Mediated by Androgen Production in Japanese Eel, Anguilla japonica1, Biology of Reproduction, vol.77, issue.6, pp.970-977, 2007.
DOI : 10.1095/biolreprod.107.062299

F. Ohtake, A. Baba, I. Takada, M. Okada, K. Iwasaki et al., Dioxin receptor is a ligand-dependent E3 ubiquitin ligase, Nature, vol.435, issue.7135, pp.562-566, 2007.
DOI : 10.1038/nature05683

F. Ohtake, Y. Fujii-kuriyama, K. Kawajiri, and S. Kato, Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system, The Journal of Steroid Biochemistry and Molecular Biology, vol.127, issue.1-2, pp.102-107, 2011.
DOI : 10.1016/j.jsbmb.2011.03.007

F. Ohtake, K. Takeyama, T. Matsumoto, H. Kitagawa, Y. Yamamoto et al., Modulation of oestrogen receptor signalling by association with the activated dioxin receptor, Nature, vol.423, issue.6939, pp.545-550, 2003.
DOI : 10.1038/nature01606

O. Palevitch, E. Abraham, N. Borodovsky, G. Levkowitz, Y. Zohar et al., Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish, Developmental Dynamics, vol.95, issue.1, pp.66-75, 2009.
DOI : 10.1002/dvdy.21823

M. Pasmanik and G. V. Callard, Aromatase and 5??-reductase in the teleost brain, spinal cord, and pituitary gland, General and Comparative Endocrinology, vol.60, issue.2, pp.244-251, 1985.
DOI : 10.1016/0016-6480(85)90320-X

E. Pellegrini, K. Mouriec, I. Anglade, A. Menuet, L. Page et al., Identification of aromatase-positive radial glial cells as progenitor cells in the ventricular layer of the forebrain in zebrafish, The Journal of Comparative Neurology, vol.1334, issue.1, pp.150-167, 2007.
DOI : 10.1002/cne.21222
URL : https://hal.archives-ouvertes.fr/hal-00096389

M. Peschka, P. H. Roberts, and T. P. Knepper, Analysis, fate studies and monitoring of the antifungal agent clotrimazole in the aquatic environment, Analytical and Bioanalytical Chemistry, vol.38, issue.10, pp.959-968, 2007.
DOI : 10.1007/s00216-007-1480-z

P. I. Pinto, H. R. Teodosio, M. Galay-burgos, D. M. Power, G. E. Sweeney et al., Identification of estrogen-responsive genes in the testis of sea bream (Sparus auratus) using suppression subtractive hybridization, Molecular Reproduction and Development, vol.18, issue.3, pp.318-329, 2006.
DOI : 10.1002/mrd.20402

J. V. Planas, P. Swanson, and W. W. Dickhoff, Regulation of Testicular Steroid Production in Vitro by Gonadotropins (GTH I and GTH II) and Cyclic AMP in Coho Salmon (Oncorhynchus kisutch), General and Comparative Endocrinology, vol.91, issue.1, pp.8-24, 1993.
DOI : 10.1006/gcen.1993.1099

T. Porsbring, H. Blanck, H. Tjellstrom, and T. Backhaus, Toxicity of the pharmaceutical clotrimazole to marine microalgal communities, Aquatic Toxicology, vol.91, issue.3, pp.203-211, 2009.
DOI : 10.1016/j.aquatox.2008.11.003

B. Querat, Y. Arai, A. Henry, Y. Akama, T. J. Longhurst et al., Pituitary Glycoprotein Hormone ?? Subunits in the Australian Lungfish and Estimation of the Relative Evolution Rate of These Subunits Within Vertebrates1, Biology of Reproduction, vol.70, issue.2, pp.356-363, 2004.
DOI : 10.1095/biolreprod.103.022004

C. Remacle, P. Delaere, and P. Jacquet, Effects of Sex-Hormones and Gonadotropin on Ovary of Carassius-Auratus L in Organ-Culture, General and Comparative Endocrinology, vol.29, issue.2, pp.254-254, 1976.

P. H. Roberts and K. V. Thomas, The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment, Science of The Total Environment, vol.356, issue.1-3, pp.1-3, 2005.
DOI : 10.1016/j.scitotenv.2005.04.031

A. Rodriguez-mari, Y. L. Yan, R. A. Bremiller, C. Wilson, C. Canestro et al., Characterization and expression pattern of zebrafish anti-M??llerian hormone (amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development, Gene Expression Patterns, vol.5, issue.5, pp.655-667, 2005.
DOI : 10.1016/j.modgep.2005.02.008

S. Safe, F. Wang, W. Porter, R. Duan, and A. Mcdougal, Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms, Toxicology letters, vol.102103, pp.343-350, 1998.

J. T. Sanderson, J. Boerma, G. W. Lansbergen, and M. Van-den-berg, Induction and Inhibition of Aromatase (CYP19) Activity by Various Classes of Pesticides in H295R Human Adrenocortical Carcinoma Cells, Toxicology and Applied Pharmacology, vol.182, issue.1, pp.44-54, 2002.
DOI : 10.1006/taap.2002.9420

R. W. Schulz, L. R. De-franca, J. J. Lareyre, F. Legac, H. Chiarini-garcia et al., Spermatogenesis in fish, General and Comparative Endocrinology, vol.165, issue.3, pp.390-411, 2010.
DOI : 10.1016/j.ygcen.2009.02.013
URL : https://hal.archives-ouvertes.fr/hal-01205002

H. Segner, Zebrafish (Danio rerio) as a model organism for investigating endocrine disruption, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.149, issue.2, pp.187-195, 2009.
DOI : 10.1016/j.cbpc.2008.10.099

H. Segner, J. M. Navas, C. Schafers, and A. Wenzel, Potencies of estrogenic compounds in in vitro screening assays and in life cycle tests with zebrafish in vivo, Ecotoxicology and Environmental Safety, vol.54, issue.3, pp.315-322, 2003.
DOI : 10.1016/S0147-6513(02)00040-4

H. Singh, R. W. Griffith, A. Takahashi, H. Kawauchi, P. Thomas et al., Regulation of gonadal steroidogenesis in Fundulus heteroclitus by recombinant salmon growth hormone and purified salmon prolactin, General and Comparative Endocrinology, vol.72, issue.1, pp.144-153, 1988.
DOI : 10.1016/0016-6480(88)90190-6

N. S. Sipes, S. Padilla, and T. B. Knudsen, Zebrafish-As an integrative model for twenty-first century toxicity testing, Birth Defects Research Part C: Embryo Today: Reviews, vol.281, issue.pt 1, pp.256-267, 2011.
DOI : 10.1002/bdrc.20214

M. Y. Song and H. O. Gutzeit, Effect of 17-alpha-ethynylestradiol on germ cell proliferation in organ and primary culture of medaka (Oryzias latipes) testis, Development, Growth and Differentiation, vol.33, issue.4, pp.327-337, 2003.
DOI : 10.1006/excr.2000.4998

N. Stamatis, D. Hela, and I. Konstantinou, Occurrence and removal of fungicides in municipal sewage treatment plant, Journal of Hazardous Materials, vol.175, issue.1-3, pp.1-3, 2010.
DOI : 10.1016/j.jhazmat.2009.10.084

H. J. Stan and T. Heberer, Pharmaceuticals in the aquatic environment, Analusis, vol.25, issue.7, pp.20-23, 1997.

D. M. Stocco, StAR Protein and the Regulation of Steroid Hormone Biosynthesis, Annual Review of Physiology, vol.63, issue.1, pp.193-213, 2001.
DOI : 10.1146/annurev.physiol.63.1.193

D. M. Stocco and B. J. Clark, Role of the steroidogenic acute regulatory protein (StAR) in steroidogenesis, Biochemical Pharmacology, vol.51, issue.3, pp.197-205, 1996.
DOI : 10.1016/0006-2952(95)02093-4

M. Stromstedt, M. R. Waterman, T. B. Haugen, K. Tasken, M. Parvinen et al., Elevated expression of lanosterol 14 alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats, Endocrinology, vol.139, issue.5, pp.2314-2321, 1998.

J. P. Sumpter, Xenoendocrine disrupters -environmental impacts, Toxicology Letters, vol.103, pp.337-342, 1998.

J. P. Sumpter and S. Jobling, Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment, Environmental Health Perspectives, vol.103, issue.Suppl 7, pp.173-178, 1995.
DOI : 10.1289/ehp.95103s7173

K. Suzuki, A. Kanamori, Y. Nagahama, and H. Kawauchi, Development of salmon GTH I and GTH II radioimmunoassays, General and Comparative Endocrinology, vol.71, issue.3, pp.459-467, 1988.
DOI : 10.1016/0016-6480(88)90275-4

P. Swanson, K. Suzuki, H. Kawauchi, and W. W. Dickhoff, Isolation and Characterization of Two Coho Salmon Gonadotropins, GTH I and GTH II1, Biology of Reproduction, vol.44, issue.1, pp.29-38, 1991.
DOI : 10.1095/biolreprod44.1.29

A. Tchoudakova and G. V. Callard, Identification of Multiple CYP19 Genes Encoding Different Cytochrome P450 Aromatase Isozymes in Brain and Ovary, Endocrinology, vol.139, issue.4, pp.2179-2189, 1998.
DOI : 10.1210/en.139.4.2179

K. V. Thomas and M. J. Hilton, The occurrence of selected human pharmaceutical compounds in UK estuaries, Marine Pollution Bulletin, vol.49, issue.5-6, pp.5-6, 2004.
DOI : 10.1016/j.marpolbul.2004.02.028

Y. E. Timsit and M. Negishi, CAR and PXR: The xenobiotic-sensing receptors???, Steroids, vol.72, issue.3, pp.231-246, 2007.
DOI : 10.1016/j.steroids.2006.12.006

E. R. Trosken, K. Scholz, R. W. Lutz, W. Volkel, J. A. Zarn et al., Comparative assessment of the inhibition of human recombinant CYP19 (aromatase) by azoles used as fungicides in agriculture and as antimycotic agents and antitumor drugs in humans, Pharmacology, vol.369, pp.115-115, 2004.

E. R. Trosken, E. Straube, W. K. Lutz, W. Volkel, and C. Patten, Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS, Journal of the American Society for Mass Spectrometry, vol.71, issue.115, pp.1216-1221, 2004.
DOI : 10.1016/j.jasms.2004.04.036

V. L. Trudeau, Neuroendocrine regulation of gonadotrophin II release and gonadal growth in the goldfish, Carassius auratus, Reviews of Reproduction, vol.2, issue.1, pp.55-68, 1997.
DOI : 10.1530/ror.0.0020055

H. P. Tseng, T. H. Hseu, D. R. Buhler, W. D. Wang, and C. H. Hu, Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva, Toxicology and Applied Pharmacology, vol.205, issue.3, pp.247-258, 2005.
DOI : 10.1016/j.taap.2004.10.019

J. L. Turgeon, Y. Kimura, D. W. Waring, and P. L. Mellon, Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line, Molecular Endocrinology, vol.10, issue.4, pp.439-450, 1996.

C. R. Tyler, S. Jobling, and J. P. Sumpter, Endocrine Disruption in Wildlife: A Critical Review of the Evidence, Critical Reviews in Toxicology, vol.28, issue.4, pp.319-361, 1998.
DOI : 10.1080/10408449891344236

C. R. Tyler and E. J. Routledge, Oestrogenic effects in fish in English rivers with evidence of their causation, Pure and Applied Chemistry, vol.70, issue.9, pp.1795-1804, 1998.
DOI : 10.1351/pac199870091795

C. R. Tyler, R. Van-aerle, T. H. Hutchinson, S. Maddix, and H. Trip, An in vivo testing system for endocrine disruptors in fish early life stages using induction of vitellogenin, Environmental Toxicology and Chemistry, vol.42, issue.2, pp.337-347, 1999.
DOI : 10.1002/etc.5620180234

H. Ueda, A. Kambegawa, and Y. Nagahama, Involvement of gonadotrophin and steroid hormones in spermiation in the amago salmon, Oncorhynchus rhodurus, and goldfish, Carassius auratus, General and Comparative Endocrinology, vol.59, issue.1, pp.24-30, 1985.
DOI : 10.1016/0016-6480(85)90415-0

J. C. Van-de-steene, C. P. Stove, and W. E. Lambert, A field study on 8 pharmaceuticals and 1 pesticide in Belgium: Removal rates in waste water treatment plants and occurrence in surface water, Science of The Total Environment, vol.408, issue.16, pp.3448-3453, 2010.
DOI : 10.1016/j.scitotenv.2010.04.037

H. Vandenbossche, P. Marichal, L. Lejeune, M. C. Coene, J. Gorrens et al., Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans., Antimicrobial Agents and Chemotherapy, vol.37, issue.10, pp.2101-2105, 1993.
DOI : 10.1128/AAC.37.10.2101

V. P. Vidal, M. C. Chaboissier, D. G. De-rooij, and A. Schedl, Sox9 induces testis development in XX transgenic mice, Nature Genetics, vol.28, issue.3, pp.216-217, 2001.
DOI : 10.1038/90046

D. A. Vilela, S. G. Silva, M. T. Peixoto, H. P. Godinho, and L. R. Franca, Spermatogenesis in teleost: insights from the Nile tilapia (Oreochromis niloticus) model, Fish Physiology and Biochemistry, vol.28, issue.1-4, pp.1-4, 2003.
DOI : 10.1023/B:FISH.0000030523.16010.62

D. L. Villeneuve, L. S. Blake, J. D. Brodin, K. J. Greene, I. Knoebl et al., Transcription of Key Genes Regulating Gonadal Steroidogenesis in Control and Ketoconazole- or Vinclozolin-Exposed Fathead Minnows, Toxicological Sciences, vol.98, issue.2, pp.395-407, 2007.
DOI : 10.1093/toxsci/kfm124

D. L. Villeneuve, P. Larkin, I. Knoebl, A. L. Miracle, M. D. Kahl et al., A Graphical Systems Model to Facilitate Hypothesis-Driven Ecotoxicogenomics Research on the Teleost Brain???Pituitary???Gonadal Axis, Environmental Science & Technology, vol.41, issue.1, pp.321-330, 2007.
DOI : 10.1021/es061739x

D. L. Villeneuve, A. L. Miracle, K. M. Jensen, S. J. Degitz, M. D. Kahl et al., Development of quantitative real-time PCR assays for fathead minnow (Pimephales promelas) gonadotropin ?? subunit mRNAs to support endocrine disruptor research, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.145, issue.2, pp.171-183, 2007.
DOI : 10.1016/j.cbpc.2006.11.003

A. M. Vinggaard, U. Hass, M. Dalgaard, H. R. Andersen, E. Bonefeld-jorgensen et al., Prochloraz: an imidazole fungicide with multiple mechanisms of action, International Journal of Andrology, vol.106, issue.1, pp.186-191, 2006.
DOI : 10.1016/j.toxlet.2003.09.012

A. M. Vinggaard, C. Hnida, V. Breinholt, and J. C. Larsen, Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro, Toxicology in Vitro, vol.14, issue.3, pp.227-234, 2000.
DOI : 10.1016/S0887-2333(00)00018-7

A. M. Vinggaard, C. Nellemann, M. Dalgaard, E. B. Jorgensen, and H. R. Andersen, Antiandrogenic Effects in Vitro and in Vivo of the Fungicide Prochloraz, Toxicological Sciences, vol.69, issue.2, pp.344-353, 2002.
DOI : 10.1093/toxsci/69.2.344

H. F. Vischer, J. C. Granneman, M. H. Linskens, R. W. Schulz, and J. Bogerd, Both recombinant African catfish LH and FSH are able to activate the African catfish FSH receptor, Journal of Molecular Endocrinology, vol.31, issue.1, pp.133-140, 2003.
DOI : 10.1677/jme.0.0310133

J. G. Vos, E. Dybing, H. A. Greim, O. Ladefoged, C. Lambre et al., Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation, Critical Reviews in Toxicology, vol.29, issue.3, pp.71-133, 2000.
DOI : 10.1080/15287399109531540
URL : https://hal.archives-ouvertes.fr/ineris-00962782

M. Vosges, L. Page, Y. Chung, B. C. Combarnous, Y. Porcher et al., 17??-Ethinylestradiol disrupts the ontogeny of the forebrain GnRH system and the expression of brain aromatase during early development of zebrafish, Aquatic Toxicology, vol.99, issue.4, pp.479-491, 2010.
DOI : 10.1016/j.aquatox.2010.06.009
URL : https://hal.archives-ouvertes.fr/hal-00592402

Y. J. Wang and W. Ge, Cloning of zebrafish ovarian P450c17 20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues, General and Comparative Endocrinology, vol.1717, issue.1352, pp.241-249, 2004.

K. H. Watanabe, Z. Li, K. J. Kroll, D. L. Villeneuve, N. Garcia-reyero et al., A Computational Model of the Hypothalamic-Pituitary-Gonadal Axis in Male Fathead Minnows Exposed to 17??-Ethinylestradiol and 17??-Estradiol, Toxicological Sciences, vol.109, issue.2, pp.180-192, 2009.
DOI : 10.1093/toxsci/kfp069

T. Yamaguchi, S. Yamaguchi, T. Hirai, and T. Kitano, Follicle-stimulating hormone signaling and Foxl2 are involved in transcriptional regulation of aromatase gene during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus, Biochemical and Biophysical Research Communications, vol.359, issue.4, pp.935-940, 2007.
DOI : 10.1016/j.bbrc.2007.05.208

J. A. Zarn, B. J. Bruschweiler, and J. R. Schlatter, Azole Fungicides Affect Mammalian Steroidogenesis by Inhibiting Sterol 14??-Demethylase and Aromatase, Environmental Health Perspectives, vol.111, issue.3, pp.255-261, 2003.
DOI : 10.1289/ehp.5785

W. L. Zhang, L. Y. Zhou, B. Senthilkumaran, B. F. Huang, C. C. Sudhakumari et al., Molecular cloning of two isoforms of 11??-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus, General and Comparative Endocrinology, vol.165, issue.1, pp.34-41, 2010.
DOI : 10.1016/j.ygcen.2009.05.018

X. W. Zhang, M. Hecker, P. D. Jones, J. Newsted, D. Au et al., Responses of the Medaka HPG Axis PCR Array and Reproduction to Prochloraz and Ketoconazole, Environmental Science & Technology, vol.42, issue.17, pp.6762-6769, 2008.
DOI : 10.1021/es800591t

J. Zhao, P. Mak, A. Tchoudakova, G. Callard, and S. Chen, Different Catalytic Properties and Inhibitor Responses of the Goldfish Brain and Ovary Aromatase Isozymes, General and Comparative Endocrinology, vol.123, issue.2, pp.180-191, 2001.
DOI : 10.1006/gcen.2001.7661

Q. Zhou, Y. Li, R. Nie, P. Friel, D. Mitchell et al., Expression of Stimulated by Retinoic Acid Gene 8 (Stra8) and Maturation of Murine Gonocytes and Spermatogonia Induced by Retinoic Acid In Vitro1, Biology of Reproduction, vol.78, issue.3, pp.537-545, 2008.
DOI : 10.1095/biolreprod.107.064337

Y. Zohar, J. A. Munoz-cueto, A. Elizur, and O. Kah, Neuroendocrinology of reproduction in teleost fish, General and Comparative Endocrinology, vol.165, issue.3, pp.438-455, 2010.
DOI : 10.1016/j.ygcen.2009.04.017
URL : https://hal.archives-ouvertes.fr/hal-00461596