Contribution à l'étude de la morbi-mortalité lors de l'usage de drogues récréatives : GHB-THC, seuls ou associés à l'éthanol

Abstract : The objective of this thesis was to study the time-course of the respiratory effects of THC/ethanol and GHB/ethanol associations. Respiration was studied using whole body plethysmography in non-anesthetized rats during the four hours following intraperitoneal injection. In a first step, both GHB and ethanol affected the respiratory pattern. Ethanol caused bradypnea at doses greater than 3 g.kg-1 and GHB induced apneusis above 600 mg.kg-1. Arterial blood gases modifications were metabolic: acidemia with ethanol and alkalosis with GHB. At those doses, both substances altered consciousness and body temperature of animals. Ethanol induced hypothermia and GHB a temperature triphasic change: hypothermia/ hyperthermia/hypothermia. Blood determinations and kinetic studies reinforced the likelihood, and clinical and forensic relevancies of our animal model. Association studies showed that the respiratory effects of THC and GHB were unchanged in presence of ethanol. Association with 3 g.kg-1 ethanol dose only provoked a reduction in minute volume and in mean inspiratory flow, but mechanisms were different. Ethanol and THC induced a decrease in tidal volume; ethanol and GHB an increase in expiratory apnea duration. The observed kinetic interaction between ethanol and GHB did not explain phenomenon intensity; a potentialization could occur.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00781683
Contributor : Abes Star <>
Submitted on : Monday, January 28, 2013 - 10:47:12 AM
Last modification on : Friday, September 20, 2019 - 9:36:02 AM
Long-term archiving on: Monday, June 17, 2013 - 4:03:11 PM

File

va_roussel_olivier.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00781683, version 1

Citation

Olivier Roussel. Contribution à l'étude de la morbi-mortalité lors de l'usage de drogues récréatives : GHB-THC, seuls ou associés à l'éthanol. Médecine humaine et pathologie. Université René Descartes - Paris V, 2012. Français. ⟨NNT : 2012PA05P628⟩. ⟨tel-00781683⟩

Share

Metrics

Record views

628

Files downloads

1974