entre l'os frontal et les os pariétaux liés par les sutures sagittale et coronale, se trouve une membrane cartilagineuse appelée « fontanelle antérieure ». Ce cartilage est relativement souple et ne s'ossifie pas avant l'âge de 18 mois, Au cours de la palpation de la voûte crânienne à ce niveau, on peut sentir les battements cardiaques sous les doigts ,
Epidemiology and prevention of head injuries: literature review, Journal of Clinical Nursing, vol.29, issue.1, pp.46-57, 2008. ,
DOI : 10.1097/00005373-200009000-00004
Oral pharmacokinetics of meloxicam in the rat using a high-performance liquid chromatographic method in micro-whole blood samples, Methods and Findings in Experimental and Clinical Pharmacology, vol.29, issue.9, pp.587-591, 2007. ,
DOI : 10.1358/mf.2007.29.9.1116314
Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice, Journal of Neuroscience Research, vol.112, issue.16, pp.3605-3612, 2008. ,
DOI : 10.1002/jnr.21809
Meloxicam in rheumatoid arthritis, Expert Opinion on Drug Metabolism & Toxicology, vol.13, issue.2, pp.739-751, 2005. ,
DOI : 10.1007/PL00011190
Cyclooxygenase-1 and -2 Differentially Modulate Lipopolysaccharide-Induced Blood???Brain Barrier Disruption through Matrix Metalloproteinase Activity, Journal of Cerebral Blood Flow & Metabolism, vol.57, issue.2, pp.370-380, 2010. ,
DOI : 10.1111/j.1471-4159.2008.05430.x
Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2, Journal of Neuroinflammation, vol.5, issue.1, p.17, 2008. ,
DOI : 10.1186/1742-2094-5-17
Experimental traumatic brain injury, Experimental & Translational Stroke Medicine, vol.2, issue.1, p.16, 2010. ,
DOI : 10.1186/2040-7378-2-16
Paracetamol (Acetaminophen): mechanisms of action, Pediatric Anesthesia, vol.47, issue.Suppl 1, pp.915-921, 2008. ,
DOI : 10.1111/j.1460-9592.2008.02764.x
Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis., Journal of Clinical Investigation, vol.97, issue.11, pp.2672-2679, 1996. ,
DOI : 10.1172/JCI118717
Neurobehavioral consequences of traumatic brain injury, Mt Sinai J Med, vol.73, pp.999-1005, 2006. ,
Edwin Smith Surgical Papyrus: the oldest known surgical treatise, Am Surg, vol.65, pp.1190-1192, 1999. ,
Glial and neuronal control of brain blood flow, Nature, vol.15, issue.7321, pp.232-243, 2010. ,
DOI : 10.1038/nature09613
COX-2 inhibitors vs. NSAIDs in gastrointestinal damage and prevention, Expert Opinion on Pharmacotherapy, vol.96, issue.371, pp.31-40, 2001. ,
DOI : 10.1074/jbc.273.17.10095
Pharmacology of traumatic brain injury: where is the "golden bullet, Mol Med, vol.14, pp.731-740, 2008. ,
Modulation of cytochrome-derived epoxyeicosatrienoic acids pathway: A promising pharmacological approach to prevent endothelial dysfunction in cardiovascular diseases?, Pharmacology & Therapeutics, vol.131, issue.1, pp.1-17, 2011. ,
DOI : 10.1016/j.pharmthera.2011.03.015
Fatigue and??traumatic brain injury, Annales de R??adaptation et de M??decine Physique, vol.49, issue.6, pp.283-288, 2006. ,
DOI : 10.1016/j.annrmp.2006.04.018
URL : https://hal.archives-ouvertes.fr/hal-00272334
A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice, J Pharmacol Exp Ther, vol.296, pp.57-63, 2001. ,
Infusion of Prostacyclin Following Experimental Brain Injury in the Rat Reduces Cortical Lesion Volume, Journal of Neurotrauma, vol.18, issue.3, pp.275-285, 2001. ,
DOI : 10.1089/08977150151070919
The enzymatic conversion of essential fatty acids into prostaglandins, J Biol Chem, vol.239, pp.4006-4008, 1964. ,
Clinical Pharmacokinetics of Nimesulide, Clinical Pharmacokinetics, vol.35, issue.4, pp.247-274, 1998. ,
DOI : 10.2165/00003088-199835040-00001
Fenofibrate, a peroxisome proliferator-activated receptor ?? agonist, exerts neuroprotective effects in traumatic brain injury, Neuroscience Letters, vol.388, issue.1, pp.7-12, 2005. ,
DOI : 10.1016/j.neulet.2005.06.019
Simvastatin in traumatic brain injury: Effect on brain edema mechanisms, Critical Care Medicine, vol.39, issue.10, pp.2300-2307, 2011. ,
DOI : 10.1097/CCM.0b013e3182227e4a
Cysteinyl-leukotriene receptor antagonist montelukast decreases blood???brain barrier permeability but does not prevent oedema formation in traumatic brain injury, Brain Injury, vol.153, issue.6, pp.577-584, 2009. ,
DOI : 10.1179/016164103101201896
The lesion(s) in traumatic brain injury: implications for clinical neuropsychology, Archives of Clinical Neuropsychology, vol.16, issue.2, pp.95-131, 2001. ,
DOI : 10.1093/arclin/16.2.95
Rethinking the role of cyclooxygenase-1 in neuroinflammation: More than homeostasis, Cell Cycle, vol.9, issue.15, pp.2919-2920, 2010. ,
DOI : 10.4161/cc.9.15.12715
Inhibitors of cyclooxygenases: mechanisms, selectivity and uses, J Physiol Pharmacol, vol.57, pp.113-124, 2006. ,
COX-3 and the mechanism of action of paracetamol/acetaminophen, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.72, issue.2, pp.85-87, 2005. ,
DOI : 10.1016/j.plefa.2004.10.005
Recovery from Global Cerebral Ischemia in Rabbits: Influence of Indomethacin, European Neurology, vol.20, issue.3, pp.230-234, 1981. ,
DOI : 10.1159/000115240
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976. ,
DOI : 10.1016/0003-2697(76)90527-3
Pathophysiology of cerebral ischemia and brain trauma: Similarities and differences, Journal of Cerebral Blood Flow & Metabolism, vol.784, pp.133-150, 2004. ,
DOI : 10.1097/01.WCB.0000111614.19196.04
Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition, The FASEB Journal, vol.20, issue.9, pp.1352-1360, 2006. ,
DOI : 10.1096/fj.05-5346com
The Epidemiology of Traumatic Brain Injury: A Review, Epilepsia, vol.2, issue.10, pp.2-10, 2003. ,
DOI : 10.1046/j.1528-1157.44.s10.3.x
All roads lead to disconnection? ??? Traumatic axonal injury revisited, Acta Neurochirurgica, vol.1241, issue.2, pp.181-193, 2006. ,
DOI : 10.1007/s00701-005-0674-4
Pharmacokinetics of meloxicam in animals and the relevance to humans, Drug Metab Dispos, vol.26, pp.576-584, 1998. ,
Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration, Experimental Neurology, vol.204, issue.1, pp.220-233, 2007. ,
DOI : 10.1016/j.expneurol.2006.10.013
A role for cyclooxygenase-1 in ??-amyloid-induced neuroinflammation, Aging, vol.1, issue.4, pp.350-353, 2009. ,
DOI : 10.18632/aging.100039
Nimesulide as a promising neuroprotectant in brain ischemia: New experimental evidences, Pharmacological Research, vol.57, issue.4, pp.266-273, 2008. ,
DOI : 10.1016/j.phrs.2008.03.003
Cyclooxygenase Inhibition in Ischemic Brain Injury, Current Pharmaceutical Design, vol.14, issue.14, pp.1401-1418, 2008. ,
DOI : 10.2174/138161208784480216
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats, Journal of Neurochemistry, vol.92, issue.4, pp.1108-1120, 2007. ,
DOI : 10.1111/j.1471-4159.2006.04280.x
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-?? in the Rat, Journal of Pharmacology and Experimental Therapeutics, vol.323, issue.2, pp.488-498, 2007. ,
DOI : 10.1124/jpet.107.127035
Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia, Journal of Neuroinflammation, vol.4, issue.1, p.25, 2007. ,
DOI : 10.1186/1742-2094-4-25
Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat, Journal of Neuroinflammation, vol.2, issue.1, p.3, 2005. ,
DOI : 10.1186/1742-2094-2-3
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat, Brain Research, vol.1007, issue.1-2, pp.98-108, 2004. ,
DOI : 10.1016/j.brainres.2004.01.078
Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia, Journal of Neurochemistry, vol.95, issue.3, pp.545-555, 2003. ,
DOI : 10.1046/j.1471-4159.2003.01812.x
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia, European Journal of Pharmacology, vol.453, issue.2-3, pp.189-195, 2002. ,
DOI : 10.1016/S0014-2999(02)02422-6
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin, New England Journal of Medicine, vol.345, issue.25, pp.1809-1817, 2001. ,
DOI : 10.1056/NEJMoa003199
What has inflammation to do with traumatic brain injury?, Child's Nervous System, vol.17, issue.2, pp.221-226, 2010. ,
DOI : 10.1007/s00381-009-1029-x
Animal models of head trauma, NeuroRX, vol.10, issue.3, pp.410-422, 2005. ,
DOI : 10.1602/neurorx.2.3.410
Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats, Experimental Brain Research, vol.147, issue.2, pp.193-199, 2002. ,
DOI : 10.1007/s00221-002-1245-z
Activation Of Cyclo-Oxygenase-2 Contributes To Motor And Cognitive Dysfunction Following Diffuse Traumatic Brain Injury In Rats, Clinical and Experimental Pharmacology and Physiology, vol.10, issue.11, pp.922-925, 2001. ,
DOI : 10.1016/0301-0082(95)00016-O
The cyclooxygenases, Genome Biology, vol.5, issue.9, p.241, 2004. ,
DOI : 10.1186/gb-2004-5-9-241
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression, Proceedings of the National Academy of Sciences, vol.99, issue.21, pp.13926-13931, 2002. ,
DOI : 10.1073/pnas.162468699
Neuroanatomical correlation of behavioral deficits in the CCI model of TBI, Journal of Neuroscience Methods, vol.190, issue.1, pp.1-9, 2010. ,
DOI : 10.1016/j.jneumeth.2010.04.004
Combination Therapy with Fenofibrate, a Peroxisome Proliferator-Activated Receptor ?? Agonist, and Simvastatin, a 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor, on Experimental Traumatic Brain Injury, Journal of Pharmacology and Experimental Therapeutics, vol.326, issue.3, pp.966-974, 2008. ,
DOI : 10.1124/jpet.108.140368
Neurological Recovery-Promoting, Anti-Inflammatory, and Anti-Oxidative Effects Afforded by Fenofibrate, a PPAR Alpha Agonist, in Traumatic Brain Injury, Journal of Neurotrauma, vol.24, issue.7, pp.1119-1131, 2007. ,
DOI : 10.1089/neu.2006.0216
THE ROLE OF SECONDARY BRAIN INJURY IN DETERMINING OUTCOME FROM SEVERE HEAD INJURY, The Journal of Trauma: Injury, Infection, and Critical Care, vol.34, issue.2, pp.216-222, 1993. ,
DOI : 10.1097/00005373-199302000-00006
Early and Late Systemic Hypotension as a Frequent and Fundamental Source of Cerebral Ischemia Following Severe Brain Injury in the Traumatic Coma Data Bank, Acta Neurochir, vol.59, pp.121-125, 1993. ,
DOI : 10.1007/978-3-7091-9302-0_21
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to ??-amyloid, Aging, vol.1, issue.2, pp.234-244, 2009. ,
DOI : 10.18632/aging.100021
The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research, Trends in Pharmacological Sciences, vol.30, issue.4, pp.174-181, 2009. ,
DOI : 10.1016/j.tips.2009.01.002
Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury, The FASEB Journal, vol.22, issue.5, pp.1491-1501, 2008. ,
DOI : 10.1096/fj.07-9411com
Neutralization of interleukin-1?? reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice, European Journal of Neuroscience, vol.7, issue.Suppl 1, pp.110-123, 2011. ,
DOI : 10.1111/j.1460-9568.2011.07723.x
Neutralization of interleukin-1?? modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice, European Journal of Neuroscience, vol.58, issue.Suppl 1, pp.385-396, 2009. ,
DOI : 10.1111/j.1460-9568.2009.06820.x
Eye and visual function in traumatic brain injury, The Journal of Rehabilitation Research and Development, vol.46, issue.6, pp.811-818, 2009. ,
DOI : 10.1682/JRRD.2008.08.0109
CLINICAL TRIALS: Halt of Celebrex Study Threatens Drug's Future, Other Trials, Science, vol.306, issue.5705, p.2170, 2004. ,
DOI : 10.1126/science.306.5705.2170a
Isoprostanes: nouveaux marqueurs du stress oxydant. Aspects fondamentaux et cliniques, La Revue de M??decine Interne, vol.21, issue.3, pp.304-307, 2000. ,
DOI : 10.1016/S0248-8663(00)80056-9
Regional Expression and Role of Cyclooxygenase-2 Following Experimental Traumatic Brain Injury, Journal of Neurotrauma, vol.17, issue.1, pp.69-81, 2000. ,
DOI : 10.1089/neu.2000.17.69
???We are the forgotten victims???: Perspectives of adult siblings of persons with traumatic brain injury, Brain Injury, vol.26, issue.12, pp.1416-1427, 2010. ,
DOI : 10.1080/02699050600743725
Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil, Stroke, vol.22, issue.10, pp.1259-1264, 1991. ,
DOI : 10.1161/01.STR.22.10.1259
COX-3: in the wrong frame in mind, Immunology Letters, vol.86, issue.1, p.121, 2003. ,
DOI : 10.1016/S0165-2478(02)00268-7
Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments, Current Opinion in Neurology, vol.23, issue.3, pp.293-299, 2010. ,
DOI : 10.1097/WCO.0b013e328337f451
Pharmacology of Meloxicam, A New Non-Steroidal Anti-Inflammatory Drug with an Improved Safety Profile Through Preferential Inhibition of COX-2, Rheumatology, vol.35, issue.suppl 1, pp.4-12, 1996. ,
DOI : 10.1093/rheumatology/35.suppl_1.4
Meloxican: Influence on arachidonic acid metabolism, vivo findings, pp.29-38, 1996. ,
DOI : 10.1016/0006-2952(95)02110-8
Injury-Related Production of Cysteinyl Leukotrienes Contributes to Brain Damage following Experimental Traumatic Brain Injury, Journal of Neurotrauma, vol.26, issue.11, pp.1977-1986, 2009. ,
DOI : 10.1089/neu.2009.0877
The Edwin Smith Surgical Papyrus, Child's Nervous System, vol.15, issue.6-7, pp.281-284, 1999. ,
DOI : 10.1007/s003810050395
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products, British Journal of Pharmacology, vol.124, issue.69, pp.894-912, 2011. ,
DOI : 10.1111/j.1476-5381.2011.01276.x
A population-based study of risk of epilepsy after hospitalization for traumatic brain injury, Epilepsia, vol.79, issue.suppl 2, pp.891-898, 2010. ,
DOI : 10.1111/j.1528-1167.2009.02384.x
Albumin-catalyzed metabolism of prostaglandin D 2 . Identification of products formed in vitro, J Biol Chem, vol.258, pp.11713-11718, 1983. ,
Mouse closed head injury model induced by a weight-drop device, Nature Protocols, vol.20, issue.9, pp.1328-1337, 2009. ,
DOI : 10.1038/nprot.2009.148
Traumatic brain injury and olfactory deficits: The tale of two smell tests!, Brain Injury, vol.42, issue.1, pp.27-33, 2010. ,
DOI : 10.1080/0269905031000070242
The structures of prostaglandin endoperoxide H synthases-1 and -2, Prostaglandins Other Lipid Mediat, pp.68-69, 2002. ,
Head Trauma, Neuroimaging Clinics of North America, vol.20, issue.4, pp.527-556, 2010. ,
DOI : 10.1016/j.nic.2010.08.001
Le monitorage de la pression intracr??nienne am??liore-t-il le devenir des traumatis??s cr??niens graves???, Annales Fran??aises d'Anesth??sie et de R??animation, vol.29, issue.9, pp.171-175, 2010. ,
DOI : 10.1016/j.annfar.2010.06.006
New insights into the role of COX 2 in inflammation, Journal of Molecular Medicine, vol.78, issue.3, pp.121-129, 2000. ,
DOI : 10.1007/s001090000094
Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat, British Journal of Pharmacology, vol.283, issue.5, pp.642-653, 2005. ,
DOI : 10.1007/BF01117450
The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain, British Journal of Pharmacology, vol.9, issue.1 ,
DOI : 10.1111/j.1476-5381.2009.00618.x
Cyclooxygenase-2-specific Inhibitor Improves Functional Outcomes, Provides Neuroprotection, and Reduces Inflammation in a Rat Model of Traumatic Brain Injury, Neurosurgery, vol.56, issue.3, pp.590-604, 2005. ,
DOI : 10.1227/01.NEU.0000154060.14900.8F
Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1, Journal of Biological Chemistry, vol.279, issue.23, pp.24866-24872, 2004. ,
DOI : 10.1074/jbc.M403106200
The physiology and pathophysiology of nitric oxide in the brain, Progress in Neurobiology, vol.76, issue.2, pp.126-152, 2005. ,
DOI : 10.1016/j.pneurobio.2005.06.001
Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease, Chemical Reviews, vol.111, issue.10, pp.5866-5898, 2011. ,
DOI : 10.1021/cr200246d
Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood???brain barrier permeability, Neurological Research, vol.147, issue.1, pp.629-635, 2010. ,
DOI : 10.1098/rstb.2003.1358
Antioxidant therapies for traumatic brain injury, Neurotherapeutics, vol.104, issue.suppl 2, pp.51-61, 2010. ,
DOI : 10.1016/j.nurt.2009.10.021
Spatial and Temporal Characteristics of Neurodegeneration after Controlled Cortical Impact in Mice: More than a Focal Brain Injury, Journal of Neurotrauma, vol.22, issue.2, pp.252-265, 2005. ,
DOI : 10.1089/neu.2005.22.252
Inhibition of prostaglandin synthesis in man, Biochemical and Biophysical Research Communications, vol.49, issue.3, pp.720-726, 1972. ,
DOI : 10.1016/0006-291X(72)90470-6
ISomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.431, issue.1, pp.189-193, 1976. ,
DOI : 10.1016/0005-2760(76)90273-3
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models, Biochimie, vol.92, issue.6, pp.651-659, 2010. ,
DOI : 10.1016/j.biochi.2010.02.007
Pattern of craniofacial injuries in patients admitted to Tanta University Hospital ??? Egypt, Journal of Forensic and Legal Medicine, vol.17, issue.1, pp.26-32, 2010. ,
DOI : 10.1016/j.jflm.2009.07.008
COX-2 inhibitors, The Lancet, vol.353, issue.9149, pp.307-314, 1999. ,
DOI : 10.1016/S0140-6736(98)12154-2
Neuroinflammation and Memory: The Role of Prostaglandins, Molecular Neurobiology, vol.22, issue.17, pp.15-32, 2009. ,
DOI : 10.1007/s12035-009-8066-z
Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury, Neuroscience Letters, vol.357, issue.1, pp.21-24, 2004. ,
DOI : 10.1016/j.neulet.2003.12.036
Receptor in a Murine Model of Diffuse Brain Injury, Journal of Neurotrauma, vol.20, issue.9, pp.841-851, 2003. ,
DOI : 10.1089/089771503322385773
Clinical Pharmacokinetics of Indomethacin, Clinical Pharmacokinetics, vol.6, issue.4, pp.245-258, 1981. ,
DOI : 10.2165/00003088-198106040-00001
Prostaglandin synthases: recent developments and a novel hypothesis, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.70, issue.2, pp.101-113, 2004. ,
DOI : 10.1016/j.plefa.2003.04.002
Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain, Biochemical Journal, vol.391, issue.3, pp.561-566, 2005. ,
DOI : 10.1042/BJ20050451
Cyclooxygenase-2 Activity Following Traumatic Brain Injury in the Developing Rat, Pediatric Research, vol.21, issue.3, pp.271-276, 2007. ,
DOI : 10.1203/PDR.0b013e3180db2902
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity., Proceedings of the National Academy of Sciences, vol.84, issue.5, pp.1417-1420, 1987. ,
DOI : 10.1073/pnas.84.5.1417
Cyclooxygenase-2---10 Years Later, Journal of Pharmacology and Experimental Therapeutics, vol.300, issue.2, pp.367-375, 2002. ,
DOI : 10.1124/jpet.300.2.367
Blockade of Acute Microglial Activation by Minocycline Promotes Neuroprotection and Reduces Locomotor Hyperactivity after Closed Head Injury in Mice: A Twelve-Week Follow-Up Study, Journal of Neurotrauma, vol.27, issue.5, pp.911-921, 2010. ,
DOI : 10.1089/neu.2009.1223
Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice, Brain Research, vol.1291, pp.122-132, 2009. ,
DOI : 10.1016/j.brainres.2009.07.031
Indomethacin/Prochlorperazine/Caffeine, CNS Drugs, vol.30, issue.1, pp.343-358, 2011. ,
DOI : 10.2165/11206740-000000000-00000
Longitudinal outcomes of patients with traumatic brain injury: A preliminary study, Brain Injury, vol.17, issue.13-14, pp.1606-1615, 2010. ,
DOI : 10.1080/026990598122908
Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury, Journal of Neurotrauma, vol.19, issue.1, pp.1-15, 2002. ,
DOI : 10.1089/089771502753460196
Perphenazine (trilafon), a new potent tranquilzer and antiemetic. I. Behavioral mode of action, Arch Int Pharmacodyn Ther, vol.118, pp.358-374, 1959. ,
Neuroprotection in traumatic brain injury, Drug Discovery Today, vol.13, issue.23-24, pp.1082-1089, 2008. ,
DOI : 10.1016/j.drudis.2008.09.006
Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice, BMC Neuroscience, vol.10, issue.1, p.108, 2009. ,
DOI : 10.1186/1471-2202-10-108
Effect of indomethacin pretreatment on acute mortality in experimental brain injury, Journal of Neurosurgery, vol.71, issue.4 ,
DOI : 10.3171/jns.1989.71.4.0565
Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous system, Molecular Brain Research, vol.126, issue.1, pp.78-80, 2004. ,
DOI : 10.1016/j.molbrainres.2004.03.015
Inhibition of Cyclooxygenase 2 by Nimesulide Decreases Prostaglandin E2 Formation But Does Not Alter Brain Edema or Clinical Recovery After Closed Head Injury in Rats, Journal of Neurosurgical Anesthesiology, vol.12, issue.1, pp.44-50, 2000. ,
DOI : 10.1097/00008506-200001000-00009
The management of cranial injuries in antiquity and beyond, Neurosurgical Focus, vol.23, issue.1, p.8, 2007. ,
DOI : 10.3171/FOC-07/07/E8
Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat, Restor Neurol Neurosci, vol.24, pp.55-63, 2006. ,
Metabolism in Traumatic Brain Injury in the Rat, Journal of Neurotrauma, vol.19, issue.9, pp.1051-1064, 2002. ,
DOI : 10.1089/089771502760341965
Cyclooxygenase enzymes: catalysis and inhibition, Current Opinion in Structural Biology, vol.11, issue.6, pp.752-760, 2001. ,
DOI : 10.1016/S0959-440X(01)00277-9
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685, 1970. ,
DOI : 10.1038/227680a0
CNS injury biomechanics and experimental models, Prog Brain Res, vol.161, pp.13-26, 2007. ,
DOI : 10.1016/S0079-6123(06)61002-9
Peroxisome Proliferator-activated Receptors ?? and ?? Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs, Journal of Biological Chemistry, vol.272, issue.6, pp.3406-3410, 1997. ,
DOI : 10.1074/jbc.272.6.3406
In vivo accuracy of two intraparenchymal intracranial pressure monitors, Intensive Care Medicine, vol.64, issue.Suppl 1, pp.875-879, 2011. ,
DOI : 10.1007/s00134-011-2182-8
R??animation des??patients traumatis??s cr??niens graves, La Presse M??dicale, vol.36, issue.7-8, pp.1117-1126, 2007. ,
DOI : 10.1016/j.lpm.2007.01.017
Free Radical Pathways in CNS Injury, Journal of Neurotrauma, vol.17, issue.10, pp.871-890, 2000. ,
DOI : 10.1089/neu.2000.17.871
The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury, Journal of Neurochemistry, vol.12, issue.4, pp.965-977, 2010. ,
DOI : 10.1111/j.1471-4159.2010.06674.x
Selective inhibition of inducible nitric oxide synthase reduces neurological deficit but not cerebral edema following traumatic brain injury, Neuropharmacology, vol.50, issue.2, pp.182-190, 2006. ,
DOI : 10.1016/j.neuropharm.2005.08.020
Systemic inflammatory response following acute traumatic brain injury, Frontiers in Bioscience, vol.Volume, issue.14, pp.3795-3813, 2009. ,
DOI : 10.2741/3489
Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation, PLoS ONE, vol.148, issue.5, p.19948, 2011. ,
DOI : 10.1371/journal.pone.0019948.t003
Les cytochromes P450 astrocytaires, une famille d???enzymes cl??s dans le m??tabolisme c??r??bral et la neuroprotection, Revue Neurologique, vol.160, issue.6-7, pp.651-658, 2004. ,
DOI : 10.1016/S0035-3787(04)71014-0
Clinical trials in traumatic brain injury: Past experience and current developments, Neurotherapeutics, vol.334, issue.1, pp.115-126, 2010. ,
DOI : 10.1016/j.nurt.2009.10.022
Traumatic Brain Injury: A Disease Process, Not an Event, Journal of Neurotrauma, vol.27, issue.8, pp.1529-1540, 2010. ,
DOI : 10.1089/neu.2010.1358
Contribution of NO/ONOO??? pathway to the deleterious effect of traumatic brain injury in mice, Drug Discovery Today, vol.5, issue.9, pp.432-433, 2000. ,
DOI : 10.1016/S1359-6446(00)01554-3
Protective effect of melatonin in a model of traumatic brain injury in mice, Journal of Pineal Research, vol.21, issue.1, pp.41-46, 1998. ,
DOI : 10.1016/0304-3940(96)12493-9
Reduction of tyrosine nitration after N??-nitro-l-arginine-methylester treatment of mice with traumatic brain injury, European Journal of Pharmacology, vol.353, issue.1, pp.53-57, 1998. ,
DOI : 10.1016/S0014-2999(98)00432-4
Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors, Journal of Neurotrauma, vol.13, issue.1, pp.209-214, 1996. ,
DOI : 10.1089/neu.1996.13.11
Current concepts: Diffuse axonal injury???associated traumatic brain injury, Archives of Physical Medicine and Rehabilitation, vol.82, issue.10, pp.1461-1471, 2001. ,
DOI : 10.1053/apmr.2001.25137
Prostanoid signaling: Dual role for prostaglandin E2 in neurotoxicity, NeuroToxicology, vol.32, issue.3, pp.312-319, 2011. ,
DOI : 10.1016/j.neuro.2011.02.004
Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin, Pharmacol Rev, vol.30, pp.293-331, 1978. ,
Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory?, Injury, vol.41, pp.10-13, 2010. ,
DOI : 10.1016/j.injury.2010.03.032
Modulation of immune response by head injury, Injury, vol.38, issue.12, pp.1392-1400, 2007. ,
DOI : 10.1016/j.injury.2007.10.005
Central Nervous System Models of Mechanically Induced Trauma: A Review, Journal of Neurotrauma, vol.15, issue.11, pp.911-928, 1998. ,
DOI : 10.1089/neu.1998.15.911
Phospholipase A2, Journal of Biochemistry, vol.131, issue.3, pp.285-292, 2002. ,
DOI : 10.1093/oxfordjournals.jbchem.a003101
URL : https://hal.archives-ouvertes.fr/hal-00497527
Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2, Journal of Biological Chemistry, vol.275, issue.42, pp.32783-32792, 2000. ,
DOI : 10.1074/jbc.M003505200
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation, Science, vol.334, issue.6057, pp.809-813, 2011. ,
DOI : 10.1126/science.1209200
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249428
A mouse model of sensorimotor controlled cortical impact: Characterization using longitudinal magnetic resonance imaging, behavioral assessments and histology, Journal of Neuroscience Methods, vol.160, issue.2, pp.187-196, 2007. ,
DOI : 10.1016/j.jneumeth.2006.09.007
Traumatic brain injury: Can the consequences be stopped?, Canadian Medical Association Journal, vol.178, issue.9, pp.1163-1170, 2008. ,
DOI : 10.1503/cmaj.080282
Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders, Brain Research Reviews, vol.52, issue.2, pp.201-243, 2006. ,
DOI : 10.1016/j.brainresrev.2006.02.002
Workshop on Animal Models of Traumatic Brain Injury, Journal of Neurotrauma, vol.11, issue.6, pp.723-732, 1994. ,
DOI : 10.1089/neu.1994.11.723
Inhibition of inducible prostaglandin E2 synthase by 15-deoxy-??12,14-prostaglandin J2 and polyunsaturated fatty acids, Biochemical Pharmacology, vol.63, issue.6, pp.1183-1189, 2002. ,
DOI : 10.1016/S0006-2952(02)00844-4
Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide, Inflammopharmacology, vol.14, issue.3-4, pp.120-137, 2006. ,
DOI : 10.1007/s10787-006-1505-9
Management of Intracranial Hypertension, Neurologic Clinics, vol.26, issue.2, pp.521-541, 2008. ,
DOI : 10.1016/j.ncl.2008.02.003
Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond, Journal of Pharmacy & Pharmaceutical Sciences, vol.11, issue.2, pp.81-110, 2008. ,
DOI : 10.18433/J3T886
Regulation of fibroblast cyclooxygenase synthesis by interleukin-1, J Biol Chem, vol.263, pp.3022-3028, 1988. ,
The impact of neurotrauma on society: an international perspective, Prog Brain Res, vol.161, pp.3-9, 2007. ,
DOI : 10.1016/S0079-6123(06)61001-7
Effects of head injury on olfaction and taste, Otolaryngologic Clinics of North America, vol.37, issue.6, pp.1167-1184, 2004. ,
DOI : 10.1016/j.otc.2004.06.005
Assessment of impulsivity after moderate to severe traumatic brain injury, Neuropsychological Rehabilitation, vol.8, issue.5, pp.778-797, 2010. ,
DOI : 10.1097/01.nmd.0000180777.41295.65
Assessing Impulsivity Changes in Alzheimer Disease, Alzheimer Disease & Associated Disorders, vol.22, issue.3, pp.278-283, 2008. ,
DOI : 10.1097/WAD.0b013e318166d692
Psychiatric comorbidity following traumatic brain injury, Brain Injury, vol.27, issue.13-14, pp.1321-1333, 2007. ,
DOI : 10.1080/02699050210128861
Pathophysiology of Traumatic Brain Injury, Critical Care Nursing Quarterly, vol.23, issue.3, pp.14-25, 2000. ,
DOI : 10.1097/00002727-200011000-00003
Cytosolic phospholipase A 2 alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation ,
Closed head injury???an inflammatory disease?, Brain Research Reviews, vol.48, issue.2, pp.388-399, 2005. ,
DOI : 10.1016/j.brainresrev.2004.12.028
COX-3--a virtual pain target in humans?, The FASEB Journal, vol.17, issue.15, pp.2174-2175, 2003. ,
DOI : 10.1096/fj.03-0595lte
COX-3: just another COX or the solitary elusive target of paracetamol?, The Lancet, vol.361, issue.9362, pp.981-982, 2003. ,
DOI : 10.1016/S0140-6736(03)12841-3
Persistent accumulation of cyclooxygenase-1???expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury, Journal of Neurosurgery, vol.96, issue.5, pp.892-899, 2002. ,
DOI : 10.3171/jns.2002.96.5.0892
Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation, Biochemical Pharmacology, vol.82, issue.1, pp.53-64, 2011. ,
DOI : 10.1016/j.bcp.2011.03.025
Treatment of patent ductus arteriosus: indomethacin or ibuprofen?, Journal of Perinatology, vol.79, pp.60-62, 2008. ,
DOI : 10.1542/peds.2005-1528
COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells, Molecular Brain Research, vol.119, issue.2, pp.213-215, 2003. ,
DOI : 10.1016/j.molbrainres.2003.09.006
Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease, Journal of Allergy, vol.60, issue.3, p.794890, 2012. ,
DOI : 10.1007/s10875-008-9190-7
Depression and Cognitive Complaints Following Mild Traumatic Brain Injury, American Journal of Psychiatry, vol.166, issue.6, pp.653-661, 2009. ,
DOI : 10.1176/appi.ajp.2009.08111676
Variants of cyclooxygenase-1 and their roles in medicine, Thrombosis Research, vol.110, issue.5-6, pp.265-268, 2003. ,
DOI : 10.1016/S0049-3848(03)00380-3
Minocycline Restores Olfactory Bulb Volume and Olfactory Behavior after Traumatic Brain Injury in Mice, Journal of Neurotrauma, vol.29, issue.2, pp.354-361, 2012. ,
DOI : 10.1089/neu.2011.2055
Evaluation of late cognitive impairment and anxiety states following traumatic brain injury in mice: The effect of minocycline, Neuroscience Letters, vol.511, issue.2, pp.110-115, 2012. ,
DOI : 10.1016/j.neulet.2012.01.051
Minocycline Restores sAPP?? Levels and Reduces the Late Histopathological Consequences of Traumatic Brain Injury in Mice, Journal of Neurotrauma, vol.28, issue.10, pp.2135-2143, 2011. ,
DOI : 10.1089/neu.2010.1738
Linking impact to cellular and molecular sequelae of CNS injury: Modeling in vivo complexity with in vitro simplicity, Prog Brain Res, vol.161, pp.27-39, 2007. ,
DOI : 10.1016/S0079-6123(06)61003-0
Arachidonic acid cytochrome P450 epoxygenase pathway, The Journal of Lipid Research, vol.50, issue.Supplement, pp.52-56, 2009. ,
DOI : 10.1194/jlr.R800038-JLR200
Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury, Brain Research, vol.1076, issue.1, pp.216-224, 2006. ,
DOI : 10.1016/j.brainres.2005.12.106
The Edwin Smith Papyrus: The Birth of Analytical Thinking in Medicine and Otolaryngology, The Laryngoscope, vol.14, issue.2, pp.182-188, 2006. ,
DOI : 10.1097/01.mlg.0000191461.08542.a3
Time Course of Intracranial Hypertension after Traumatic Brain Injury, Journal of Neurotrauma, vol.24, issue.8, pp.1339-1346, 2007. ,
DOI : 10.1089/neu.2007.0300
COX2 inhibitors for acquired brain injuries: Is the time ripe?*, Critical Care Medicine, vol.38, issue.2, pp.723-724, 2010. ,
DOI : 10.1097/CCM.0b013e3181bc80b9
Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain, Brain, Behavior, and Immunity, vol.22, issue.3, pp.285-298, 2008. ,
DOI : 10.1016/j.bbi.2007.09.011
Prolonged Cyclooxygenase-2 Induction in Neurons and Glia Following Traumatic Brain Injury in the Rat, Journal of Neurotrauma, vol.17, issue.8, pp.695-711, 2000. ,
DOI : 10.1089/089771500415436
Anti-inflammatory and side effects of cyclooxygenase inhibitors, Pharmacol Rep, vol.59, pp.247-258, 2007. ,
15-Deoxy-??12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling, Biochemical Pharmacology, vol.82, issue.10, pp.1335-1351, 2011. ,
DOI : 10.1016/j.bcp.2011.07.100
A systematic review of brain injury epidemiology in Europe, Acta Neurochirurgica, vol.8, issue.s, pp.255-268, 2006. ,
DOI : 10.1007/s00701-005-0651-y
Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis, Journal of Biological Chemistry, vol.275, issue.42, pp.32775-32782, 2000. ,
DOI : 10.1074/jbc.M003504200
Assessment of coma and impaired consciousness. A practical scale, Lancet, vol.2, pp.81-84, 1974. ,
Cyclooxygenase-independent actions of cyclooxygenase inhibitors, The FASEB Journal, vol.15, issue.12, pp.2057-2072, 2001. ,
DOI : 10.1096/fj.01-0390rev
The Novel Nitric Oxide Synthase Inhibitor 4-amino-tetrahydro-L-biopterine Prevents Brain Edema Formation and Intracranial Hypertension following Traumatic Brain Injury in Mice, Journal of Neurotrauma, vol.26, issue.11, pp.1963-1975, 2009. ,
DOI : 10.1089/neu.2008.0853
The Anti-Inflammatory Drug Carprofen Improves Long-Term Outcome and Induces Gliogenesis after Traumatic Brain Injury, Journal of Neurotrauma, vol.29, issue.2, pp.375-384, 2012. ,
DOI : 10.1089/neu.2010.1673
Memory and anatomical change in severe non missile traumatic brain injury: ???1 vs. ???8years follow-up, Brain Research Bulletin, vol.87, issue.4-5, pp.373-382, 2012. ,
DOI : 10.1016/j.brainresbull.2012.01.008
Edema and brain trauma, Neuroscience, vol.129, issue.4, pp.1021-1029, 2004. ,
DOI : 10.1016/j.neuroscience.2004.06.046
The mechanism of action of aspirin, Thrombosis Research, vol.110, issue.5-6, pp.255-258, 2003. ,
DOI : 10.1016/S0049-3848(03)00379-7
CYCLOOXYGENASES 1 AND 2, Annual Review of Pharmacology and Toxicology, vol.38, issue.1, pp.97-120, 1998. ,
DOI : 10.1146/annurev.pharmtox.38.1.97
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs, Nature New Biology, vol.231, issue.25, pp.232-235, 1971. ,
DOI : 10.1038/newbio231232a0
Prostaglandins and cycloxygenases in the spinal cord, Progress in Neurobiology, vol.64, issue.4, pp.327-363, 2001. ,
DOI : 10.1016/S0301-0082(00)00063-0
Multifunctional drugs for head injury, Neurotherapeutics, vol.6, issue.Suppl 1, pp.28-42, 2009. ,
DOI : 10.1016/j.nurt.2008.10.036
A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors, Biochemical Journal, vol.357, issue.3, pp.709-718, 2001. ,
DOI : 10.1042/bj3570709
Experimental models of traumatic axonal injury, Journal of Clinical Neuroscience, vol.17, issue.2, pp.157-162, 2010. ,
DOI : 10.1016/j.jocn.2009.07.099
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos, Experimental Neurology, vol.218, issue.2, pp.193-202, 2009. ,
DOI : 10.1016/j.expneurol.2009.03.020
Levels after Traumatic Brain Injury, Journal of Neurotrauma, vol.25, issue.10, pp.1187-1194, 2008. ,
DOI : 10.1089/neu.2008.0542
Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?, Proceedings of the National Academy of Sciences, vol.99, issue.21, pp.13371-13373, 2002. ,
DOI : 10.1073/pnas.222543099
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis, Proceedings of the National Academy of Sciences, vol.96, issue.13, pp.7563-7568, 1999. ,
DOI : 10.1073/pnas.96.13.7563
Pathophysiology of traumatic brain injury, British Journal of Anaesthesia, vol.99, issue.1, pp.4-9, 2007. ,
DOI : 10.1093/bja/aem131
COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease, The Lancet, vol.355, issue.9204, pp.646-648, 2000. ,
DOI : 10.1016/S0140-6736(99)12031-2
Feasibility of the Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI) in Adults, Journal of Neurotrauma, vol.27, issue.6, pp.975-981, 2010. ,
DOI : 10.1089/neu.2009.1193
Structured Interviews for the Glasgow Outcome Scale and the Extended Glasgow Outcome Scale: Guidelines for Their Use, Journal of Neurotrauma, vol.15, issue.8, pp.573-585, 1998. ,
DOI : 10.1089/neu.1998.15.573
Aspirin and Salicylate : An Old Remedy With a New Twist, Circulation, vol.102, issue.17, pp.2022-2023, 2000. ,
DOI : 10.1161/01.CIR.102.17.2022
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing., Proceedings of the National Academy of Sciences, vol.88, issue.7, pp.2692-2696, 1991. ,
DOI : 10.1073/pnas.88.7.2692
Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate, Proceedings of the National Academy of Sciences, vol.96, issue.9, pp.5292-5297, 1999. ,
DOI : 10.1073/pnas.96.9.5292
The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity, Journal of Genetics and Genomics, vol.37, issue.2, pp.117-123, 2010. ,
DOI : 10.1016/S1673-8527(09)60030-8
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta, Nature, vol.396, pp.77-80, 1998. ,
Effects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in rats, Acta Anaesthesiologica Scandinavica, vol.98, issue.5, pp.658-663, 2008. ,
DOI : 10.1111/j.1399-6576.2008.01635.x
Soluble Epoxide Hydrolase: A Novel Therapeutic Target in Stroke, Journal of Cerebral Blood Flow & Metabolism, vol.25, issue.12, pp.1931-1940, 2007. ,
DOI : 10.1152/ajprenal.00165.2003
Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors, Neuroscience Letters, vol.363, issue.3, pp.247-251, 2004. ,
DOI : 10.1016/j.neulet.2004.03.088