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Role du striatum dans la perception temporelle via un modele rat transgenique de la maladie de huntington

Abstract : In order to assess the role of striatal plasticity in temporal perception, we have realized a behavioral and electrophysiological study of a transgenic rat model for Huntington’s disease that implicates progressive neurodegeneration of the striatum. For that purpose, we have done a longitudinal study (4-15 months) of Huntington’s disease at a motor, motivational and temporal level, and a presymptomatic study (4-5 months) of temporal estimation and of in vivo electrophysiological prefronto-striatal pathway. We have detected a dysfunction in temporal perception as well as an alteration of synaptic plasticity at a presymptomatic stage, suggesting the existence of a correlation between those two dysfunctions. At a symptomatic stage, the temporal discriminative behavior is deeply altered, correlating with striatum degeneration.
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Sophie Höhn. Role du striatum dans la perception temporelle via un modele rat transgenique de la maladie de huntington. Neurosciences [q-bio.NC]. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA11T076⟩. ⟨tel-00769407⟩

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