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Régulation des systèmes d'adhérence cellulaire par le CRF2 : un effecteur du stress dans le tube digestif

Abstract : Stress is involved in the initiation and the exacerbation of several diseases especially in the intestine. Stress effects depends on the expression of specific neuromediators (CRF) and there receptors. Our study is about regulation and function of the CRF2, a stress receptor expressed in human enterocytes and colorectal cancer cells. In vivo, we showed that stress and inflammation are responsible for the increased expression of the CRF2 in colon epithelial cells of rats. In tumors, the CRF2 expression is increased with the tumor. In vitro, in HT-29 cells, the CRF2 activation leads to the alteration of adherens junctions and focal adhesions by a Src/ERK/FAK pathway. These mechanisms are responsible for the regulation of epithelial cell permeability and the increased migration of tumor cells. This work contributes to the understanding of the pathways involved in the regulation of intestinal diseases by stress.
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https://tel.archives-ouvertes.fr/tel-00767103
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Submitted on : Wednesday, December 19, 2012 - 2:54:21 PM
Last modification on : Friday, November 6, 2020 - 3:51:40 AM
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  • HAL Id : tel-00767103, version 1

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Benjamin Ducarouge. Régulation des systèmes d'adhérence cellulaire par le CRF2 : un effecteur du stress dans le tube digestif. Sciences agricoles. Université de Grenoble, 2012. Français. ⟨NNT : 2012GRENV008⟩. ⟨tel-00767103⟩

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