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Theses

Ingénierie de fragments d'anticorps pour l'imagerie in vivo de cancers de la sphère génitale

Abstract : Prognosis of cancers dramatically improved with the development on the market of therapeutic antibodies. With the increase of these new biodrugs, associated with the identification of new biomarkers, new opportunities emerge for the in vivo molecular imaging.. Indeed, to use new molecular tracers specific of tumoral biomarkers will allow to study and characterize the cancer heterogeneity, to monitor the expression of these markers during the tumor evolution, but also to check the treatment effectiveness on patients’ tumoral regression. To answer this evolution of in vivo molecular diagnosis, it is favorable to develop new molecular probes. The aim of this thesis answers this new need with the engineering and labeling of a new recombinant antibody format suitable to in vivo imaging : the 12G4 diabody directed against the type II human receptor for the anti-Müllerian hormone, a biomarker of some cancers of the genital area.
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Submitted on : Wednesday, December 19, 2012 - 10:38:16 AM
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Céline Ortega. Ingénierie de fragments d'anticorps pour l'imagerie in vivo de cancers de la sphère génitale. Médecine humaine et pathologie. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA114849⟩. ⟨tel-00766847⟩

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