Skip to Main content Skip to Navigation
Theses

Prise en compte des erreurs de mesure dans l’analyse du risque associe a l’exposition aux rayonnements ionisants dans une cohorte professionnelle : application à la cohorte française des mineurs d'uranium

Abstract : In epidemiological studies, measurement errors in exposure can substantially bias the estimation of the risk associated to exposure. A broad variety of methods for measurement error correction has been developed, but they have been rarely applied in practice, probably because their ability to correct measurement error effects and their implementation are poorly understood. Another important reason is that many of the proposed correction methods require to know measurement errors characteristics (size, nature, structure and distribution).The aim of this thesis is to take into account measurement error in the analysis of risk of lung cancer death associated to radon exposure based on the French cohort of uranium miners. The mains stages were (1) to assess the characteristics (size, nature, structure and distribution) of measurement error in the French uranium miners cohort, (2) to investigate the impact of measurement error in radon exposure on the estimated excess relative risk (ERR) of lung cancer death associated to radon exposure, and (3) to compare the performance of methods for correction of these measurement error effects.The French cohort of uranium miners includes more than 5000 miners chronically exposed to radon with a follow-up duration of 30 years. Measurement errors have been characterized taking into account the evolution of uranium extraction methods and of radiation protection measures over time. A simulation study based on the French cohort of uranium miners has been carried out to investigate the effects of these measurement errors on the estimated ERR and to assess the performance of different methods for correcting these effects.Measurement error associated to radon exposure decreased over time, from more than 45% in the early 70’s to about 10% in the late 80’s. Its nature also changed over time from mostly Berkson to classical type from 1983. Simulation results showed that measurement error leads to an attenuation of the ERR towards the null, with substantial bias on ERR estimates in the order of 60%. All three error-correction methods allowed a noticeable but partial reduction of the attenuation bias. An advantage was observed for the simulation-extrapolation method (SIMEX) in our context, but the performance of the three correction methods highly depended on the accurate determination of the characteristics of measurement error.This work illustrates the importance of measurement error correction in order to obtain reliable estimates of the exposure-risk relationship between radon and lung cancer. Corrected risk estimates should prove of great interest in the elaboration of protection policies against radon in radioprotection and in public health.
Document type :
Theses
Complete list of metadatas

Cited literature [189 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00763492
Contributor : Abes Star :  Contact
Submitted on : Tuesday, December 11, 2012 - 1:02:01 AM
Last modification on : Friday, June 12, 2020 - 8:16:52 PM
Long-term archiving on: : Saturday, December 17, 2016 - 11:48:24 PM

File

VD_ALLODJI_RODRIGUE_09122011.p...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00763492, version 1

Collections

Citation

Setcheou Rodrigue Allodji. Prise en compte des erreurs de mesure dans l’analyse du risque associe a l’exposition aux rayonnements ionisants dans une cohorte professionnelle : application à la cohorte française des mineurs d'uranium. Médecine humaine et pathologie. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA11T092⟩. ⟨tel-00763492⟩

Share

Metrics

Record views

930

Files downloads

4847