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Etablissement des références nationales, en termes de dose absorbée, par calorimétrie dans l’eau, pour les faisceaux de rayons X de moyenne énergie, applicables en radiothérapie

Nicolas Perichon 1
1 LNHB - Laboratoire National Henri Becquerel
DM2I - Département Métrologie Instrumentation & Information : DRT/LIST/DM2I
Abstract : LNE-LNHB current references for medium energy X-rays are established in terms of air kerma. Absorbed dose to water, which is the quantity of interest for radiotherapy, is obtained by transfer dosimetric techniques following a methodology described in international protocols. The aim of the thesis is to establish standards in terms of absorbed dose to water in the reference protocol conditions by water calorimetry. The basic principle of water calorimetry is to measure the absorbed dose from the rise in temperature of water under irradiation. A calorimeter was developed to perform measurements at a 2 cm depth in water according to IAEA TRS-398 protocol for medium energy x-rays. Absorbed dose rates to water measured by calorimetry were compared to the values established using protocols based on references in terms of air kerma. A difference lower than 2.1% was reported. Standard uncertainty of water calorimetry being 0.8%, the one associated to the values from protocols being around 3.0%, results are consistent considering the uncertainties. Thanks to these new standards, it will be possible to use IAEA TRS-398 protocol to determine absorbed dose to water: a significant reduction of uncertainties is obtained (divided by 3 by comparison with the application of the IAEA TRS-277 protocol). Currently, none of the counterparts’ laboratories own such an instrument allowing direct determination of standards in the reference conditions recommended by the international radiotherapy protocols.
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Submitted on : Monday, December 10, 2012 - 3:42:11 PM
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Nicolas Perichon. Etablissement des références nationales, en termes de dose absorbée, par calorimétrie dans l’eau, pour les faisceaux de rayons X de moyenne énergie, applicables en radiothérapie. Physique Nucléaire Expérimentale [nucl-ex]. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA112153⟩. ⟨tel-00763348⟩

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