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Étude de l’influence des éléments transposables sur la régulation des gènes chez les mammifères

Hussein Mortada 1
1 Eléments transposables, évolution, populations
GINSENG - Département génétique, interactions et évolution des génomes [LBBE]
Abstract : Transposable elements are genomic sequences able to replicate themselves and to move within genomes. Their ability to integrate near genes and to produce chromosomal rearrangements by recombination between copies, make transposable elements mutagens. Moreover, transposable elements are able to alter the expression of neighboring genes through their promoter regions. Transposable elements form 45% of the human genome and may represent up to 90% of certain plant genomes. In the first part of my thesis, I examined the factors that determine the distribution of these elements. I have been interested in a particular factor, which is the function of the genes in the vicinity of transposable element insertions. In the second part, I determined the impact of epigenetic modifications alterations (histone modifications) in different gene components, including transposable elements, on the variation of gene expression in tumoral conditions.
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Hussein Mortada. Étude de l’influence des éléments transposables sur la régulation des gènes chez les mammifères. Sciences agricoles. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : 2011LYO10178⟩. ⟨tel-00753718⟩

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