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Synthesis of thermoresponsive copolymers by RAFT polymerization : characterization and study of their interaction with proteins

Abstract : The synthesis of well-defined azlactone-functionalized thermoresponsive copolymers was performed using the RAFT polymerization and their interaction with primary amines and proteins was studied. Three different strategies have been developed. The first strategy was based on the synthesis of a novel azlactone-functionalized chain transfer agent which was used to target well defined  azlactone-functionalized thermoresponsive polymers. In the second approach, ω-azlactone-terminated thermoresponsive copolymers were prepared by a combination of RAFT polymerization and “thiol ene” Michaël’s addition. In the last strategy, RAFT copolymerization of 2-vinyl-4,4 dimethylazlactone with other monomers has been performed to target well-defined azlactone functionalized copolymers. Finally, the reactivity of such reactive thermoresponsive copolymers was successfully demonstrated by bioconjugation with a model protein (lysozyme).
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Submitted on : Friday, November 16, 2012 - 4:17:14 PM
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The Hien Ho. Synthesis of thermoresponsive copolymers by RAFT polymerization : characterization and study of their interaction with proteins. Other. Université du Maine, 2012. English. ⟨NNT : 2012LEMA1013⟩. ⟨tel-00752921⟩

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