Abstract : DIAM (Dispositif d'Irradiation d'Agrégats Moléculaires) is a n ewly designed experimental setup to investigate processes resulting from the irradaition of molecular nano-systems by 20-150 keV protrons. One of its specificities relies on the original techique of mass spectrometry named COINTOF (Correlated Ion and Neutral Time of Flight) consisting in correlated measurments of the time of fkight of charged and neutral fragments produced by the dissociation of a single molecular ion parent. A strategy of treatment and analysis of the detection signals was developed to distinguish two fragments close in time (<1ns). The collected data are structured in the software ROOT for the statistical analysis of the correlations. The COINTOF technique is illustrated in the case of collision induced dissociation of protonated water clusters on atomic targets. The methodology of the analysis is explained through the study of dissociation channel of the protonated water trimer producing the charged fragment H3O+ and two water molecules. The distribution of the time of flight difference between the two neutral fragments is measured providing a,n estimate of the kinetic energy release of a few eV. In parallel, a second time-of-flight mass spectrometer was designed. It associated a linear time-of-flight and an orthogonal time-of-flight and integrates position detectors (delay line anode). Simulations demonstrate the potentials of the new analyzer. Finally, research works were led at the laboratory R.-J. A. Lévesque (Université de Montréal) on the imaging capabilities of the multi-pixel detectors of the MPX-ATLAS collaboration.